Article
Biochemistry & Molecular Biology
Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kaemmerer
Summary: The study found that overexpression of PDE2 can reduce the likelihood of ventricular arrhythmia, mainly by preventing the increase of cellular triggers mediated by Epac and CaMKII, indicating that activating myocardial PDE2 may be a novel intracellular antiarrhythmic therapeutic strategy in heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Jinhuang Shen, Fan Cao, Zhiyong Huang, Xinhua Ma, Nana Yang, Haitao Zhang, Yonghong Zhang, Zhiqiang Zhang
Summary: This study investigated the anti-inflammatory activity of limonoids from Chukrasia tabularisis on lipopolysaccharide (LPS)-mediated RAW264.7 cells. The results showed that limonoid 2 had significant anti-inflammatory effects by inhibiting JAK2/STAT3, iNOS/eNOS, and NF-κB signaling pathways and regulating inflammatory mediators.
FOOD & NUTRITION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Khaled Elkholey, Monika Niewiadomska, Lynsie Morris, Seabrook Whyte, Jeremy Houser, Mary Beth Humphrey, Stavros Stavrakis
Summary: This study found that low-level transcutaneous vagus nerve stimulation (LLTS) improved cardiac function in a rat model of heart failure with preserved ejection fraction (HFpEF) through its anti-inflammatory and antifibrotic effects.
CIRCULATION-HEART FAILURE
(2022)
Article
Biochemistry & Molecular Biology
Yongli Han, Lingling Luo, Hongli Li, Lijun Zhang, Yingxuan Yan, Minglv Fang, Jing Yu, Xiaoyan Gao, Ying Liu, Cheng Huang, Shengjie Fan
Summary: Nonalcoholic steatohepatitis (NASH) and hepatic fibrosis are leading causes of cirrhosis, but there is currently no effective treatment. This study found that natural compounds—nomilin (NML) and obacunone (OBA), found in citrus fruits—can inhibit liver damage, inflammation, and fibrosis in mouse models of NASH and hepatic fibrosis. These effects were achieved through enhanced antioxidant and anti-inflammatory capacities. The findings suggest that NML and OBA could be potential strategies for treating NASH.
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Review
Chemistry, Analytical
Nasreddine El Omari, Naoual El Menyiy, Gokhan Zengin, Bey Hing Goh, Monica Gallo, Domenico Montesano, Daniele Naviglio, Abdelhakim Bouyahya
Summary: Tomentosin, a natural compound found in medicinal plants, has been shown to possess unique anticancer mechanisms and anti-inflammatory properties, making it a potential candidate for cancer-fighting drugs. Its ability to modulate telomerase expression on tumor cells has sparked further research into its anticancer effects, while its demonstrated anti-inflammatory action suggests it could serve as a chemo-preventive agent.
Review
Integrative & Complementary Medicine
Zhen Zhang, Fei Chen, Jingjing Wan, Xia Liu
Summary: Inflammation plays a significant role in the development of heart failure after myocardial infarction. Currently, there are no approved anti-inflammatory drugs for preventing heart failure following myocardial infarction. Traditional Chinese medicine has been used clinically for cardiovascular diseases. This article summarizes recent progress in the use of Chinese medicine to improve cardiac function and inhibit inflammation in patients with myocardial infarction or heart failure, providing evidence for their potential application in reducing the onset of heart failure following myocardial infarction.
Article
Biochemistry & Molecular Biology
Shuai Yuan, Heidi M. Schmidt, Katherine C. Wood, Adam C. Straub
Summary: CoQ is ubiquitously embedded in lipid bilayers of various cellular organelles, playing a crucial role in maintaining mitochondrial function and heart health. Clinical studies have shown promising results for CoQ supplementation in treating heart failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Diana Chaar, Benjamin Dumont, Branka Vulesevic, Paul-Eduard Neagoe, Agnes Rakel, Martin G. Sirois, Michel White
Summary: The study found that patients with heart failure with reduced ejection fraction (HFrEF) exhibit a significant decrease in circulating VEGF, while neutrophil-derived IL-8 is significantly increased in these patients. These findings suggest alterations in the inflammatory levels in patients with HFrEF.
Review
Endocrinology & Metabolism
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Assefa Agegnehu Teshome, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Muluken Teshome Azezew
Summary: Diabetes Mellitus is a global health issue that can lead to various complications, including cardiovascular diseases such as heart failure. While hypertension and coronary artery disease are commonly associated with heart failure in diabetes patients, it is also prevalent even in the absence of these risk factors. Understanding the cellular and molecular mechanisms by which diabetes increases the risk of heart failure is crucial for developing effective therapeutics to prevent these changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Yu-Xia Jiang, Jia-Ying Yao, Nan Qin, Jun-Jie Tan, Feng Han, Shi-Jin Qu, Shi-Jun He, Chang-Heng Tan
Summary: Six new B-seco limonoids, named fraxinifolines A-F (1-6), along with four known A,D-di-seco ones, were isolated from Tetradium fraxinifolium twigs with leaves. The structures and absolute configurations were determined by analyzing MS, NMR, single-crystal X-ray diffraction and biogenetic pathway. Anti-inflammatory bioassay revealed that limonoids 1-3 exhibited significant immunosuppressive effect on the production of proinflammatory cytokines (IL-1β and/or TNF-α) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Article
Chemistry, Multidisciplinary
Xiangka Hu, Ping Shao, Xiaojuan Liu, Ling Han, Liuming Gui, Zengxiaorui Cai, Mushuang Qi, Chunmei Dai
Summary: Yuxuebi tablet (YXB) has good anti-inflammatory effects, which may be related to inhibiting the phosphorylation of NF -KB, JUN, and p38, as well as reducing COX-2 expression and inflammatory factor levels.
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Rita Metrani, Guddadarangavvanahally K. Jayaprakasha, Bhimanagouda S. Patil
Summary: The optimized conditions for extracting volatile compounds in melons included blending the sample for 1 minute, adding 1 mL of 30% NaCl, using a 50/30 μm DVB/CAR/PDMS coated SPME fiber for adsorption, and extraction at 80°C for 30 minutes. Through the combination of HS-SPME-GC-MS and chemometric classification, 20 potential markers were identified to differentiate various melon varieties.
FOOD ANALYTICAL METHODS
(2022)
Review
Pathology
Linh Pham, Konstantina Kyritsi, Tianhao Zhou, Ludovica Ceci, Leonardo Baiocchi, Lindsey Kennedy, Sanjukta Chakraborty, Shannon Glaser, Heather Francis, Gianfranco Alpini, Keisaku Sato
Summary: This review summarizes the roles of immune cells in primary liver cancer, including HCC and CCA, and discusses the potential of immunotherapy as a treatment for liver cancer.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Ludovica Ceci, Tianhao Zhou, Ilaria Lenci, Vik Meadows, Lindsey Kennedy, Ping Li, Burcin Ekser, Martina Milana, Wenjun Zhang, Chaodong Wu, Keisaku Sato, Sanjukta Chakraborty, Shannon S. Glaser, Heather Francis, Gianfranco Alpini, Leonardo Baiocchi
Summary: This review provides an overview of the research progress on the risk factors and mechanisms of cholangiocarcinoma. These studies contribute to understanding the etiology and treatment options for cholangiocarcinoma.
Article
Chemistry, Applied
Kishan Biradar, Jashbir Singh, Syamkumar S. Pillai, Kevin M. Crosby, Bhimanagouda S. Patil
Summary: A rapid ultra-high performance liquid chromatography method was developed for the simultaneous separation of capsaicinoid and capsinoid compounds in peppers. The method was successfully used to analyze different pepper cultivars and detect multiple capsaicinoid and capsinoid compounds.
Review
Medicine, Research & Experimental
Ji Yeon Noh, Matthew Herrera, Bhimanagouda S. Patil, Xiao-Di Tan, Gus A. Wright, Yuxiang Sun
Summary: The orexigenic hormone ghrelin and its receptor GHS-R play important roles in metabolism and inflammation. However, the expression and function of GHS-R in immune cells are still poorly understood. This review summarizes recent findings and calls for further research on the immunological roles of ghrelin signaling.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Chandrima Das, Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini S. Yadav, Santanu Adhikary, Clayton R. Hunt, Kamlesh K. Yadav, Shruti Pandita, Siddhartha Roy, John A. Tainer, Zamal Ahmed, Tej K. Pandita
Summary: Therapy resistance in breast cancer presents a significant challenge for clinical management. Metabolic heterogeneity and epigenetic regulation play important roles in DNA damage repair and resistance to genotoxic therapies. Understanding these mechanisms could lead to novel targeted therapies that sensitize cancer cells to conventional treatments.
Review
Biochemistry & Molecular Biology
Priyanka Banerjee, Niyanshi Gaddam, Tej K. Pandita, Sanjukta Chakraborty
Summary: Cellular senescence, driven by various mechanisms and senescence-associated secretory phenotype (SASP), is an important area of research in age-related diseases. The impact of senescence and SASP on different cell types, the immune system, and the vascular system has been widely discussed, but the impact on lymphatic biology and pathological lymphangiogenesis remains underexplored. In this review, the role of senescence on lymphatic pathobiology, its impact on cancer, and potential therapeutic interventions are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Ashleigh Little, Abigail Medford, April O'Brien, Jonathan Childs, Sharon Pan, Jolaine Machado, Sanjukta Chakraborty, Shannon Glaser
Summary: Biliary epithelium, also known as cholangiocytes, is a heterogeneous population of epithelial cells in the liver with different responses and functions depending on their size and location in the biliary tract. Recent findings have shown that the intrahepatic biliary tree exhibits heterogeneity in terms of morphology, function, hormone expression and signaling, response to injury, and roles in liver regeneration. This review summarizes the significant characteristics and differences between small and large cholangiocytes, as well as the in vitro and in vivo models used to evaluate heterogeneity. Future studies elucidating the role of biliary heterogeneity in liver diseases characterized by ductular reaction may provide new therapeutic approaches.
SEMINARS IN LIVER DISEASE
(2023)
Article
Cell Biology
Priyanka Banerjee, Subhashree Kumaravel, Sukanya Roy, Niyanshi Gaddam, Johnny Odeh, Kayla J. Bayless, Shannon Glaser, Sanjukta Chakraborty
Summary: Conjugated bile acids (BA) are elevated in liver pathologies and metastatic lymph nodes. This study investigates the effects of BAs on lymphangiogenesis. The results indicate that BAs promote lymphatic network expansion and enhance LEC invasion, migration, and tube formation through ROS-mediated activation of p90RSK and upregulation of VEGFR3. Furthermore, BAs induce YAP expression, a regulator of lymphangiogenesis. Overall, this study establishes a novel mechanism by which BAs promote lymphangiogenesis.
Review
Pathology
Priyanka Banerjee, Niyanshi Gaddam, Vanessa Chandler, Sanjukta Chakraborty
Summary: The liver plays a critical role in targeting and clearing foreign material, but stress-induced factors can disrupt its normal functioning and lead to liver diseases such as steatosis, inflammation, fibrosis, cirrhosis, and liver cancers. Oxidative stress and inflammatory signaling play a key role in this process, causing mitochondrial dysfunction, increased reactive oxygen species expression, and depletion of ATP. Changes in the liver vasculature also contribute to the pathogenesis of these diseases.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Editorial Material
Hematology
Sanjukta Chakraborty, Brandon J. Dixon, Joseph M. Rutkowski, Jorge A. Castorena-Gonzalez, Jerome W. Breslin
Article
Food Science & Technology
Nitin Dhowlaghar, Tushar Dhanani, Syamkumar Sivasankara Pillai, Bhimanagouda S. Patil
Summary: In this study, we extracted flavonoids and anthocyanins from dried red onion peels using accelerated solvent extraction (ASE) to produce red onion peel extract (ROPE). High-performance liquid chromatography analysis identified important flavonols and anthocyanins in ROPE. The total flavonoid content of ROPE was 459.15 mg/g +/- 16.45 (DW), while the total anthocyanin content was 33.14 mg/g +/- 0.99 (DW). ROPE showed strain-specific effects against L. monocytogenes, inhibiting biofilm formation, motility, and quorum sensing in a concentration-dependent manner. The results suggest that red onion peel waste has the potential to be a source of natural antibacterial compounds for food safety in the circular economy.
Editorial Material
Pathology
Jessica L. Maiers, Sanjukta Chakraborty
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Correction
Food Science & Technology
Bhimu Patil, Jonathan Beauchamp, Liangli Yu, Michael Appell, Michael Morello, Michael Tunick, Mina Kim, Nitin Dhowlaghar, Tony Jin, Zhuohong Xie, Youngmok Kim
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
April O'Brien, Tianhao Zhou, Tori White, Abigail Medford, Lixian Chen, Konstantina Kyritsi, Nan Wu, Jonathan Childs, Danaleigh Stiles, Ludovica Ceci, Sanjukta Chakraborty, Burcin Ekser, Leonardo Baiocchi, Guido Carpino, Eugenio Gaudio, Chaodong Wu, Lindsey Kennedy, Heather Francis, Gianfranco Alpini, Shannon Glaser
Summary: This study found that suppression of FGF1 and miR-16 signaling can reduce hepatic fibrosis, biliary proliferation, inflammation, senescence, and angiogenesis. This may provide therapeutic options for treating cholangiopathies such as PSC.
HEPATOLOGY COMMUNICATIONS
(2022)