期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 142, 期 -, 页码 74-86出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.06.003
关键词
1,2,3-Triazines; Benzo[1,2,3]triazines; Hetero-fused 1,2,3-triazines; Antiproliferative activity; Antitumor activity; Nitrogen heterocycles
1,2,3-Triazines are a class of biologically active compounds that exhibit a broad spectrum of activities, including antibacterial, antifungal, antiviral, antiproliferative, analgesic and anti-inflammatory properties. This review, which covers the literature from the end of last century to 2016, treats, through a comprehensive, systematic approach, the 1,2,3-triazine and related benzo- and hetero-fused derivatives possessing antitumor activity. Their efficacy, combined with a simple synthesis confers to these molecules a great potential as scaffold for the development of antitumor compounds. (C) 2017 Elsevier Masson SAS. All rights reserved.
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