Genotoxicity testing: progress and prospects for the next decade

Main issues addressed in the 2014-2015 revisions to the OECD Genetic Toxicology Test Guidelines

(2017) Veronique Thybaud et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Applications of chemogenomic library screening in drug discovery

(2017) Lyn H. Jones et al.   NATURE REVIEWS DRUG DISCOVERY

New future of cell biology and toxicology: thinking deeper

(2016) Jianying Gu et al.   CELL BIOLOGY AND TOXICOLOGY

Biomonitoring of humans exposed to arsenic, chromium, nickel, vanadium, and complex mixtures of metals by using the micronucleus test in lymphocytes

(2016) Balasubramanyam Annangi et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: Past, present and future

(2016) Armen Nersesyan et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead

(2016) Laetitia Gonzalez et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

New Quantitative Structure–Activity Relationship Models Improve Predictability of Ames Mutagenicity for Aromatic Azo Compounds

(2016) Serena Manganelli et al.   TOXICOLOGICAL SCIENCES

DNA Damage Response and Immune Defense: Links and Mechanisms

(2016) Rania Nakad et al.   Frontiers in Genetics

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

(2015) Jellert T. Gaublomme et al.   CELL

Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research

(2015) Gill Langley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

CETSA: a target engagement assay with potential to transform drug discovery

(2015) Annika Jenmalm Jensen et al.   Future Medicinal Chemistry

Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays☆

(2015) Carole L. Yauk et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

(2015) Ralph E Kleiner et al.   Nature Chemical Biology

Functional genomics to uncover drug mechanism of action

(2015) Sebastian M B Nijman   Nature Chemical Biology

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

High-Throughput In Vivo Genotoxicity Testing: An Automated Readout System for the Somatic Mutation and Recombination Test (SMART)

(2015) Benoit Lombardot et al.   PLoS One

Investigating the Different Mechanisms of Genotoxic and Non-Genotoxic Carcinogens by a Gene Set Analysis

(2014) Won Jun Lee et al.   PLoS One

Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century

(2014) Erwin van Vliet   ALTEX-Alternatives to Animal Experimentation

Metabolomics in toxicology and preclinical research

(2014) Tzutzuy Ramirez   ALTEX-Alternatives to Animal Experimentation

Composition and applications of focus libraries to phenotypic assays

(2014) Anne Mai Wassermann et al.   Frontiers in Pharmacology

Evaluation of cytotoxic, oxidative stress and genotoxic responses of hydroxyapatite nanoparticles on human blood cells

(2013) Hasan Turkez et al.   JOURNAL OF APPLIED TOXICOLOGY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis

(2013) Seul Ji Lee et al.   Scientific Reports

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

(2012) Hasan Turkez et al.   CYTOTECHNOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Genetic toxicology in the 21st century: Reflections and future directions

(2011) Brinda Mahadevan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Improvements in the reliability ofin vitrogenotoxicity testing

(2011) David Kirkland   Expert Opinion on Drug Metabolism & Toxicology

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

(2011) S. Creton et al.   MUTAGENESIS

Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver

(2011) Hasan Türkez et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action

(2010) John R. Ridpath et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

THE LYMPHOCYTE CYTOKINESIS-BLOCK MICRONUCLEUS CYTOME ASSAY AND ITS APPLICATION IN RADIATION BIODOSIMETRY

(2010) Michael Fenech   HEALTH PHYSICS

Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing

(2010) James M. Parry et al.   MUTAGENESIS

Strategies in case of positive in vivo results in genotoxicity testing

(2010) Véronique Thybaud et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity

(2010) Ahmed M. Osman et al.   REPRODUCTIVE TOXICOLOGY

Omics in mechanistic and predictive toxicology

(2010) Seema Singh et al.   TOXICOLOGY MECHANISMS AND METHODS

Fluorescence in situ hybridization in combination with the comet assay and micronucleus test in genetic toxicology

(2010) Galina G Hovhannisyan   Molecular Cytogenetics

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

(2008) Shixuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

(2008) S. Bonassi et al.   CARCINOGENESIS

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Daniel Krewski et al.   RISK ANALYSIS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Proteomics and human embryonic stem cells

(2008) Dennis Van Hoof et al.   Stem Cell Research