Article
Environmental Sciences
Hung-Jen Lin, Samiraj Ramesh, Yung-Ming Chang, Chuan-Te Tsai, Chin-Chuan Tsai, Marthandam Asokan Shibu, Shanmugam Tamilselvi, B. Mahalakshmi, Wei-Wen Kuo, Chih-Yang Huang
Summary: The combination therapy of AOF and ADMSCs can significantly reduce oxidative stress induced by D-galactose in aging rat hearts, playing a positive role in cardiac remodeling, fibrosis, and inflammatory signals.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Integrative & Complementary Medicine
Afifa Safdar, Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Ab Aziz, Usman Rashid
Summary: This study showed that goat milk supplementation in D-galactose-induced aging rat model can protect against memory decline and improve short-term, long-term, and spatial memory.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sareer Ahmad, Amjad Khan, Waqar Ali, Myeung Hoon Jo, Junsung Park, Muhammad Ikram, Myeong Ok Kim
Summary: In this study, Fisetin was found to protect against d-galactose-induced oxidative stress, neuroinflammation, and memory impairment in mice by regulating antioxidant mechanisms, inhibiting inflammatory pathways, and preventing ROS accumulation. This suggests that Fisetin may be beneficial in addressing age-related neurological disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marwa Mohamed Atef, Marwa Nagy Emam, Rehab E. Abo El Gheit, Eman M. Elbeltagi, H. A. Alshenawy, Doaa A. Radwan, Reham L. Younis, Rania Nagi Abd-Ellatif
Summary: This study aimed to examine the protective effect of Geraniol (GE) on D-galactose (D-gal) induced cognitive impairment. The results showed that GE effectively improved aging-related memory impairment through increasing GSH, BDNF, Ach levels, and SOD activity. Additionally, GE treatment caused a decrease in the levels of MDA, inflammatory mediators, ER stress sensors, and AchE activity, as well as improved neuronal architecture and spatial memory.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that hyperbaric oxygen therapy can counteract obesity-induced aging-induced osteoporosis, restore the expression levels of certain genes in bone tissue, partially improve bone microarchitecture, and protect against obesity-induced demineralization in obese-aged rats.
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Research has shown that hyperbaric oxygen therapy (HBOT) has a therapeutic effect on osteoporosis in both obese and lean aged rats. HBOT can partially improve bone microarchitecture and protect bone health in obese aged rats, while completely restoring bone microarchitecture in lean aged rats.
Article
Nutrition & Dietetics
Liu-Hong Shen, Lei Fan, Yue Zhang, Yu Shen, Zhe-Tong Su, Guang-Neng Peng, Jun-Liang Deng, Zhi-Jun Zhong, Xiao-Feng Wu, Shu-Min Yu, Sui-Zhong Cao, Xiao-Lan Zong
Summary: The study found that cow placenta extract has strong antioxidant properties, can increase the activity of various enzymes, decrease the content of malondialdehyde, and regulate gene and protein expression in mouse skin to delay skin aging.
Article
Neurosciences
Jinghao Huang, Dengchao Chen, Xinyi Lin, Chengxia Yang, Xianzhong Lin
Summary: MiRNA-124 plays a significant role in memory formation and neurodegenerative diseases. This study investigated the involvement of miRNA-124 in memory impairment induced by d-galactose and explored the underlying neuroprotective mechanism. The results showed that d-galactose administration caused memory impairments in mice, which were alleviated by miRNA-124 agomir injection in the hippocampus, leading to reduced neural damage and neuroinflammation. Molecular analysis and immunohistochemistry revealed that miRNA-124 reduced neuroinflammation through microglial polarization and downregulation of inflammatory mediators. These findings suggest that miRNA-124 may be a potential target for the pathogenesis of memory impairment and neurodegenerative diseases.
Article
Integrative & Complementary Medicine
Yanfang Liao, Yiyi Lai, Huilin Xu, Li Gao, Xiaomei Fu, Xue Wang, Qi Wang, Jiangang Shen, Jiansong Fang, Shuhuan Fang
Summary: This study investigated the effect of Bushen-Yizhi formula on D-gal-induced learning memory in rats and explored its potential metabolic mechanism. The results showed that Bushen-Yizhi formula improved mitochondrial dysfunction, reduced oxidative stress, suppressed neuroinflammation, and inhibited neuroapoptosis through the activation of the AMPK/SIRT1 pathway.
Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Article
Biochemistry & Molecular Biology
Ali H. El-Far, Yaser H. A. Elewa, Elsayeda-Zeinab A. Abdelfattah, Abdel-Wahab A. Alsenosy, Mustafa S. Atta, Khalid M. Abou-Zeid, Soad K. Al Jaouni, Shaker A. Mousa, Ahmed E. Noreldin
Summary: Administering D-galactose in aging animal models can cause oxidative damage, but a combination of thymoquinone and curcumin has shown promising results in preventing these alterations in brain and heart tissues. The combination significantly reduced necrosis and modulated the expression of various genes related to oxidative stress, suggesting its potential in aging prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Noreen Samad, Muhammad Abubaker Hassan Azdee, Imran Imran, Tanveer Ahmad, Faleh Alqahtani
Summary: This study found that the fruit peel of Mukia madrespatana has powerful antioxidative and neuromodulatory properties, which can improve behavioral and cognitive impairments caused by aging.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Shu-ping Yang, Qing Su, Ya-ru Zhang, Yun Sun, Yu-rong Chai
Summary: Metformin has a therapeutic effect on thymus degeneration by improving mitochondrial function, alleviating thymus atrophy caused by D-galactose, altering T lymphocyte subsets and cellular senescent cells, and increasing the expression of specific genes in thymic epithelial cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Antoine Kavaye Kandeda, Danide Nguedia, Etienne Djeuzong, Jonas Kouamouo, Theophile Dimo
Summary: The study demonstrates that an aqueous macerate of Z. jujuba reduces long-term spatial memory impairment in D-galactose-treated rats, potentially through its anti-inflammatory activity.
METABOLIC BRAIN DISEASE
(2022)
Article
Medicine, Research & Experimental
Patcharapong Pantiya, Chanisa Thonusin, Titikorn Chunchai, Hiranya Pintana, Benjamin Ongnok, Wichwara Nawara, Busarin Arunsak, Aphisek Kongkaew, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Long-term dietary restriction or aerobic exercise can effectively attenuate cognitive function in aging rats by reducing oxidative stress, cellular senescence, neuroinflammation, and improving mitochondria, brain metabolism, adult neurogenesis, and synaptic integrity. However, transient interventions did not improve cognitive function.
