Article
Biochemistry & Molecular Biology
Ruben M. L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, John D. Catravas
Summary: The study found that young (p24) mice exposed to hydrochloric acid (HCl) may suffer long-term complications, characterized by stronger and more persistent inflammation and less fibrosis, mainly affecting the airways rather than lung tissue, compared to adult mice. Further research is needed to characterize time- and dose-dependent injury of HCl in young animals and to identify new key molecular targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Cell Biology
Cui Zhu, Duilio M. Potenza, Yang Yang, Guillaume Ajalbert, Kirsten D. D. Mertz, Stephan von Gunten, Xiu-Fen Ming, Zhihong Yang
Summary: This study demonstrates the elevated levels of Arg-II in aging lung of female mice, which is mainly expressed in bronchial ciliated epithelium, club cells, alveolar type 2 (AT2) pneumocytes, and fibroblasts. It also reveals a critical role of Arg-II in pulmonary fibroblast activation via paracrine release of IL-1 beta and TGF-beta 1, contributing to pulmonary inflammaging and fibrosis.
Article
Medicine, Research & Experimental
Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Summary: This study found that repeated exposure to schistosomiasis causes persistent pulmonary hypertension, which may be associated with perivascular fibrosis observed in patients with schistosomiasis.
Article
Pharmacology & Pharmacy
Chun-Jung Chang, Chiou-Feng Lin, Chih-Hsin Lee, Hsiao-Chi Chuang, Fu-Chia Shih, Shu-Wen Wan, Chi Tai, Chia-Ling Chen
Summary: Abnormal activation of transforming growth factor (TGF)-beta leads to the upregulation of various signaling molecules, contributing to pulmonary lesions and collagen deposition in lung fibrosis. Interferon (IFN)-gamma signaling is significantly reduced in myofibroblasts, while treatments like BIBF 1120 can effectively inhibit TGF-beta-induced activation of myofibroblasts and attenuate fibrosis. Blockade of SHP2 enhances the anti-fibrotic efficacy of IFN-gamma in myofibroblasts.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Peiyu Gu, Dandan Wang, Ji Zhang, Xin Wang, Zhiyong Chen, Lina Gu, Mengying Liu, Fanqing Meng, Jun Yang, Hourong Cai, Yonglong Xiao, Yin Chen, Mengshu Cao
Summary: IPF is a chronic lung disease with unknown cause, and the role of IL-22 in inhibiting TGF-beta 1 signaling pathway could be protective against pulmonary fibrosis. IL-22 shows potential as a therapeutic target for treating IPF.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xia Guo, Oluwaseun Adeyanju, Christudas Sunil, Venkatakirankumar Mandlem, Ayobami Olajuyin, Steven Huang, Shi-You Chen, Steven Idell, Torry A. Tucker, Guoqing Qian
Summary: DOCK2 plays a crucial role in pulmonary fibrosis by modulating FMT, with its upregulation dependent on TGF-beta induction and Smad3, ERK pathways, and contributing to the changes in lung fibroblast phenotypes.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Summary: This study identified and characterized KSM as a potent CHIT1 inhibitor with strong antifibrotic effects on pulmonary fibrosis. KSM inhibited fibrotic cellular processes and physical association between CHIT1 and TGFBRAP1, suggesting its therapeutic potential by regulating the TGF-beta pathway.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soo-Jin Park, Hwa-Jeong Hahn, Sei-Ryang Oh, Hyun-Jun Lee
Summary: In this study, the researchers investigated the effect of theophylline on pulmonary fibrosis and found that it could attenuate fibrotic changes and improve lung function. Theophylline works by inhibiting Th17 differentiation and TGF-beta signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Yung Hyun Choi, Joyce H. Lee, Mi-Hwa Lee, Chang-Hee Kang, Chang-Min Lee, Gi-Young Kim
Summary: In this study, the anti-fibrotic effects of derrone on TGF-beta 1-stimulated MRC-5 lung fibroblast cells and bleomycin-induced lung fibrosis were investigated. It was found that high concentrations of derrone increased cytotoxicity in MRC-5 cells, but low concentrations did not induce significant cell death. Derrone reduced the expression of TGF-beta 1, fibronectin, elastin, and collagen1 alpha 1 in TGF-beta 1-stimulated MRC-5 cells, and also attenuated fibrotic histopathological changes in bleomycin-treated mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ping Zhang, Jiaxin Wang, Weiren Luo, Jifan Yuan, Chunhong Cui, Ling Guo, Chuanyue Wu
Summary: The study highlights the crucial role of kindlin-2 in lung fibroblast activation, collagen matrix synthesis, and pulmonary fibrosis progression. Therapeutic interventions targeting the kindlin-2 signaling pathway show promise in controlling this deadly lung disease.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Ji-hong Yuan, Yu Ma, Ling-hong Yuan, Jing-jing Gong, Ling-li Xu, Lv Wang, Yong-mei Jin
Summary: This study investigates whether baicalein can attenuate lung fibrosis by regulating lung fibroblast senescence. The results suggest that baicalein can mitigate lung fibrosis, fibroblast senescence, and activation of the TGF-beta 1/Smad signaling pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cell Biology
Michael H. Bourne Jr, Theodore J. Kottom, Deanne M. Hebrink, Malay Choudhury, Edward B. Leof, Andrew H. Limper
Summary: Phosphodiesterase type 5 inhibitor (PDE5-I) vardenafil shows potential in the treatment of idiopathic pulmonary fibrosis (IPF) by suppressing extracellular matrix (ECM) generation and exhibiting significant synergistic effects when used in combination with nintedanib.
Article
Pharmacology & Pharmacy
Hanjing Sheng, Gang Lin, Shengxian Zhao, Weibin Li, Zhaolin Zhang, Weidong Zhang, Li Yun, Xiaoyang Yan, Hongyu Hu
Summary: This study evaluated the anti-fibrotic role of Piceatannol (PIC) in a mouse model of pulmonary fibrosis and found that PIC reduces the number of activated myofibroblasts by promoting autophagy. The study demonstrates for the first time the protective effects of PIC against pulmonary fibrosis and suggests its potential as a candidate compound for pulmonary fibrosis therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Han, Mao Jiang, Rongling He, Xin Lv, Xiaohua Liao, Yijun He, Fan Zhang, Lingzhi Long, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Gaoyun Hu, Jie Meng
Summary: The study found that the newly synthesized drug MFD can alleviate lung fibrosis by suppressing TGF-beta/Smad2 and MAPK pathways, reducing cell apoptosis and EMT in the fibrotic process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Carlo Avalon, Jacob Fuqua, Seth Deskins, Tyler Miller, Justin Conte, Daniel Martin, Gary Marano, Naveena Yanamala, James Mills, Christopher Bianco, Brijesh Patel, Karthik Seetharam, Raymond Raylman, Partho P. Sengupta, Yasmin S. Hamirani
Summary: This study found that xSPECT/CT SUV is correlated with Perugini score and H/CL ratio in ATTR-CA, and it shows good consistency with CMR results.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Oncology
Asude Berber, Habiba Abdelhalim, Saman Zeeshan, Sreya Vadapalli, Barr von Oehsen, Naveena Yanamala, Partho Sengupta, Zeeshan Ahmed
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Quincy A. Hathaway, Naveena Yanamala, Partho P. Sengupta
Article
Cardiac & Cardiovascular Systems
Jeremy Bernard, Naveena Yanamala, Rohan Shah, Karthik Seetharam, Alexandre Altes, Marlene Dupuis, Oumhani Toubal, Haifa Mahjoub, Helene Dumortier, Jean Tartar, Erwan Salaun, Kim O'Connor, Mathieu Bernier, Jonathan Beaudoin, Nancy Cote, Andre Vincentelli, Florent Leven, Sylvestre Marechaux, Philippe Pibarot, Partho P. Sengupta
Summary: This preliminary study explored data-driven approaches and explainable AI to delineate phenotypes of primary mitral regurgitation severity and identify patients who benefit from surgery. The study found that patients with high-severity phenotypes showed improved event-free survival after surgery, while those with low-severity phenotypes did not benefit from surgery. Phenotyping provided incremental prognostic value in conventionally severe or moderate-severe MR subjects.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Infectious Diseases
Aditya Radhakrishnan, Stephanie Spencer, Naveena Yanamala, Sarath Malepati
Summary: This research evaluates the efficacy of EZC Pak as an alternative to antibiotics for non-specific upper respiratory infections. The results show that EZC Pak participants recovered faster, had lower symptom severity, and higher patient satisfaction compared to the placebo group. EZC Pak could be a potential alternative to antibiotic use.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, Research & Experimental
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. . Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. . Mays, Kaitlin Fiedler, Scott A. . Hahn, Sonia R. . Salvatore, Francisco J. . Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Summary: The deficiency of CYB5R3 in type II alveolar epithelial cells (AECII) contributes to the activation of fibrosis. Treatment with sGC agonists can reduce the fibrotic outcomes caused by CYB5R3 deficiency in AECII. CYB5R3 plays a critical role in maintaining resilience after lung injury and fibrosis, and sGC can be used as a therapeutic target for fibrotic conditions in the lung and beyond.
Meeting Abstract
Critical Care Medicine
S. D. Stacey, A. J. Vrsan, Z. E. Miller, J. Calyeca, J. A. Chamucero-Millares, T. Khaliullin, V. Peters, L. Rosas, B. A. Whitson, S. M. Black, M. N. Ballinger, A. D. Schenk, J. Rosenheck, D. R. Nunley, B. C. Keller, B. F. Reader, W. K. Washburn, A. L. Mora, M. Rojas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
J. A. Ovando Ricardez, T. Khaliullin, J. Calyeca, S. D. Stacey, V. Peters, L. Rosas, N. D. Vanegas, A. Ma, D. Chung, Q. Ma, A. L. Mora, M. Rojas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
T. Khaliullin, E. R. Sekera, A. B. Hummon, M. Rojas, A. L. Mora
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
J. Calyeca, J. D. Londino, T. Khaliullin, S. M. Scott, A. Chambers, J. Scott, M. Darner, M. Bueno, D. Alvarez, M. Rojas, A. L. Mora
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Cell Biology
Aditi U. Gurkar, Akos A. Gerencser, Ana L. Mora, Andrew C. Nelson, Anru R. Zhang, Anthony B. Lagnado, Archibald Enninful, Christopher Benz, David Furman, Delphine Beaulieu, Diana Jurk, Elizabeth L. Thompson, Fei Wu, Fernanda Rodriguez, Grant Barthel, Hao Chen, Hemali Phatnani, Indra Heckenbach, Jeffrey H. Chuang, Jeremy Horrell, Joana Petrescu, Jonathan K. Alder, Jun Hee Lee, Laura J. Niedernhofer, Manoj Kumar, Melanie Konigshoff, Marta Bueno, Miiko Sokka, Morten Scheibye-Knudsen, Nicola Neretti, Oliver Eickelberg, Peter D. Adams, Qianjiang Hu, Quan Zhu, Rebecca A. Porritt, Runze Dong, Samuel Peters, Stella Victorelli, Thomas Pengo, Timur Khaliullin, Vidyani Suryadevara, Xiaonan Fu, Ziv Bar-Joseph, Zhicheng Ji, Joao F. Passos
Summary: Cellular senescence is a major driver of aging and age-related diseases. Mapping senescent cells faces challenges due to lack of specific markers, low abundance, and heterogeneity. Single-cell technologies provide characterization of senescence but often lack spatial insights. The SenNet initiative aims to map senescent cells throughout lifespan using spatial imaging methods. This review discusses the existing and emerging methodologies, limitations, and the importance of developing spatially resolved methods for an atlas of senescent cells.
Article
Cell Biology
Patty J. Lee, Christopher C. Benz, Philip Blood, Katy Boerner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, David Furman, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Indra Heckenbach, Ziv-Bar Joseph, Pragati Katiyar, So-Jin Kim, Melanie Koenigshoff, George A. Kuchel, Haesung Lee, Jun Hee Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, Joao F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Morten Scheibye-Knudsen, Birgit Schilling, Pixu Shi, Jonathan C. Silverstein, Vidyani Suryadevara, Jichun Xie, Jinhua Wang, A. Ian Wong, Laura J. Niedernhofer, Siyuan (Steven) Wang, Hannah Anvari, Julia Balough, Christopher Benz, Joanna Bons, Boris Brenerman, William Evans, Akos Gerencser, Heather Gregory, Malene Hansen, Jamie Justice, Pankaj Kapahi, Natalia Murad, Amy O'Broin, Mary Ellen Pavone, Mark Powell, Gary Scott, Elisheva Shanes, Mahalakshmi Shankaran, Eric Verdin, Daniel Winer, Fei Wu, Andrew Adams, Philip D. Blood, Andreas Bueckle, Ivan Cao-Berg, Hao Chen, Michael Davis, Shane Filus, Yuhan Hao, Austin Hartman, Euxhen Hasanaj, Jesse Helfer, Bruce Herr, Ziv Bar Joseph, Gesmira Molla, Gloria Mou, Juan Puerto, Ellen M. Quardokus, Alexander J. Ropelewski, Matt Ruffalo, Rahul Satija, Melissa Schwenk, Robin Scibek, William Shirey, Max Sibilla, Joel Welling, Zhou Yuan, Richard Bonneau, Angela Christiano, Benjamin Izar, Vilas Menon, David M. Owens, Hemali Phatnani, Colin Smith, Yousin Suh, Andrew F. Teich, Valerie Bekker, Cliburn Chan, Elias Coutavas, Matthew G. Hartwig, Zhicheng Ji, Andrew B. Nixon, Zhixun Dou, Jayaraj Rajagopal, Nikolai Slavov, David Holmes, Diana Jurk, James L. Kirkland, Anthony Lagnado, Tamara Tchkonia, Kristin Abraham, Amanda Dibattista, Yih-Woei Fridell, T. Kevin Howcroft, Chamelli Jhappan, Viviana Perez Montes, Mercy Prabhudas, Haluk Resat, Veronica Taylor, Manoj Kumar, Francisco Cigarroa, Rachel Cohn, Tiffany M. Cortes, Elise Courtois, Jeffrey Chuang, Monica Dave, Sergii Domanskyi, Elizabeth Ann Lieser Enninga, Giray Naim Eryilmaz, Sara E. Espinoza, Jon Gelfond, James Kirkland, Chia-Ling Kuo, Julia S. Lehman, Cristina Aguayo-Mazzucato, Alexander Meves, Meenakshi Rani, Shane Sanders, Asa Thibodeau, Stefan G. Tullius, Duygu Ucar, Brian White, Qian Wu, Ming Xu, Seiji Yamaguchi, Naziheh Assarzadegan, Chun-Seok Cho, Irene Hwang, Yongha Hwang, Jingyue Xi, Oyedele A. Adeyi, Constantin F. Aliferis, Alessandro Bartolomucci, Xiao Dong, Mickayla J. DuFresne-To, Sayeed Ikramuddin, Steve G. Johnson, Andrew C. Nelson, Xavier S. Revelo, Claudia Trevilla-Garcia, John M. Sedivy, Elizabeth L. Thompson, Paul D. Robbins, Jinhua Wang, Katherine M. Aird, Jonathan K. Alder, Delphine Beaulieu, Marta Bueno, Jazmin Calyeca, Julian A. Chamucero-Millaris, Stephen Y. Chan, Dongjun Chung, Anthony Corbett, Vera Gorbunova, Kymberly M. Gowdy, Aditi Gurkar, Jeffrey C. Horowitz, Qianjiang Hu, Gagandeep Kaur, Timur O. Khaliullin, Robert Lafyatis, Serafina Lanna, Dongmei Li, Anjun Ma, Alison Morris, Thivanka M. Muthumalage, Victor Peters, Gloria S. Pryhuber, Brenda F. Reader, Lorena Rosas, John C. Sembrat, Sadiya Shaikh, Hangchuan Shi, Sean D. Stacey, Claudette St Croix, Cankun Wang, Qixin Wang, Andrew Watts, Liangcai Gu, Yiing Lin, Peter S. Rabinovitch, Mariya T. Sweetwyne, Maxim N. Artyomov, Samuel J. Ballentine, Milan G. Chheda, Sherri R. Davies, John F. DiPersio, Ryan C. Fields, James A. J. Fitzpatrick, Robert S. Fulton, Shin-ichiro Imai, Sanjay Jain, Tao Ju, Vladimir M. Kushnir, Daniel C. Link, Michael Ben Major, Stephen T. Oh, Daniel Rapp, Michael P. Rettig, Shelia A. Stewart, Deborah J. Veis, Kiran R. Vij, Michael C. Wendl, Matthew A. Wyczalkowski, Joseph E. Craft, Archibald Enninful, Negin Farzad, Peter Gershkovich, Stephanie Halene, Yuval Kluger, Jennifer VanOudenhove, Mina Xu, Junchen Yang, Mingyu Yang
Summary: Cells respond to stress by undergoing senescence, and the heterogeneity of senescent cells and their secretory phenotype need further characterization. The Cellular Senescence Network (SenNet) was established to create a map of senescent cells across the human lifespan and improve diagnostic and therapeutic approaches.
Meeting Abstract
Critical Care Medicine
T. Khaliullin, M. Bueno, J. Calyeca, T. Tabib, A. C. Straub, R. A. Lafyatis, M. Rojas, A. L. Mora
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
J. Calyeca, J. D. Londino, M. Bueno, D. Alvarez, T. Khaliullin, E. Polyak, S. Scott, T. Tabib, J. Sembrat, R. Lafayatis, M. Rojas, A. L. Mora
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Heenaben B. Patel, Naveena Yanamala, Brijesh Patel, Sameer Raina, Peter D. Farjo, Srinidhi Sunkara, Marton Tokodi, Nobuyuki Kagiyama, Grace Casaclang-Verzosa, Partho P. Sengupta
Summary: The ECG-derived machine learning model is effective in predicting patient subgroups at risk of major adverse cardiac events, providing a cost-effective strategy for integrated assessment of systolic and diastolic dysfunction.
JOURNAL OF PATIENT-CENTERED RESEARCH AND REVIEWS
(2022)