Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2fromMycobacterium tuberculosis

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

(2016) Daniel T. Hoagland et al.   ADVANCED DRUG DELIVERY REVIEWS

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

(2016) Ekaterina V. Filippova et al.   FEBS Journal

Non-classical transpeptidases yield insight into new antibacterials

(2016) Pankaj Kumar et al.   Nature Chemical Biology

Assembly of the Mycobacterial Cell Wall

(2015) Monika Jankute et al.   Annual Review of Microbiology

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants

(2014) Adam B. Shapiro et al.   ANALYTICAL BIOCHEMISTRY

A fluorescent carbapenem for structure function studies of penicillin-binding proteins, β-lactamases, and β-lactam sensors

(2014) Cynthia M. June et al.   ANALYTICAL BIOCHEMISTRY

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable β-Lactam Antibiotic

(2014) Neeraj Dhar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nonclassical Transpeptidases of Mycobacterium tuberculosis Alter Cell Size, Morphology, the Cytosolic Matrix, Protein Localization, Virulence, and Resistance to  -Lactams

(2014) M. K. Schoonmaker et al.   JOURNAL OF BACTERIOLOGY

Genetic characterization of mycobacterial L,D-transpeptidases

(2014) A. N. Sanders et al.   MICROBIOLOGY-SGM

Structure of LdtMt2, anL,D-transpeptidase fromMycobacterium tuberculosis

(2013) Dominic Böth et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural basis for the inhibition ofMycobacterium tuberculosisL,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

(2013) Hyoun Sook Kim et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structures of free and inhibited forms of theL,D-transpeptidase LdtMt1fromMycobacterium tuberculosis

(2013) Stefania Correale et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3

(2013) Adam B. Shapiro et al.   ANALYTICAL BIOCHEMISTRY

T Cell–Mediated Host Immune Defenses in the Lung

(2013) Kong Chen et al.   Annual Review of Immunology

In VitroCross-Linking of Mycobacterium tuberculosis Peptidoglycan by l,d-Transpeptidases and Inactivation of These Enzymes by Carbapenems

(2013) Mathilde Cordillot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis

(2013) Wen-Juan Li et al.   CELL RESEARCH

Key Targets and Relevant Inhibitors for the Drug Discovery of Tuberculosis

(2013) Xiuming Xiong et al.   CURRENT DRUG TARGETS

Kinetic Analysis of Enterococcus faecium l,d-Transpeptidase Inactivation by Carbapenems

(2012) Vincent Dubée et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo

(2012) Kathleen England et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1by Carbapenems and Cephalosporins

(2012) Vincent Dubée et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy and safety of meropenem–clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB

(2012) Saverio De Lorenzo et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis [Case study]

(2012) M. C. Payen et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Meropenem inhibits D,D-carboxypeptidase activity inMycobacterium tuberculosis

(2012) Pradeep Kumar et al.   MOLECULAR MICROBIOLOGY

Dynamics Induced by β-Lactam Antibiotics in the Active Site of Bacillus subtilis l,d-Transpeptidase

(2012) Lauriane Lecoq et al.   STRUCTURE

Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2

(2012) Sabri B. Erdemli et al.   STRUCTURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New tuberculosis drugs on the horizon

(2011) Stewart T Cole et al.   CURRENT OPINION IN MICROBIOLOGY

Meropenem/Clavulanate and Linezolid Treatment for Extensively Drug-resistant Tuberculosis

(2011) Nicolas Dauby et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation

(2008) M. Lavollay et al.   JOURNAL OF BACTERIOLOGY