Review
Gastroenterology & Hepatology
Federico Mocchegiani, Paolo Vincenzi, Grazia Conte, Daniele Nicolini, Roberta Rossi, Andrea Benedetti Cacciaguerra, Marco Vivarelli
Summary: Intraductal papillary neoplasms of the bile duct (IPNBs) are a rare variant of biliary tumors characterized by papillary growth within the bile duct lumen. Several classifications have been proposed, but specific guidelines for management have not been developed. Advanced diagnostic methods are needed for accurate diagnosis and proper treatment. The recent subclassification of IPNBs highlights their histopathological and clinical features, prognosis, and survival. Surgical resection is the main treatment, but endoscopic approaches are also used. Genetic research is exploring targeted therapies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pathology
Shoji Kubo, Shogo Tanaka, Masahiko Kinoshita, Hiroji Shinkawa, Takeaki Ishizawa, Yasunori Sato
Summary: This study investigated the clinicopathological findings of intraductal papillary neoplasm of the bile duct (IPNB) in patients with occupational cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane. The results showed that both micro and ordinary IPNBs exhibited similar clinicopathological characteristics, but IPNB with invasive carcinoma was only found in ordinary IPNB. These findings suggest that carcinogens may induce micro IPNB, which then progresses to ordinary IPNB and eventually develops into IPNB with invasive carcinoma in patients with occupational cholangiocarcinoma.
Review
Surgery
Jae Ri Kim, Kee-Taek Jang, Jin-Young Jang
Summary: This review examines previous studies and summarizes the current understanding of the clinical, radiological, morphological, and pathological characteristics of intraductal papillary neoplasm of the bile duct (IPNB). The authors also highlight areas of ambiguity and controversy. The review serves as a guide for future research on this recently established disease entity.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Gastroenterology & Hepatology
Yuji Sakai, Masayuki Ohtsuka, Harutoshi Sugiyama, Rintaro Mikata, Shin Yasui, Izumi Ohno, Yotaro Iino, Jun Kato, Toshio Tsuyuguchi, Naoya Kato
Summary: Bile duct epithelial tumours, specifically IPNB, exhibit distinctive histological features and clinical characteristics, showing similarities to IPMN of the pancreas. IPNB is considered a precancerous lesion of biliary carcinoma, with a better prognosis compared to normal bile duct cancer. Early diagnosis and accurate localization using cholangioscopy are crucial for the management of IPNB.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Sung Yong Han, Dong Uk Kim, Hyeong Seok Nam, Dae Hwan Kang, Sung Ill Jang, Dong Ki Lee, Dong Woo Shin, Kwang Bum Cho, Min Jae Yang, Jae Chul Hwang, Jin Hong Kim, Hoonsub So, Sung Jo Bang, Min Je Sung, Chang-Il Kwon, Dong Wook Lee, Chang-Min Cho, Jae Hee Cho
Summary: This study evaluated the predictors of malignancy in intraductal papillary neoplasm of the bile duct (IPNB) according to anatomical location and investigated the prognosis without surgery. The results showed that extrahepatic IPNB (E-IPNB) had a higher rate of malignancy than intrahepatic IPNB (I-IPNB), with mural nodule > 12 mm in I-IPNB and mural nodule enhancement in E-IPNB being predictive factors for malignancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Wen-Hui Chan, Chien-Ming Chen, Shang-Yu Wang, Ren-Chin Wu, Tse-Ching Chen, Hao-Kang Lee, Cheng-Hui Lin, Chun-Nan Yeh
Summary: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare condition characterized by papillary growth within the bile duct lumen. It is considered as the biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. Fistula formation from IPNB is uncommon, but we report a case of IPNB complicated with hepatogastric fistula.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jun-Yi Wu, Li-Ming Huang, Yan-Nan Bai, Jia-Yi Wu, Yong-Gang Wei, Zhi-Bo Zhang, Mao-Lin Yan
Summary: HCC patients with B1-B3 BDTT have more advanced tumor stages and adverse clinicopathological features. The imaging features of HCC with BDTT on CT and MRI scans, including HCC lesions and intrahepatic bile duct dilation, might facilitate the early diagnosis of B1-B3 BDTT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kristin Stendahl, Syed M. Gilani, Olca Basturk, Pei Hui, Carlie Sigel, Guoping Cai
Summary: Our study analyzed cytomorphologic and molecular features of intraductal papillary neoplasm of the bile duct (IPNB) cases. The cytomorphologic features of IPNB included papillary/complex papillary architecture, columnar cells with vacuolated cytoplasm, enlarged nuclei, and fine granular chromatin. Most cases had adenocarcinoma or high-grade dysplasia, and KRAS mutations were found in a significant number of cases, which may have diagnostic and therapeutic implications.
CANCER CYTOPATHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Raffaella M. Pozzi Mucelli, Carlos Fernandez Moro, Marco Del Chiaro, Roberto Valente, Lennart Blomqvist, Nikolaos Papanikolaou, Johannes-Matthias Lohr, Nikolaos Kartalis
Summary: Volume and elongation value cannot predict malignancy in BD- and/or mixed-type IPMN. Mural nodules, MPD >= 5 mm, and elevated CA19-9 serum levels are associated with higher malignancy risk even after the exclusion of solid masses.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Doo Young Lee, Jaeseung Shin, Sungwon Kim, Song-Ee Baek, Suji Lee, Nak-Hoon Son, Mi-Suk Park
Summary: The study evaluated the performance of a CT-based radiomics model in identifying malignant IPMNs and compared it with the 2017 ICGs. The CT radiomics model exhibited better diagnostic performance than the ICGs, potentially allowing a more quantitative assessment of IPMNs.
EUROPEAN RADIOLOGY
(2023)
Review
Surgery
Lehat Zibari, Muhammad S. Naseer, Het Patel, Hosein Shokouh-Amiri, Gregory Wellman, David Dies, Veron Browne, Gazi B. Zibari
Summary: This article reports a rare case of intraductal papillary mucinous neoplasm of the intrahepatic bile duct, which has papillary and mucinous features similar to pancreatic intraductal papillary mucinous neoplasm (IPMN). The patient underwent partial liver resection, cholecystectomy, and lymphadenectomy.
FRONTIERS IN SURGERY
(2023)
Article
Medicine, Research & Experimental
Xin Wu, Binglu Li, Chaoji Zheng
Summary: This study retrospectively analyzed the medical records of patients with intraductal papillary neoplasm of the bile duct and found that it is a premalignant neoplasm that can involve both intrahepatic and extrahepatic bile ducts. The clinicopathological features of this disease are controversial, and the long-term prognosis is poor. There is still much to be understood and resolved regarding the recognition and treatment of this disease.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Oncology
Binjie Li, Zhiqiang Liu, Zhuo Meng, Mingyang Li, Weijun Tian, Quanyan Liu
Summary: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare tumor characterized by papillary or villous structures within the bile duct. We report two cases of IPNB that underwent surgical resection, including hepatic segmentectomy, bile duct resection, cholecystectomy, and hepaticojejunostomy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hiroki Fukuya, Akifumi Kuwano, Shigehiro Nagasawa, Yusuke Morita, Kosuke Tanaka, Masayoshi Yada, Akihide Masumoto, Kenta Motomura
Summary: This case report highlights a rare occurrence of multicentric recurrence of IPNB in a patient who underwent POCS. Observation may be a reasonable approach for the management of gastric subtype IPNB.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Young Kon Kim, Seon Kyoung Kim, Honsoul Kim, Soohyun Ahn
Summary: The high-risk features for malignant IPMN showed comparable diagnostic accuracy between CT and MRI, with MRI being superior in detecting mural nodules. However, both modalities had similar performance in distinguishing malignant from benign IPMNs.
EUROPEAN RADIOLOGY
(2021)