Article
Biochemistry & Molecular Biology
Xia Wang, Ruijuan Guan, Xiaomei Zhao, Jun Chen, Danian Zhu, Linlin Shen, Nana Song
Summary: TASKs, specifically TASK1 and TASK3, in orexin neurons play a crucial role in regulating respiratory chemoreflex, with orexin neurons sensing extracellular pH changes and projecting to the NTS to modulate respiration. Blocking TASKs or OX1R can affect breathing response to acidosis in the LH.
Article
Behavioral Sciences
Helena Pinos, Ricardo Sanchez-Serrano, Beatriz Carrillo, Jose Manuel Fernandez-Garcia, Rocio Garcia-Ubeda, Ana de Paz, Gabriela E. Lopez-Tolsa, Pedro Vidal, Valeria Gutierrez-Ferre, Ricardo Pellon, Paloma Collado
Summary: This study investigated the changes in orexin and POMC populations in the hypothalamic nuclei of male Wistar rats after the ABA procedure. The results showed that ABA led to a significant decrease in body weight and an increase in activity. Moreover, the number of POMC cells decreased in the ABA group, and the number of orexin A-ir positive cells decreased in the LH in both the D and ABA groups.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Sotelo, Jean Tyan, Chelsea Markunas, Bibi A. Sulaman, Lorraine Horwitz, Hankyu Lee, Joshua G. Morrow, Gideon Rothschild, Bo Duan, Ada Eban-Rothschild
Summary: The transition from wakefulness to sleep involves specific behaviors, such as nest-building and grooming, which are associated with stereotypic electroencephalogram (EEG) patterns. The ability to build a nest promotes sleep initiation and consolidation, while the lack of nesting material disrupts sleep. Neuronal ensembles in the lateral hypothalamus regulate the motivation to engage in nest-building behavior and control sleep initiation and intensity.
Article
Pharmacology & Pharmacy
Tzu-Ling Li, Yen-Hsien Lee, Feng-Hsu Wu, Ling-Ling Hwang
Summary: Orexin-A directly excites over half of DMH neurons, including those innervating the RVLM, through decreasing K+ conductance, activating NCX, and/or increasing NSCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Biology
Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu
Summary: The study reveals the crucial roles of the centrosomal protein Cenpj in neurogenesis, cerebral cortex development, and body weight regulation. Deletion of Cenpj leads to obesity in mice and affects hypothalamic cell proliferation, neuron number, and function, providing insights into the pathological mechanisms of related diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Neurosciences
Jun Jiang, Guangyuan Zou, Jiayi Liu, Shuqin Zhou, Jing Xu, Hongqiang Sun, Qihong Zou, Jia-Hong Gao
Summary: Animal experiments demonstrate the crucial role of the hypothalamus in regulating sleep-wake cycles, while neuroimaging studies suggest the presence of wake-promoting and sleep-promoting regions within the human hypothalamus. Functional network organization of the hypothalamus shifts between wakefulness and sleep, with different brain regions showing varying connectivity patterns.
HUMAN BRAIN MAPPING
(2021)
Article
Biology
Chelsea L. Faber, Jennifer D. Deem, Bao Anh Phan, Tammy P. Doan, Kayoko Ogimoto, Zaman Mirzadeh, Michael W. Schwartz, Gregory J. Morton
Summary: The DMH leptin receptor-expressing neurons in the brain are critical determinants of daily feeding and metabolic rhythms. Silencing these neurons can lead to increased body weight, adiposity, and alterations in feeding and metabolic rhythms.
Article
Neurosciences
Michael C. Tackenberg, Jacob J. Hughey, Douglas G. McMahon
Summary: The research shows that selective activation of VIPergic SCN neurons induces photoperiodic network plasticity in the SCN, underlying photoperiodic entrainment of behavior.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Kyle D. Ketchesin, Darius D. Becker-Krail, Xiangning Xue, Rashaun S. Wilson, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn, George C. Tseng, Ryan W. Logan
Summary: Substance use disorders disrupt sleep and circadian rhythms, increasing the risk of relapse. This study investigates the effects of cocaine and morphine on the diurnal rhythms of proteome in the nucleus accumbens (NAc), a key brain region for reward and motivation. The results show that cocaine and morphine differentially alter proteome diurnal rhythms in the NAc, with distinct proteins expressed at different times of the day. Cocaine altered proteins related to glucocorticoid signaling and metabolism, while morphine was associated with neuroinflammation. These findings provide insights into the regulation of NAc proteome and the differential effects of cocaine and morphine.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Alexandra M. Yaw, Thu V. Duong, Duong Nguyen, Hanne M. Hoffmann
Summary: Using PER2::Luciferase mice, researchers found that the phase relationships of reproductive tissues changed during the estrous cycle and pregnancy, accompanied by changes in PER2::LUC period in the SCN, uterus, and ovary.Progesterone was found to regulate Per2-luciferase expression and shorten PER2::LUC period in uterine tissue during pregnancy, suggesting a role of sex steroids in driving phase relationship adaptations. Despite changes in SCN PER2::LUC period during late pregnancy, onset of locomotor activity did not correlate with SCN or arcuate nucleus PER2::LUC period.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biology
Palma-Gomez Madahi, Osnaya Ivan, Balderas Adriana, Ortega Diana, Escobar Carolina
CHRONOBIOLOGY INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Maricruz Resendiz-Flores, Carolina Escobar
Article
Biology
Nadia Saderi, Adrian Baez-Ruiz, Lucia E. Azuara-Alvarez, Carolina Escobar, Roberto C. Salgado-Delgado
JOURNAL OF BIOLOGICAL RHYTHMS
(2019)
Article
Neurosciences
Estefania Espitia-Bautista, Carolina Escobar
Summary: The study showed that a diet rich in fat is a stronger stimulus than a diet rich in sugar for the development of reward-seeking behavior and plastic changes in the corticolimbic system. This may be due to the differing caloric density of the diets.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Geovanni Munoz-Escobar, Natali N. Guerrero-Vargas, Carolina Escobar
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Carolina Escobar, Estefania Espitia-Bautista, Mara A. Guzman-Ruiz, Natali N. Guerrero- Vargas, Miguel Angel Hernandez-Navarrete, Manuel Angeles-Castellanos, Brenda Morales-Perez, Ruud M. Buijs
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Rodrigo Ivan Osnaya-Ramirez, Madahi Palma-Gomez, Carolina Escobar
BEHAVIORAL NEUROSCIENCE
(2020)
Review
Endocrinology & Metabolism
Rebeca Mendez-Hernandez, Carolina Escobar, Ruud M. Buijs
Article
Neurosciences
Natali N. Guerrero-Vargas, Carmen Zarate-Mozo, Mara A. Guzman-Ruiz, Alfredo Cardenas-Rivera, Carolina Escobar
Summary: Research shows that shift-work can have detrimental effects on health, leading to mood disorders and neuroinflammation, but time-restricted feeding can prevent these effects.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biology
Oscar D. Ramirez-Plascencia, Nadia Saderi, Skarleth Cardenas Romero, Omar Flores Sandoval, Adrian Baez-Ruiz, Herick Martinez Barajas, Roberto Salgado-Delgado
Summary: Temporal coordination according to daytime enhances physiological processes, but modern lifestyle habits like eating during rest phase can disrupt internal synchronization, affecting homeostasis and health. Studies on rats show that eating during rest period leads to changes in circadian activity of brain nuclei, contributing to metabolic alterations and circadian dysregulation within the central nervous system.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biology
Alexandra J. Trott, Ben J. Greenwell, Tejas R. Karhadkar, Natali N. Guerrero-Vargas, Carolina Escobar, Ruud M. Buijs, Jerome S. Menet
Summary: Shift work has been shown to have impacts on the heart transcriptome in rats, independent of food consumption. Restricting food intake during shift work affects the expression of hundreds of genes related to extracellular matrix components and inflammatory markers in the heart. While maintaining food access during shift work has less effects on gene expression, it still leads to cardiac fibrosis without inflammation.
Article
Materials Science, Biomaterials
Mariana Gutierrez-Perez, Shellye Gonzalez-Gonzalez, Karla P. Estrada-Rodriguez, Estefania Espitia-Bautista, Mara A. Guzman-Ruiz, Rene Escalona, Carolina Escobar, Natali N. Guerrero-Vargas
Summary: Inhabitants of urban areas are exposed to light at night, which disrupts their circadian rhythms. The study focused on female rats and found that exposure to dim light at night (DLAN) resulted in the loss of activity and body temperature fluctuations. DLAN also decreased nocturnal food intake and disrupted reproductive function and behavior, possibly due to decreased melatonin levels. This study emphasizes the importance of avoiding light at night to maintain physiological circadian organization, particularly in females.
Article
Neurosciences
Veronica E. Lopez-Alonso, Samantha Hernandez-Correa, Carolina Escobar, Rodrigo E. Escartin-Perez, Juan M. Mancilla-Diaz, Daniel Diaz-Urbina
Summary: Sugar solutions increase the risk of obesity and binge-type behavior by promoting hedonic feeding. Dopamine release is enhanced in the brain's reward regions when rodents ingest sugar solutions, indicating changes in hedonic intake and reward processes. The dopamine receptors D2R/D3R contribute to the enjoyment of palatable solutions, but it is unknown if the D4R also regulates the hedonic intake of sugar solutions.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Gastroenterology & Hepatology
Roberto C. Salgado-Delgado, Ricardo Espinosa-Tanguma, Belkis Valdes Abadia, Oscar D. Ramirez-Plascencia, Carolina Escobar, Nadia Saderi
Summary: This study found that restricting food intake to the rest phase disrupts the expression of genes involved in metabolism and circadian regulation, as well as alters hormone secretion, gastric emptying, and intestinal motility. These findings highlight the importance of meal timing in regulating energy balance and the function of the stomach and small intestine, and suggest a potential link between feeding time and gastrointestinal diseases and metabolic issues.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Clinical Neurology
Francisco Estrada-Rojo, Carolina Escobar, Luz Navarro
REVISTA MEXICANA DE NEUROCIENCIA
(2020)