Article
Chemistry, Organic
Chengqiang Cao, Yi Yang, Xin Li, Yunxia Liu, Hui Liu, Zengdian Zhao, Lei Chen
Summary: The reaction, catalyzed by palladium, efficiently constructs two new bonds with high yields, while the alkene group is easily functionalized, leading to the formation of products with a unique structure that is difficult to synthesize.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Miguel A. Munoz-Torres, Fernando Martinez-Lara, Marta Solas, Samuel Suarez-Pantiga, Roberto Sanz
Summary: The combination of organolithium chemistry with gold catalysis offers a new synthetic strategy for accessing polysubstituted indoles and carbazoles. This method utilizes ketopyrroles as starting materials and involves a series of reactions to selectively synthesize the desired products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Cesar Ruiz-Zambrana, Ana Gutierrez-Blanco, Sergio Gonell, Macarena Poyatos, Eduardo Peris
Summary: Two NDI-functionalized complexes of rhodium and iridium were prepared using NDI bis-imidazolium salts as N-heterocyclic carbene precursors. Reduction of the complexes resulted in enhanced electron-richness of the metal and increased catalytic activity in cycloisomerization reactions of alkynoic acids. Two-electron reduction of the ligand further enhanced the catalytic activity, demonstrating the catalyst's ability to switch between three redox species with distinct catalytic activities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Changpeng Chen, Feng-Shou Liu, Michal Szostak
Summary: The discovery of NHCs as ancillary ligands has greatly improved catalytic processes, with BIAN-NHC ligands in particular showing enhanced reactivity due to combinations of electronic and steric properties. The development of BIAN-NHC ligands has led to major advancements in catalysis and offers a practical alternative to classical NHCs.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Hayato Fujimoto, Kosuke Yasu, Mamoru Tobisu
Summary: This report discusses recent studies on catalytic transformations involving a non-classical mode of molecular activation by tertiary phosphines and N-heterocyclic carbenes (NHCs). The results show that by designing specific catalytic protocols, synthetic transformations that are otherwise unattainable can be achieved, including intermolecular carbofluorination of alkynes and hydroalkenylation of enol ethers. The use of imidazolium-based NHCs was explored for nucleophilic aromatic substitution reactions as well as nucleophilic activation of styrene derivatives, generating non-stabilized vinyl anion equivalents.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2023)
Article
Chemistry, Multidisciplinary
Sebastian Mummel, Felix Lederle, Eike G. Huebner, Jan C. Namyslo, Martin Nieger, Andreas Schmidt
Summary: Sydnone methides are rare compounds that can form pi-electron rich anionic N-heterocyclic carbenes and coordinate with various metals, while also undergoing C-C coupling reactions under specific catalysts. Studies have determined their electronic properties and NMR spectra.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Bastiaan Kooij, Zhaowen Dong, Paul Varava, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Laura Piveteau, Kay Severin
Summary: This study reports the preparation and structural characterization of vanadium complexes with N-heterocyclic vinylidene ligands, enabled by utilizing diazoolefins as ligand precursors. Structural and theoretical analysis show that N-heterocyclic vinylidenes can act as strong 6e(-) donor ligands, forming strong metal-carbon interactions.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Stefan Czarnocki, Louis Monsigny, Michal Sienkiewicz, Anna Kajetanowicz, Karol Grela
Summary: A modular and flexible strategy for synthesizing N-heterocyclic carbene (NHC) ligands bearing Bronsted base tags has been proposed and used to prepare two tagged NHC ligands with different acid residues. These tagged NHC ligands serve as an attractive starting point for the synthesis of olefin metathesis ruthenium catalysts with non-dissociating ligands. The impact of the Bronsted base tags on the activity of the obtained olefin metathesis catalysts has been investigated.
Article
Biochemistry & Molecular Biology
Svetlana A. Kondrashova, Shamil K. Latypov
Summary: The study examines the scopes and limitations of theoretical methods for estimating various NMR metrics of NHCs using computational approximations on a range of model NHCs and their derivatives. It concludes that the most reliable methods are the 31P/13C NMR shifts of NHC-phosphinidene adducts and 13C CSs of carbenes, while the method based on the analysis of 77Se CS NHC-selenoureas has some limitations due to exchange effects. The accuracy of estimating the HEP metric may also be limited due to the nonlinear effect of electron distribution. 13C CSs of NHC-azolium salts are deemed unreliable due to the influence of counterion exchange.
Article
Chemistry, Organic
Jacob C. Hood, Maksim V. Anokhin, Douglas A. Klumpp
Summary: N-Heterocyclic alcohols have been proven to be excellent substrates for superacid-promoted Friedel-Crafts reactions. The ionization of N-heterocyclic alcohols produces reactive, dicationic intermediates, leading to good to excellent yields of arylation products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Filippo Campagnolo, Matteo Bevilacqua, Marco Baron, Cristina Tubaro, Andrea Biffis, Daniele Zuccaccia
Summary: This study investigates the catalytic performance of dinuclear and mononuclear gold complexes in two reactions, highlighting the importance of NHC ligands and counterions in the catalytic cycles and activation process. Dinuclear catalysts show higher initial activity but poorer stability compared to mononuclear complexes.
Article
Chemistry, Multidisciplinary
Hyunho Kim, Minseop Kim, Hayoung Song, Eunsung Lee
Summary: The synthesis of ambiphilic N-heterocyclic carbene ligand indol-2-ylidene (IdY, A) was described, along with its ambiphilicity and synthetic utility. Experimental and computational studies showed that IdY lies between CAAC-5 and CAArC, with copper complexes capable of carboboration of terminal alkynes with high regioselectivity and good yields within 30 minutes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jana Hatzfeld, Steffen Skowaisa, Elisabeth Jackel, Julia Kaufmann, Edgar Haak
Summary: Various triaminocyclopentadienyl ruthenium complexes were synthesized from Ru-3(CO)(12) and tested for their ability to catalyze cascade conversions of propargyl alcohols. The substrate scope of catalytic cycloadditions was extended to terpenoid-derived propargyl alcohols containing an internal alkyne moiety, resulting in a wide range of cyclic terpenoid and phloroglucinol adducts obtained by complementary application of both types of catalysts.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Mummadi Sandeep, Bangarigalla Shantharjun, Geetala Pradeep Kumar, Kallu Rajender Reddy
Summary: A simple, mild, and efficient oxidative copper-catalyzed regioselective trifluoromethylation of imidazo[1,5-a]-N-heteroarenes has been developed. This method offers biologically relevant trifluoromethylated fused imidazoles in moderate to good yields with good functional group tolerance under mild conditions. Key features include short reaction time and room temperature reaction.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sebastian Planer, Jenni Frosch, Marvin Koneczny, Damian Trzybinski, Krzysztof Wozniak, Karol Grela, Matthias Tamm
Summary: This study explores the use of lithium complexes with weakly coordinating borate moieties for the preparation of silver(I) or copper(I) WCA-NHC complexes. Reactions in different solvents and with different metals are investigated, revealing various transformations during the process.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang
Summary: A new activatable polymeric nanoprobe (APN(SO)) for real-time in vivo near-infrared fluorescence imaging and urinalysis of hepatic ischemia-reperfusion injury (IRI) is reported, which can detect IRI at least 7 hours earlier than typical clinical assays in a mouse model.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Xinting Han, Lulu Ren, Yan Ma, Xiao Gong, Hangxiang Wang
Summary: In this study, a self-repairing superhydrophobic coating with good anti-corrosion and photothermal properties was fabricated by the spaying method. The coating exhibited excellent corrosion resistance and was capable of self-repairing under sunlight. This research provides a new idea for the application of superhydrophobic coatings.
Article
Chemistry, Physical
Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu
Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.
Article
Nanoscience & Nanotechnology
X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Summary: STAT3 is a key converging point of multiple oncogenic pathways and is constitutively activated in various cancer cells. Stattic, a selective inhibitor of STAT3, has shown promising potential for targeted cancer therapy and has been formulated in nanoparticles to enhance its therapeutic effects against tumor growth and metastasis.
MATERIALS TODAY NANO
(2022)
Correction
Chemistry, Multidisciplinary
Qiong Bian, Lingling Huang, Yihua Xu, Ruxuan Wang, Yueting Gu, Anran Yuan, Xiaolu Ma, Jingyi Hu, Yuefeng Rao, Donghang Xu, Hangxiang Wang, Jianqing Gao
Article
Nanoscience & Nanotechnology
Xiao Gong, Zheng Xiong, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: A facile method is reported to prepare multifunctional cotton fabrics with high flame retardancy, high electrical conductivity, superamphiphobicity, and high electromagnetic shielding. This was achieved by modifying the cotton fabric surface with phytic acid, coating with tannic acid and 3-aminopropyltriethoxysilane, and reducing the surface energy with fluorine-containing molecules. The resulting composite cotton fabric exhibited excellent properties in all these aspects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Summary: This study describes a novel therapeutic strategy that utilizes polymeric prodrug design and cell membrane cloaking to create a highly effective and low-toxicity treatment. In animal model experiments, this biomimetic therapy exhibited a higher level of tumor accumulation and effectively suppressed tumor growth and metastasis.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Xiao Gong, Qingqing Xu, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: This paper reports the synthesis of carbon nanodots that can efficiently absorb UV and high-energy blue light. These carbon nanodots can be easily synthesized in large scale and embedded in cellulose films, resulting in ultrahigh efficient UV and blue light shielding with guaranteed visible light transmission rate.
Article
Pharmacology & Pharmacy
Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song, Hangxiang Wang
Summary: This study developed an oral liposome called budsomes to deliver the anti-inflammatory drug budesonide for the treatment of inflammatory bowel disease (IBD). The budsomes showed high stability in the stomach and released active budesonide after accumulation in inflamed intestinal tissues. Compared to free budesonide treatment, budsomes exhibited higher therapeutic efficiency and induced remission of acute colitis without adverse side effects.
Article
Multidisciplinary Sciences
Jianqin Wan, Lulu Ren, Xiaoyan Li, Shasha He, Yang Fu, Peirong Xu, Fanchao Meng, Shiyun Xian, Kanyi Pu, Hangxiang Wang
Summary: A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist system is developed to induce near-infrared light-induced immunogenic cell death (ICD) in dying tumor cells and release a potent immunoadjuvant. In mouse models, this system effectively eliminates tumors, suppresses tumor recurrence and metastasis, and activates tumor-specific T cells. This study provides a simple and cost-effective approach to generate in situ cancer vaccines for the photodynamic immunotherapy of metastatic cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Summary: Immune checkpoint blockade therapies have made a significant impact on cancer treatment, but many patients do not respond to these therapies. Researchers have developed a combination chemoimmunotherapy nanosystem that includes a gemcitabine prodrug nanoparticle decorated with an anti-PD-L1 antibody and a STING agonist. This nanosystem enhances drug delivery to ICB-refractory tumors, activates CD8+ T cell responses, and transforms low-immunogenic tumors into inflamed tumors. In multiple mouse tumor models, the triple-combination nanovesicles induce a strong antitumor immune response and result in regression of large tumors and reduction in metastatic burden. These findings provide a basis for developing chemoimmunotherapeutic strategies for treating ICB-nonresponsive tumors.
Article
Multidisciplinary Sciences
Xiaona Chen, Fanchao Meng, Yiting Xu, Tongyu Li, Xiaolong Chen, Hangxiang Wang
Summary: The authors developed esterase-activatable pro-drugs based on STING agonist MSA-2 that are incorporated into liposomal vesicles for targeted intravenous administration. These pro-drugs, delivered via liposomes (SAProsomes), show enhanced pharmacokinetic properties and immune stimulatory capacity. The best candidate, SAProsome-3, effectively stimulates secretion of inflammatory cytokines and creates a tumoricidal immune landscape, leading to durable remission and decreased metastatic burden in breast cancer and melanoma mouse models.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Medicine, General & Internal
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Summary: A nanotherapeutic strategy was developed to deliver rapamycin and 7-ethyl-10-hydroxycamptothecin in a nanoparticle, which exhibited synergistic effects against hepatocellular carcinoma and alleviated drug resistance.
Article
Engineering, Biomedical
Tongyu Li, Weiwei Shi, Jie Yao, Jingyun Hu, Qiong Sun, Jing Meng, Jian Wan, Haihan Song, Hangxiang Wang
Summary: This study presents a strategy to integrate multiple structurally disparate drugs into a self-assembling nanococktail platform. In vitro and in vivo assays demonstrate that this nanococktail therapy can effectively mitigate chemoresistance and improve the therapeutic efficacy in lung cancer. The findings suggest the potential of this approach in synergistically treating chemoresistant cancers.
BIOMATERIALS RESEARCH
(2022)
