Synthesis of (±)-Pregabalin by Utilizing a Three-Step Sequential-Flow System with Heterogeneous Catalysts

Amine-functionalized Metal-Organic Frameworks: An Efficient and Recyclable Heterogeneous Catalyst for the Knoevenagel Condensation Reaction

(2016) Ik-Mo Lee et al.   SYNLETT

Catalytic Hydrogenation of Aliphatic Nitro Compounds with Polysilane/Bone Charcoal-Supported Palladium Catalysts under Continuous-Flow Conditions

(2016) Yuki Saito et al.   Asian Journal of Organic Chemistry

Benzimidazole-Containing Porous Organic Polymers as Highly Active Heterogeneous Solid-Base Catalysts

(2015) Yangxin Wang et al.   ChemCatChem

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

(2015) Shū Kobayashi   Chemistry-An Asian Journal

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

(2015) Tetsu Tsubogo et al.   NATURE

Development and Scale-up of an Organocatalytic Enantioselective Process to Manufacture (S)-Pregabalin

(2015) Maria Moccia et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Unprecedented Hydrophobic Amplification in Noncovalent Organocatalysis “on Water”: Hydrophobic Chiral Squaramide Catalyzed Michael Addition of Malonates to Nitroalkenes

(2015) Han Yong Bae et al.   ACS Catalysis

A general post-synthetic modification approach of amino-tagged metal–organic frameworks to access efficient catalysts for the Knoevenagel condensation reaction

(2015) Yi Luan et al.   Journal of Materials Chemistry A

Graphene based material as a base catalyst for solvent free Aldol condensation and Knoevenagel reaction at room temperature

(2014) Sk Manirul Islam et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Amino-functionalized Zr(IV) metal–organic framework as bifunctional acid–base catalyst for Knoevenagel condensation

(2014) Yang Yang et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin

(2014) Lingling Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mn-grafted imine-functionalized mesoporous SBA-15 as an efficient catalyst for Knoevenagel condensation under mild conditions

(2014) Hesamaldin Mahmoudi et al.   Reaction Kinetics Mechanisms and Catalysis

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Amine functionalized K10 montmorillonite: a solid acid–base catalyst for the Knoevenagel condensation reaction

(2013) G. Bishwa Bidita Varadwaj et al.   DALTON TRANSACTIONS

Microporous carbon nitride as an effective solid base catalyst for Knoevenagel condensation reactions

(2013) Jie Xu et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Polystyrene-immobilized DABCO as a highly efficient and recyclable organocatalyst for the Knoevenagel condensation reaction

(2013) Da-Zhen Xu et al.   RSC Advances

Nitridated Fibrous Silica (KCC-1) as a Sustainable Solid Base Nanocatalyst

(2013) Mohamed Bouhrara et al.   ACS Sustainable Chemistry & Engineering

Schiff Base Structured Acid-Base Cooperative Dual Sites in an Ionic Solid Catalyst Lead to Efficient Heterogeneous Knoevenagel Condensations

(2012) Mingjue Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

ZIF-8 crystal coatings on a polyimide substrate and their catalytic behaviours for the Knoevenagel reaction

(2012) Rizhe Jin et al.   DALTON TRANSACTIONS

Silica grafted polyethylenimine as heterogeneous catalyst for condensation reactions

(2011) Sonia M. Ribeiro et al.   APPLIED CATALYSIS A-GENERAL

Imidazolium chloride immobilized SBA-15 as a heterogenized organocatalyst for solvent free Knoevenagel condensation using microwave

(2011) Mst. Nargis Parvin et al.   APPLIED CATALYSIS A-GENERAL

Homogeneous-like solid base catalysts based on pyridine-functionalized swelling porous polymers

(2011) Yong-Lai Zhang et al.   CATALYSIS COMMUNICATIONS

Enhanced catalysis under flow conditions using SiliaBond functionalized silica gels

(2011) Valerica Pandarus et al.   Catalysis Science & Technology

A Simple Organocatalytic Enantioselective Synthesis of Pregabalin

(2009) Oriol Bassas et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

(2008) Carlos A. Martinez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

(2008) Sandra Izquierdo et al.   TETRAHEDRON-ASYMMETRY