Review
Anesthesiology
R. Andrew Moore, Emma Fisher, David P. Finn, Nanna B. Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S. C. Rice, Michael Rowbotham, Mark Wallace, Christopher Eccleston
Summary: Systematic reviews on the efficacy and safety of cannabinoids, cannabis, and cannabis-based medicines in managing pain are generally of low quality and cannot be relied upon for decision-making. Current reviews lack quality and a new high-quality systematic review of randomized controlled trials is needed to critically assess the clinical evidence for these treatments in pain management.
Review
Medicine, General & Internal
Donatella Bagagiolo, Debora Rosa, Francesca Borrelli
Summary: Based on the available clinical evidence, osteopathic manipulative treatment (OMT) may be effective for musculoskeletal disorders. However, the evidence for pediatric conditions, primary headache, and IBS is limited and inconclusive. Further high-quality research is needed to confirm and expand the efficacy and safety of OMT.
Review
Chemistry, Medicinal
Rachel Riera, Rafael Leite Pacheco, Angela Maria Bagattini, Ana Luiza Cabrera Martimbianco
Summary: The debate surrounding the therapeutic use of cannabinoids is growing, with evidence suggesting potential benefits for certain health conditions such as ulcerative colitis and chemotherapy-related nausea and vomiting. However, the certainty of evidence is generally low for other outcomes, indicating a lack of support for or against routine use.
PHYTOTHERAPY RESEARCH
(2022)
Review
Clinical Neurology
Xianshuai Zhang, Tianying Chang, Wenlong Hu, Mingpeng Shi, Yating Chai, Siyi Wang, Guohui Zhou, Mingze Han, Minghui Zhuang, Jie Yu, He Yin, Liguo Zhu, Changwei Zhao, Zhenhua Li, Xing Liao
Summary: Yoga seems to be an effective and safe non-pharmacological therapeutic modality for managing chronic low back pain. However, the methodological quality and quality of evidence for systematic reviews/meta-analyses in the included studies were generally low, and these results should be interpreted cautiously.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Giovanni E. Ferreira, Christina Abdel-Shaheed, Martin Underwood, Nanna B. Finnerup, Richard Day, Andrew McLachlan, Sam Eldabe, Joshua R. Zadro, Christopher G. Maher
Summary: This study provides a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for different pain conditions. The results show that antidepressants are effective in some pain conditions, particularly proton pump inhibitors, postoperative pain, neuropathic pain, and fibromyalgia. However, there is insufficient evidence to support the efficacy of antidepressants in other pain conditions. A more nuanced approach is needed when prescribing antidepressants for pain conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Qiao Shen, Zixuan Huang, Hongyao Leng, Xufei Luo, Xianlan Zheng
Summary: This overview of systematic reviews synthesizes current evidence on the efficacy and safety of non-pharmacological interventions for preventing and treating pain in newborn infants. The analysis included 29 reviews and found that facilitated tucking, kangaroo care, sweet solutions, and familiar odour were effective and safe in reducing pain from medical procedures in neonates. However, sucrose alone was less effective than local anaesthesia or a combination of the two during circumcision. Further research is needed to identify the best non-pharmacological approaches for pain in neonates.
Article
Health Care Sciences & Services
Tat-Thang Vo, Aidan Cashin, Cecilia Superchi, Pham Hien Trang Tu, Thanh Binh Nguyen, Isabelle Boutron, David MacKinnon, Tyler Vanderweele, Hopin Lee, Stijn Vansteelandt
Summary: The bias assessment practice in recently published systematic reviews of mediation studies is found to be suboptimal, with a lack of consensus, rigorous development, and validation of assessment tools. A consensus-based bias assessment tool specifically designed for mediation studies is needed to improve the quality and consistency of assessments.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Integrative & Complementary Medicine
Han Yang, Zhi-yong Xiao, Zi-han Yin, Zheng Yu, Jia-jia Liu, Yan-qun Xiao, Yao Zhou, Juan Li, Jie Yang, Fan-rong Liang
Summary: This study aims to summarize and evaluate the current evidence on the efficacy and safety of acupuncture for PCOS, as well as assess the quality and risks of bias of the available systematic reviews. A total of 11 eligible systematic reviews were included, and the findings suggest that combining acupuncture with other medicines can effectively improve the clinical pregnancy rate and ovulation rate, and reduce hormonal imbalances and insulin resistance. Acupuncture alone also shows improvements in the clinical pregnancy rate, and compared to no intervention, it has a better effect in promoting the recovery of menstrual cycle and reducing body mass index.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Review
Pediatrics
Eman Shamsaee, Alaw Huws, Andrea Gill, Stephen J. McWilliam, Daniel B. Hawcutt
Summary: There is limited published data to guide clinicians in prescribing ibuprofen for obese children. Four studies met the inclusion criteria, but the efficacy and tolerability of ibuprofen and the differences in adverse drug reactions between obese and non-obese children have not been determined.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Medicine, General & Internal
Christina Abdel Shaheed, Giovanni Ferreira, Alissa Dmitritchenko, Andrew McLachlan, Richard O. Day, Bruno Saragiotto, Christine Lin, Vicki Langendyk, Fiona Stanaway, Jane Latimer, Steven Kamper, Hanan McLachlan, Harbeer Ahedi, Christopher G. Maher
Summary: A systematic review was conducted to evaluate the efficacy and safety of paracetamol as an analgesic medication, with moderate to strong evidence supporting its effectiveness in conditions such as knee or hip osteoarthritis, post-craniotomy pain, tension-type headache, and perineal pain after childbirth. However, there is strong evidence that paracetamol is not effective in relieving acute low back pain. Further investigations on typical dosing regimens are needed.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Review
Medicine, General & Internal
Massimo Franchini, Fabiana Corsini, Daniele Focosi, Mario Cruciani
Summary: This study aimed to summarize evidence on the efficacy and safety of convalescent plasma (CP) in treating COVID-19. Results showed a reduction in mortality with CP over standard therapy when administered early and at high titer, without increased adverse reactions, although there was variability in the certainty of the evidence.
Review
Immunology
Lene Kristine Juvet, Anna Hayman Robertson, Ida Laake, Siri Mjaaland, Lill Trogstad
Summary: The study synthesized evidence from 16 systematic reviews on the safety of H1N1pdm09 vaccines, concluding that short-term serious adverse events were rare, adjuvanted vaccines had higher local event risks, and Pandemrix vaccine was strongly associated with an increased risk of narcolepsy in children.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Health Care Sciences & Services
Ludmilla Maria Souza Mattos de Araujo Vieira, Marcela Alves de Andrade, Tatiana de Oliveira Sato
Summary: This study conducted a systematic review to examine the evidence for telerehabilitation in managing musculoskeletal pain. A total of 16 systematic reviews were included, with 11 reviews having meta-analyses and most of them having high methodological quality. The results showed that 5 reviews supported the effectiveness of telehealth intervention for chronic pain conditions, while 2 high-quality reviews reported the absence of evidence for non-specific low back pain.
Review
Biochemistry & Molecular Biology
Alessandra Bennici, Carmen Mannucci, Fabrizio Calapai, Luigi Cardia, Ilaria Ammendolia, Sebastiano Gangemi, Gioacchino Calapai, Daniel Griscti Soler
Summary: Products derived from Cannabis sativa are commonly used for treating chronic neuropathic pain, with nabiximols being the only product approved by regulatory authorities for neuropathic pain and spasticity in European countries and Canada. Safety and risk-benefit profiles of other cannabis preparations widely used for medical purposes remain unclear, highlighting the need for further research on adverse reactions.
Review
Oncology
Vasileios Georgoulis, Anna-Bettina Haidich, Konstantinos I. Bougioukas, Eleftheria Hatzimichael
Summary: This overview presents a summary of systematic reviews on the safety and efficacy of carfilzomib in multiple myeloma. The results show that carfilzomib is effective in relapsed/refractory multiple myeloma, but is associated with cardiovascular adverse events, nephrotoxicity, and serious infections.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
