Article
Oncology
Frida E. Lundberg, Helgi Birgisson, Tom B. Johannesen, Gerda Engholm, Anni Virtanen, David Pettersson, Elinborg J. Olafsdottir, Mats Lambe, Paul C. Lambert, Lina S. Morch, Anna L. Johansson, Therese M-L Andersson
Summary: The survival of patients with colon and rectal cancer has improved in all Nordic countries over the past decades. The study shows that the survival rate has improved for both men and women in all age groups. The largest improvement was observed in Danish men and women with rectal cancer. The probability of death and life-years lost varied across countries.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Theodoros Michelakos, Filippos Kontos, Tomohiro Kurokawa, Lei Cai, Ananthan Sadagopan, Danielle Krijgsman, Wilko Weichert, Lindy G. Durrant, Peter J. K. Kuppen, Cristina R. Ferrone, Soldano Ferrone
Summary: The expression levels of HLA class I loci gene products were found to be associated with various genetic events and survival outcomes in colon and rectal cancer patients. Higher HLA-A expression in rectal tumors treated with neoadjuvant radiation and high HLA-B/C expression levels were independent predictors of favorable overall survival in colon and rectal cancer. T-cells and HLA-B/C antigens appeared to play a key role in controlling the growth of colon/rectal cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Surgery
Ali Reza Safarpour, Alimohammad Bananzadeh, Ahmad Izadpanah, Leila Ghahramani, Seyed Mohammad Kazem Tadayon, Faranak Bahrami, Seyed Vahid Hoseini
Summary: This study describes the 13-year results of colorectal cancer patients and highlights the significance of screening for early diagnosis and improved survival. Tumor stage was identified as a prognostic factor for patient survival.
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Zahra Mohseni, Dmitry Tumin, David N. Collier, Natalie Taft, Suzanne Lazorick
Summary: This study retrospectively examined the consumption of fruit juice and sugar-sweetened beverages (SSBs) in children with obesity and found that an increase in calorie intake from these beverages was associated with an increase in body mass index. However, with longer follow-up, calorie intake from SSBs and juice decreased, although the body mass index did not decrease.
Article
Oncology
Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Lindsay L. Peterson
Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Oncology
Cimarron E. Sharon, Michael Wang, Gabriella N. Tortorello, Nikhita J. Perry, Kevin L. Ma, Julia C. Tchou, Oluwadamilola M. Fayanju, Najjia N. Mahmoud, John T. Miura, Giorgos C. Karakousis
Summary: Patients with multiple comorbidities are more likely to be diagnosed with early-stage colon cancer but late-stage breast cancer. This finding may reflect differences in practice patterns for routine screening in these patients. Providers should continue guideline directed screenings to detect cancers at an earlier stage and optimize outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Martina Kastrup Loft, Malene Roland Vils Pedersen, Hans Bjarke Rahr, Soren Rafael Rafaelsen
Summary: Accurate preoperative classification of rectal polyps and cancer is crucial, with magnetic resonance imaging and endorectal ultrasound recommended for initial evaluation. Elastography can improve ultrasound accuracy, as shown in six eligible studies, all reporting increased diagnostic accuracy with elastography compared to ultrasound alone. Despite improved diagnostics, discrimination between rectal adenomas and early cancer remains challenging, highlighting the potential of elastography in aiding the differentiation.
Article
Psychology, Biological
Renata Emmanuele Assuncao Santos, Hilton Justino da Silva, Maria Giselda da da Silva, Danielly Alves Mendes Barbosa, Cynthya Myllena Martins Silva, Nilian Cerqueira Azevedo, Isabeli Lins Pinheiro, Pablo Erick da Silva Lopes, Raquel da Silva Aragao, Kelli Nogueira Ferraz Pereira
Summary: Childhood obesity is a significant public health problem and has been linked to changes in food consumption and masticatory performance. A study was conducted to evaluate the food consumption and masticatory performance in normal weight, overweight, and obese children aged 7-12 years. The results showed that obese children consumed fewer fresh foods, consumed more ultra-processed foods, had lower masticatory performance, and ate faster compared to children of normal weight.
PHYSIOLOGY & BEHAVIOR
(2023)
Review
Food Science & Technology
Giovanna Muscogiuri, Isabella Zanata, Luigi Barrea, Alessia Cozzolino, Emanuele Filice, Erika Messina, Annamaria Colao, Antongiulio Faggiano
Summary: Chronotype is closely related to the development and progression of tumors, especially gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Patients with an evening chronotype are more likely to have unhealthy lifestyle, obesity, metabolic syndrome, and sleep disturbances, which are associated with poor prognosis and tumor development. A tailored nutritional approach can help align the circadian rhythm and manage patients with NENs and sleep disturbances effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Sanaa Nakad Borrego, Katherine Kurnit, Laura Jane Turner, Russell R. Broaddus
Summary: This study aimed to investigate the association between aging or body mass index and MLH1 methylation in sporadic endometrial cancer. The results showed that age and body mass index were associated with MLH1 methylation in different grades of endometrial cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Multidisciplinary Sciences
Jimenez Urrego Angela Maria, Calero-Florez Mario, Hernandez-Carrillo Mauricio, Gutierrez-Posso Ana Gisset, Holguin Ruiz Jorge Alirio, Perlaza-Pelaez Guillermo, Botero-Carvajal Alejandro
Summary: This study investigates the occurrence of childhood cancer in the city of Cali, Colombia between 2015 and 2016. Significant differences were found in relation to the type of cancer. Despite an increase in survival rates in 2016, there was no significant change in the proportion of cancer mortality. The study has important implications for collective health and public policies in Latin America.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Chen, Li Ding, Zhi-wen Zhang, Xue-han Wu, Yu-tao Que, Yu-ru Ma, Yi-yan Liu, Zi-qiang Wen, Xin-yue Yang, Bao-lan Lu, Yong Bao, Shao-qing Niu, Shen-ping Yu
Summary: This study explored the potential of dynamic contrast-enhanced MRI (DCE-MRI) quantitative parameters in predicting severe acute radiation-induced rectal injury (RRI) in rectal cancer patients. The results showed that K-trans demonstrated moderate diagnostic performance in predicting severe acute RRI, providing important non-invasive and objective evidence for perioperative management and treatment strategies in rectal cancer patients.
EUROPEAN RADIOLOGY
(2023)
Review
Health Care Sciences & Services
Cigdem Sari Ozturk, Ebru Kilicarslan Toruner
Summary: This study aimed to investigate the effect of virtual reality interventions on relieving pain and anxiety in children and adolescents receiving cancer treatment. A total of 7 randomized controlled trials were included in the meta-analysis. The results showed that virtual reality had a significant effect in reducing anxiety and pain. Age was identified as an important moderator in the use of virtual reality for pain management.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Oncology
Luigi D'Antonio, Cristiano Fieni, Stefania Livia Ciummo, Simone Vespa, Lavinia Lotti, Carlo Sorrentino, Emma Di Carlo
Summary: IL-30 is involved in the proliferation and migration of colorectal cancer stem cells and CRC cells, and its inactivation inhibits tumorigenicity and metastatic ability.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Britt W. Jensen, Julie Aarestrup, Kim Blond, Marit E. Jorgensen, Andrew G. Renehan, Dorte Vistisen, Jennifer L. Baker
Summary: Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D confers additional risk for obesity-related cancer, but the effect does not differ across childhood BMI trajectories.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Michael E. Kelly, Niall J. O'Sullivan, Jarlath C. Bolger, Francesco Polignano, Haney Youssef, Andrew Renehan, Lee Malcomson, Sue Alves, Tom Cecil, Jurgen Mulsow, Brendan Moran, Faheez Mohamed
Summary: This study reviewed data from the UK and Ireland Colorectal Peritoneal Metastases Registry to assess the influence of age on the efficacy of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases. The results indicated that age did not appear to impact morbidity or long-term survival following CRS and HIPEC. Good survival outcomes were observed when complete cytoreduction was achieved.
BRITISH JOURNAL OF CANCER
(2023)
Article
Computer Science, Information Systems
Jiarun Cao, Elke M. van Veen, Niels Peek, Andrew G. Renehan, Sophia Ananiadou
Summary: The automatic extraction of relations between gene mutations and cancer entities from cancer literature using text mining is crucial for precision cancer medicine. In this study, we propose a deep learning model that can jointly extract mutations and their associated cancers. By using two different knowledge bases and integrating them using sentence-based and attribute-aware methods, our model outperforms baseline models and achieves high F1 scores on three public datasets.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Anesthesiology
Ronan M. G. Berg, Andreas Ronit, Nicolai Haase, Morten Hylander Moller, Klaus. T. T. Kristiansen, Trine Jonassen, Christian Wamberg, Anne Sofie Andreasen, Thomas Mohr, Morten. H. H. Bestle, Vibeke. L. L. Jorgensen, Niels. R. R. Hammer, Anja. U. U. Mitchell, Margit Smitt, Anders Moller Greve, Martin Erik Nyeland, Britt Wang Jensen, Anne Helms Andreasen, Janne Petersen, Espen Jimenez Solem, Matilde Winther-Jensen, Ronni. R. R. Plovsing
Summary: This study analyzed the PaCO2 trajectories of critically ill COVID-19 patients in Denmark and found that different PaCO2 trajectories were associated with mortality. The results showed that high, low, and progressively increasing PaCO2 trajectories corresponded to different risks of death.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Psychology, Clinical
Katja Biering Leth-Moller, Johannes Hebebrand, Katrine Strandberg-Larsen, Jennifer Lyn Baker, Britt Wang Jensen
Summary: This study found that higher body mass index (BMI) in girls aged 6-15 years was associated with a decreased risk of anorexia nervosa (AN) and an increased risk of bulimia nervosa (BN). It also showed that birthweight was associated with an increased risk of BN.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Pediatrics
J. Aarestrup, D. C. Pedersen, L. G. Bjerregaard, B. W. Jensen, K. B. Leth-Moller, R. K. Jacobsen, W. Johnson, J. L. Baker
Summary: Among Danish schoolchildren, the prevalence of underweight remained stable until the 1950s to 1970s, and then declined until the early 2000s. The prevalence of overweight plateaued until the 1950s to 1970s and then increased steeply. The prevalence of obesity particularly increased from the 1980s onwards. These trends slightly differed by age.
Article
Public, Environmental & Occupational Health
Lise G. Bjerregaard, Miriam Wuest, Torben S. D. Johansen, Thorkild I. A. Sorensen, Christian M. Dahl, Jennifer L. Baker
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Leonie K. Elsenburg, Andreas Rieckmann, Jessica Bengtsson, Theis Lange, Jennifer L. Baker, Thorkild I. A. Sorensen, Naja Hulvej Rod
Summary: This study examined the association between childhood adversity in early childhood (0-5 years) and body mass index (BMI) in childhood (6-7 years) and adolescence (12-15 years). The findings showed that boys and girls exposed to moderate or high material deprivation and loss or threat of loss had slightly higher BMI z-scores, particularly in adolescence. However, the effect sizes were generally small, suggesting that weight changes in childhood may not be a major mechanism linking early childhood adversity with later-life morbidity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Signe Falcon Soby, Thorkild I. A. Sorensen, Randi Jepsen, Rasmus Koster-Rasmussen
Summary: Obesity is associated with lower life satisfaction, and higher BMI is negatively correlated with self-reported global life satisfaction. Weight loss among individuals with BMI >= 25 is also associated with lower life satisfaction. However, in individuals with BMI >= 25 and good self-reported health, there is no relationship between weight loss and life satisfaction.
Article
Biology
Thorkild I. A. Sorensen
Summary: Human obesity is caused by the accumulation of a small portion of energy intake as fat, accompanied by growth of lean body mass. The energy balance regulation is not related to excess fat storage, but rather to the availability of energy supplies. Obesity predominantly occurs among individuals genetically predisposed and/or facing social or mental challenges. The proposed theory suggests that social disruptions are perceived as threats of future food shortages, leading the body to build up energy reserves through fat accumulation independent of the energy balance regulation.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Editorial Material
Biology
David B. Allison, Thorkild I. A. Sorensen, Kevin D. Hall, John R. Speakman
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Dorthe C. Pedersen, Julie Aarestrup, Kim Blond, Britt W. Jensen, Zorana J. Andersen, Lene Mellemkjaer, Anne Tjonneland, Jennifer L. Baker
Summary: This study found that the timing of excess gain in BMI across the lifecourse impacts subsequent risks of post-menopausal breast cancer. Women with BMI trajectories characterized by steep increases in childhood and adolescence and stabilization afterwards had lower risks of post-menopausal breast cancer, while women with trajectories characterized by low gain in childhood and adolescence followed by a subsequent steep increase in adulthood had higher risks.
CANCER EPIDEMIOLOGY
(2023)