期刊
FISH & SHELLFISH IMMUNOLOGY
卷 67, 期 -, 页码 667-674出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2017.06.055
关键词
Common carp (Cyprinus carpio L.); XBP1; Innate immunity; Real-time RT-PCR
资金
- National Natural Science Foundation of China [31602186]
- Shandong Provincial Natural Foundation of China [ZR2014CZ004, ZR2014CQ051]
- University Independent Innovation Project of Jinan [200906020]
X box-binding protein-1 (XBP1) is a transcription factor that is essential for the unfolded protein response (UPR) and the differentiation of plasma cells, and some findings have also uncovered its function in innate immunity. XBP1 typically has two different transcripts, un-spliced (XBP1u) and spliced forms (XBP1s), but XBP1s is an active transcription factor in the regulation of target genes. To date, there is no evidence about the identification and function of XBP1 in common carp. Moreover, no data are currently available regarding the role of fish XBP1 in innate immunity. Thus, to determine whether XBP1 is involved in innate immune response in common carp, we cloned CcXBP1s and examined the expression of XBP1s and a XBP1s stimulated gene (IL-6) after Aeromonas hydrophila (A. hydrophila) and polyinosinic-polycytidylic acid (polyi:C) challenges. The results imply that CcMiPls, as an active transcription factor, might play regulation roles in the antibacterial and antiviral innate immune responses of common carp. This allows us to gain new insights into the immunological function of XBP1 in fish innate immunity and the evolution of this important class of genes across vertebrates. (C) 2017 Elsevier Ltd. All rights reserved.
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