Article
Immunology
Marina Saresella, Federica Piancone, Ivana Marventano, Ambra Hernis, Daria Trabattoni, Mattia Invernizzi, Francesca La Rosa, Mario Clerici
Summary: The study found that receiving the BNT162b2 vaccine significantly increased the number of inflammatory monocytes and various types of NK cells, as well as enhanced the production of interferon-gamma and the content of perforin and granzyme in NK cells. The vaccine also reduced the expression of the inhibitory receptor ILT-2 and increased the expression of the stimulatory molecule 2DS2. These effects were long-lasting and were further enhanced with each vaccine dose. It is worth noting that the reduction of ILT-2 expressing NK cells was more significant in individuals who had recovered from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yan Zhang, Ada W. C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G. E. Marsh, Robert Busch, Derek C. Macallan, Becca Asquith
Summary: Inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses and affect T cell lifespan. The iKIR-ligand genotype is significantly associated with CD8+ T cell lifespan, with individuals having 4 iKIR-ligand gene pairs having double the lifespan compared to individuals with 2 gene pairs. The iKIR-ligand genotype also alters the immune aging phenotype of CD8+ and CD4+ T cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Ye Li, Rafet Basar, Guohui Wang, Enli Liu, Judy S. Moyes, Li Li, Lucila N. Kerbauy, Nadima Uprety, Mohsen Fathi, Ali Rezvan, Pinaki P. Banerjee, Luis Muniz-Feliciano, Tamara J. Laskowski, Emily Ensley, May Daher, Mayra Shanley, Mayela Mendt, Sunil Acharya, Bin Liu, Alexander Biederstadt, Hind Rafei, Xingliang Guo, Luciana Melo Garcia, Paul Lin, Sonny Ang, David Marin, Ken Chen, Laura Bover, Richard E. Champlin, Navin Varadarajan, Elizabeth J. Shpall, Katayoun Rezvani
Summary: The activation of chimeric antigen receptor (CAR) in natural killer (NK) cells promotes the transfer of tumor-specific antigen from tumor cells to NK cells, resulting in decreased tumor antigen density and impaired CAR-NK cell targeting ability. This phenomenon can lead to self-recognition and continuous CAR-mediated engagement, causing cell death in NK cells expressing the trogocytic antigen (NKTROG+) and reduced NK cell responsiveness. However, a dual-CAR system that incorporates both an activating CAR against the tumor antigen and an inhibitory NK self-recognizing CAR can prevent trogocytic antigen-mediated cell death in NK cells, while maintaining activation signaling against the tumor antigen, thereby enhancing CAR-NK cell activity.
Article
Biochemistry & Molecular Biology
Lucas Henrique Rodrigues da Silva, Luana Correia Croda Catharino, Viviane Jennifer da Silva, Gabriela Coeli Menezes Evangelista, Jose Alexandre Marzagao Barbuto
Summary: Natural killer (NK) cells are innate lymphocytes that play a vital role in immune surveillance against tumors. Various NK-based therapies, including transfer of expanded and activated cells, genetic engineering, cytokine therapy, and tumor-specific antibody-guided cells, are being used in cancer treatment. This article also discusses the potential approaches to control glioblastoma.
Article
Immunology
Yu Zhang, Chenjing Ye, Haojie Zhu, Youran Zhuang, Shaozhen Chen, Yingxi Weng, Jinhua Ren, Xiaofeng Luo, Jing Zheng, Xiaoyun Zheng, Jing Li, Lingqiong Lan, Yongxin Xie, Zhongchao Han, Jianda Hu, Ting Yang
Summary: This study investigated the impact of KIR mismatch and KIR alleles on haplo-HSCT outcome in AML patients. The results showed that both KIR ligand mismatch (KLM) and KIR receptor-ligand mismatch (RLM) were associated with a decreased risk of aGVHD and relapse, as well as better overall survival. RLM was more accurate in predicting HSCT outcome than KLM. Patients with a higher number of donor activating KIRs (aKIR) had a lower incidence of aGVHD and relapse. RLM and a high number of donor aKIRs together provided a better donor selection strategy for improving haplo-HSCT outcome in AML patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Adele Dhuyser, Thomas Remen, Michael Peres, Vitalina Chamberlain-Evans, Neda Nemat-Gorgani, Arnaud Campidelli, Sandra Clement, Marie Therese Rubio, John Trowsdale, Alice Aarnink, James Traherne
Summary: This study compared the accuracy of different prediction models for NK cell alloreactivity in genoidentical and haploidentical donor-recipient pairs. The results showed significant variations among different models and correlations with the matching fashion. The study also identified a model strongly correlated with the incidence of acute graft-versus-host disease, indicating the importance of KIR-based alloreactivity. This research helps resolve discrepancies in KIR-based alloreactivity predictions and emphasizes the need for careful consideration of models in clinical studies and medical practice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Junqi Wang, Xiaolin Liu, Tianqiang Jin, Yuqing Cao, Yu Tian, Feng Xu
Summary: NK cells have potential in tumor immunotherapy, but their metabolism in the liver cancer microenvironment is not fully understood. The interaction between immune checkpoints and metabolic checkpoints in NK cells plays a role in their development and function. Understanding NK cell metabolic reprogramming is important for improving the efficacy of liver cancer therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Hematology
Xiang Wang, Xue-Fei Liu, Qian-Nan Shang, Xing-Xing Yu, Ze-Ying Fan, Xun-Hong Cao, Ming-Rui Huo, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiang-Yu Zhao
Summary: This study found that donors with activating KIR genes, specifically KIR2DS1, KIR2DS3, and KIR3DS1, were associated with an increased risk of EBV reactivation after HSCT. The risk was higher when the cognate ligands for the corresponding activating receptors were absent. Measures to prevent EBV reactivation in patients with donors carrying activating genes could improve patient prognosis after HSCT.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Obstetrics & Gynecology
Juliana Peron Gothe, Amilcar Castro de Mattos, Carolina Fernanda Silveira, Kelly Cristina Malavazi
Summary: Blastocyst nidation is a crucial stage for successful pregnancy, and the immune system may play a hostile role in the maternal-fetal interface. Natural killer cells, as the most abundant lymphocyte in the uterus, have immune surveillance during the implantation window. This review summarizes the main techniques used for natural killer cell testing in the implantation window and explores the relationship between NK cells and endometrial receptivity with reproductive failure.
REPRODUCTIVE SCIENCES
(2023)
Article
Immunology
Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold
Summary: During pregnancy, there are significant shifts in NK cell populations, with an increase in CD56(bright) NK cells and a decrease in CD56(dim) NK cells. These changes occur in both pregnant women with multiple sclerosis and healthy pregnant women, potentially contributing to disease amelioration in multiple sclerosis during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Evangelia Dounousi, Anila Duni, Katerina K. Naka, Georgios Vartholomatos, Carmine Zoccali
Summary: Adverse innate immune responses play a role in diseases such as cardiovascular disease and chronic kidney disease. Monocyte subsets are crucial in the inflammatory cascade in atherogenesis and heart failure. The roles of NK cells and NKT cells in advanced CKD require further clarification.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Review
Immunology
Eunju Shin, Seong Ho Bak, Taeho Park, Jin Woo Kim, Suk-Ran Yoon, Haiyoung Jung, Ji-Yoon Noh
Summary: Gene-engineered immune cell therapies, particularly using CAR-T cells, have significantly impacted cancer treatment. However, there are limitations in targeting a broader range of cancer types. NK cells, a type of innate immune cells, offer a unique biology and can be genetically engineered to serve as a source for immune cell therapies. NK cell-based therapies, including NK cells, CAR-NK cells, and antibodies stimulating NK cell cytotoxicity, have emerged as promising approaches for various cancers. This review provides an overview of NK cell characteristics and discusses diseases that could benefit from NK-based therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jei-Ming Peng, Ching-Feng Chiu, Jai-Hong Cheng, Hui-Ying Liu, Yin-Lun Chang, Jia-Wun Luo, Yu-Ting Weng, Hao-Lun Luo
Summary: Cancer cells resist immune cytotoxicity by upregulating vimentin and remodeling actin cytoskeleton when attacked by immune cells. The expression level of vimentin is correlated with natural killer cell infiltration, and this mechanism is observed in patient tumors, suggesting its potential application in evaluating immune response in clinical diagnosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hao Chi, Xixi Xie, Yingjie Yan, Gaoge Peng, Dorothee Franziska Strohmer, Guichuan Lai, Songyun Zhao, Zhijia Xia, Gang Tian
Summary: This study established a reliable signature based on genes related to NK cells in HNSCC, providing a new perspective for assessing immunotherapy response and prognosis. The 17-NRGs signature demonstrated excellent predictive performance and offered new perspectives for evaluating pre-immune efficacy, facilitating future precision immuno-oncology research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Aviad Ben-Shmuel, Batel Sabag, Guy Biber, Mira Barda-Saad
Summary: NK cells, as innate lymphoid cells, play essential roles in eliminating virally infected and malignant cells, with their immune response regulated by a balance of activating and inhibitory signals from surface receptors. The cytoskeleton is crucial for facilitating most NK cell effector functions, however, the exact mechanisms of how specific cytoskeletal architectures at the immunological synapse promote these functions and impact downstream signaling pathways remain unclear. Pioneering studies using advanced imaging techniques have begun to uncover the complexity of cytoskeletal organization dictating NK cell activation threshold, highlighting the significant role of cytoskeleton organization in NK cell function in health and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Brent M. Hanson, Julia G. Kim, Ashley W. Tiegs, Emily K. Osman, Shelby A. Neal, Ruth B. Lathi, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Emily K. Osman, Tianren Wang, Min Yang, Yiping Zhan, Caroline R. Juneau, Scott J. Morin, Emre Seli, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Amber M. Klimczak, Christine V. Whitehead, Shelby A. Neal, Ashley W. Tiegs, Emily K. Osman, Brent M. Hanson, Julia G. Kim, Marie D. Werner, Jason M. Franasiak, Richard Thomas Scott
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Brent M. Hanson, Julia G. Kim, Emily K. Osman, Ashley W. Tiegs, Shelby A. Neal, Ruth B. Lathi, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Emily K. Osman, Shelby A. Neal, Ashley W. Tiegs, Brent M. Hanson, Julia G. Kim, Jason M. Franasiak, Richard Thomas Scott
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Ashley W. Tiegs, Shelby A. Neal, Emily K. Osman, Julia G. Kim, Brent M. Hanson, Jason M. Franasiak, Richard Thomas Scott, Linnea R. Goodman
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Shelby A. Neal, Xin Tao, Li Sun, Brent M. Hanson, Julia G. Kim, Emily K. Osman, Ashley W. Tiegs, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Article
Obstetrics & Gynecology
Evelin E. Lara-Molina, Jason M. Franasiak, Diego Marin, Xin Tao, Patricia Diaz-Gimeno, Mireia Florensa, Marta Martin, Emre Seli, Antonio Pellicer
FERTILITY AND STERILITY
(2020)
Article
Genetics & Heredity
Katherine A. Green, George Patounakis, Michael P. Dougherty, Marie D. Werner, Richard T. Scott, Jason M. Franasiak
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Review
Obstetrics & Gynecology
Mauro Cozzolino, Jason Franasiak, Alessandra Andrisani, Guido Ambrosini, Amerigo Vitagliano
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2020)
Article
Genetics & Heredity
Andres Reig, Jason Franasiak, Richard T. Scott, Emre Seli
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Obstetrics & Gynecology
Amber M. Klimczak, Jason M. Franasiak
FERTILITY AND STERILITY
(2021)
Review
Obstetrics & Gynecology
Jason M. Franasiak, Diana Alecsandru, Eric J. Forman, Laura C. Gemmell, Jeffrey M. Goldberg, Natalia Llarena, Cheri Margolis, Joop Laven, Sam Schoenmakers, Emre Seli
Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Andres Reig, Jason M. Franasiak
FERTILITY AND STERILITY
(2022)