Article
Pharmacology & Pharmacy
Qingping Xu, Yuhong Cao, Xiaoyi Zhong, Xue Qin, Jingyun Feng, Huan Peng, Yongshao Su, Zhichao Ma, Sigui Zhou
Summary: Our study investigated the cardioprotective effects of riboflavin in heart failure by activating SCAD and the DJ-1-Keap1-Nrf2 signaling pathway. In vivo, riboflavin improved cardiac function, reduced myocardial fibrosis, and inhibited oxidative stress and cardiomyocyte apoptosis. In vitro, riboflavin decreased reactive oxygen species and inhibited cell apoptosis. These effects were mediated through the restoration of FAD levels, SCAD expression, activation of DJ-1, and inhibition of the Keap1-Nrf2/HO1 pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qingyun Tan, Yuying Fang, Xing Peng, Huihao Zhou, Jun Xu, Qiong Gu
Summary: The study demonstrated that Ajudecunoid C (ADC), a compound isolated from Ajuga nipponensis, showed inhibitory activity against ferroptosis induced by erastin and RSL3 in HT22 mouse hippocampal neuronal cells. ADC prevented ferroptosis by scavenging free radicals and activating the NRF2-antioxidant response elements (AREs) pathway, making it a promising lead compound for drugs targeting ferroptosis-related neurological diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sen Guo, Bin-Bin Zhang, Lu Gao, Xiao-Yue Yu, Ji-Hong Shen, Fan Yang, Wen-Cai Zhang, Ya-Ge Jin, Gang Li, Yan-Ge Wang, Zhan-Ying Han, Yuan Liu
Summary: Heart failure severely impairs human health, and cardiac hypertrophy is one of the main causes. This study found that RNF13 plays a protective role in cardiac hypertrophy by activating the p62-NRF2 axis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng, Li Chen
Summary: This study investigated the effects of salidroside (SAL) on pancreatic beta-cell pyroptosis in diabetic mice. The results showed that SAL can protect beta-cells against pyroptosis by activating AMPK and inhibiting NLRP3/GSDMD signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chuo Li, Yusheng Zhang, Rongrong Liu, Yuzhen Mai
Summary: The study demonstrated that Ramelteon could increase cell viability, reduce oxidative stress, and mitigate MPP+-induced neurotoxicity through a mitochondrial-dependent pathway.
Article
Biochemistry & Molecular Biology
James N. N. Tsoporis, Hajera Amatullah, Sahil Gupta, Shehla Izhar, Amin M. M. Ektesabi, Chirag M. M. Vaswani, Jean-Francois Desjardins, Golam Kabir, Ana Paula Teixera Monteiro, Amir K. K. Varkouhi, Nikolaos Kavantzas, Vasileios Salpeas, Ioannis Rizos, John C. C. Marshall, Thomas G. G. Parker, Howard Leong-Poi, Claudia C. C. dos Santos
Summary: Oxidative stress is an early contributor to sepsis-induced myocardial depression, and DJ-1 plays a role as an antioxidant. DJ-1 deficiency improves survival and bacterial clearance in sepsis. This study investigates the role of DJ-1 in sepsis-induced myocardial depression and suggests DJ-1 as a potential therapeutic target.
Article
Chemistry, Medicinal
Fen Guo, Xiaoxue Wang, Xinxin Liu
Summary: Iridencin alleviated MPP+-induced neurotoxicity in BV-2 cells by regulating the Keap1/Nrf2 pathway, suppressing inflammation and oxidative stress.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xian Wu, Yixian Ren, Yue Wen, Sixin Lu, Huihui Li, Honglin Yu, Wenjun Li, Fei Zou
Summary: Mitochondrial dysfunction, oxidative stress, and misfolded protein aggregation are related to the pathogenesis of Parkinson's disease. This study identifies the role of ZKSCAN3 in autophagy-lysosomal dysregulation and demonstrates the potential therapeutic effects of the SIRT1-ZKSCAN3 pathway in PD.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Juan Wei, Jinmei Zhao, Tingting Su, Sha Li, Wenjun Sheng, Lidan Feng, Yang Bi
Summary: Sea buckthorn seed extract can protect intestinal barrier function by regulating the Nrf2-mediated pathway to attenuate oxidative stress and enhance tight junction expression, thus preventing alcohol-induced intestinal barrier dysfunction.
Article
Toxicology
Jiaying Pan, Jie Zhu, Liang Li, Tao Zhang, Zhenyu Xu
Summary: Salidroside protects against LPS-induced kidney injury by activating the SIRT1/Nrf2 pathway.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Naoko Yamagishi, Yuta Yamamoto, Toshio Nishi, Takao Ito, Yoshimitsu Kanai
Summary: Lansoprazole exerts antioxidant effects by activating the Nrf2 pathway and provides hepatoprotection in a drug-induced hepatitis animal model. The cytoprotective effect of lansoprazole on liver epithelial cells against cisplatin-induced cytotoxicity is mediated through the p38 MAPK signaling pathway. This study suggests the potential application of lansoprazole in preventing and treating oxidative liver injury.
Article
Biochemistry & Molecular Biology
Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U. Liu, Genxiang Mao, Jian Sima
Summary: Salidroside (SAL), a natural compound, attenuates Alzheimer's disease (AD) pathology by targeting the NRF2/SIRT3 pathway for mitochondrial and neurite protection, suggesting it as a potential anti-aging drug candidate.
CELL AND BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Jiacong Xiao, Gangyu Zhang, Bohao Chen, Qi He, Jiale Mai, Weijian Chen, Zhaofeng Pan, Junzheng Yang, Jianliang Li, Yanhuai Ma, Ting Wang, Haibin Wang
Summary: The aim of this study was to investigate the therapeutic effects of quercetin (QUE) against iron overload-induced osteoporosis and its potential molecular mechanisms. The results showed that QUE can attenuate oxidative stress damage induced by iron overload by activating the Nrf2/HO-1 signaling pathway, thus protecting bone health.
Article
Biochemistry & Molecular Biology
Shengjie Li, Aoxiang Zhuge, Jiafeng Xia, Shuting Wang, Longxian Lv, Kaicen Wang, Huiyong Jiang, Ren Yan, Liya Yang, Xiaoyuan Bian, Xianwan Jiang, Qiangqiang Wang, Shengyi Han, Lanjuan Li
Summary: This study found that Bifidobacterium longum R0175 can alleviate APAP-induced liver injury by activating the Nrf2 pathway. The gut microbiome plays a crucial role in this process. B. longum R0175 can reduce inflammation, oxidative stress levels, hepatocyte death, and improve microbiome dysbiosis induced by APAP.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Medicinal
Heng Fan, Bin-jie Su, Jian-wei Le, Jian-hua Zhu
Summary: Pretreatment with SLDS can protect the kidneys of septic rats by inhibiting inflammation and apoptosis of kidney tubular epithelial cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)