Review
Food Science & Technology
Dorgeles Kouakou Dje Kouadio, Frank Wieringa, Valerie Greffeuille, Christele Humblot
Summary: Micronutrient deficiencies or hidden hunger is a major public health problem, particularly in low- and middle-income countries, with significant impact on child development. Traditional methods of treatment and prevention have not always been effective and may have undesired side-effects. Gut microbiota, along with the gastrointestinal mucosa, plays a crucial role in enhancing the absorption of micronutrients and protecting against pathogens. However, the exact relationship between micronutrient malnutrition and gut microbiota is still poorly understood. This review provides current knowledge on the interaction between micronutrients and gut microbiota, specifically focusing on iron, zinc, vitamin A, and folate.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Microbiology
Siew Wen Lau, Ann Qi Chong, Nyuk Ling Chin, Rosnita A. Talib, Roseliza Kadir Basha
Summary: Sourdough, the oldest form of leavened bread, is now known to possess many desirable health benefits from its natural fermentation process. The microbial communities found in sourdough starters are complex and diverse, with potential positive impacts on health, particularly in gastrointestinal health.
Article
Nutrition & Dietetics
Gemma Llibre-Nieto, Alba Lira, Mercedes Vergara, Cristina Sole, Meritxell Casas, Valenti Puig-Divi, Gemma Sole, Antonia Humanes, Laia Grau, Josep Maria Barradas, Mireia Miquel, Jordi Sanchez-Delgado
Summary: Patients with decompensated cirrhosis commonly have micronutrient deficiencies, with vitamin D, vitamin A, vitamin B6 and zinc being the most prevalent. The severity of hepatic insufficiency correlates with varying levels of micronutrient deficiencies, such as lower zinc, vitamin E and vitamin A, and higher vitamin B12 and ferritin levels.
Article
Nutrition & Dietetics
Isabella Stelle, Lorraine K. McDonagh, Ilias Hossain, Anastasia Z. Kalea, Dora I. A. Pereira
Summary: Despite challenges such as rural location and cultural context, the staff conducting the iron deficiency anaemia trial in the Upper River Region of the Gambia believed that the overall impact was beneficial. They perceived that the facilitators and benefits outweighed the barriers, including impacts on education and healthcare, locally recruited staff, and local partnerships. This study serves as a useful example of community involvement and partnership for further health improvement programs.
Article
Chemistry, Applied
Mostafa S. Elshahed, Anca Miron, Ana Clara Aprotosoaie, Mohamed A. Farag
Summary: Pectins are indigestible polysaccharides that can be degraded by gut bacteria, producing short chain fatty acids. Understanding how pectins function as prebiotics in the gut can help target beneficial bacteria and favor a balanced microbiota community for maximizing health benefits.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Xiaofei Wang, Yue Qi, Hao Zheng
Summary: Polyphenols, important secondary metabolites produced by plants, have multiple health benefits. Most dietary polyphenols are not absorbed in the gastrointestinal tract, but are transformed into bioactive metabolites by gut microbiota in the large intestine. Dietary polyphenols can modulate the composition of gut microbes, which in turn catabolize polyphenols to release bioactive metabolites.
Review
Food Science & Technology
Yantao Yin, Remigio Martinez, Wangang Zhang, Mario Estevez
Summary: Pomegranate and gut microbiota have a mutual influence on each other, with bioactive compounds in pomegranate affecting the composition and function of gut microbiota, while gut microbiota biotransforms pomegranate phenolics into bioactive metabolites. These metabolites contribute to intestinal health by strengthening the intestinal barrier and reducing inflammatory processes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, General & Internal
Nina D. Anfinogenova, Oksana M. Novikova, Irina A. Trubacheva, Elena V. Efimova, Nazary P. Chesalov, Wladimir Y. Ussov, Aleksandra S. Maksimova, Tatiana A. Shelkovnikova, Nadezhda I. Ryumshina, Vadim A. Stepanov, Sergey V. Popov, Alexey N. Repin
Summary: This study aimed to assess the clinical pharmacology patterns of medications in older cardiovascular patients using electronic health records (EHRs). The study found high prevalence rates of drug-drug interactions (DDIs), with a significantly higher number of DDIs among prescribed medications compared to taken drugs. Serious DDIs were more common among prescribed medications, and polypharmacy was also more prevalent in prescribed medications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Food Science & Technology
S. Mithul Aravind, Santad Wichienchot, Rong Tsao, S. Ramakrishnan, S. Chakkaravarthi
Summary: In the past two decades, there has been intensive research on the beneficial health roles of dietary polyphenols in preventing oxidative stress related chronic diseases. As our understanding of the role of gut microbiota advances, the need to examine the prebiotic role of dietary polyphenols has emerged. Further research should focus on the importance of human trials and the links of polyphenols-gut microbiota-nerve-brain to unlock the mechanisms behind the observed benefits of dietary polyphenols.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Richard D. Semba, Sufia Askari, Sarah Gibson, Martin W. Bloem, Klaus Kraemer
Summary: This review summarizes the potential effects of climate change on agricultural yield and micronutrient quality of plant foods, as well as the availability of animal foods. The study suggests that climate change is likely to affect the availability of micronutrient-rich foods, rather than their nutrient content. Mitigating and adaptive strategies should be considered to reduce the risk of micronutrient deficiencies in vulnerable populations.
ADVANCES IN NUTRITION
(2022)
Article
Medicine, General & Internal
Canaan Negash Seifu, Paul Patrick Fahey, Evan Atlantis
Summary: This study aimed to estimate the prevalence of micronutrient deficiencies and anaemia in Australian adults and their association with BMI categories. Findings showed varying prevalence rates of deficiencies and anaemia across different BMI groups, with severe obesity consistently associated with vitamin D deficiency, while obesity class I showed a negative association with iron deficiency. No consistent association was found between BMI groups and vitamin B-12 deficiency and anaemia.
Article
Nutrition & Dietetics
Mary E. Phillips, Kathryn H. Hart, Adam E. Frampton, M. Denise Robertson
Summary: Pancreatico-duodenectomy (PD) reduces the absorptive capacity for vitamins and minerals, leading to deficiencies in vitamin A, D, E, iron, selenium, magnesium, copper, and zinc. Routine supplementation can decrease the occurrence of deficiencies in vitamin A, E, and selenium, but iron, vitamin D, and zinc deficiencies still remain prevalent despite supplementation.
Review
Agronomy
Edward Marques, Heather M. Darby, Jana Kraft
Summary: This article emphasizes the importance of biofortified foods through conventional breeding and agronomic approaches, identifying key areas for further research to enhance the efficacy of these methods.
Article
Medicine, General & Internal
Sharon A. M. Stevelink, Ava Phillips, Matthew Broadbent, Andy Boyd, Sarah Dorrington, Amelia Jewell, Ray Leal, Ioannis Bakolis, Ira Madan, Matthew Hotopf, Nicola T. Fear, Johnny Downs
Summary: This study describes the process and outcomes of linking mental healthcare records with benefit records in the UK. The study found that women, younger patients, and ethnic minority groups were less likely to be successfully linked. Benefit receipt was high among patients accessing mental health services, with 83% of patients receiving benefits at some point between 2005 and 2020.
Article
Plant Sciences
Aurelien D'Oria, Galatea Courbet, Aurelia Lornac, Sylvain Pluchon, Mustapha Arkoun, Anne Maillard, Philippe Etienne, Sylvain Diquelou, Alain Ourry
Summary: This study analyzed the specific variation in the functional ionome in Brassica napus and Triticum aestivum plants subjected to micronutrient or beneficial mineral nutrient deprivation, revealing numerous interactions between elements. It was found that deficiencies in certain beneficial nutrients can strongly modify the plant ionome, highlighting the importance of these elements in plant functioning.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Transplantation
Marco van Londen, Jessica van der Weijden, Robert S. Niznik, Aidan F. Mullan, Stephan J. L. Bakker, Stefan P. Berger, Ilja M. Nolte, Jan-Stephan F. Sanders, Gerjan Navis, Andrew D. Rule, Martin H. de Borst
Summary: A new model was developed to predict post-donation measured glomerular filtration rate (mGFR) based on pre-donation serum creatinine, age, and sex. The model showed good accuracy and precision in predicting mGFR, and performed well in high-risk subgroups.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Surgery
Coby Eelderink, Daan Kremer, Ineke J. Riphagen, Tim J. Knobbe, Leon J. Schurgers, Andreas Pasch, D. J. Mulder, Eva Corpeleijn, Gerjan Navis, Stephan. J. L. Bakker, Martin H. de Borst, Charlotte A. te Velde-Keyzer
Summary: In this trial, vitamin K supplementation did not affect serum calcification propensity but prevented the progression of arterial stiffness, and it significantly improved vitamin K status.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Transplantation
Joanna Sophia J. Vinke, Aaltje L. Ziengs, Anne M. Buunk, Lisanne van Sonderen, Antonio W. Gomes-Neto, Stephan J. L. TransplantLines Investigators, Stefan P. Berger, Stephan J. L. Bakker, Michele F. Eisenga, Jacoba M. Spikman, Martin H. De Borst
Summary: This study investigated iron deficiency as a potentially modifiable risk factor for cognitive impairment in kidney transplant recipients (KTRs). The results showed that iron deficiency was associated with lower scores in memory, mental speed, and attention and executive functioning. Therefore, iron deficiency may be an important factor in cognitive impairment after kidney transplantation.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Joanna Sophia J. Vinke, Dania H. A. Altulea, Michele F. F. Eisenga, Renate L. L. Jagersma, Tessa M. M. Niekolaas, Debbie van Baarle, Marieke van Der Heiden, Maurice Steenhuis, Theo Rispens, Wayel H. H. Abdulahad, Jan-Stephan F. Sanders, Martin H. H. De Borst
Summary: This study aimed to investigate whether iron supplementation improves immune response after SARS-CoV-2 vaccination in iron-deficient kidney transplant recipients. The results showed that iron supplementation efficiently restored iron status but did not improve humoral or cellular immune response against SARS-CoV-2.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Amber de Haan, Chantal F. Morel, Mark Eijgelsheim, Margriet F. C. de Jong, Jan Broekroelofs, Liffert Vogt, Nine V. A. M. Knoers, Martin H. de Borst
Summary: Through massively parallel sequencing (MPS), we identified genetic variations associated with Fabry disease in two families. The study highlights the close relationship between GLA mutations and the phenotypic heterogeneity of Fabry disease, and emphasizes the importance of MPS in patients with unexplained kidney failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Pien Rawee, Daan Kremer, Ilja M. M. Nolte, Henri G. D. Leuvenink, Daan J. J. Touw, Martin H. H. De Borst, Stephan J. L. Bakker, Mark R. R. Hanudel, Michele F. F. Eisenga
Summary: Heavy metal exposure has been linked to an increased risk of chronic kidney disease (CKD) and its progression. Iron deficiency, another common problem in CKD patients, is hypothesized to play a crucial role in the damaging effects of heavy metal exposure. Iron receptors upregulated by iron deficiency may lead to increased uptake of heavy metals in the intestine, while iron deficiency may also contribute to the retention of heavy metals in the kidney. Iron supplementation might be a strategy to combat these detrimental processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Amarens van der Vaart, Coby Eelderink, Andre P. van Beek, Stephan J. L. Bakker, Peter R. van Dijk, Martin H. de Borst
Summary: This study explores the relationship between fibroblast growth factor 23 (FGF23) and glucose metabolism. It finds that glucose loading affects FGF23 levels in overweight individuals and that higher FGF23 levels are associated with glucose, insulin, and proinsulin levels, as well as the development of diabetes and obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Urology & Nephrology
Tamas Szili-Torok, Daan Kremer, Stephan J. L. Bakker, Uwe J. F. Tietge, Martin H. de Borst
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Joanna S. J. Vinke, Michele F. Eisenga, Jan-Stephan F. Sanders, Stefan P. Berger, Jacoba M. Spikman, Wayel H. Abdulahad, Stephan J. L. Bakker, Carlo A. J. M. Gaillard, Arjan D. van Zuilen, P. van der Meer, Martin H. de Borst
Summary: This article presents a clinical trial aimed at investigating the effect of intravenous iron on exercise tolerance in iron-deficient kidney transplant recipients. The study will include 158 participants who will be randomly assigned to receive either iron or placebo treatment. The primary outcome measure is the change in exercise capacity as measured by the 6-minute walk test, and secondary measures include hemoglobin levels, quality of life, among others.
Article
Cardiac & Cardiovascular Systems
Ali A. A. Al-Mubarak, Niels Grote Beverborg, Victor Zwartkruis, Colinda van Deutekom, Martin H. H. de Borst, Ron T. T. Gansevoort, Stephan J. L. Bakker, Daan J. J. Touw, Rudolf A. A. de Boer, Peter van der Meer, Michiel Rienstra, Nils Bomer
Summary: This study aimed to investigate the association between micronutrient deficiencies and the development of atrial fibrillation (AFib). Selenium deficiency was found to be associated with new-onset AFib in non-smoking participants.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Letter
Urology & Nephrology
Tamas Szili-Torok, Uwe J. F. Tietge, Max J. Verbeek, Stephan J. L. Bakker, Martin H. de Borst
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Martin Gritter, Kuang-Yu Wei, Rosa D. Wouda, Usha M. Musterd-Bhaggoe, Kyra L. Dijkstra, Jesper Kers, Christian Ramakers, Liffert Vogt, Martin H. de Borst, Alexander H. J. Danser, Ewout J. Hoorn, Joris Rotmans
Summary: This study investigates the effects of low and high potassium diets on rats with normal kidney function and rats with chronic kidney disease (CKD). The results show that CKD increases the susceptibility to the negative effects of low and high potassium diets. Low potassium diet causes inflammation and kidney function decline, while high potassium diet causes hypertension and kidney fibrosis. A high potassium citrate diet can attenuate the hypertensive effect of high potassium diet.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Yuanxin Xu, Martin H. H. de Borst, Stephan J. L. Bakker, Uwe J. F. Tietge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)
