Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Qijing Wu, Wei Li, Jing Zhao, Wei Sun, Qianqian Yang, Chong Chen, Ping Xia, Jingjing Zhu, Yiceng Zhou, Guoshun Huang, Chen Yong, Min Zheng, Enchao Zhou, Kun Gao
Summary: Apigenin has a protective role against DOX-induced nephrotoxicity without compromising its cytotoxicity in malignant tumors. It may serve as a potential protective agent against renal injury and inflammatory diseases, offering promise in attenuating renal toxicity in cancer patients undergoing DOX treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Nemat Ali, Abdullah F. AlAsmari, Faisal Imam, Mohammad Z. Ahmed, Faleh Alqahtani, Metab Alharbi, Mohammed AlSwayyed, Fawaz AlAsmari, Mohammed Alasmari, Abdulrahman Alshammari, Omer I. Fantoukh, Mohammed M. Alanazi
Summary: The study demonstrated that diosmin is effective in preventing Doxorubicin-induced nephrotoxicity by improving antioxidant mechanisms, reducing inflammation and apoptosis, and restoring kidney structure.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dhaneshvaree Patel, Poonam Yadav, Sumeet K. Singh, Sampat S. Tanwar, Abhishek Sehrawat, Amit Khurana, Jasvinder S. Bhatti, Umashanker Navik
Summary: The present study investigated the therapeutic potential of betaine on doxorubicin-induced nephrotoxicity. The results showed that betaine could attenuate kidney damage by reducing inflammatory and fibrotic mediators and enhancing antioxidant capacity in renal tissue.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ziad H. Al-Oanzi
Summary: The study aimed to assess the combined effects of baicalein (BL) and losartan (LT) on DOX-induced nephrotoxicity in male rats. The rats were divided into five groups: control, DOX, DOX+LT, DOX+BL, and DOX+LT+BL. The DOX group showed significantly increased levels of renal indicators, pro-inflammatory cytokines, and oxidative stress markers compared to the control group. However, the combination therapy of BL and LT demonstrated protective effects through antioxidant and anti-inflammatory activities.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Chemical
Penny Vlahos, Stephen L. Schensul, Shuchi Anand, Emma Shipley, Saranga Diyabalanage, Chaoran Hu, Toan Ha, Allison Staniec, Lalarukh Haider, Jean J. Schensul, Pasan Hewavitharane, Tudor Silva, Rohana Chandrajith, Nishantha Nanayakkara
Summary: This study reveals that exposure to well water in Wilgamuwa, Sri Lanka is associated with kidney function decline, and identifies a cluster with significantly higher CKDu progression than surrounding areas through geospatial analysis. Analysis of household well samples shows that 68% exceed global water quality standards.
Article
Biochemistry & Molecular Biology
Adriana Elena Bulboaca, Alina Porfire, Sorana D. Bolboaca, Cristina Ariadna Nicula, Dana Gabriela Festila, Alexandra Roman, Ruxandra Mioara Rajnoveanu, Armand Rajnoveanu, Gabriela Dogaru, Paul-Mihai Boarescu, Vasile Rus, Corneliu Angelo Bulboaca, Alexandra Ina Bulboaca, Ioana Stanescu
Summary: This study demonstrated the protective effects of Curcumin nanoformulation on nephrotoxicity induced by Gentamicin in rats, showing improvements in oxidative stress, antioxidant capacity, and renal function. The nanoformulation was more effective than conventional Curcumin in improving kidney function and structure.
Article
Biochemistry & Molecular Biology
Nur Elena Zaaba, Sumaya Beegam, Ozaz Elzaki, Javed Yasin, Bilal Mohamed Nemmar, Badreldin H. Ali, Ernest Adeghate, Abderrahim Nemmar
Summary: This study found that alpha-bisabolol (BIS) can protect against cisplatin-induced acute kidney injury (AKI) by reducing inflammation and oxidative stress, indicating its potential as a nephroprotective agent.
Article
Medicine, Research & Experimental
Chen Yu, Hua Dong, Qingchen Wang, Junzhe Bai, Yan-Ni Li, Juan-Juan Zhao, Jia-Zhu Li
Summary: Danshensu has protective effects against cisplatin-induced nephrotoxicity by improving kidney damage, attenuating abnormal renal function indicators and oxidative stress, activating Nrf2/HO-1, and inhibiting the NF-kappa B pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Claudia Morais Sequeira, Marcela Anjos Martins, Renata Alves, Ana Lucia Rosa Nascimento, Giuly Cristina Rodrigues Mello Botti, Vinicius Novaes Rocha, Cristiane Matsuura
Summary: The study demonstrated that aerobic exercise training could effectively prevent doxorubicin-induced cardiomyopathy and preserve cardiomyocyte ultrastructure, partially through activation of the physiological protein synthesis pathway and reduction of oxidative stress.
Review
Medicine, Research & Experimental
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
Summary: This review aims to provide a comprehensive collection of potential cytoprotective remedies in overcoming nephrotoxicity caused by anti-neoplastic drug metabolism and renal oxidative stress. There is an increasing need for renal replacement therapy and higher mortality rates from end-stage renal disease in the next decade, making the discussion of 43 different cytoprotective compounds crucial.
Article
Environmental Sciences
Yixi Zhou, Xijing Zhao, Weiping Hu, Fengkai Ruan, Chengyong He, Jiyi Huang, Zhenghong Zuo
Summary: Propylene glycol (PG) has nephrotoxic effects, causing oxidative stress and inflammatory responses. The administration of 1 and 5 g/kg/day PG for 28 days in mice resulted in kidney issues and abnormal blood markers.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Osama Y. Althunibat, Mohammad H. Abukhalil, Saleem H. Aladaileh, Haitham Qaralleh, Wesam Al-Amarat, Manal A. Alfwuaires, Abdulmohsen I. Algefare, Nader Ibrahim Namazi, Sahar J. Melebary, Ahmad O. Babalghith, Carlos Adam Conte-Junior
Summary: Formononetin protects against gentamicin-induced renal damage in rats by exhibiting antioxidant, anti-inflammatory, and antiapoptotic activities and augmenting Nrf2 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xing Wen, Qihan Huang, Minghui Zhu, Jun Lu
Summary: Cisplatin is an effective chemotherapy drug for solid tumors but also causes various side effects, especially nephrotoxicity. Previous studies have shown a correlation between selenoenzymes and cisplatin-induced renal damage. This study established mouse models with different selenium intake levels and found that selenium deficiency increased sensitivity to cisplatin-induced damage, while selenium supplementation protected against renal injury.
Article
Cell Biology
Jonatan Barrera-Chimal, Nathalie Henley, Michael Philip Grant, Schrodinger Cenatus, Pedro Geraldes, Vincent Pichette, Casimiro Gerarduzzi
Summary: This study evaluated the effects of chronic oral tungsten exposure on renal inflammation in mice. It was found that tungsten exposure led to lysosome accumulation in renal tubular epithelial cells, interstitial infiltration of immune cells, and increased levels of proinflammatory cytokines. Tungsten also reduced cell viability and increased reactive oxygen species generation. Overall, prolonged tungsten exposure resulted in oxidative injury and chronic renal inflammation.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amany E. Abdel-Maged, Amany M. Gad, Sara A. Wandan, Samar S. Azab
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Noha F. Abdelkader, Mohammed Elyamany, Amany M. Gad, Naglaa Assaf, Hala M. Fawzy, Wesam H. Elesawy
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Maha G. Elfeky, Eman M. Mantawy, Amany M. Gad, Hala M. Fawzy, Ebtehal El-Demerdash
Article
Pharmacology & Pharmacy
Iman S. Ahmed, Osama S. Elnahas, Nouran H. Assar, Amany M. Gad, Rania El Hosary
Article
Neurosciences
Amany El-Shahawy Abdel-Maged, Amany M. Gad, Laila Ahmed Rashed, Samar S. Azab, Eman A. Mohamed, Azza S. Awad
MOLECULAR NEUROBIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mennat-Allah M. Hassan, Amany M. Gad, Esther T. Menze, Osama A. Badary, Reem N. El-Naga
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Medicine, Research & Experimental
Noha M. Mounier, Amany El-Shahawy Abdel-Maged, Sara A. Wahdan, Amany M. Gad, Samar S. Azab
Article
Pharmacology & Pharmacy
Lamiaa A. Ahmed, Rana H. Abd El-Rhman, Amany M. Gad, Sherifa K. Hassaneen, Mohamad F. El-Yamany
Summary: The study found that dibenzazepine can provide hepatoprotective effects in acute liver injury in rats, reducing the adverse effects of oxidative stress, inflammation, and apoptosis caused by paracetamol. Compared to silymarin, dibenzazepine showed superior results, possibly due to its more significant regulation of Notch signaling and autophagy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rana H. Abd El-Rhman, Reem N. El-Naga, Amany M. Gad, Mariane G. Tadros, Sherifa K. Hassaneen
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Amira M. AboYoussef, Marwa M. Khalaf, Marina N. Malak, Mohamed A. Hamzawy
Summary: The study demonstrated that sildenafil has potential anticancer effects in urethane-induced lung cancer in BALB/c mice, by inducing cell cycle arrest, apoptosis, and inhibiting metastatic activity through regulating various proteins and pathways. It highlights the importance of future research on sildenafil as a treatment for lung cancer.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marwa M. Khalaf, Emad H. M. Hassanein, Abdel-Gawad S. Shalkami, Ramadan A. M. Hemeida, Wafaa R. Mohamed
Summary: Diallyl disulfide (DADS) effectively alleviated MTX-induced hepatotoxicity through modulation of multiple pathways, including alleviating liver histopathological changes, restoring oxidative stress and inflammation, and regulating apoptosis signaling pathways. Additionally, DADS enhanced the antitumor efficacy of MTX.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Immunology
Marwa M. Khalaf, Samar M. Hassan, Ahmed M. Sayed, Amira M. Abo-Youssef
Summary: Nephrotoxicity caused by vancomycin is associated with oxidative stress and inflammation. Scopoletin attenuates vancomycin-induced renal damage and inflammation by modulating the Nrf2/HO-1 and NF-kappa B/p38 MAPK pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marwa M. Khalaf, Amira M. Abo-Youssef, Marina N. Malak, Mohamed A. Hamzawy
Summary: The study demonstrates that Aliskiren has potential therapeutic effects on lung cancer by inhibiting the RAS/NF-B cell signaling, leading to reduced metastasis and angiogenesis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Immunology
Marwa M. Khalaf, Mahmoud M. El-Sayed, Mohamed A. Kandeil, Sanaa Ahmed
Summary: Parkinson's disease (PD) drugs do not stop disease progression, so finding novel therapeutic medications to halt it is crucial. Research on antidiabetic medicines is valuable for this purpose, and in this study, the neuroprotective benefits of Dulaglutide (DUL) were investigated using the PD model Rotenone (ROT).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Mostafa K. Mohammad, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Amany M. Gad
Summary: This study demonstrates the potential antidepressant effect of meloxicam in a chronic restraint stress model. Meloxicam improved depression-like behavior, neurohistopathological changes, and decreased neurotransmitter levels. These effects may be mediated through inhibition of the COX-2/NOX1/NOX4 pathway and activation of the Nrf2/HO-1 antioxidant pathway.