Review
Obstetrics & Gynecology
Sara E. Arian, Kamran Hessami, Ali Khatibi, Alvin K. To, Alireza A. Shamshirsaz, William Gibbons
Summary: This study investigated the impact of endometrial receptivity array (ERA) before frozen embryo transfer in patients undergoing in vitro fertilization (IVF). The results showed that the use of ERA did not significantly increase the success rate of IVF cycles, such as the live birth rate. The importance of ERA in improving the pregnancy rate is still unclear.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Wen-bi Zhang, Qing Li, Hu Liu, Wei-jian Chen, Chun-lei Zhang, He Li, Xiang Lu, Jun-ling Chen, Lu Li, Han Wu, Xiao-xi Sun
Summary: The study defined the transcriptomic signature of endometrial receptivity in Chinese women and developed a bioinformatic predictor for endometrial dating with high accuracy. This method can be used to monitor the window of implantation and predict the personal window of implantation for Chinese women, providing a new approach for evaluating endometrial status in this population.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Carrie Riestenberg, Lindsay Kroener, Molly Quinn, Kaycee Ching, Gayane Ambartsumyan
Summary: The study aimed to compare the live birth rate between patients undergoing ERA/pET and standard timing FET in first autologous single euploid programmed embryo transfer cycles. The findings do not support the routine use of ERA in an unselected patient population undergoing their first autologous single euploid programmed embryo transfer.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Laurentiu Craciunas, Oonagh Pickering, Justin Chu, Meenakshi Choudhary, Justina Zurauskiene, Arri Coomarasamy
Summary: This study characterized the endometrial transcriptomic profiles of women with recurrent miscarriage and aimed to develop an endometrial receptivity test for predicting subsequent pregnancy outcomes. Women with four or more miscarriages showed differential gene expression related to immunity, energy production, hormone secretion, adhesion, and cell proliferation. Women who achieved a subsequent live birth had enrichment of genes related to regulation of cell structure and proliferation, while those who suffered another miscarriage had enrichment of genes related to immunity, transmembrane transport, and coagulation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
E. Giacomini, G. M. Scotti, V. S. Vanni, D. Lazarevic, S. Makieva, L. Privitera, S. Signorelli, L. Cantone, V Bollati, V Murdica, G. Tonon, E. Papaleo, M. Candiani, P. Vigano
Summary: The transcriptomic cargo of UF-EVs reflects the RNA profile of the endometrial tissue as well as changes between the non-receptive and the receptive phase, supporting its use for a novel endometrial receptivity test. These findings suggest that UF-EVs could serve as a reservoir for potential less-invasive collection of receptivity markers, advancing the field of reproductive medicine with real-time monitoring of endometrial status.
HUMAN REPRODUCTION
(2021)
Article
Medicine, Research & Experimental
Aihua He, Yangyun Zou, Cheng Wan, Jing Zhao, Qiong Zhang, Zhongyuan Yao, Fen Tian, Hong Wu, Xi Huang, Jing Fu, Chunxu Hu, Yue Sun, Lan Xiao, Tianli Yang, Zhaojuan Hou, Xin Dong, Sijia Lu, Yanping Li
Summary: The study established an RNA-Seq-based endometrial receptivity test tool to accurately predict the window of implantation and significantly improve pregnancy outcomes in patients with repeated implantation failure (RIF), indicating the clinical potential of rsERT-guided personalized embryo transfer (pET).
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Iwona Sidorkiewicz, Maciej Jozwik, Angelika Buczynska, Anna Erol, Marcin Jozwik, Marcin Moniuszko, Katarzyna Jarzabek, Magdalena Niemira, Adam Kretowski
Summary: Aberrant metabolism has been identified as a main driver of cancer. In this study, transcriptomic profiles of metabolism-related pathways in endometrial cancer (EC) were established using NanoString nCounter Technology. 11 deregulated genes associated with 'central carbon metabolism in cancer' were identified, and drug repurposing validated several drug candidates. These findings have significant implications for personalized therapeutic strategies in EC.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Jigal Haas, Robert F. Casper
Summary: This brief review examines the investigation of the endometrial cavity before embryo transfer using various techniques, including hysteroscopy, endometrial biopsy, and ultrasound imaging. These investigative tools are currently controversial and require large prospective controlled trials for validation. Retained embryos during embryo transfer do not appear to have a negative impact on pregnancy outcome, and physical activity immediately after embryo transfer has no impact on pregnancy outcome, according to consistent data.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Rui Xiang, Peigen Chen, Zhi Zeng, Huijun Liu, Juan Zhou, Chuanchuan Zhou, Jintao Peng, Haitao Zeng
Summary: This study analyzed the transcriptomic data of the secretory eutopic endometrium in patients with endometriosis after surgery. The results showed that surgical treatment of endometriosis influences genes and biological processes related to endometrial receptivity, but more evidence is needed to support these findings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Antonio Parraga-Leo, Patricia Sebastian-Leon, Almudena Devesa-Peiro, Diana Marti-Garcia, Nuria Pellicer, Jose Remohi, Francisco Dominguez, Patricia Diaz-Gimeno
Summary: This study reveals novel hormonal and non-hormonal regulators and their relative contributions to endometrial progression and pathology, providing new leads for the potential causes of endometrial-factor infertility.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Youwen Mei, Yacong Wang, Xue Ke, Xuefei Liang, Yonghong Lin, Fang Wang
Summary: Endometrial receptivity array (ERA), a promising test for improving reproductive outcomes, shows controversial effectiveness in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Zhi Wang, Kexin Nie, Hao Su, Yueheng Tang, Hongzhan Wang, Xiaohu Xu, Hui Dong
Summary: Berberine could improve ovulation in PCOS by reducing the number of cystic follicles, lowering serum luteinizing hormone and total cholesterol levels, and improving glucolipid metabolism, possibly through up-regulating LHCGR and CYP19A1. In addition, berberine could enhance endometrial receptivity by down-regulating alpha v beta 3 and LPAR3.
Article
Biochemistry & Molecular Biology
Diqi Yang, Ai Liu, Yanyan Zhang, Sha Nan, Ruiling Yin, Qianghui Lei, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: This study demonstrated the role of CRIM1 in regulating endometrial receptivity in goats, affecting cell proliferation, adhesion, and PG secretion, providing a new target for diagnosing and treating early pregnancy failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Roland Takacs, Judit Vago, Szilard Poliska, Peter Natesan Pushparaj, Laszlo Ducza, Patrik Kovacs, Eun-Jung Jin, Richard Barrett-Jolley, Roza Zakany, Csaba Matta
Summary: Chondrogenesis is a complex process involving the differentiation of cartilage progenitor cells. In this study, the researchers used RNA sequencing to investigate the gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. They identified differentially expressed genes and confirmed their involvement in chondrogenic differentiation. Transient gene silencing experiments revealed the role of ATOH8 and EBF1 in regulating key osteochondrogenic marker genes during chondrogenesis. These findings provide a comprehensive understanding of the molecular mechanism of chondrogenesis and offer new insights for cartilage tissue engineering.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amber Rose Hart, Norhayati Liaqat Ali Khan, Keerthie Dissanayake, Kasun Godakumara, Aneta Andronowska, Saji Eapen, Paul R. Heath, Alireza Fazeli
Summary: Successful embryo implantation and endometrial receptivity require communication between the embryo and the maternal endometrium, which is facilitated by extracellular vehicles (EVs). This study investigated the influence of menstrual cycle hormones (estrogen, progesterone, and estrogen plus progesterone) on endometrial-derived EVs. The results showed that hormonal stimulation affected the size and proteome of EVs, with proteins involved in embryo implantation, endometrial receptivity, and embryo development being enhanced in the EVs from the receptive phase (estrogen plus progesterone). This supports the concept of EV-mediated communication between the embryo and the maternal endometrium.
Review
Obstetrics & Gynecology
Gustavo N. Cecchino, Juan A. Garcia-Velasco
FERTILITY AND STERILITY
(2019)
Article
Obstetrics & Gynecology
Mauro Cozzolino, Maria Cruz, Azadeh Patel, Jayesh Patel, Alberto Pacheco, Juan Antonio Garcia-Velasco
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Obstetrics & Gynecology
D. Alecsandru, A. Pacheco, A. Guerrero-Mayo, A. Fabris, P. Aparicio, A. Barrio, A. Pellicer, Juan A. Garcia-Velasco
REPRODUCTIVE BIOMEDICINE ONLINE
(2020)
Article
Immunology
Diana Alecsandru, Natalia Lopez-Palacios, Mercedes Castano, Pilar Aparicio, Juan Antonio Garcia-Velasco, Concepcion Nunez
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Obstetrics & Gynecology
Sergio Reis Soares, Maria Cruz, Vanessa Vergara, Antonio Requena, Juan Antonio Garcia-Velasco
HUMAN REPRODUCTION
(2019)
Article
Environmental Sciences
Diana C. Santa-Cruz, Rafael A. Caparros-Gonzalez, Borja Romero-Gonzalez, Maria Isabel Peralta-Ramirez, Raquel Gonzalez-Perez, Juan Antonio Garcia-Velasco
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Medicine, General & Internal
Justin Tan, Maria Cerrillo, Maria Cruz, Gustavo Nardini Cecchino, Juan Antonio Garcia-Velasco
Summary: This study compared IVF outcomes in women with endometriosis undergoing fresh ET versus deferred ET after cryopreservation, finding no significant differences in patient characteristics and response to stimulation between the two groups. There were also no significant differences in implantation rate, clinical pregnancy rate, and miscarriage rate between fresh and deferred ET groups. Prospective studies are needed to further validate these findings and improve IVF protocols for women with endometriosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Alberto Pacheco, Arancha Blanco, Fernando Bronet, Maria Cruz, Jaime Garcia-Fernandez, Juan Antonio Garcia-Velasco
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biology
Cristina Rodriguez-Varela, Giulia Mariani, Pilar Dolz, Juan Antonio Garcia-Velasco, Vicente Serra, Antonio Pellicer, Elena Labarta
Summary: The COVID-19 pandemic has had an impact on infertility treatments, resulting in a reduction in the total number of treatments performed but not significantly affecting pregnancy rates. The psychological status of pregnant women did not seem to affect their final pregnancy outcome.
Review
Nutrition & Dietetics
Ana Arnanz, Juan A. Garcia-Velasco, Jose Luis Neyro
Summary: The vitamin D endocrine system plays a crucial role in human fertility, and its deficiency can be related to various reproductive issues. This deficiency has been linked to in vitro fertilization outcomes, ovarian reserve and fertility, and endocrine disorders such as polycystic ovary disease. It may also be associated with uterine fibroids and pregnancy-related complications. The optimal dose of vitamin D supplementation for infertility or during pregnancy is still uncertain, and further clinical studies are needed to determine its benefits and appropriate dosage.
Editorial Material
Obstetrics & Gynecology
Juan A. Garcia-Velasco
FERTILITY AND STERILITY
(2022)
Letter
Obstetrics & Gynecology
Filippo Maria Ubaldi, Alberto Vaiarelli, Danilo Cimadomo, Maria Cerrillo, Laura Rienzi, Juan A. Garcia-Velasco
HUMAN REPRODUCTION
(2023)
Letter
Obstetrics & Gynecology
Juan A. Garcia-Velasco, Danilo Cimadomo, Maria Cerrillo, Alberto Vaiarelli, Filippo Maria Ubaldi
HUMAN REPRODUCTION
(2023)
Article
Biology
A. M. Portillo, E. Varela, J. A. Garcia-Velasco
Summary: This paper proposes a discrete model for the temporal evolution of a population of cells sorted according to their telomeric length. The model assumes asymmetric distribution of genetic material during cell division, with one daughter cell having the same telomere length as the mother and the other having shorter telomeres. The model takes into account telomerase activity, cell death, and the Hayflick limit. A partial differential equation with boundary conditions is derived to represent the continuous model. The model is applied to study the aging rate of human follicular growth.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Barbara Herranz-Blanco, Elza Daoud, Paola Vigano, Juan Antonio Garcia-Velasco, Enrico Colli
Summary: Endometriosis affects more than 10% of women of reproductive age and significantly impacts their quality of life. Diagnosis often takes several years due to the invasive nature of the gold standard diagnostic method, laparoscopy. Two studies were conducted to develop a diagnostic test combining serum biomarkers and clinical variables, resulting in a specific and accurate test for early disease identification.
