Article
Multidisciplinary Sciences
Julia K. Mader, Felix Aberer, Kerstin Sarah Drechsler, Tina Poettler, Katharina M. Lichtenegger, Wolfgang Koele, Gerald Sendlhofer
Summary: This study aimed to investigate the perspectives of patients with type 2 diabetes regarding medication errors and the handling of these errors in the hospital routine. The results showed that patients experienced at least one medication error during hospitalization, but these errors rarely resulted in harm to the patients. The study revealed the importance of an honest and respectful doctor-patient relationship in the perception of medication errors and general complaints.
Article
Nutrition & Dietetics
Eric C. Westman
Summary: Type 2 Diabetes Mellitus is characterized by chronically elevated blood glucose and insulin levels, and a carbohydrate-restricted diet may be an effective treatment method.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Zhi-Hui Song, Xing-Long Wang, Xiao-Feng Wang, Jing Liu, Sang-Quzhen Luo, Shan-Shan Xu, Xiao Cheng, Jie Bai, Li-ming Dong, Chao Zhang, Jian-Bo Zhou
Summary: There is a gap between the current medication treatment management of Chinese inpatients with type 2 diabetes and the guidelines, especially in the application of GLP-1RAs and SGLT-2i in patients with concomitant ASCVD, diabetic nephropathy, and renal insufficiency. Physicians and pharmacists should pay more attention to achieving blood pressure and LDL-c standards in type 2 diabetic patients and provide timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Thea N. Golden, Rebecca A. Simmons
Summary: Intrauterine growth restriction (IUGR) is a common complication of pregnancy that increases the risk of type 2 diabetes mellitus (T2DM) later in life for the offspring. The development and balance of the fetal immune system, the role of pancreatic-resident macrophages, and cytokines derived from beta-cells and macrophages play key roles in islet development and function. Therapeutic immunomodulation may be beneficial for treating T2DM, particularly in cases induced by IUGR.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Chaoqun Liu, Ganxiang Cao, Jieying Li, Shaoyan Lian, Ke Zhao, Ying Zhong, Jiahong Xu, Yumeng Chen, Jun Bai, Hao Feng, Guanhao He, Xiaomei Dong, Pan Yang, Fangfang Zeng, Ziqiang Lin, Sui Zhu, Xinqi Zhong, Wenjun Ma, Tao Liu
Summary: This study used data from the China Health and Retirement Longitudinal Survey (CHARLS) and found that long-term exposure to PM2.5 pollutant may increase the risk of type 2 diabetes and make type 2 diabetes patients susceptible to arthritis.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Liyang Jia, Shiqiong Huang, Boyu Sun, Yongguang Shang, Chunsheng Zhu
Summary: Type 2 diabetes mellitus (T2DM) is a major cause of mortality worldwide, often leading to other cardiometabolic risk factors and diabetes-related death. While lifestyle intervention and antidiabetic drugs have been proposed for T2DM management, issues like side effects and drug resistance remain unresolved. The emerging field of pharmacomicrobiomics examines the interplay between the gut microbiome and drug response or toxicity. Increasing evidence supports the gut microbiome as a target for improving drug efficacy and safety through composition manipulation. This review explores the distinct gut microbiome composition in T2DM, its role in disease development, and the potential for personalized treatments utilizing pharmacomicrobiomics.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Public, Environmental & Occupational Health
Yanhuan Wang, Lina Xu, Na Wang, Ling Zhu, Fouxi Zhao, Kelin Xu, Tao Liu, Chaowei Fu
Summary: The study found that in Southwest China, higher adherence to vegetable-grain dietary patterns and lower adherence to junk food patterns significantly lowered the incidence of type 2 diabetes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Yifeng Fu, Siying Li, Yunhua Xiao, Gang Liu, Jun Fang
Summary: This study explores the importance of microbiota metabolites in type 2 diabetes (T2D), as well as the role of medication and dietary components in reducing the risk of developing diabetes. A deeper understanding of the link between gut microbial metabolites and T2D will enhance our knowledge of the disease and may offer new treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xiaoyan Lv, Doris S. F. Yu, Yingjuan Cao, Jinghua Xia
Summary: The study found that empty-nest elderly patients with T2DM primarily focus on medication compliance and lifestyle changes in their self-care, but lack attention to blood glucose monitoring, complication prevention, and negative emotions. They also lack social support, where friends and spouses play important roles in self-care motivation. Therefore, there is a need to enhance diabetes education, access to medical resources, and social support for better diabetes management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Gastroenterology & Hepatology
Yoscelina Estrella Martinez-Lopez, Diego A. Esquivel-Hernandez, Jean Paul Sanchez-Castaneda, Daniel Neri-Rosario, Rodolfo Guardado-Mendoza, Osbaldo Resendis-Antonio
Summary: The association between type 2 diabetes and gut microbiota composition provides a new approach for disease tracking and improving treatment outcomes. Understanding the metabolic disturbances in the gut microbiome as the disease progresses is crucial for developing strategies towards healthy microbiota compositions. This article dissects recent associations between gut microbiota and type 2 diabetes, and discusses advances in modulating the microbiome through drugs, diet, and exercise. Computational approaches are also presented for unraveling the metabolic activity underlying host-microbiota interactions. Overall, the combination of physiology and computational modeling holds promise for optimizing the diagnosis and treatment of type 2 diabetes patients in a personalized manner.
Article
Cardiac & Cardiovascular Systems
Iacopo Chiodini, Agostino Gaudio, Andrea Palermo, Nicola Napoli, Fabio Vescini, Alberto Falchetti, Daniela Merlotti, Cristina Eller-Vainicher, Vincenzo Carnevale, Alfredo Scillitani, Giuseppe Pugliese, Domenico Rendina, Antonio Salcuni, Francesco Bertoldo, Stefano Gonnelli, Ranuccio Nuti, Vincenzo Toscano, Vincenzo Triggiani, Simone Cenci, Luigi Gennari
Summary: The risk of bone fragility in type 2 diabetes patients should not be underestimated. Diagnoses and treatments should consider diabetes-specific factors and stratify risk based on individual profiles.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, Research & Experimental
Zheng Shen, Zheng-Yang Li, Meng-Ting Yu, Kai-Leng Tan, Si Chen
Summary: The term type III diabetes (T3DM) is proposed for Alzheimer's disease (AD) due to similarities in molecular and cellular features with type 2 diabetes (T2DM). Astrocytes play a crucial role in AD progression and severity, and targeting them could help alleviate neurodegeneration in the diabetic brain. Recent studies have shown the significant role of astrocytes in brain metabolism, neurovascular coupling, synapses, and synaptic plasticity. This review discusses how astrocyte dysfunction contributes to the pathological and clinical features of AD and T2DM from a metabolic perspective.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Alvaro Diaz, Ignacio Gonzalez-Alayon, Valentina Perez-Torrado, Mariana Suarez-Martins
Summary: The interaction between CD40 and CD154 plays a central role in immunology, involving processes such as DC priming of CD4(+) T cells, CD4(+) T cell help to B cells, and classical macrophage activation. While the role of CD40 and CD154 in Th2 immune responses is still not fully understood, they are crucial for inducing most Th2 responses despite not causing significant up-regulation of CD40 in DC in Th2 systems. Exogenous CD40 ligation can shift Th2-biased systems towards Th1 by enhancing IL-12 production, indicating the importance of these interactions in immune polarization.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yaochen Xie, Qian Zhou, Qiaojun He, Xiaoyi Wang, Jincheng Wang
Summary: The treatment of diabetes mellitus, particularly type 2 diabetes mellitus, has been a focus of research for many years. Incretin-based hypoglycemic agents, including GLP-1 receptor agonists and DPP-4 inhibitors, have been approved and widely used. Understanding the physiological disposition and characteristics of these drugs is crucial for developing more effective treatments and guiding clinical decisions. This review summarizes the functional mechanisms and other information of approved or investigational drugs for type 2 diabetes mellitus, as well as their metabolism, excretion, and potential drug-drug interactions. It also discusses the similarities and differences between GLP-1 receptor agonists and DPP-4 inhibitors in terms of metabolism and excretion.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Letter
Dermatology
Mai Shi, Aimin Yang, Elaine Chow, Eric S. H. Lau, Claudia H. T. Tam, Alice P. S. Kong, Andrea O. Y. Luk, Ronald C. W. Ma, Christina M. T. Cheung, Juliana C. N. Chan, Agnes W. S. Chan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anna Birukov, Ruijin Lu, Guoqi Yu, Yan Qiao, Mohammad Rahman, Qi Sun, Ronald C. Ma, Zhen Chen, Frank B. Hu, Cuilin Zhang
Review
Endocrinology & Metabolism
Calvin Ke, Emaad Mohammad, Juliana C. N. Chan, Alice P. S. Kong, Fok-Han Leung, Baiju R. R. Shah, Douglas Lee, Andrea O. O. Luk, Ronald C. W. Ma, Elaine Chow, Xiaolin Wei
Summary: This review compared the implementation of team-based diabetes care in Ontario, Canada and Hong Kong. The study found discrepancies in accessibility and referral procedures, follow-up processes, and financing models between the two jurisdictions. Adequate infrastructure, processes, and staff support are essential for team-based care. Policymakers and funders should invest in skilled health professionals, infrastructure, and processes to improve care quality.
CURRENT DIABETES REPORTS
(2023)
Article
Endocrinology & Metabolism
Claudia H. T. Tam, Cadmon K. P. Lim, Andrea O. Y. Luk, Mai Shi, Hoi Man Cheung, Alex C. W. Ng, Heung-man Lee, Eric S. H. Lau, Baoqi Fan, Guozhi Jiang, Alice P. S. Kong, Risa Ozaki, Elaine Y. K. Chow, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y. Y. Leung, Elaine Y. N. Cheung, Man Wo Tsang, Grace Kam, Ip Tim Lau, June K. Y. Li, Vincent T. F. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Xiaodan Fan, Ting Fung Chan, Kevin Y. L. Yip, Si Lok, Weichuan Yu, Stephen K. W. Tsui, Hui-Yao Lan, Cheuk Chun Szeto, Nelson L. S. Tang, Brian Tomlinson, Yu Huang, Alicia J. Jenkins, Anthony Keech, Wing-Yee So, Juliana C. N. Chan, Ronald C. W. Ma
Summary: The objective of this study was to uncover genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. The study identified a novel variant associated with CHD and blood pressure (BP) in Chinese T2D patients, and found that this variant interacts with BP goal attainment to have divergent effects on CHD risk.
Article
Endocrinology & Metabolism
Baoqi Fan, Cadmon K. P. Lim, Emily W. M. Poon, Eric S. H. Lau, Hongjiang Wu, Aimin Yang, Mai Shi, Claudia H. T. Tam, Samuel Y. S. Wong, Eric Kam-Pui Lee, Maggie H. T. Wang, Natural H. S. Chu, Risa Ozaki, Alice P. S. Kong, Elaine Chow, Ronald C. W. Ma, Andrea O. Y. Luk, Juliana C. N. Chan
Summary: This study examined the associations of GAD antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses, and severe hypoglycemia in Chinese patients with type 2 diabetes (T2D). The results showed that GADA+ and high CP were associated with early insulin initiation, while GADA+ and low CP increased the risk of severe hypoglycemia.
Article
Multidisciplinary Sciences
Kelly Yichen Li, Claudia Ha Ting Tam, Hongbo Liu, Samantha Day, Cadmon King Poo Lim, Wing Yee So, Chuiguo Huang, Guozhi Jiang, Mai Shi, Heung Man Lee, Hui-yao Lan, Cheuk-Chun L. Szeto, Robert L. G. Hanson, Robert G. Nelson, Katalin Susztak, Juliana C. N. Y. Chan, Kevin Y. Yip, Ronald C. W. Ma
Summary: In this study, the authors identified CpG sites associated with kidney function and subsequent decline, highlighting the potential of methylation markers in risk stratification of kidney disease in individuals with type 2 diabetes. The use of both single-site and multisite analysis proved to have functional significance in the kidney.
NATURE COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Helena J. Teede, Chau Thien Tay, Joop Laven, Anuja Dokras, Lisa J. Moran, Terhi T. Piltonen, Michael F. Costello, Jacky Boivin, Leanne M. Redman, Jacqueline A. Boyle, Robert. J. Norman, Aya Mousa, Anju E. Joham
Summary: The recommended assessment and management of polycystic ovary syndrome (PCOS) based on the best available evidence, clinical expertise, and consumer preference can improve the care and health outcomes for PCOS patients. The international evidence-based guidelines provide prioritized questions and outcomes, as well as 254 recommendations and practice points.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Hongjiang Wu, Aimin Yang, Eric S. H. Lau, Xinge Zhang, Baoqi Fan, Mai Shi, Chuiguo Huang, Ronald C. W. Ma, Alice P. S. Kong, Elaine Chow, Wing-Yee So, Juliana C. N. Chan, Andrea O. Y. Luk
Summary: The study analyzed data from 758,254 people with type 2 diabetes and 758,254 matched controls in Hong Kong. It found that type 2 diabetes was associated with increased risks of hospital bed-days for a wide range of medical conditions, and the association varied by age and sex. The study highlights the importance of considering age and sex differences in planning preventive and therapeutic strategies for type 2 diabetes, particularly focusing on mental health disorders.
Article
Endocrinology & Metabolism
Richard David Leslie, Ronald Ching Wan Ma, Paul W. Franks, Kristen J. Nadeau, Ewan R. Pearson, Maria Jose Redondo
Summary: This article discusses the heterogeneity of diabetes and proposes different models for disease management. It emphasizes the importance of precision medicine in defining disease risk and complications risk, which can lead to improved health outcomes and new therapeutic approaches.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Xinge Zhang, Hongjiang Wu, Baoqi Fan, Mai Shi, Eric S. H. Lau, Aimin Yang, Elaine Chow, Alice P. S. Kong, Juliana C. N. Chan, Ronald C. W. Ma, Andrea O. Y. Luk
Summary: This study found that prediabetes is associated with an increased risk of cardiovascular disease and all-cause mortality, with a stronger relationship observed in younger individuals. The risk attenuates with increasing age.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Endocrinology & Metabolism
Juliana N. M. Lui, Eric S. H. Lau, Aimin Yang, Hongjiang Wu, Amy Fu, Vanessa Lau, Kitman Loo, Theresa Yeung, Rebecca Yue, Ronald C. W. Ma, Alice P. S. Kong, Risa Ozaki, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan
Summary: This study investigated the temporal impacts of diabetes-related complications on health-related quality of life (HRQoL) in a 12-year prospective cohort of Chinese patients with type 2 diabetes. The study found that hemorrhagic stroke had the largest decrement in HRQoL, followed by ischemic stroke, peripheral vascular disease, lower extremity amputation, and chronic kidney disease, among others. The impacts on HRQoL persisted for up to 2 years after the occurrence of congestive heart failure or ischemic stroke, and 1 year after hemorrhagic stroke or CKD G3-G4 without renal replacement therapy.
JOURNAL OF DIABETES
(2023)
Review
Medicine, Research & Experimental
Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks
Summary: This systematic review examines whether sociodemographic, clinical, behavioral, and molecular factors modify the effectiveness of dietary or lifestyle interventions to prevent type 2 diabetes. The evidence suggests that individual characteristics have a low to very low impact on intervention effectiveness.
COMMUNICATIONS MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims
Summary: This article provides an overview of T1D disease modifying therapies and features linked to treatment response through a systematic review of randomized-controlled trials. The quality of prevention and intervention trials is generally high, but the quality of precision analyses is low, and certain factors should be considered in future trial designs.
COMMUNICATIONS MEDICINE
(2023)
Review
Medicine, Research & Experimental
Laura M. Jacobsen, Jennifer L. Sherr, Elizabeth Considine, Angela Chen, Sarah M. Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie, Maria J. Redondo, Korey K. Hood, Peter A. Gottlieb, Pieter Gillard, Jessie J. Wong, Irl B. Hirsch, Richard E. Pratley, Lori M. Laffel, Chantal Mathieu, I ADA EASD PMD
Summary: Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.
COMMUNICATIONS MEDICINE
(2023)