期刊
AGE
卷 37, 期 2, 页码 -出版社
SPRINGER
DOI: 10.1007/s11357-015-9758-0
关键词
Telomere; Diet; Aging
资金
- Alzheimer's Association [IIRG08-92010]
- NIH [P01AG07232, R01AG037212, R01AG028506, P60MD000206, K99AG042483]
Leukocyte telomere length (LTL) is considered as the marker of biological aging and may be related to environmental factors. The current study aimed to examine the relation between Mediterranean-type diet and LTL. We used a cross-sectional study of 1743 multi-ethnic community residents of New York aged 65 years or older. Mediterranean-type diet (MeDi) was calculated from dietary information collected using a food frequency questionnaire. LTL was measured from leukocyte DNA using a real-time PCR method to measure T/S ratio, the ratio of telomere (T) to single-copy gene (S) sequence. Regression analysis showed that the MeDi score was not associated with LTL in the overall study population (beta=12.5; p=0.32) after adjusting for age, sex, education, ethnicity, caloric intake, smoking, and physical and leisure activities. However, we found a significant association between MeDi and LTL among non-Hispanic whites (beta=48.3; p=0.05), and the results held after excluding dementia subjects (beta=49.6; p=0.05). We further found that, in the whole population, vegetable and cereal consumption above the sex-specific population median was associated with longer LTL (beta=89.1, p=0.04) and shorter LTL (beta=-93.5; p=0.03), respectively. Among non-Hispanic whites, intake of meat or dairy below sex-specific population medians was associated with longer LTL (beta=154.7, p=0.05; beta=240.5, p<0.001, respectively). We found that higher adherence to a MeDi was associated with longer LTL among whites but not among African Americans and Hispanics. Additionally, a diet high in vegetables but low in cereal, meat, and dairy might be associated with longer LTL among healthy elderly.
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