PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production

Guillain-Barré syndrome

(2016) Hugh J Willison et al.   LANCET

Are Th17 cells and their cytokines a therapeutic target in Guillain–Barré syndrome?

(2015) Xiujuan Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells

(2015) Hiroaki Kimura et al.   Journal of Immunology Research

Coactivator MYST1 Regulates Nuclear Factor-κB and Androgen Receptor Functions During Proliferation of Prostate Cancer Cells

(2014) Anbalagan Jaganathan et al.   MOLECULAR ENDOCRINOLOGY

Mitigated Tregs and Augmented Th17 Cells and Cytokines are Associated with Severity of Experimental Autoimmune Neuritis

(2014) X. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Assembly of the 20S proteasome

(2013) Mary J. Kunjappu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Th1/Th2/Th17/Treg cytokines in Guillain–Barré syndrome and experimental autoimmune neuritis

(2013) Hong-Liang Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Glatiramer acetate ameliorates experimental autoimmune neuritis

(2013) Cun-Jin Zhang et al.   IMMUNOLOGY AND CELL BIOLOGY

Diagnosis, treatment and prognosis of Guillain-Barré syndrome (GBS)

(2013) Pieter A. van Doorn   PRESSE MEDICALE

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice

(2012) Y. Nagayama et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The immunoproteasome in antigen processing and other immunological functions

(2012) Michael Basler et al.   CURRENT OPINION IN IMMUNOLOGY

Th17 helper cell and T-cell immunoglobulin and mucin domain 3 involvement in Guillain–Barré syndrome

(2012) Song-lan Liang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

How does adaptation sweep through the genome? Insights from long-term selection experiments

(2012) M. K. Burke   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

The role of cytokines in Guillain–Barré syndrome

(2010) Ming-Ou Lu et al.   JOURNAL OF NEUROLOGY

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

FTY720 attenuates lesional interleukin-17+cell accumulation in rat experimental autoimmune neuritis

(2009) Z-Y. Zhang et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Bortezomib in the front-line treatment of multiple myeloma

(2008) Paul G Richardson et al.   Expert Review of Anticancer Therapy