Review
Cell Biology
Martin J. Gibala, Martin J. MacInnis
Summary: Brief, intense interval training improves V_O2max through various physiological changes, including increased maximal cardiac output and blood volume, as well as changes in capillary and mitochondrial density. However, the specific mechanisms underlying these improvements are still unclear and require further investigation using contemporary technologies.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Multidisciplinary Sciences
Victor Sabino de Queiros, Nicholas Rolnick, Phelipe Wilde de Alcantara Varela, Breno Guilherme de Araujo Tinoco Cabral, Paulo Moreira Silva Dantas
Summary: High-frequency BFR training can generate significant neuromuscular adaptations, but strength declines and muscle fiber atrophy were reported in resistance training to failure. There is a lack of studies comparing low-frequency and high-frequency in short-term BFR training. Comparisons between resistance exercises of similar intensities are also lacking, limiting conclusions on the specific effects of proximity to failure or BFR.
Article
Endocrinology & Metabolism
Candela Diaz-Canestro, Brandon Pentz, Arshia Sehgal, David Montero
Summary: This study found that in a sample of 60 healthy, moderately active women and men matched by age and cardiorespiratory fitness, women had smaller anthropometrical indices and LBM compared to men. Cardiovascular sex differences during exercise were reduced in women when normalized by total or leg LBM. Furthermore, total and leg LBM were identified as strong independent determinants of cardiac and aerobic capacities in women, independent of body fat percentage, a relationship not observed in age- and fitness-matched men.
Article
Biology
Jort Veen, Diego Montiel-Rojas, Fawzi Kadi, Andreas Nilsson
Summary: The study investigates the impact of reallocating time spent in different intensities of physical activity (PA) on sarcopenia risk in older adults. The results show that reallocating sedentary time to at least light-intensity PA is significantly related to a lower sarcopenia risk score (SRS), even after adjustment for PA type and protein intake. Similarly, reallocating time in light- to moderate-to-vigorous-intensity PA is also related to a lower SRS. These findings emphasize the importance of displacing sedentary behaviors for more active pursuits in older adults to alleviate age-related deterioration of muscle health.
Article
Physiology
Hakan Yapici, Mehmet Gulu, Fatma Hilal Yagin, Dondu Ugurlu, Ertan Comertpay, Oguz Eroglu, Melike Kocoglu, Monira I. I. Aldhahi, Raci Karayigit, Sameer Badri AL-Mhanna
Summary: The study aimed to investigate the combined effects of chocolate milk consumption and resistance training on muscle hypertrophy, body composition, and maximal strength in untrained healthy men. The results showed that the group who consumed chocolate milk along with resistance training had significantly greater improvements in muscle thickness, maximal strength, body composition, and peak power compared to the group who only did resistance training. Chocolate milk consumption can be considered as a suitable post-exercise nutritional supplement for enhancing muscle performance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Tine Vrist Dam, Line Barner Dalgaard, Steffen Ringgaard, Frank Ted Johansen, Mads Bisgaard Bengtsen, Maike Mose, Katrine Meyer Lauritsen, Niels Ortenblad, Claus H. Gravholt, Mette Hansen
Summary: The use of transdermal estrogen therapy enhanced muscle mass response to resistance training in early postmenopausal women, resulting in significantly greater muscle cross-sectional area and fat-free mass compared to a placebo group.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Junmin Mi, Litao Zhang, Wei Sun, Zhen Wang, Pengbo Yang, Jiachen Zhang, Yani Zhang
Summary: This study identifies the research hotspots of resistance training (RT) intervention in aging and predicts the research frontiers and development trends using bibliometric analysis. The research results can provide references for further exploration and government policies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Sport Sciences
Marcos D. Polito, Rafael R. Papst, Paulo Farinatti
Summary: The study revealed that different combinations of resistance training factors can improve strength and muscle mass in untrained young and older adults. In older adults, greater training frequency and duration were found to be beneficial for strength and muscle mass gains, while excessive training volume may hinder progress.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Sport Sciences
Marcelo Conrado De Freitas, Fabricio Eduardo Rossi, Lucas Antonio Colognesi, Joao Vitor N. S. De Oliveira, Nelo Eidy Zanchi, Fabio Santos Lira, Jason M. Cholewa, Luis Alberto Gobbo
Summary: The study investigated the effects of postactivation potentiation (PAP) from heavy back squats on resistance exercise performance in trained men. Results showed that PAP improved total volume during resistance exercise and increased force production during maximum voluntary isometric contraction (MVIC), but no relationship was found between relative 1RM values and the PAP response in trained men.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Joshua R. Smith, Bryan J. Taylor
Summary: Exercise limitation is a common manifestation of cardiovascular diseases and can be improved through exercise-based cardiac rehabilitation. Inspiratory muscle dysfunction is a underestimated complication of cardiovascular diseases that contributes to breathlessness and exercise intolerance. This review explores the prevalence of inspiratory muscle weakness, its impact on physiological function and clinical outcomes, and evaluates the effects of exercise-based cardiac rehabilitation on inspiratory muscle function in patients with cardiovascular diseases. The assessment of global respiratory muscle function and implementation of inspiratory muscle training are recommended for phase II cardiac rehabilitation programs.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Endocrinology & Metabolism
Marleen A. Baak, Adriyan Pramono, Francesca Battista, Kristine Beaulieu, John E. Blundell, Luca Busetto, Eliana Carraca, Dror Dicker, Jorge Encantado, Andrea Ermolao, Nathalie Farpour-Lambert, Euan Woodward, Alice Bellicha, Jean-Michel Oppert
Summary: This study found that all types of exercise training can increase maximal oxygen consumption in adults with overweight or obesity, but resistance training is less effective in improving this parameter. Additionally, incorporating resistance exercise into the training program can enhance muscle strength.
Review
Sport Sciences
Jonathon Weakley, Brad J. Schoenfeld, Johanna Ljungberg, Shona L. Halson, Stuart M. Phillips
Summary: Resistance training using lower loads can effectively enhance strength, gait speed, mobility, and health, and can be a viable alternative to traditional higher load training. These findings are important for those who face barriers to regular resistance training, such as confidence with external loads and access to training facilities. Lower load resistance training can lead to similar or even superior physiological adaptations and is beneficial for individuals at risk of cardiovascular and metabolic diseases, as well as those with reduced mobility.
SPORTS MEDICINE-OPEN
(2023)
Review
Sport Sciences
Kevin J. Gries, Scott W. Trappe
Summary: The Exercise Boom of the 1970's resulted in a significant portion of the population adopting habitual exercise. This review highlights the physiological basis for the elite performances seen in masters athletes and emphasizes the health implications of lifelong exercise. The findings demonstrate the importance of remaining physically active throughout the lifespan for improved aerobic capacity and skeletal muscle health.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Daniel M. Over, Nicola Arjomandkhah, Jordan D. Beaumont, Stuart Goodall, Martin J. Barwood
Summary: The study found that menthol applied topically to the skin improves perception and increases force generation. Nine trained male subjects were tested after spraying menthol on their legs during different weightlifting tasks. The results showed an improved performance in the isometric and dynamic lifting tasks after the application of menthol.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Physiology
Gen-Min Lin, Kun-Zhe Tsai, Xuemei Sui, Carl J. Lavie
Summary: This study examined the correlations between time and estimated power output (EPO) for a run field test and VO2 max obtained from cardiopulmonary exercise testing (CPET). The results showed that EPO had a stronger correlation with VO2 max compared to time.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Maud Kamal, Sonia Lameiras, Marc Deloger, Adeline Morel, Sophie Vacher, Charlotte Lecerf, Celia Dupain, Emmanuelle Jeannot, Elodie Girard, Sylvain Baulande, Coraline Dubot, Gemma Kenter, Ekaterina S. Jordanova, Els M. J. J. Berns, Guillaume Bataillon, Marina Popovic, Roman Rouzier, Wulfran Cacheux, Christophe Le Tourneau, Alain Nicolas, Nicolas Servant, Suzy M. Scholl, Ivan Bieche
Summary: This study analyzed the association between different viral integration signatures and clinical parameters in 272 cervical cancer patients, revealing MACROD2 gene as a hotspot of HPV integration. The type of viral integration was dependent on HPV genotype, and a high HPV copy number was associated with longer progression-free survival.
BRITISH JOURNAL OF CANCER
(2021)
Review
Environmental Sciences
Damien Vitiello, Florent Palacin, Luc Poinsard, Marine Kirsch, Steeve Jouini, Veronique Billat
Summary: This review provides a state-of-the-art analysis of the impact of marathons on cardiac fatigue over the past 10 years. While marathons have been found to have negligible effects on LV and RV systolic and contractile function, they may negatively impact LV diastolic function, especially in recreational runners. Athletes are advised to adapt their training and have regular medical monitoring to preserve their cardiac health while continuing to participate in marathons.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Claire A. Molinari, Pierre Bresson, Florent Palacin, Veronique Billat
Summary: This study found that physiologically controlled pacing was more effective than freely chosen pacing, leading to better performance, reduced physiological strain, and a more positively skewed speed distribution in 3000m running races.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Pierre Verrelle, Didier Meseure, Frederique Berger, Audrey Forest, Renaud Leclere, Andre Nicolas, Emilie Fortas, Xavier Sastre-Garau, Marick Lae, Sabah Boudjemaa, Rodrigue Mbagui, Valentin Calugaru, Dalila Labiod, Leanne De Koning, Genevieve Almouzni, Jean-Pierre Quivy
Summary: The subnuclear distribution of CENP-A serves as an independent predictive marker for local disease control and curability by chemoradiation therapy in locally advanced head and neck squamous cell cancer patients, providing a reliable marker for precision medicine. This study highlights the potential clinical applicability of CENP-A labeling as a cost-effective marker compatible with clinical time constraints during therapy.
Article
Oncology
Toulsie Ramtohul, Khadija Ait Rais, Sophie Gardrat, Raymond Barnhill, Sergio Roman-Roman, Nathalie Cassoux, Manuel Rodrigues, Pascale Mariani, Leanne De Koning, Gaelle Pierron, Vincent Servois
Summary: The study showed that MRI melanin quantification was an independent prognostic factor for overall survival in patients with liver metastases of uveal melanoma (LMUM). Liver metastases with high MRI melanin content and high genetic risk were associated with lower overall survival. The level of pigmentation in M3/8g LMUM identified two subsets that were correlated with distinct clinical outcomes.
Article
Environmental Sciences
Jean-Renaud Pycke, Veronique Billat
Summary: This study demonstrates that the best marathon performances are achieved through a pace distribution that is not constant and exhibits negative asymmetry. The performance of a marathon is influenced by oscillations in pacing, and even the best performances can be improved upon.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Anne Bredart, Aude Rault, Johanna Terrasson, Etienne Seigneur, Leanne De Koning, Elisabeth Hess, Alexia Savignoni, Paul Cottu, Jean-Yves Pierga, Sophie Piperno-Neumann, Manuel Rodrigues, Carole Bouleuc, Sylvie Dolbeault
Summary: This study aims to develop and pilot-test a specific question prompt list (QPL) to assist patients with resistant cancers in their communication and support needs. The study adopts a mixed methods collaborative approach, including professional interviews, patient needs assessment, and focus group discussions. It is expected that the QPL will improve oncologists' response to patient needs and facilitate patients' psychological adjustment.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Environmental Sciences
Veronique Billat, Luc Poinsard, Florent Palacin, Jean Renaud Pycke, Michael Maron
Summary: This study examines the relationship between Rate of Perceived Exertion (RPE) and physiological variables during a marathon race. The results show that respiratory frequency and heart rate progressively increase in all runners, while oxygen uptake and ventilatory rate have different kinetics according to individuals. However, indexing the physiological parameters and speed by RPE shows a decreased tendency for all runners.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Veronique Billat, Florent Palacin, Luc Poinsard, Johnathan Edwards, Michael Maron
Summary: The present study found that heart rate does not reflect the oxygen uptake of recreational runners during a marathon. Instead, learning about the relationship between running sensations during training and racing using RPE (Rate of Perceived Exertion) is recommended.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Helene Salaun, Leanne de Koning, Mathilde Saint-Ghislain, Vincent Servois, Toulsie Ramtohul, Agathe Garcia, Alexandre Matet, Nathalie Cassoux, Pascale Mariani, Sophie Piperno-Neumann, Manuel Rodrigues
Summary: Although the combined PD-1/CTLA-4 inhibition therapy with nivolumab/ipilimumab does not improve clinical outcomes compared to other therapies, it is more toxic and should be considered as an option rather than a standard treatment for metastatic uveal melanoma patients.
Article
Sport Sciences
Sabrina Demarie, Emanuele Chirico, Veronique Billat
Summary: This study aimed to determine the most accurate predictor of swimming working capacity in pentathletes. The results showed a strong correlation between CV and 200m swimming performance. CV was identified as the most suitable test for refining swimming training loads in pentathletes.
Article
Physics, Multidisciplinary
Florent Palacin, Luc Poinsard, Jean Renaud Pycke, Veronique Billat
Summary: In this study, researchers investigated the relationship between the signals received from physiological and mechanical running parameters and the completion of a marathon. The results showed that the entropy information of stride length had a significant impact on runners' performance, indicating that integrating stride length's entropy feedback into new cardioGPS watches could improve marathon runners' performance.
Article
Chemistry, Multidisciplinary
Sabrina Demarie, Jean Renaud Pycke, Alessia Pizzuti, Veronique Billat
Summary: The study analyzed the pace strategy of finalists in swimming and running world events held in 2021-2022. The results showed statistically significant differences between swimming and running in terms of total time, average time of splits, median time of splits, and maximal length of split sequences. However, there was no significant difference in the number of sequences of splits and the percentage of splits faster than the median speed.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Fariba Nemati, Leanne de Koning, David Gentien, Franck Assayag, Emilie Henry, Khadija Ait Rais, Gaelle Pierron, Odette Mariani, Michele Nijnikoff, Gabriel Champenois, Andre Nicolas, Didier Meseure, Sophie Gardrat, Nicolas Servant, Philippe Hupe, Maud Kamal, Christophe Le Tourneau, Sophie Piperno-Neumann, Manuel Rodrigues, Sergio Roman-Roman, Didier Decaudin, Pascale Mariani, Nathalie Cassoux
Summary: This study investigated the feasibility of using patient-derived xenografts (PDXs) to screen for potential therapies for uveal melanoma. The results showed that PDX models demonstrated consistency with patient samples in terms of morphology, gene mutations, and chromosome status. PDXs could serve as a valid tool for selecting personalized treatment options.
Article
Gastroenterology & Hepatology
Laetitia Gerossier, Anaelle Dubois, Alexia Paturel, Nadim Fares, Damien Cohen, Phillippe Merle, Joel Lachuer, Anne Wierinckx, Pierre Saintigny, Brigitte Bancel, Janick Selves, Anne Schnitzler, Berengere Ouine, Aurelie Cartier, Leanne de Koning, Vincent Puard, Ivan Bieche, Hector Hernandez-Vargas, Janet Hall, Isabelle Chemin
Summary: This study demonstrates the potential of PARP inhibitors in treating hepatocellular carcinoma, especially for HBV-associated tumors. HBV infection leads to higher levels of DNA damage, and increased expression levels of PARP1 and PARP2 in tumors were observed.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
