期刊
EXPERIMENTAL PARASITOLOGY
卷 178, 期 -, 页码 30-36出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2017.05.003
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资金
- Canadian Institutes for Health Research [320382, MOP130369]
- Canada Research Chairs, Canadian Natural Sciences and Engineering Research Council
- Centre for Host-Parasite Interactions (Fonds de Recherche du Quebec - Nature et Technologies)
- European Research Council [ERC-2013-CoG 614739-A_HERO]
To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized the excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed by mass spectrometry. Fourteen miRNAs were identified in T muris exosome-like vesicles, as well as 73 proteins of nematode origin, 11 of which were unique to this study. Comparison with published nematode protein secretomes revealed high conservation at the functional level. (C) 2017 Elsevier Inc. All rights reserved.
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