期刊
EXPERIMENTAL DERMATOLOGY
卷 26, 期 9, 页码 830-832出版社
WILEY
DOI: 10.1111/exd.13286
关键词
IL-6; inflammation; skin; suction blister; UVA radiation; UVA-1
类别
UVA-1 is a known promotor of skin ageing. Cytokines like IL-1 alpha, Il-1 beta or TNF-alpha, VEGF and IL-6 orchestrate UV effects, and IL-6 is furthermore an effector of UVA-induced photoageing. We investigated how fractionated UVA-1 doses influence the cytokine milieu and especially the IL-6 levels in the skin in vivo. In a study with 35 participants, we exposed previously unirradiated human skin to three UVA-1 irradiation regimes. Cytokine levels in interstitial skin fluid were measured up to 48 hours postexposure and compared to unirradiated control skin fluid. Our results show that IL-6 levels increased significantly after UVA-1 exposure at selected time points. The other candidates IL-1 alpha, Il-1 beta or TNF-alpha and VEGF show no significant response after UVA-1 exposure in vivo. UVA-1 thus raises selectively IL-6 levels in vivo, a fact that underlines its role in photoageing and has potential implications for its modulatory effect on photoageing pathology.
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