Article
Oncology
Alanah Varricchio, Sidra Khan, Zoe K. Price, Rohan A. Davis, Sunita A. Ramesh, Andrea J. Yool
Summary: Glioblastoma is a highly lethal brain tumor with invasive spreading capabilities. This study found that blocking glutamate receptors and aquaporin-1 channels can limit the motility of tumor cells without causing harm to normal brain cells. Using combination therapy can focus the effects on cancer cells while minimizing off-target effects.
Article
Multidisciplinary Sciences
Mahdie Mousavi, Fereshteh Koosha, Ali Neshastehriz
Summary: A novel nanocomplex, SPIO@AuNP-Cisplatin-Alginate (SACA), was synthesized and characterized. The combination of SACA and 6 MV X-ray significantly decreased the viability of U87MG cells and increased apoptosis, indicating that this nanocomplex effectively enhanced the radiosensitivity of cancer cells.
Article
Pharmacology & Pharmacy
Yu-Chen Lo, Wen-Jen Lin
Summary: This study designed a nano-delivery strategy with blood-brain barrier-penetrating and glioma-targeting abilities to enhance the cellular uptake of PBC and target glioma cells, leading to effective cell death.
Article
Biochemical Research Methods
Bilgesu Onur Sucu, Elif Beyza Koc, Ozgecan Savlug Ipek, Afranur Mirat, Furkan Almas, Melike Aybala Guzel, Berna Dogan, Damla Uludag, Nihal Karakas, Serdar Durdagi, Mustafa Guzel
Summary: Glioblastoma Multiforme (GBM) is a highly aggressive and deadly brain cancer. Current treatment options for GBM are ineffective due to the rapid progression of the disease and the inability of drugs to cross the blood-brain barrier. This study synthesized novel CAPE analogs and found that one compound significantly decreased the viability of GBM cells. In silico studies also showed that these compounds interacted with critical targets involved in GBM disease pathway. Further research on these novel CAPE analogs may provide insight into their mechanism of action.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2022)
Article
Biochemistry & Molecular Biology
Amin Tadayoni Nia, Zahra Bazi, Ayyoob Khosravi, Morteza Oladnabi
Summary: Studies have shown that increased expression of the WDR81 gene in glioblastoma leads to decreased autophagy and increased exosome production. Silencing the WDR81 gene with siRNA can reduce exosome levels in glioblastoma cells, suggesting a potential new gene therapy strategy. Further research is needed to explore the implications of this discovery.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Valeria Manganelli, Roberta Misasi, Gloria Riitano, Antonella Capozzi, Vincenzo Mattei, Tuba Rana Caglar, Davide Ialongo, Valentina Noemi Madia, Antonella Messore, Roberta Costi, Roberto Di Santo, Maurizio Sorice, Tina Garofalo
Summary: This research investigated a new HPSE inhibitor, RDS 3337, and its role in regulating the autophagic process and the balance between apoptosis and autophagy in U87 glioblastoma cells. The results showed that RDS 3337 inhibited autophagic-lysosomal flux, leading to the accumulation of lipidated LC3-II form. This inhibition of autophagic flux activated apoptosis mechanisms. These findings suggest a potential role for HPSE inhibitors in controlling tumor growth progression by balancing apoptosis and autophagy.
Article
Medicine, Research & Experimental
Hamid Soraya, Neda Abbaspour Sani, Nassrollah Jabbari, Jafar Rezaie
Summary: The study demonstrates that metformin inhibits cell survival and expression of certain miRNAs in U87 MG cells, while promoting exosome biogenesis and secretion, as well as increasing CD63 protein levels.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Oncology
Sander Bekeschus, Mikael Ispirjan, Eric Freund, Frederik Kinnen, Juliane Moritz, Fariba Saadati, Jacqueline Eckroth, Debora Singer, Matthias B. Stope, Kristian Wende, Christoph A. Ritter, Henry W. S. Schroeder, Sascha Marx
Summary: This study demonstrates the potential of gas plasma treatment in inducing cell cycle arrest, apoptosis, and immunomodulation in patient-derived GBM tissue samples. The findings suggest that gas plasma technology could be a valuable addition to current treatment strategies in neurosurgery and neuro-oncology.
Article
Biochemistry & Molecular Biology
Viktoria Pevna, Georges Wagnieres, Veronika Huntosova
Summary: This study found that combining PDT with PBM in the treatment of glioblastoma can improve treatment efficacy and lead to apoptosis. PBM stimulates autophagy and results in changes in specific protein levels within the cells.
Article
Multidisciplinary Sciences
Jan Rix, Ortrud Uckermann, Katrin Kirsche, Gabriele Schackert, Edmund Koch, Matthias Kirsch, Roberta Galli
Summary: The study combined Brillouin spectroscopy and Raman spectroscopy to investigate the relationship between biomechanical properties and biochemical composition in U87-MG human glioblastoma cells at the subcellular level. The results showed that the nucleus and nucleoli are stiffer than the perinuclear region and the cytoplasm, and culturing conditions affect the biomechanics of the cell cytoplasm.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Cell Biology
Berrin Ozdil, Duygu Calik-Kocaturk, Cisem Altunayar-Unsalan, Eda Acikgoz, Fatih Oltulu, Volkan Gorgulu, Aysegul Uysal, Gulperi Oktem, Ozan Unsalan, Gunnur Guler, Huseyin Aktug
Summary: Current cancer studies focus on molecular-targeting diagnostics and interactions with surroundings, but there are still gaps in characterization based on topological differences and elemental composition. In this study, atomic force microscopy, scanning electron microscopy accompanied by energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy were used to report the topology and chemistry of GBM cells and healthy cells. The results showed differences in gene expression, morphology, and surface roughness between the two cell types, providing further insight into rapid cancer cell characterization.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Junfang Li, Xiaoling Hu, Tian Luo, Yingmei Lu, Yiyue Feng, Honghua Zhang, Dan Liu, Xiaohong Fan, Yuqing Wang, Liming Jiang, Yuying Wang, Xiangyong Hao, Tao Shi, Zhen Wang
Summary: Novel N-2-(phenylamino) benzamide derivatives showed promising results as anti-glioblastoma agents, with some compounds demonstrating improved COX-2 inhibition and anti-proliferation, anti-migration, and anti-invasion effects. Compound I-1 exhibited tumor growth inhibition in experimental models and higher safety compared to temozolomide.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Eno I. Essien, Thomas P. Hofer, Michael J. Atkinson, Natasa Anastasov
Summary: Using a combined radiation and drug-screening platform, researchers investigated the efficacy of combining a histone deacetylase inhibitor (HDACi) and MAPK/ERK kinase inhibitor (MEKi) with radiation against glioblastoma stem-like cells (GSLCs). The results demonstrated that the combined radiochemotherapy effectively inhibited sphere formation and reduced the expression of GSLC markers in glioblastoma-derived spheres, suggesting a potential new strategy to improve the treatment of glioblastoma.
Article
Oncology
Danielle M. Burgenske, Surabhi Talele, Jenny L. Pokorny, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Mark A. Schroeder, Lihong He, Zeng Hu, Gautham Gampa, Matthew L. Kosel, Paul A. Decker, Gaspar J. Kitange, Anne Schmitt-Hoffmann, Felix Bachmann, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Caterina Giannini, Paul McSheehy, Heidi A. Lane, William F. Elmquist, Jann N. Sarkaria
Summary: The study assessed the use of the tumor checkpoint controller lisavanbulin in the treatment of glioblastoma. The results showed that lisavanbulin monotherapy and its combination with standard treatments significantly extended the survival of patients and had good brain penetration. These findings provide important clinical evidence for the application of lisavanbulin in clinical treatment.
Article
Multidisciplinary Sciences
Farhad Shiri, Haidong Feng, Kevin E. Petersen, Himanshu Sant, Gina T. Bardi, Luke A. Schroeder, Michael L. Merchant, Bruce K. Gale, Joshua L. Hood
Summary: Nanoscale and microscale cell-derived extracellular vesicles types and subtypes have significant importance in biology and medicine. Researchers have developed a miniaturized device that uses elasto-inertial effect to separate different types of extracellular vesicles, which can be applied in microfluidic applications. The device has successfully re-isolated and recovered extracellular vesicles in the experiment.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Richard Aarnio, Erika Atencio Herre, Salli Karna, Senthil Palani, Helena Virtanen, Heidi Liljenback, Jenni Virta, Aake Honkaniemi, Vesa Oikonen, Chunlei Han, Sanna Laurila, Marco Bucci, Semi Helin, Emrah Yatkin, Lauri Nummenmaa, Pirjo Nuutila, Jing Tang, Anne Roivainen
Summary: Photoperiod affects the availability of mu-opioid receptors (MOR) in brown adipose tissue (BAT), and sympathetic innervation may regulate thermogenesis via the peripheral MOR system.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Integrative & Complementary Medicine
Ashwaq H. S. Yehya, Muhammad Asif, Amin M. S. Abdul Majid, Chern E. Oon
Summary: This study aimed to evaluate the cytotoxic activity and synergistic effects of C5EOSEW5050ESA in gemcitabine-resistant pancreatic cancer cells. The results showed that C5EOSEW5050ESA sensitized resistant cells to C5EOSEW5050ESA-gemcitabine combination treatment by reducing the expression of multidrug-resistant genes and epithelial-mesenchymal transition markers through the inhibition of Notch signaling pathway. This study provides valuable insights into using C5EOSEW5050ESA as a potential complementary treatment for resistant pancreatic cancer.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Polymer Science
Hassan A. Almoustafa, Mohammed Abdullah Alshawsh, Fouad Saleih R. Al-Suede, Salah Abdulrazak Alshehade, Amin Malik Shah Abdul Majid, Zamri Chik
Summary: PEG-coated PLGA nanoparticles are used for cancer treatment due to their biocompatibility, nonimmunogenicity, and ability to accumulate in tumor sites. In this study, HA-PEG-PLGA NPs were tested on a mouse model of breast cancer metastasis and showed significant inhibition of tumor growth and less metastasis compared to control and Free DOX groups. Further studies on pharmacokinetics and toxicity are needed before clinical research.
Article
Chemistry, Medicinal
Salah Abdalrazak Alshehade, Raghdaa Hamdan Al Zarzour, Michael Mathai, Nelli Giribabu, Atefehalsadat Seyedan, Gurjeet Kaur, Fouad Saleih Resq Al-Suede, Amin Malik Shah Abdul Majid, Vikneswaran Murugaiyah, Hassan Almoustafa, Mohammed Abdullah Alshawsh
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and Orthosiphon aristatus has been shown to inhibit its progression. Feeding C57BL/6 mice with O. aristatus extract for 8 weeks reduced liver enzyme levels and decreased serum glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, and atherogenic risk index. Histological analysis also revealed a reversal of hepatic fat accumulation and reduced NAFLD severity. Furthermore, O. aristatus demonstrated antioxidant and anti-inflammatory activities. Overall, the primary mechanism of action of O. aristatus in treating NAFLD appears to be its antioxidant activity.
Article
Hematology
Xudong Cao, Taotao Li, Beibei Xu, Kai Ding, Weimin Li, Bin Shen, Man Chu, Dengwen Zhu, Li Rui, Zhi Shang, Xiao Li, Yinyin Wang, Shuyu Zheng, Kari Alitalo, Ganqiang Liu, Jing Tang, Yoshiaki Kubota, Yulong He
Summary: This study reveals that TIE1 and TIE2 act synergistically to restrict sprouting angiogenesis during the development of the venous system.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Gabriel O. Rodriguez-Vazquez, Adriana O. Diaz-Quinones, Nataliya Chorna, Iris K. Salgado-Villanueva, Jing Tang, Walter I. Silva Ortiz, Hector M. Maldonado
Summary: Drug synergy is crucial in chemotherapy for acute lymphocytic leukemia and other cancers as it allows for reduced dosing and side effects. This study analyzed the pharmacodynamic synergy between the anti-metabolite cytarabine and WEE1 inhibitor adavosertib on acute leukemia cell lines and found that they exhibited mutually synergistic drug interactions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Timo-Pekka K. Lehto, Juho Pylvalainen, Kevin Sandeman, Anu Kenttamies, Stig Nordling, Ian G. Mills, Jing Tang, Tuomas Mirtti, Antti Rannikko
Summary: Magnetic resonance imaging (MRI) is commonly used for prostate biopsy triage, but a significant number of prostate cancers are not visible using MRI. This study aimed to identify factors associated with MRI visibility and their impact on metastasis and prostate-specific death. The results showed that MRI-visible prostate cancers have more aggressive features and are associated with poor prognosis. Targeted biopsy of visible lesions may be sufficient for risk stratification in MRI-positive patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Physical
Mukhlif Mohsin Slaihim, Fouad Saleih R. Al-Suede, Melati Khairuddean, Siti Balkees S. T. N. Hameed Sultan, V Mansoureh Nazari, Mohamed B. Khadeer Ahamed, Amin Malik Shah Abdul Majid
Summary: This study synthesized and characterized a new ring system based on 1,2,4-triazole compounds, and explored their anti-tumor properties against breast cancer (MCF-7) and colorectal cancer (HCT-116) cells. The results showed that compounds 6A and 7B exhibited significant cytotoxic efficacy against MCF-7 cells, with an IC50 of 38 and 53 μM, respectively, while other compounds demonstrated moderate cytotoxicity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Soil Science
Hanbo Yun, Qing Zhu, Jing Tang, Wenxin Zhang, Deliang Chen, Philippe Ciais, Qingbai Wu, Bo Elberling
Summary: This study quantified the effects of warming and permafrost thawing on nitrogen availability and plant growth in permafrost-affected ecosystems. The results showed that most sites on the Tibetan Plateau have experienced warming and thawing, leading to increased inorganic nitrogen availability. Deep-rooted plant species were able to utilize the added nitrogen, and a feedback mechanism of climate warming was identified, where released nitrogen favored deep-rooted plants. These findings explain the important changes in plant composition and growth observed across the study sites.
SOIL BIOLOGY & BIOCHEMISTRY
(2023)
Editorial Material
Genetics & Heredity
Kecheng Zhou, Wenyu Wang, Jing Tang
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Romain David, Arina Rybina, Jean-Marie Burel, Jean-Karim Heriche, Pauline Audergon, Jan-Willem Boiten, Frederik Coppens, Sara Crockett, Katrina Exter, Sven Fahrner, Maddalena Fratelli, Carole Goble, Philipp Gormanns, Tobias Grantner, Bjoern Gruening, Kim Tamara Gurwitz, John M. Hancock, Henriette Harmse, Petr Holub, Nick Juty, Geoffrey Karnbach, Emma Karoune, Antje Keppler, Carla Lancelotti, Jessica Klemeier, Jean-Luc Legras, Allyson L. Lister, Dario Livio Longo, Rebecca Ludwig, Benedicte Madon, Marzia Massimi, Vera Matser, Rafaele Matteoni, Michaela Th Mayrhofer, Christian Ohmann, Maria Panagiotopoulou, Helen Parkinson, Isabelle Perseil, Claudia Pfander, Roland Pieruschka, Michael Raess, Andreas Rauber, Audrey S. Richard, Paolo Romano, Antonio Rosato, Alex Sanchez-Pla, Susanna-Assunta Sansone, Ugis Sarkans, Beatriz Serrano-Solano, Jing Tang, Ziaurrehman Tanoli, Jonathan Tedds, Harald Wagener, Martin Weise, Hans Westerhoff, Rudolf Wittner, Jonathan Ewbank, Niklas Blomberg, Philip Gribbon
Summary: The main goals of the life science communities in the Open Science framework are to increase reuse and sustainability of data resources, software tools, and workflows. This article presents key findings and recommendations for generating and establishing sustainable life science resources based on the work done within the EOSC-Life consortium. The article also highlights the challenges to sustainability in the life sciences and how EOSC-Life provides a model for sustainable data management according to FAIR principles.
Article
Multidisciplinary Sciences
Huimin Zhu, Renyi Zhou, Dongsheng Cao, Jing Tang, Min Li
Summary: This article introduces a deep learning approach called PGMG, guided by pharmacophore, to generate bioactive molecules. The molecules generated by PGMG have strong docking affinities and high scores of validity, uniqueness, and novelty.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Tolou Shadbahr, Michael Roberts, Jan Stanczuk, Julian Gilbey, Philip Teare, Soeren Dittmer, Matthew Thorpe, Ramon Vinas Torne, Evis Sala, Pietro Lio, Mishal Patel, Jacobus Preller, James H. F. Rudd, Tuomas Mirtti, Antti Sakari Rannikko, John A. D. Aston, Jing Tang, Carola-Bibiane Schonlieb
Summary: This study demonstrates the importance of evaluating imputation quality when building classification models for incomplete data. The researchers developed a new method for assessing imputation quality and found that a classifier model trained on poorly imputed data can compromise its performance. They also discovered that commonly used measures for assessing imputation quality often result in imputed data that does not match the underlying data distribution.
COMMUNICATIONS MEDICINE
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Wenyu Wang, Jie Bao, Shan Huang, Jehad Aldahdooh, Yinyin Wang, Johanna Eriksson, Ziaurrehman Tanoli, Massimiliano Gaetani, Jing Tang
BRITISH JOURNAL OF PHARMACOLOGY
(2023)