Article
Multidisciplinary Sciences
Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe, L. David Sibley
Summary: The study revealed that the protein TgIST from Toxoplasma gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface, thus inhibiting the expression of immunity genes.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Nicholas Rinkenberger, Michael E. Abrams, Sumit K. Matta, John W. Schoggins, Neal M. Alto, L. David Sibley
Summary: The study investigated the role of IFN gamma-induced ISGs in restricting Toxoplasma gondii infection, and identified RARRES3 as a novel factor restricting parasite infection. The limited number of ISGs capable of restricting T. gondii infection when individually expressed suggests that IFN gamma-mediated immunity to T. gondii infection is a complex, multifactorial process.
Article
Endocrinology & Metabolism
Gao Chen, Shu-Shu Liu, Meng-Zheng Wu, Chun-Jun Qin, Fei-Fei Liu, Jian-Ying Liu, Li Liu
Summary: By detecting serum TB-IGRA and pleural effusion TB-RNA in patients with tuberculous pleural effusion, it was found that the combined use of TB-IGRA and TB-RNA has high sensitivity, specificity, and accuracy in the diagnosis of tuberculous pleural effusion, and can prevent some missed diagnoses of complicated pleural effusion.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Parasitology
Long Cheng, Sajid Ur Rahman, Hai-Yan Gong, Rong-Sheng Mi, Yan Huang, Yan Zhang, Ju-Liang Qin, Cheng-Cong Yin, Min Qian, Zhao-Guo Chen
Summary: A new mouse model for Toxoplasma pneumonia was established in this study, and transcriptome analysis revealed the molecular mechanisms of the disease. The infected mice showed symptoms such as weight loss, ruffled fur, and respiratory crackles, and lung tissue sections exhibited severe lymphocytic infiltration, pulmonary edema, and typical symptoms of pneumonia. Transcriptome analysis also identified differentially expressed genes associated with the immune system and microbial infections.
PARASITES & VECTORS
(2023)
Article
Cell Biology
Joseph T. Clark, Orr-El Weizman, Daniel L. Aldridge, Lindsey A. Shallberg, Julia Eberhard, Zachary Lanzar, Devon Wasche, John D. Huck, Ting Zhou, Aaron M. Ring, Christopher A. Hunter
Summary: IL-18 promotes IFN-g production by NK and T cells, which is important for resistance to T. gondii infection. However, endogenous IL-18 has a limited role in controlling this parasite. High levels of IL-18BP, induced by IFN-g, inhibit IL-18 activity. Blocking IL-18BP using a decoy IL-18 construct enhances immune responses and improves parasite control. This study highlights strategies for modulating the IL-18 regulatory pathway for optimal anti-pathogen responses.
Review
Infectious Diseases
Hao Chen, Atsushi Nakagawa, Mikio Takamori, Seitarou Abe, Daisuke Ueno, Nobuyuki Horita, Seiya Kato, Nobuhiko Seki
Summary: This study evaluated the diagnostic accuracy of IGRA in the diagnosis of tuberculosis in people living with HIV. The results showed that IGRA was useful in diagnosing tuberculosis in this population, with QFT performing better than T-SPOT.
Review
Immunology
Chi Eun Oh, Edgar Ortiz-Brizuela, Mayara L. Bastos, Dick Menzies
Summary: The study compared QuantiFERON-TB Gold Plus (QFT-Plus) with QuantiFERON-TB Gold In-Tube (QFT-GIT) in terms of sensitivity and specificity in patients with active tuberculosis and healthy individuals at low risk of LTBI, showing no significant differences between the two tests. The agreement and reproducibility of QFT-Plus were similar to QFT-GIT, indicating the need for further research on its performance in immunocompromised patients and children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Jidong Guo, Qiang Li, Xuxia Zhang, Cong Yao, Rongmei Liu, Yu Pang, Mengqiu Gao
Summary: The study identified that increased IL-10 secretion by PBMCs is inversely correlated with IGRA assay results. Glucocorticoids use and extrapulmonary TB were significantly associated with false-negative IGRA results. Combination testing to measure IL-10 secretion and IFN-gamma release is recommended for improved IGRAs specificity.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Laure Burguet, Alexandre Duvignaud, Duc Nguyen, Marie-Catherine Receveur, Hannah Kaminski, Isabelle Pellegrin, Anne-Marie Rogues, Olivia Peuchant, Karine Moreau, Pierre Merville, Lionel Couzi
Summary: This study describes the investigation, follow-up, management, and outcomes in a cohort of chronic kidney disease (CKD) and kidney transplant recipients (KTR) exposed to a case of pulmonary tuberculosis (TB). The findings suggest that latent TB treatment may be reasonably avoided in vulnerable high-priority contacts with a negative interferon gamma release assay and in countries with low TB prevalence. No incident cases of TB disease occurred.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Public, Environmental & Occupational Health
Yiyun Ma, Yuni Xu, Xiaoqiang Cao, Xiaojuan Chen, Yeteng Zhong
Summary: This study systematically reviewed the diagnostic value of IGRA in HIV-infected individuals with active tuberculosis, finding that it has good diagnostic value and can aid in the screening of the disease. Its diagnostic effectiveness can be improved by modifying and optimizing the assay design.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Biology
Joseph T. Clark, David A. Christian, Jodi A. Gullicksrud, Joseph A. Perry, Jeongho Park, Maxime Jacquet, James C. Tarrant, Enrico Radaelli, Jonathan Silver, Christopher A. Hunter
Summary: IL-33 plays a crucial role in resistance to the parasite Toxoplasma gondii by promoting innate immune responses. IL-33 acts in synergy with IL-12 to enhance ILC-mediated resistance to T. gondii.
Article
Immunology
Rachiel Gumbo, Wynand J. Goosen, Peter E. Buss, Lin-Mari de Klerk-Lorist, Konstantin Lyashchenko, Robin M. Warren, Paul D. van Helden, Michele A. Miller, Tanya J. Kerr
Summary: This study aimed to evaluate the available immunological assays for detecting Mycobacterium bovis infection in leopards. The results showed that immunoassays and the tuberculin skin test may be potential tools for identifying infected leopards. The GeneXpert (R) assay provided a rapid and direct method for detecting infected leopards.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rachiel Gumbo, Tashnica T. T. Sylvester, Sven D. C. Parsons, Peter E. E. Buss, Robin M. M. Warren, Paul D. D. van Helden, Michele A. A. Miller, Tanya J. J. Kerr
Summary: Gwadar Peninsula, located in the south of Gwadar city in Balochistan, Pakistan, is an important geographical location connecting Central Asia and the Middle East, and it is a crucial part of the China-Pakistan Economic Corridor. In recent years, Gwadar Peninsula has experienced rapid economic growth and is expected to become an important engine for Pakistan's economic development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Ao Cheng, Huanan Zhang, Baike Chen, Shengyao Zheng, Hongyi Wang, Yijia Shi, Siyao You, Ming Li, Liping Jiang
Summary: Toxoplasma gondii infection is a severe global health threat. By promoting host cell autophagy or attenuating the inhibition of autophagic targeting, novel therapeutic strategies against T. gondii can be developed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Kathryn Winglee, Andrew N. Hill, Robert Belknap, Jason E. Stout, Tracy L. Ayers
Summary: Interferon-gamma release assays are important diagnostic tools for tuberculosis infection, but there has been little research on their performance in populations prioritized for tuberculosis testing in the United States. This study found that there is a certain degree of discordance and variability in the results of the QFT and TSPOT tests.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Virology
Nasrin Keshavarz Valian, Babak Pourakbari, Kosar Asna Ashari, Reihaneh Hosseinpour Sadeghi, Shima Mahmoudi
Summary: This study evaluated the frequency and coinfection rate of HCoV-OC43 in the current COVID-19 pandemic, finding that both HCoV-OC43 and SARS-COV-2 had similar occurrence rates in children with respiratory symptoms. Patients with HCoV-OC43 had significantly lower median lymphocyte counts compared to those with SARS-COV-2 infection. Further research on the cocirculation of these coronaviruses in different regions is recommended.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Mehrnoush Afsharipour, Shima Mahmoudi, Hojatollahh Raji, Babak Pourakbari, Setareh Mamishi
Summary: This study evaluated the prevalence and antimicrobial susceptibility of nosocomial infections (NIs) in an Iranian referral pediatrics hospital over a 3-year period. The study found a concerning high frequency of antimicrobial resistance to commonly tested antibiotics, emphasizing the need for effective infection control programs and rational antibiotic use policies.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Medicine, General & Internal
Alireza Aziz-Ahari, Mahsa Keyhanian, Setareh Mamishi, Shima Mahmoudi, Ebrahim Ebrahimi Bastani, Fatemeh Asadi, Mohammadreza Khaleghi
Summary: This study evaluated the value of chest CT severity score in assessing the severity and short-term prognosis of COVID-19. The results showed that the CT score could differentiate between recovered patients and deceased individuals, and could predict the need for intubation and ICU admission.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Infectious Diseases
Setareh Mamishi, Babak Pourakbari, Mehrzad Mehdizadeh, Amene Navaeian, Hamid Eshaghi, Bahareh Yaghmaei, Reihaneh Hosseinpour Sadeghi, Shiva Poormohammadi, Yasmine Mahmoudieh, Shima Mahmoudi
Summary: This study describes the epidemiological, clinical, laboratory, and imaging features of hospitalized children with COVID-19 in an Iranian referral pediatrics hospital. It compares these parameters between different groups of patients and highlights the association between underlying diseases and severe COVID-19 in children. The study also suggests that MIS-C cases tend to have a milder form of the disease. Further research on specific immunological responses in children is recommended to explore the delayed inflammatory syndrome.
BMC INFECTIOUS DISEASES
(2022)
Article
Virology
Babak Pourakbari, Mona Mirbeyk, Shima Mahmoudi, Reihaneh H. Hosseinpour Sadeghi, Nima Rezaei, Raheleh Ghasemi, Fatemeh Esfandiari, Setareh Mamishi
Summary: This study evaluated the antibody response after the second dose of COVID-19 vaccine in healthcare workers. The results showed that Oxford/AstraZeneca and Sputnik V had similar outcomes in inducing high levels of anti-SARS-CoV-2 spike antibodies and neutralizing antibodies, which were higher than Sinopharm and COVAXIN.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Pediatrics
Sepideh Benvari, Shima Mahmoudi, Mohsen Mohammadi
Summary: This systematic review and meta-analysis evaluated the viral shedding pattern in gastrointestinal specimens of children with COVID-19. The pooled prevalence of gastrointestinal SARS-CoV-2 RNA in children with COVID-19 was 86%. After respiratory specimen had become negative, 72% of children had persistent shedding in gastrointestinal specimens. The gastrointestinal RNA had a positive test result for more than 70 days after symptoms onset.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Setareh Mamishi, Arezu Akhlaghi, Babak Pourakbari, Mohammadreza Modaresi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Rohola Shirzadi, Zohreh Shalchi, Shima Mahmoudi
Summary: This study investigated the antibiotic susceptibility pattern and genotyping of Staphylococcus aureus and Pseudomonas aeruginosa strains isolated from sputum samples of children with cystic fibrosis. The results showed a high sensitivity of P. aeruginosa to several antibiotics and a high resistance of S. aureus to penicillin and erythromycin. Genotyping revealed the presence of major clusters in the hospital for both bacteria, suggesting the possibility of transmission within the hospital. This highlights the importance of infection prevention measures.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2023)
Article
Pediatrics
Mahsa Soti Khiabani, Mahya Sadat Mohammadi, Mahmoud Reza Ashrafi, Syeda Bushra Haider, Syeda Iqra Haider, Shima Mahmoudi, Setareh Mamishi
Summary: This study aimed to determine the occurrence of concomitant infections with febrile seizures and assess the frequency of meningitis among children presenting with febrile seizures. The study found that leukocytosis and increased CRP can predict the occurrence of aseptic meningitis in these patients.
Article
Pediatrics
Shima Mahmoudi, Babak Pourakbari, Sepideh Benvari, Reihaneh Hosseinpour Sadeghi, Mohammad Reza Abdolsalehi, Mohammad Ali Shahbabaie, Fatemeh Jalali, Fatemeh Safari, Amene Navaeian, Setareh Mamishi
Summary: This study aimed to investigate the differences between the clinical and laboratory features of children infected with VOCs. The study included 87 pediatric cases with confirmed COVID-19, and the variants identified were primarily Alpha, Delta, and Omicron. These variants may manifest different clinical features, and further studies with larger sample sizes are needed to fully understand their clinical manifestations.
Article
Medicine, General & Internal
Shaghayegh Ashraf Talesh, Shima Mahmoudi, Mehdi Mohebali, Setareh Mamishi
Summary: Visceral leishmaniasis (VL) and epididymo-orchitis, which are rarely seen in patients with chronic granulomatous disease (CGD), were reported in this study. This is the first case in the literature showing this combination following an inflammatory syndrome.
CLINICAL CASE REPORTS
(2023)
Letter
Pediatrics
Setareh Mamishi, Fatemeh Jalali, Sepideh Benvari, Babak Pourakbari, Mohammad Reza Abdolsalehi, Reihaneh Hosseinpour Sadeghi, Mohammad Shahbabaie, Amene Navaeian, Shima Mahmoudi
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Pediatrics
Mohammad Reza Abdolsalehi, Sedigheh Madani, Shima Mahmoudi, Amene Navaeian, Mahmoud Khodabandeh, Reihaneh Hosseinpour Sadeghi, Babak Pourakbari, Setareh Mamishi
Summary: This study assessed the association between BMI and outcomes of hospitalized pediatric patients with COVID-19 in Iran. The results showed that BMI was not significantly related to COVID-19 outcomes in pediatric cases, but after subgroup analysis, lower BMI in children with underlying comorbidities was independently associated with a poor prognosis of COVID-19.
ARCHIVES DE PEDIATRIE
(2023)
Review
Virology
Golnaz Ghazizadeh Esslami, Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi
Summary: This study aimed to evaluate the serological, immunological, and cardiac parameters of multisystem inflammatory syndrome associated with SARS-CoV-2 infection. The findings suggest that MIS-C has diverse clinical and laboratory features, and hyperinflammation and cardiac dysfunction are common complications.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Elmira Haji Esmaeil Memar, Morteza Heidari, Homa Ghabeli, Elham Pourbakhtyaran, Roya Haghighi, Seyyed Mohammad Mahdi Hosseiny, Setareh Mamishi, Shima Mahmoudi, Hamid Eshaghi, Ali Reza Tavasoli, Mahmoud Mohammadi, Reza Shervin Badv, Gholamreza Zamani, Masood Ghahvehchi Akbari, Bahram Yarali, Rohola Shirzadi, Masoud Mohammadpour, Bahareh Yaghmaei, Meisam Sharifzadeh Ekbatani, Zeynab Najafi, Mahmoud Reza Ashrafi
Summary: This study aimed to determine the frequency of different types of neurologic findings in hospitalized children with COVID-19. The research found that neurologic manifestations were common in hospitalized children with COVID-19, including seizures, muscle weakness, loss of consciousness, and focal neurological disorders.
ARCHIVES OF IRANIAN MEDICINE
(2023)
Review
Medical Laboratory Technology
Nasrin K. Valian, Behzad Houshmand, Mohammadreza T. Ardakani, Shima Mahmoudi
Summary: This study aimed to evaluate the microbiological characteristics of HIV-infected patients with periodontal disease. A systematic review of 22 articles revealed a higher prevalence of periodontitis in HIV-infected male patients (83%) compared to females (28%). Additionally, more than 140 bacterial species associated with periodontal disease were identified from HIV-infected patients.
CLINICAL LABORATORY
(2023)
