期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2017, 期 22, 页码 3234-3239出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700173
关键词
Iodine-mediated reactions; Regioselectivity; Iodination; Electrophilic substitution; Arenes
资金
- Linnaeus University, Kalmar, Sweden
- Carl-Tryggers Foundation, Stockholm, Sweden
N-Iodosuccinimide (NIS) in pure trifluoroacetic acid (TFA) offers a time-efficient and general method for the iodination of a wide range of mono-and disubstituted benzenes at room temperature, as demonstrated in this paper. The starting materials were generally converted into mono-iodinated products in less than 16 hours at room temperature, without byproducts. A few deactivated substrates needed addition of sulfuric acid to increase the reaction rate. Another exception was methoxybenzenes that preferentially were iodinated by NIS in acetonitrile with only catalytic amounts of TFA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据