期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 131, 期 -, 页码 222-236出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.03.005
关键词
Prodrugs; Triterpenoids; Drug-like property
资金
- National Natural Science Foundation of China [81260506, 81660570]
- Joint Foundation of Guizhou Province Department of Science and Technology and Guizhou Medical University [7357]
- Excellent Scientific and Technological Yong Talent of Guizhou Province [32]
- Innovation Team of Natural Science Foundation of Department of Education of Guizhou Province [57]
Triterpenoids are structurally diverse organic compounds that exist widely as natural products. Triterpenoids and their derivatives possess a wide range of biological effects including hepatoprotective, hypoglycemic, immunomodulatory, anti-inflammatory, anti-oxidant, and antitumor activities. In particular, the lupane-, oleanane-, and ursane-type triterpenes have been reported to exhibit pharmacological effects without prominent toxicity even at higher concentrations. Whereas, the poor drug-like properties (e.g., low solubility and selectivity, poor bioavailability, and short half-life) severely limit their applications. This review summarized the advances in prodrug strategies for improving the drug-like properties of different types of triterpenoids, and the information indicated in the review will surely stimulate further efforts toward the development of these compounds for potential clinical uses. (C) 2017 Elsevier Masson SAS. All rights reserved.
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