Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries

Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury

(2016) Robert D. Welch et al.   JOURNAL OF NEUROTRAUMA

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy

(2016) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury

(2016) Jussi P. Posti et al.   NEUROSURGERY

Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest

(2016) Ericka L. Fink et al.   RESUSCITATION

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

(2016) Linda Papa et al.   JAMA Neurology

WP1130 increases doxorubicin sensitivity in hepatocellular carcinoma cells through usp9x-dependent p53 degradation

(2015) Hao Liu et al.   CANCER LETTERS

Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid

(2015) Hongyan Lv et al.   CLINICA CHIMICA ACTA

Serum UCH-L1 as a Novel Biomarker to Predict Neuronal Apoptosis Following Deep Hypothermic Circulatory Arrest

(2015) Ya-Ping Zhang et al.   International Journal of Medical Sciences

S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells

(2015) Takashi Toyama et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Acute Diagnostic Biomarkers for Spinal Cord Injury: Review of the Literature and Preliminary Research Report

(2015) Shoji Yokobori et al.   World Neurosurgery

The Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) C Terminus Plays a Key Role in Protein Stability, but Its Farnesylation Is Not Required for Membrane Association in Primary Neurons

(2014) Paul Bishop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function

(2014) Viorica Raluca Contu et al.   JOURNAL OF NEUROCHEMISTRY

GFAP Out-Performs S100β in Detecting Traumatic Intracranial Lesions on Computed Tomography in Trauma Patients with Mild Traumatic Brain Injury and Those with Extracranial Lesions

(2014) Linda Papa et al.   JOURNAL OF NEUROTRAUMA

Biomarkers Improve Clinical Outcome Predictors of Mortality Following Non-Penetrating Severe Traumatic Brain Injury

(2014) Linda Papa et al.   Neurocritical Care

Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

(2014) Dang Suong et al.   PROTEIN AND PEPTIDE LETTERS

Rapid Accumulation of Endogenous Tau Oligomers in a Rat Model of Traumatic Brain Injury

(2013) Bridget E. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers Track Damage after Graded Injury Severity in a Rat Model of Penetrating Brain Injury

(2013) J. Susie Zoltewicz et al.   JOURNAL OF NEUROTRAUMA

Experimental Traumatic Brain Injury Induces Rapid Aggregation and Oligomerization of Amyloid-Beta in an Alzheimer's Disease Mouse Model

(2013) Patricia M. Washington et al.   JOURNAL OF NEUROTRAUMA

Acute Biomarkers of Traumatic Brain Injury: Relationship between Plasma Levels of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein

(2013) Ramon Diaz-Arrastia et al.   JOURNAL OF NEUROTRAUMA

Traumatic Brain Injury Precipitates Cognitive Impairment and Extracellular Aβ Aggregation in Alzheimer's Disease Transgenic Mice

(2013) Naoki Tajiri et al.   PLoS One

Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?

(2013) Margarida V. Caldeira et al.   PROGRESS IN NEUROBIOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

(2012) Christopher W. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure

(2012) Stefania Mondello et al.   BMC Neurology

Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure

(2012) Yajun Li et al.   EPILEPSY RESEARCH

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Identification of tyrosine nitration in UCH-L1 and GAPDH

(2011) Joy D. Guingab-Cagmat et al.   ELECTROPHORESIS

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

(2011) Tushar K. Maiti et al.   FEBS Journal

Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and αII-Spectrin Breakdown Product 145 kDa Correlate with Outcome after Pediatric TBI

(2011) Rachel P. Berger et al.   JOURNAL OF NEUROTRAUMA

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest

(2011) George J. Arnaoutakis et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

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(2011) Hannelore Ehrenreich et al.   MOLECULAR MEDICINE

Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats

(2010) Ming C. Liu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Degrasyn Potentiates the Antitumor Effects of Bortezomib in Mantle Cell Lymphoma Cells In vitro and In vivo: Therapeutic Implications

(2010) L. V. Pham et al.   MOLECULAR CANCER THERAPEUTICS

A Pilot Study of Novel Biomarkers in Neonates With Hypoxic-Ischemic Encephalopathy

(2010) Martha Douglas-Escobar et al.   PEDIATRIC RESEARCH

Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1

(2010) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation

(2010) D. A. Boudreaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*

(2009) Linda Papa et al.   CRITICAL CARE MEDICINE

Anti-protein aggregation is a potential target for preventing delayed neuronal death after transient ischemia

(2009) Pengfei Ge et al.   MEDICAL HYPOTHESES

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

Cytosolic O-glycosylation is abundant in nerve terminals

(2003) Robert N. Cole et al.   JOURNAL OF NEUROCHEMISTRY