Article
Medicine, Research & Experimental
Giusy Russomanno, Kyeong Beom Jo, Vahitha B. Abdul-Salam, Claire Morgan, Jens Endruschat, Ute Schaeper, Ahmed H. Osman, Mai M. Alzaydi, Martin R. Wilkins, Beata Wojciak-Stothard
Summary: Supplementation of endothelial miR-150 attenuates pulmonary endothelial damage induced by vascular stresses in PAH and may be considered as a potential therapeutic strategy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Peripheral Vascular Disease
Gui-Feng Lu, Fei Geng, Li-Ping Deng, Da-Cen Lin, Yan-Zhen Huang, Su-Mei Lai, Yi-Chen Lin, Long-Xin Gui, James S. K. Sham, Mo-Jun Lin
Summary: This study reveals the crucial role of circular RNA circSMOC1 in the metabolic reprogramming of pulmonary artery smooth muscle cells in pulmonary arterial hypertension. It regulates pulmonary vascular remodeling by modulating PTBP1 and miR-329-3p.
Review
Medicine, General & Internal
Silvana Elena Hojda, Irina Camelia Chis, Simona Clichici
Summary: PAH is a severe medical condition that requires monitoring and treatment. Biomarkers play an important role in diagnosis, prognosis, and disease progression, providing valuable information through blood and urine tests.
Article
Biochemistry & Molecular Biology
Dan Yi, Bin Liu, Ting Wang, Qi Liao, Maggie M. Zhu, You-Yang Zhao, Zhiyu Dai
Summary: This study identified a novel mechanism of endothelial autocrine signaling in regulating PVEC proliferation and pulmonary vascular remodeling in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shuang Chen, Ping Sun, You Li, Wenqian Shen, Chao Wang, Peng Zhao, Hao Cui, Jing-Yi Xue, Guo-Qing Du
Summary: This study investigates the cardio-protective capabilities of the anti-oxidant melatonin for treating adverse right ventricular remodeling in pulmonary arterial hypertension (PAH). The findings suggest that melatonin activates the Mst1-Nrf2 pathway, reducing cardiomyocyte hypertrophy and mitochondrial oxidative stress. In vivo, melatonin pre-treatment significantly improves cardiac function, right ventricular hypertrophy, fibrosis, and dilation in PAH rats. These beneficial effects are associated with upregulation of the Mst1-Nrf2 pathway and reduced oxidative stress. Melatonin's therapeutic effects are similar to or even superior to N-acetyl cysteine, a confirmed antioxidant treatment for PAH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Yun Liu, Yong Li, Jinhai Li, Xiangrong Zuo, Quan Cao, Weiping Xie, Hong Wang
Summary: MiR-1 plays a crucial role in pulmonary arterial hypertension and cardiovascular diseases. Knockdown of miR-1 can inhibit right ventricle remodeling in model rats with PAH and attenuate fibrosis through the PI3K/AKT signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
Liang Li, Wei Xie, Yu Gui, Xi-Long Zheng
Summary: BRD4, a chromatin-binding protein, is implicated in the development of various tumors, and recent evidence suggests its significant role in cardiovascular diseases. This review summarizes BRD4's potential as a regulator in cardiovascular pathophysiology, suggesting it may be a new therapeutic target in the future.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hongyang Pi, Lu Xia, David D. Ralph, Samuel G. Rayner, Ali Shojaie, Peter J. Leary, Sina A. Gharib
Summary: In this study, metabolic profiling was used to identify the association between plasma metabolomic profiles and right ventricular dilation, mortality, and measures of disease severity in patients with pulmonary arterial hypertension (PAH). The polyamine, histidine, and sphingomyelin metabolic pathways were found to be associated with RV dilation, mortality, and disease severity.
CIRCULATION RESEARCH
(2023)
Article
Hematology
Amira Zawia, Nadine D. Arnold, Laura West, Josephine A. Pickworth, Helena Turton, James Iremonger, Adam T. Braithwaite, Jaime Canedo, Simon A. Johnston, A. A. Roger Thompson, Gaynor Miller, Allan Lawrie
Summary: The study showed that reducing CD68 macrophages globally affects the development of experimental PAH, particularly in male mice. Imbalance of macrophages can lead to changes in the PAH phenotype.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Birger Tielemans, Leanda Stoian, Allard Wagenaar, Mathias Leys, Catharina Belge, Marion Delcroix, Rozenn Quarck
Summary: Pulmonary arterial hypertension affects the pulmonary endothelium, and despite available treatments, the mortality rate remains high. A new technique allows harvesting and culturing patients' pulmonary arterial endothelial cells, maintaining their endothelial phenotype. This study highlights the potential for personalized precision medicine for patients with rare pulmonary vascular diseases.
Article
Critical Care Medicine
Nicholas A. Kolaitis
Summary: Lung transplantation is a unique and effective treatment option for patients with end-stage pulmonary arterial hypertension. However, these patients face various challenges and inequities in the organ allocation process, resulting in less favorable long-term outcomes.
Article
Cardiac & Cardiovascular Systems
Lucas R. Celant, Jeroen N. Wessels, Azar Kianzad, J. Tim Marcus, Lilian J. Meijboom, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf
Summary: This study aimed to investigate the relationship between reaching or maintaining a 45% threshold of right ventricular ejection fraction (RVEF) and treatment response, long-term functional stability, and prognosis in patients with pulmonary arterial hypertension (PAH). The findings demonstrated that patients who reached or maintained the 45% RVEF threshold had favorable prognosis and long-term stable RV function.
Article
Chemistry, Multidisciplinary
Zheng-yi Bao, Hui-min Li, Shuo-bo Zhang, Yi-qiu Fei, Ming-fei Yao, Lan-juan Li
Summary: Pulmonary arterial hypertension (PH) is a chronic disease caused by increased pulmonary vascular resistance and right heart failure. A. muciniphila has been found to have therapeutic effects on cardiovascular disorders. This study explored the therapeutic effects of A. muciniphila on hypoxia-induced PH and the underlying mechanisms.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, John Blair, Martin W. Bergmann, Heiko Bugger, Dan Burkhoff, Leonhard Bruch, David S. Celermajer, Brian Claggett, John G. F. Cleland, Donald E. Cutlip, Ira Dauber, Jean-Christophe Eicher, Qi Gao, Thomas M. Gorter, Finn Gustafsson, Chris Hayward, Jan van der Heyden, Gerd Hasenfuss, Scott L. Hummel, David M. Kaye, Jan Komtebedde, Joseph M. Massaro, Jeremy A. Mazurek, Scott McKenzie, Shamir R. Mehta, Mark C. Petrie, Marco C. Post, Ajith Nair, Andreas Rieth, Frank E. Silvestry, Scott D. Solomon, Jean-Noel Trochu, Dirk J. Van Veldhuisen, Ralf Westenfeld, Martin B. Leon, Sanjiv J. Shah
Summary: In heart failure patients, those with latent pulmonary vascular disease may worsen with atrial shunt therapy, while those without latent pulmonary vascular disease may benefit.
Review
Physiology
Michael H. Lee, Thais C. F. Menezes, Julie A. Reisz, Eloara V. M. Ferreira, Brian B. Graham, Rudolf K. F. Oliveira
Summary: Pulmonary arterial hypertension is an incurable disease characterized by dysregulated metabolism at the cellular level in the pulmonary vasculature and impaired exercise oxygen consumption. The precise interactions between altered pulmonary vascular metabolism and abnormal exercise physiology are relatively unknown.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Shaoyan Liu, Yanyan Yang, Shaoyan Jiang, Ningning Tang, Jiawei Tian, Murugavel Ponnusamy, Muhammad Akram Tariq, Zhexun Lian, Hui Xin, Tao Yu
Review
Cardiac & Cardiovascular Systems
Ningning Tang, Shaoyan Jiang, Yanyan Yang, Shaoyan Liu, Murugavel Ponnusamy, Hui Xin, Tao Yu
CARDIOVASCULAR THERAPEUTICS
(2018)
Review
Cell Biology
Kaowen Yan, Murugavel Ponnusamy, Ying Xin, Qi Wang, Peifeng Li, Kun Wang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Ying Liu, Xiang Ao, Wei Ding, Murugavel Ponnusamy, Wei Wu, Xiaodan Hao, Wanpeng Yu, Yifei Wang, Peifeng Li, Jianxun Wang
Article
Biochemistry & Molecular Biology
Lu-Yu Zhou, Mei Zhai, Yan Huang, Sheng Xu, Tao An, Yun-Hong Wang, Rong-Cheng Zhang, Cui-Yun Liu, Yan-Han Dong, Man Wang, Li-Li Qian, Murugavel Ponnusamy, Yu-Hui Zhang, Jian Zhang, Kun Wang
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Biochemistry & Molecular Biology
Xin Pang, Zhixia Zhou, Zhuang Yu, Lichun Han, Zhijuan Lin, Xiang Ao, Chang Liu, Yuqi He, Murugavel Ponnusamy, Peifeng Li, Jianxun Wang
Article
Cardiac & Cardiovascular Systems
Murugavel Ponnusamy, Fang Liu, Yu-Hui Zhang, Rui-Bei Li, Mei Zhai, Fei Liu, Lu-Yu Zhou, Cui-Yun Liu, Kao-Wen Yan, Yan-Han Dong, Man Wang, Li-Li Qian, Chan Shan, Sheng Xu, Qi Wang, Yan-Hui Zhang, Pei-Feng Li, Jian Zhang, Kun Wang
Review
Oncology
Ying Liu, Wei Ding, Hu Ge, Murugavel Ponnusamy, Qiong Wang, Xiaodan Hao, Wei Wu, Yuan Zhang, Wanpeng Yu, Xiang Ao, Jianxun Wang
Article
Cell Biology
Xiang-Qian Gao, Yu-Hui Zhang, Fang Liu, Murugavel Ponnusamy, Xue-Mei Zhao, Lu-Yu Zhou, Mei Zhai, Cui-Yun Liu, Xin-Min Li, Man Wang, Chan Shan, Pei-Pei Shan, Yin Wang, Yan-Han Dong, Li-Li Qian, Tao Yu, Jie Ju, Tao Wang, Kai Wang, Xin-Zhe Chen, Yun-Hong Wang, Jian Zhang, Pei-Feng Li, Kun Wang
NATURE CELL BIOLOGY
(2020)
Review
Oncology
Chao Yuan, Hao Qin, Murugavel Ponnusamy, Yong Chen, Zhijuan Lin
Summary: PIWI-interacting RNA is a type of non-coding small RNA found primarily in mammalian germ cells, which cooperates with PIWI protein family to participate in germ cell development and maintain genomic stability. Abnormal expression of piRNAs is associated with various human cancers, potentially serving as oncogenes or tumor suppressors and providing new opportunities for cancer diagnosis, treatment, or prognosis monitoring.
Article
Integrative & Complementary Medicine
Thabitha Aavula, Vignesh Narasimman, Saravanan Ramachandran, Radajurai Murugan, Murugavel Ponnusamy, Gururaja Perumal Pazhani, G. Sivaleela
Summary: This study investigates the antioxidant and teratogenic effects of two different methods of formulating agar from Turbinaria conoides using a zebrafish model. The results show that the formulated agars have dose-dependent toxicity and increased antioxidant activity, with FA1 having the least teratogenic activity and higher antioxidant activity compared to FA2. These findings suggest that these formulated agars could be used as alternative antioxidants.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Oncology
Li-jie Zhang, Feng Chen, Xiao-ru Liang, Murugavel Ponnusamy, Hao Qin, Zhi-juan Lin
Summary: This review summarizes the interactions among sEV, lncRNAs, and TAMs in tumors and provides new perspectives on their potential roles in cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tao Wang, Lu-Yu Zhou, Xin-Min Li, Fang Liu, Lin Liang, Xin-Zhe Chen, Jie Ju, Murugavel Ponnusamy, Kai Wang, Cui-Yun Liu, Kao-Wen Yan, Kun Wang
Summary: The role of ABRO1 in cardiomyocyte proliferation and myocardial regeneration is explored in this study. It is found that ABRO1 regulates cardiomyocyte proliferation by targeting METTL3-mediated m6A methylation of Psph mRNA. ABRO1 deletion increases cardiomyocyte proliferation and restores heart function, while ABRO1 overexpression inhibits neonatal cardiomyocyte proliferation and cardiac regeneration. The mechanism involves METTL3-mediated Psph mRNA methylation and CDK2 phosphorylation.
Article
Medicine, Research & Experimental
Tao Wang, Mei Zhai, Sheng Xu, Murugavel Ponnusamy, Yan Huang, Cui-Yun Liu, Man Wang, Chan Shan, Pei-Pei Shan, Xiang-Qian Gao, Kai Wang, Xin-Zhe Chen, Jing Liu, Jing-Yi Xie, De-Yu Zhang, Lu-yu Zhou, Kun Wang
Review
Biochemistry & Molecular Biology
Yanhan Dong, Cuiyun Liu, Yanfang Zhao, Murugavel Ponnusamy, Peifeng Li, Kun Wang
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)