Article
Radiology, Nuclear Medicine & Medical Imaging
Min Jee Kim, Hyo Sung Kwak, Seung Bae Hwang, Gyung Ho Chung
Summary: This study investigated the one-step detection of intraplaque hemorrhage in the carotid artery and vertebrobasilar artery using SNAP technology. Results showed a high prevalence of IPH in patients, with significantly higher wall thickness in the carotid IPH group and a higher prevalence of high grade stenosis in that group as well.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongye Li, Huiyu Qiao, Yongjun Han, Hualu Han, Dandan Yang, Jingli Cao, Huimin Xu, Tao Wang, Yajie Wang, Jun Shen, Xihai Zhao
Summary: This study validates the superiority of SNAP sequence over traditional MP-RAGE sequence in identifying and quantifying carotid intraplaque hemorrhage, as demonstrated by histology.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Chae Rin Lee, Jun Cheol Yang, Ui Yun Lee, Seung Bae Hwang, Gyung Ho Chung, Hyo Sung Kwak
Summary: Using SNAP imaging, the study determined the prevalence of symptomatic nonstenotic carotid disease (SyNC) in patients with acute stroke and assessed the imaging findings of carotid plaques. It found that SyNC is a relatively important source of stroke in patients with <50% stenosis and territorial infarction, and high maximal wall thickness and carotid IPH are important risk factors for SyNC.
Article
Clinical Neurology
Lu Mingming, Peng Peng, Zhang Lichen, Liu Shaohua, Yuan Fei, Zhang Hongtao, Liu Shitong, He Yao, Zhao Xihai, Cai Jianming
Summary: This study investigated the risk factors for the progression of intraplaque hemorrhage in patients with carotid atherosclerosis. The results showed that taking an antiplatelet agent at baseline, having a history of smoking, and having a larger baseline carotid plaque-containing vessel wall volume were independently predictive of plaques being in the progressed IPH group.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Zhikai Hou, Mingyao Li, Jinhao Lyu, Ziqi Xu, Yifan Liu, Jianfeng He, Jing Jing, Rong Wang, Yongjun Wang, Xin Lou, Zhongrong Miao, Ning Ma
Summary: This study compared plaque characteristics and baseline features in patients with artery-to-artery embolism and parent artery disease, finding that intraplaque enhancement and involvement of the intracranial vertebral artery were more common in the artery-to-artery embolism group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Shuai Zhang, Hui Gu, Xinxin Yu, Bing Kang, Xianshun Yuan, Ximing Wang
Summary: The study revealed a strong association between perivascular adipose tissue and intraplaque hemorrhage in the carotid artery. PFD could serve as a novel marker for identifying carotid IPH and risk stratification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Weiyu Chen, James Nadel, Sergey Tumanov, Roland Stocker
Summary: Near-infrared autofluorescence (NIRAF) is suggested as a new imaging technology for high-risk atherosclerosis. Intraplaque hemorrhage (IPH) and bilirubin have been proposed as the source of NIRAF, but their roles and underlying mechanism are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yu-Meng Sun, Hai-Yang Xu, Shuo Wang, Zhen-Jia Wang, You Zhou, Wei Yu
Summary: This study aimed to identify the imaging characteristics associated with new ipsilateral ischemic lesions (NIILs) after carotid artery stenting (CAS) using high-resolution magnetic resonance vessel wall imaging (HR-VWI). The study found that massive intraplaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), and heavy circumferential calcification were associated with NIILs after CAS. Preoperative quantitative assessment of carotid plaque using HR-VWI may be useful for predicting NIILs following CAS.
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2023)
Article
Clinical Neurology
Keisuke Tokunaga, So Tokunaga, Kenta Hara, Masahiro Yasaka, Yasushi Okada, Takanari Kitazono, Tomoyuki Tsumoto
Summary: The presence of intraplaque high-intensity signal (HIS) on time-of-flight magnetic resonance angiography (TOF-MRA) is associated with an increased risk of restenosis after carotid artery stenting (CAS), indicating that intraplaque hemorrhage is a predictor of restenosis after CAS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Christoph Strecker, Anna Kopczak, Tobias Saam, Dominik Sepp, Anja Hennemuth, Ernst Mayerhofer, Sven Poli, Ulf Ziemann, Holger Poppert, Andreas Schindler, Andreas Harloff
Summary: This study aimed to investigate the relationship between carotid bifurcation geometry and complicated carotid artery plaques (cCAPs). The results showed that low ICA/CCA ratios and low bifurcation angles were significantly associated with the presence of cCAPs. Therefore, assessing carotid geometry could be useful in identifying patients at risk of cCAPs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gemuer Wu, Chengcheng Zhu, Huiying Wang, Dingwei Fu, Xiudi Lu, Chen Cao, Xianchang Zhang, Jinxia Zhu, Lixiang Huang, Mahmud Mossa-Basha, Shuang Xia
Summary: This study investigated the predictive roles of plaque features, plaque number, and co-existing atherosclerosis in stroke recurrence using combined head-and-neck high-resolution vessel wall imaging. The presence of co-existing intracranial high signal on T1-weighted fat-suppressed images (HST1) and extracranial carotid atherosclerosis were identified as independent imaging predictors of stroke recurrence.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Xiaoyuan Fan, Xiaoqian Zhang, Zhichao Lai, Tianye Lin, Hui You, Changwei Liu, Feng Feng
Summary: In patients with carotid stenosis, carotid intraplaque hemorrhage (IPH) is associated with an elevated total burden of cerebral small vessel disease (CSVD). The total CSVD score might be a more effective imaging marker linked with clinical symptoms compared to the degree of stenosis and primary collaterals.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Ying Zhang, Jing Cao, Jingyi Zhou, Chao Zhang, Qunying Li, Shuyuan Chen, Steven Feinstein, Paul A. Grayburn, Pintong Huang
Summary: This study investigated the relationship between intraplaque neovascularisation and plaque elasticity using contrast enhanced ultrasound (CEUS) and shear wave elastography (SWE). The findings showed a negative correlation between intraplaque neovascularisation and elasticity, suggesting that more neovascularisation leads to lower elasticity in the plaque. The histopathological findings further validated this correlation.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Lu, Ruoyao Cao, Sheng Jiao, Ling Li, Chao Liu, Hailong Hu, Zhuangfei Ma, Yun Jiang, Juan Chen
Summary: This study evaluated the application of black-blood CT in carotid artery wall imaging and confirmed its accuracy in diagnosing stenosis rate and plaque burden of carotid artery. Black-blood CT showed good consistency with CTA and VW-MR in identifying stenosis rate and plaque burden, providing clear visualization of the artery wall, especially for patients with contraindication to MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Rui Shen, Xinyu Tong, Dongye Li, Zihan Ning, Hualu Han, Yongjun Han, Dandan Yang, Chenlin Du, Tao Wang, Jingli Cao, Yilan Xu, Ran Huo, Huiyu Qiao, Xihai Zhao
Summary: This study investigated the association between slice-based and time-specific hemodynamic measurements and carotid vulnerable plaque using magnetic resonance (MR) vessel wall imaging and histology. The results showed that hemodynamic measurements were significantly associated with carotid intra-plaque hemorrhage (IPH). Combining hemodynamic measurements with carotid plaque burden may be a stronger indicator for carotid vulnerable plaque features than individual measurements alone.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Liu, Yongjun Han, Maobin Guan, Ying Cai, Wei Wang, Huijun Chen, Xihai Zhao
Summary: This study investigated the impact of femoral artery atherosclerosis on the severity of white matter lesions using MRI. The results showed a significant association between plaque features of carotid and femoral arteries and severe WMLs, indicating that combining characteristics of femoral artery atherosclerosis can enhance the determination of WML severity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiteng Suo, Hui Tang, Qing Lu, Lan Zhang, Qihong Ni, Mengqiu Cao, Zengai Chen, Huilin Zhao, Beibei Sun, Jianrong Xu
Summary: The study compared three commonly used skeletal BOLD cardiovascular magnetic resonance paradigms in healthy adults: gas inhalation, cuff compression-induced ischemia and reactive hyperemia, and exercise. Ischemia and reactive hyperemia were found to have superior reproducibility, while exercise induced the largest T2* variation. Key parameters from the two paradigms showed age-related differences in young and elderly subjects.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neuroimaging
Jianjian Zhang, Xiao Li, Bing Zhao, Jin Zhang, Beibei Sun, Lingling Wang, Shenghao Ding, Xiangyu Liu, Jing Yan, Mahmud Mossa-Basha, Xiaosheng Liu, Jieqing Wan, Huilin Zhao, Jianrong Xu, Chengcheng Zhu
Summary: This study investigated the associations of irregular pulsation of intracranial aneurysms with conventional risk factors and estimated rupture risk, using four-dimensional CT angiography. It was found that irregular pulsation was related to aneurysm size, shape, and location, and aneurysms with irregular pulsation had over a six-fold higher estimated rupture risk compared to those without irregular pulsation. Further longitudinal studies are needed to validate the predictive value of irregular pulsation for aneurysm growth and rupture.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Li, Beibei Sun, Lingling Wang, Jin Zhang, Jianjian Zhang, Zizhou Zhao, Hengqu Wu, Xiaosheng Liu, Yan Zhou, Mahmud Mossa-Basha, David L. Tirschwell, Jianrong Xu, Huilin Zhao, Chengcheng Zhu
Summary: This study aimed to evaluate the association of diabetes and glycemic control with intracranial atherosclerotic plaque characteristics in patients after acute ischemic stroke. The results showed that T2DM was associated with increased intracranial plaque number, and higher HbA1c levels were associated with stronger plaque enhancement.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Yudi Cui, Haixia Xing, Jiafeng Zhou, Yongchun Chen, Boli Lin, Shenghao Ding, Huilin Zhao, Yaohua Pan, Jieqing Wan, Xiaohua Zhang, Bing Zhao
Summary: This study investigated the morphological predictors of irregular pulsation of aneurysms in elderly patients using 4D-CTA. The findings suggest that a large size ratio, posterior circulation aneurysms, the presence of a daughter dome, and aneurysm rupture are independent predictors of irregular pulsation, providing insight into the risk of aneurysm rupture.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Geriatrics & Gerontology
Beibei Sun, Lingling Wang, Xiao Li, Jin Zhang, Jianjian Zhang, Xiaosheng Liu, Hengqu Wu, Mahmud Mossa-Basha, Jianrong Xu, Bing Zhao, Huilin Zhao, Yan Zhou, Chengcheng Zhu
Summary: Increased intracranial atherosclerotic plaque number, higher culprit plaque ER, greater culprit plaque burden, and coronary artery disease (CAD) are independently associated with recurrent acute stroke.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Duygu Baylam Geleri, Hiroko Watase, Baocheng Chu, Li Chen, Huilin Zhao, Xihai Zhao, Thomas S. Hatsukami, Chun Yuan
Summary: This study demonstrates that 3D-MERGE can accurately identify advanced carotid lesions, serving as a screening tool with higher sensitivity and specificity compared to traditional 2D-MC MRI, and with a shorter scan time.
Article
Hematology
Beibei Sun, Xiaoqian Ge, Xiao Li, Jianjian Zhang, Zizhou Zhao, Xiaosheng Liu, Yan Zhou, Jianrong Xu, Huilin Zhao, Jie Sun
Summary: This study evaluated the impact of diabetes on carotid plaque neovasculature as assessed by dynamic contrast-enhanced magnetic resonance imaging. The results showed that carotid plaques in patients with diabetes had higher K-trans values, indicating leaky plaque neovasculature. This leak was associated with hemoglobin A1c and may play a role in accelerated atherosclerosis progression in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huiyu Qiao, Qiansu Yang, Ran Huo, Hualu Han, Zihan Ning, Rui Shen, Xiaowei Song, Huijun Chen, Shuo Chen, Xihai Zhao
Summary: This study evaluated carotid atherosclerosis using three-dimensional quantitative imaging (SQUMA) and found that the combination of T-1, T-2, and T-2* values and mean wall thickness showed the best performance in discriminating symptomatic vessels.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Sai Shao, Honglu Shi, Guangbin Wang, Rui Li, Qinjian Sun, Bin Yao, Hiroko Watase, Daniel S. Hippe, Chun Yuan, Xihai Zhao
Summary: This study investigated the differences in bilateral carotid plaque (BCP) characteristics and found that the left carotid plaques exhibited larger plaque burden, higher prevalence of lipid-rich necrotic core (LRNC), and greater intraplaque haemorrhage (IPH) volume compared to the right carotid plaques.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Medicine, General & Internal
Jin Zhang, Shenghao Ding, Bing Zhao, Beibei Sun, Qinhua Guo, Yaohua Pan, Xiao Li, Lingling Wang, Jianjian Zhang, Jiaqi Tian, Yan Zhou, Jianrong Xu, Chun Yuan, Jieqing Wan, Xihai Zhao, Huilin Zhao
Summary: Using MR vessel wall imaging (MR-VWI), the morphological and compositional features of chronic internal carotid artery occlusion (CICAO) were found to predict the success of endovascular recanalization.
Article
Cardiac & Cardiovascular Systems
Canran Gao, Jie Yin, Tingting Hu, Shuai Liu, Xihai Zhao, Haiyan Ding, Xue Lin, Ligang Fang
Summary: It is unclear whether long-term heavy alcohol use leads to early cardiac function decline. This study aimed to investigate the relationship between heavy alcohol use and reduced cardiac function in subclinical status, using myocardial work analysis. The results showed that epicardial adipose tissue volume and serum biomarkers were potential factors in predicting early cardiac function decline.
CLINICAL CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mingming Lu, Shitong Liu, Peng Peng, Dongqing Liu, Yuan Liu, Fugeng Sheng, Fangbin Hao, Xihai Zhao, Cong Han, Yao He, Fei Yuan, Hongtao Zhang, Jianming Cai
Summary: This study investigated the characteristics of extracranial internal carotid artery (EICA) in adult patients with Moyamoya disease (MMD) using higher-resolution MRI (HRMRI). The study found that proximal stenosis and diffuse wall thickening of EICA were significantly associated with stroke outcomes after surgery. Combining features of EICA with intracranial artery features improved the accuracy of predicting postoperative stroke outcomes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ran Huo, Wanzhong Yuan, Huimin Xu, Dandan Yang, Huiyu Qiao, Hualu Han, Tao Wang, Ying Liu, Huishu Yuan, Xihai Zhao
Summary: This study aimed to investigate the associations between carotid plaque characteristics and postoperative silent stroke (SS) in patients undergoing carotid endarterectomy (CEA). The results showed that the presence and size of intraplaque hemorrhage (IPH), particularly Type-I IPH, were significantly associated with SS in patients with severe carotid stenosis. Additionally, the volume of Type-II IPH, and maximum-area-percentage of Type-II IPH and lipid-rich necrotic core (LRNC) were also significantly associated with SS. However, no significant associations were found between carotid plaque characteristics and SS in patients with moderate carotid stenosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin Li, Hengqu Wu, Hailun Hang, Beibei Sun, Huilin Zhao, Zengai Chen, Yan Zhou, Jianrong Xu, Jinmei Chen, Dan Zhou, Xihai Zhao, Chun Yuan
Summary: This study investigated the association between carotid vulnerable plaque features coexisting with cerebral small vessel diseases (CSVDs) and acute ischemic stroke (AIS), and determined whether coexisting diseases had a stronger association with AIS than a single disease. The results showed that carotid vulnerable plaque features coexisting with lacunes or moderate-to-severe white matter hyperintensities had a stronger association with AIS compared to carotid lesions alone.
EUROPEAN RADIOLOGY
(2022)
