Article
Obstetrics & Gynecology
Flore-Anne Pain, Anthony Dohan, Gilles Grange, Louis Marcellin, Joelle Uzan-Augui, Francois Goffinet, Philippe Soyer, Vassilis Tsatsaris
Summary: The study aimed to assess the performance of ultrasound and MRI features in distinguishing different types of placenta accreta spectrum and developed a predictive score for predicting the risk of placenta percreta. The results showed that the predictive score had good accuracy in identifying placenta percreta.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Florrie N. Y. Yu, K. Y. Leung
Summary: Antenatal diagnosis of placenta accreta spectrum (PAS) disorders allows for planned management, reducing hemorrhagic morbidity. Cesarean section and placenta previa are common risk factors, and ultrasound is a promising diagnostic tool for PAS, even in the first trimester.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Hanna Elise Baumann, Laura Katharina Andrea Pawlik, Irene Hoesli, Andreas Schoetzau, Heidrun Schoenberger, Annkathrin Butenschoen, Cecile Monod, Gwendolin Manegold-Brauer
Summary: The study aimed to evaluate the sensitivity and specificity of ultrasound for the diagnosis of placenta accreta spectrum (PAS) and assess the additional value of magnetic resonance imaging (MRI). The results showed that ultrasound had high accuracy in detecting placenta increta/percreta, while MRI was a beneficial additional examination in severe forms of PAS.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Eric Jauniaux, John C. Kingdom, Robert M. Silver
Summary: The increasing prevalence of Accreta placenta and its invasive forms has led to updates in guidelines by organizations like the Royal College of Obstetricians and Gynaecologists and the American College of Obstetricians and Gynecologists, emphasizing the need for careful evaluation of high-risk women and the use of multi-modal ultrasound imaging for diagnosis.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Acoustics
A. M. Hussein, R. A. Elbarmelgy, R. M. Elbarmelgy, M. M. Thabet, E. Jauniaux
Summary: The study evaluated the effectiveness of standardized ultrasound imaging and pathology protocols for perinatal diagnosis of PAS disorders in women with a history of multiple CDs. The findings suggest that certain ultrasound features and intraoperative findings can help differentiate between PAS and non-PAS cases, providing essential information for accurate diagnosis and management.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Ahmed M. Maged, Akmal El-Mazny, Nada Kamal, Safaa I. Mahmoud, Mona Fouad, Noura El-Nassery, Amal Kotb, Wael S. Ragab, Asmaa I. Ogila, Ahmed A. Metwally, Yossra Lasheen, Radwa M. Fahmy, Maha Katta, Eman K. Shaeer, Noha Salah
Summary: This study evaluated the diagnostic accuracy of ultrasound in the diagnosis of Placenta accreta spectrum (PAS). The results showed that ultrasound has high accuracy in diagnosing PAS among women with low lying or placenta previa with previous cesarean section scars, and it is recommended for use in all suspected cases.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Shinya Matsuzaki, Rachel S. Mandelbaum, Rauvynne N. Sangara, Lauren E. McCarthy, Nicole L. Vestal, Maximilian Klar, Kazuhide Matsushima, Rodolfo Amaya, Joseph G. Ouzounian, Koji Matsuo
Summary: This study reveals an increasing trend of placenta accreta spectrum cases during cesarean delivery, with higher surgical morbidity and mortality risks for women with this condition compared to those without. Different subtypes within the placenta accreta spectrum present varying characteristics and outcomes, with women having placenta increta and percreta facing considerably higher risks of surgical morbidity and mortality.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Developmental Biology
Harit Kapoor, Mauro Hanaoka, Adrian Dawkins, Aman Khurana
Summary: Placenta Accreta Spectrum (PAS) refers to abnormally adhesive and penetrative placental tissue at a uterine scar, divided into different degrees of invasion. Recently, the incidence of PAS has increased, making it the leading cause of emergency peripartum hysterectomy. While MRI plays an important role in PAS diagnosis, there are still inconsistencies in MRI findings in the literature.
Article
Obstetrics & Gynecology
Ahmed M. Hussein, Karin Fox, Amar Bhide, Rasha A. Elbarmelgy, Rana M. Elbarmelgy, Mohamed M. Thabet, Eric Jauniaux
Summary: The study assessed whether preoperative ultrasound imaging and intraoperative features predict surgical outcomes in patients at high risk for placenta accreta spectrum (PAS). The results showed that complete praevia, subplacental hypervascularity, lacunar scores, and increased lower segment vascularization were associated with an increased risk of hysterectomy. The study highlights the importance of preoperative ultrasound imaging and intraoperative features in evaluating the need for multidisciplinary support.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Scott A. Shainker, Beverly Coleman, Ilan E. Timor, Amarnath Bhide, Bryann Bromley, Alison G. Cahill, Manisha Gandhi, Jonathan L. Hecht, Katherine M. Johnson, Deborah Levine, Joan Mastrobattista, Jennifer Philips, Lawrence J. Platt, Alireza A. Shamshirsaz, Thomas D. Shipp, Robert M. Silver, Lynn L. Simpson, Joshua A. Copel, Alfred Abuhamad
Summary: The placenta accreta spectrum encompasses various abnormal placental attachment forms, primarily driven by an increase in cesarean delivery rates. Prenatal ultrasound is crucial for detection, but standardization of definitions and examination approaches is needed. The task force aims to assess sonographic markers and provide a standardized approach to prenatal evaluation while identifying research gaps in the field.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Acoustics
Sarah K. Happe, Casey S. Yule, Catherine Y. Spong, C. Edward Wells, Jodi S. Dashe, Elysia Moschos, Martha W. F. Rac, Donald D. McIntire, Diane M. Twickler
Summary: The study validated the PAI for predicting PAS in pregnancies with previous CD, demonstrating high sensitivity and specificity. Contemporaneous application of the PAI is useful in prenatal prediction of PAS.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lulu Peng, Xiang Zhang, Jue Liu, Yi Liu, Jianwei Huang, Junwei Chen, Yun Su, Zehong Yang, Ting Song
Summary: An MRI-radiomics-clinical nomogram was developed to predict the PAS in pregnancies, showing higher accuracy in prenatal prediction compared to traditional MRI morphological-determined PAS. The nomogram incorporating radiomic features, prenatal clinical characteristics, and MRI morphological findings had robust performance in predicting PAS.
EUROPEAN RADIOLOGY
(2022)
Article
Obstetrics & Gynecology
Humaira Ali, Edwin Chandraharan
Summary: PAS disorders, including placenta accreta, increta, and percreta, are associated with serious maternal morbidity and mortality. Risk factors such as previous cesarean sections and uterine surgeries contribute to the increased incidence. Early diagnosis and planning of delivery are crucial for improving maternal and fetal outcomes.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Patricia Rekawek, Lilly Liu, Stephanie Pan, Jessica Overbey, Brian Wagner
Summary: The study found that MRI has similar rates of accuracy and inaccuracies in confirming the diagnosis of PAS compared to ultrasound. Changes in diagnosis by MRI were associated with earlier delivery and increased likelihood of interventional radiology and/or urology involvement at the time of delivery.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
D. W. Skupski, C. M. Duzyj, J. Scholl, A. Perez-Delboy, K. Ruhstaller, L. A. Plante, L. A. Hart, K. T. S. Palomares, B. Ajemian, T. Rosen, W. L. Kinzler, C. Ananth
Summary: This study assesses the performance of classic ultrasound signs and novel ultrasound signs in detecting placenta accreta spectrum (PAS). The findings indicate that combining classic and novel signs improves the detection of PAS, which has implications for obstetric management of patients with placental disorders.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, Research & Experimental
Nana Wang, Fangli Cao, Fang Liu, Yibin Jia, Jianbo Wang, Cihang Bao, Xintong Wang, Qingxu Song, Bingxu Tan, Yufeng Cheng
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Review
Oncology
Jianbo Wang, Na Shao, Xiaowen Ding, Bingxu Tan, Qingxu Song, Nana Wang, Yibin Jia, Hongbo Ling, Yufeng Cheng
Article
Oncology
Qingxu Song, Hong Liu, Jianbo Wang, Yibin Jia, Yuan Liu, Nana Wang, Bingxu Tan, Shanghui Guan, Dianzheng An, Yufeng Cheng
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2014)
Article
Oncology
Qingxu Song, Peng Hu, Jianbo Wang, Yibin Jia, Guangyu Zhang, Li Lv, Yuan Liu, Yufeng Cheng
Review
Radiology, Nuclear Medicine & Medical Imaging
Qingxu Song, Chencheng Zhang, Xin Chen, Yufeng Cheng
Article
Radiology, Nuclear Medicine & Medical Imaging
Qingxu Song, Pengxiang Chen, Xin Chen, Cong Sun, Jianbo Wang, Bingxu Tan, Hong Liu, Yufeng Cheng
Summary: The study investigated the dynamic changes of APT imaging before and after irradiation in NPC mouse models. Results showed that high-dose irradiation led to a significant decrease in tumor APT values, accompanied by necrosis and apoptosis, while low-dose irradiation showed a slight decrease in APT values. APT imaging has the potential to serve as a reliable biomarker for response assessment in NPC.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Yang Lin, Xiangwu Chen, Cancan Yu, Guixiang Xu, Xinxin Nie, Yufeng Cheng, Yuxia Luan, Qingxu Song
Summary: Ferroptosis is a promising approach for cancer therapy, but its efficacy is compromised by ROS production efficiency and tumor cell antioxidant microenvironment. In this study, a nanomedicine was developed to amplify ferroptosis sensitivity by controlling redox homeostasis. The nanomedicine combines a ferroptosis inducer and an antioxidant inhibitor, and it showed enhanced therapeutic efficacy in tumor therapy.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Environmental
Qingxu Song, Gongde Lan, Qian Li, Yang Lin, Xin Chen, Hong Liu, Yufeng Cheng, Yuxia Luan
Summary: Hypofractionated radiotherapy (HRT) is hindered by radio-resistance and inadequate immune activation. Researchers developed an injectable hydrogel platform that enables a cascade amplification of radiosensitization and immune activation to potentiate HRT. The hydrogel releases L-norvaline to spare L-arginine for radiosensitizer nitric oxide (NO) production and uses TLR7/8 agonist to repolarize tumor-associated macrophages, disrupting radio-resistance and immunosuppression. This hydrogel is a promising approach for enhancing HRT and inhibiting tumor growth and metastasis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Tianhui Wei, Wenqi Ti, Qingxu Song, Yufeng Cheng
Summary: In this study, PD-1 inhibitors combined with concurrent CRT/CT showed improved survival for inoperable ESCC patients, with BMI being positively correlated with the efficacy of PD-1 inhibitors.