Article
Medicine, Research & Experimental
Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: SHQA was found to have the strongest effect on Aβ-induced mitochondrial-associated oxidative stress and apoptosis, and exerted neuroprotective effects through activating the PI3K/Akt/Nrf2 pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Hucheng Ma, Haozhen Ren, Jun Wang, Xianwen Yuan, Xinyu Wu, Xiaolei Shi
Summary: Glabridin can significantly alleviate oxidative stress, inflammation, and apoptosis induced by APAP, exerting a protective effect by activating the PI3K/Akt/Nrf2/HO-1 pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yaqi Bian, Yan Chen, Xiufen Wang, Guozhen Cui, Carolina Oi Lam Ung, Jia-Hong Lu, Weihong Cong, Benqin Tang, Simon Ming-Yuen Lee
Summary: This study explored the potential therapeutic actions of oxyphylla A, a novel compound extracted from Alpinia oxyphylla, in reducing the expression levels of APP and Aβ proteins, as well as in attenuating cognitive decline in SAMP8 mice. Oxyphylla A was found to exert an antioxidative effect through the Akt-GSK36 and Nrf2-Keap1-HO-1 pathways, suggesting a new horizon for the discovery of therapeutic agents for AD.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hao Li, Yabin Chen, Mingjie Ding, Zhiping Yan, Wenzhi Guo, Ran Guo
Summary: Pretreatment with Pectolinarigenin (Pec) can reduce oxidative stress, inflammation, and cell apoptosis induced by hepatic ischemia/reperfusion (I/R) injury through activation of the PI3K/AKT/Nrf2 pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biotechnology & Applied Microbiology
Xuewei Wen, Song Li, Yanfei Zhang, Liang Zhu, Xiaoting Xi, Shuyuan Zhang, Yan Li
Summary: Klotho, an anti-aging protein, has antioxidant properties that protect retinal pigment epithelial cells from oxidative stress and promote cell proliferation. By activating specific signaling pathways, Klotho exerts its antioxidant effects, making it a potential option for the treatment or prevention of AMD.
Article
Pharmacology & Pharmacy
Yuan Li, Ling Chen, Da Zheng, Jian-Xia Liu, Chao Liu, Shao-Hua Qi, Peng-Chao Hu, Xiao-Fei Yang, Jia-Wei Min
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death and long-term neurological injury in newborns. This study investigated the neuroprotective effects of Echinocystic acid (EA), a natural plant extract, on neonatal HIE. The results demonstrated that EA had significant antioxidant and antiapoptotic activities, reduced cerebral infarction and neuronal injury, and improved brain atrophy and long-term neurobehavioral deficits through activation of the PI3K/Akt/Nrf2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Orthopedics
Yan-Pei Zou, Qi-Chen Zhang, Qian-Yi Zhang, Li-Bo Jiang, Xi-Lei Li
Summary: This study demonstrates that procyanidin B2 can alleviate oxidative stress-induced nucleus pulposus cell apoptosis by upregulating Nrf2 via activation of the PI3K/Akt signaling pathway. This provides a potential therapeutic approach for procyanidin B2 in intervertebral disc degeneration (IVDD).
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Food Science & Technology
Peramaiyan Rajendran, Abdullah M. Alzahrani, Vishnu Priya Veeraraghavan, Emad A. Ahmed
Summary: The study demonstrated that flavokawain A (FKA) can protect against endothelial injury induced by ochratoxin A (OTA) through the Nrf2 pathway and inhibition of NF kappa B, while also activating antioxidative and antiapoptotic signaling to prevent oxidative stress damage to endothelial cells.
Article
Food Science & Technology
Haoyue Huang, Yaping Liu, Ze Xu, Dongdong Zhang, Mingming Feng, Tong Zhao, Luoya Zhang, Wenjie Li, Xing Li
Summary: The study found that fucoidan could improve renal injury in type 2 diabetic rats through antioxidant mechanism, possibly related to the activation of PI3K/AKT/Nrf2 signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Tianshuang Xia, Xiaoyan Liu, Nani Wang, Yiping Jiang, Huanhuan Bai, Weifan Xu, Kunmiao Feng, Ting Han, Hailiang Xin
Summary: This study reveals the antioxidative and osteoprotective effects of Xanthohumol (XAN) on beta-amyloid injured osteoblasts through the regulation of the PI3K/AKT/Nrf2 pathway. This provides reference for the clinical application of XAN in the prevention and treatment of osteoporosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Cell Biology
Changsi Peng, Lu Xue, Yanling Yue, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: Asthma is an inflammatory disease characterized by airway hyperresponsiveness, airway remodeling, and airway inflammation. The development of effective drugs for asthma with high curative effects, low toxicity, and strong specificity is urgently needed. Duloxetine HCl (DUX), a selective serotonin and norepinephrine reuptake inhibitor, has been found to have potential anti-inflammatory and antioxidative effects. This study investigated the effects of DUX on asthma and found that it can relax tracheal smooth muscle and alleviate asthma symptoms through the regulation of ion channels and signaling pathways. DUX has the potential to become a new drug for the relief or treatment of asthma.
Article
Chemistry, Medicinal
Rebai Ben Ammar, Hamad Abu Zahra, Abdulmalek Mohammad Abu Zahra, Manal Alfwuaires, Sarah Abdulaziz Alamer, Ashraf M. Metwally, Thnaian A. Althnaian, Saeed Y. Al-Ramadan
Summary: Marine algae extracts have various biological properties, including anti-inflammatory and antioxidant functions. This study found that fucoxanthin exhibits anti-inflammatory and antioxidant effects in hepatocytes already affected by zearalenone-induced hepatitis. Fucoxanthin inhibits ZEA-induced inflammation and oxidative stress in hepatocytes by activating the PI3K/AKT signaling pathway and targeting Nrf2.
Article
Biochemistry & Molecular Biology
Mohsen Sedighi, Tourandokht Baluchnejadmojarad, Siamak Afshin-Majd, Mona Amiri, Malihe Aminzade, Mehrdad Roghani
Summary: Klotho pretreatment at different concentrations effectively mitigated cell damage, reduced oxidative stress, and inflammation caused by A beta 1-42 toxicity. The beneficial effects of Klotho were achieved through modulation of Wnt1/pCREB/Nrf2/HO-1 signaling pathway, leading to improved cell viability and decreased cellular damage.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
