期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 817, 期 -, 页码 71-75出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2017.05.057
关键词
A beta monomer; IGF-IR; Neuronal glucose uptake; Glut3; Neuroprotection; Brain hypometabolism
资金
- Italian Ministry of Health [RF-2010-2314258]
Conceived more than 25 years ago, the amyloid cascade hypothesis of Alzheimer's disease has evolved to accommodate new findings, namely different forms of beta-amyloid aggregates and downstream dysfunctions. Yet, the cascade does not mention its very beginning, the beta-amyloid monomer. Here, I will discuss the monomer from a functional evolutionary perspective, highlighting the potential advantages of a native unfolded state that, however, involves an amyloidogenic risk. Finally, I will make a summary of what is known about its functional role in the brain and discuss the implications of its conceivable shortage in the development of Alzheimer's disease.
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