Article
Genetics & Heredity
Watip Tangjittipokin, Pichakorn Umjai, Khwanhatai Khemaprasit, Parichat Charoentawornpanich, Chutima Chanprasert, Nipaporn Teerawattanapong, Tassanee Narkdontri, Jeerunda Santiprabhob
Summary: The study aimed to investigate genetic polymorphisms of vitamin D-related genes in children with T1D and their association with vitamin D and cytokine levels. Significant relationships were found between T1D and CYP2R1 polymorphism, as well as different VDR haplotypes between T1D patients and controls. Vitamin D gene-related variations were associated with vitamin D and circulating cytokine levels in children with T1D.
Article
Pediatrics
Xiaofang Chen, Jia Fu, Ying Qian, Xiufang Zhi, Linjie Pu, Chunyu Gu, Jianbo Shu, Ling Lv, Chunquan Cai
Summary: Low vitamin D levels may be associated with susceptibility to type 1 diabetes, and genetic polymorphisms such as SNP may modulate the risk of the disease. This study found that Chinese children carrying the C allele of the CYP2R1 gene's rs1993116 SNP had a higher risk of developing T1D, and there was a significant interaction between rs1993116 and rs12794714 of CYP2R1.
FRONTIERS IN PEDIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Katie M. O'Brien, Alexander P. Keil, Quaker E. Harmon, Chandra L. Jackson, Alexandra J. White, Mary Diaz-Santana, Jack A. Taylor, Dale P. Sandler
Summary: The use of vitamin D supplements, particularly recent use, is inversely associated with breast cancer risk, especially for ductal carcinoma in situ.
Article
Medicine, General & Internal
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: The study found that vitamin D deficiency rates among young African children were 0.6% and 7.8%, with factors such as country, age, season, inflammation, and malaria influencing the levels. In addition, variations in the GC gene were associated with vitamin D levels.
Review
Nutrition & Dietetics
Liana Najjar, Joshua Sutherland, Ang Zhou, Elina Hyppoenen
Summary: A systematic review and meta-analysis were conducted to assess the association between selected variants affecting 25-hydroxyvitamin D concentrations and T1D risk, revealing no significant correlation. Despite some heterogeneity in one of the genetic variants analyzed, overall results did not show any association with T1D susceptibility. Additionally, subgroup analysis for Caucasians also found no association with T1D.
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Fanny Loddo, Steve Nauleau, David Lapalus, Sophie Tardieu, Olivier Bernard, Farid Boubred
Summary: This population-based record-linkage study examined the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. The study found that infants prenatally exposed to maternal Vitamin D3 supplementation had a longer gestational age at birth and a lower risk of respiratory illness. This study provides evidence for the positive impact of maternal gestational Vitamin D3 supplementation on early respiratory outcomes in young children.
Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Zhenzhen Wan, Tingting Geng, Rui Li, Xue Chen, Qi Lu, Xiaoyu Lin, Liangkai Chen, Yanjun Guo, Liegang Liu, Zhilei Shan, An Pan, JoAnn E. Manson, Gang Liu
Summary: This study investigated the association between vitamin D concentration and cardiovascular disease risk in type 2 diabetes patients. The results showed that higher serum vitamin D concentrations were significantly associated with lower risks of total CVD and ischemic heart disease (IHD). Maintaining adequate vitamin D status and avoiding deficiency may help prevent CVD complications in patients with type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Silvia Savastio, Erica Pozzi, Valentina Mancioppi, Valentina Boggio Sola, Deborah Carrera, Valentina Antoniotti, Paola Antonia Corsetto, Gigliola Montorfano, Angela Maria Rizzo, Marco Bagnati, Ivana Rabbone, Flavia Prodam
Summary: This study aimed to explore the relationship between metabolic control, vitamin D status, and the AA/EPA ratio in children with type 1 diabetes (T1D). The study found that the AA/EPA ratio has an impact on insulin demand and vitamin D levels in T1D children. Additionally, the composition of the diet may affect the severity of T1D onset.
Article
Endocrinology & Metabolism
M. Gelardi, I La Mantia, S. E. Aragona, G. Cupido, G. Ciprandi
Summary: Upper respiratory infections are common in clinical practice, and antibiotics are frequently used for treatment. However, antibiotics can disrupt the balance of the microbiota, worsening symptoms. Probiotics can restore the respiratory and gut microbiota, aiding in recovery and preventing relapse.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Endocrinology & Metabolism
Yuxin Fan, Li Ding, Yalan Zhang, Hua Shu, Qing He, Jingqiu Cui, Gang Hu, Ming Liu
Summary: There is an association between vitamin D status and all-cause mortality among patients with type 2 diabetes. Very low or high concentrations of vitamin D may increase the risk of all-cause mortality in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Bin Wang, Heng Wan, Jing Cheng, Yingchao Chen, Yuying Wang, Yi Chen, Chi Chen, Wen Zhang, Fangzhen Xia, Ningjian Wang, Li Wang, Yingli Lu
Summary: Higher blood lead levels were associated with increased urinary albumin excretion in diabetic patients with vitamin D deficiency. However, this association was attenuated or non-significant in patients with sufficient vitamin D levels. The combination of high blood lead and low vitamin D levels corresponded to significantly higher urinary albumin-to-creatinine ratio. It was also found that the impact of blood lead levels on urinary albumin excretion was more pronounced in patients with reduced estimated glomerular filtration rate in the group with vitamin D deficiency.
ENVIRONMENTAL POLLUTION
(2021)
Review
Nutrition & Dietetics
Qiao-Yi Chen, Sohyun Kim, Bohyoon Lee, Gyeongin Jeong, Dong Hoon Lee, NaNa Keum, JoAnn E. Manson, Edward L. Giovannucci
Summary: Post-diagnosis vitamin D supplement use may be associated with improved overall survival among cancer patients, but not with progression-free survival, cancer-specific survival, or relapse.
Letter
Medicine, General & Internal
Yuki Murata, Morihito Takita, Masahiro Kami
Summary: This study demonstrates that a closed-loop insulin-delivery system is superior to glucose sensor-augmented insulin-pump therapy for glycemic control in children aged 1 to 7 with type 1 diabetes. However, it should be noted that unscheduled contacts with trial staff are more frequent during the closed-loop period.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Saana Paavola, Kalle Kurppa, Heini Huhtala, Paivi Saavalainen, Katri Lindfors, Katri Kaukinen
Summary: The need for re-testing once seronegative at-risk individuals for coeliac disease and the optimal timing remain unclear. In this study, we followed up a large cohort of previously screening-negative relatives and found an incidence rate of coeliac disease diagnosis or new seropositivity of 221/100,000 person-years in all relatives and 336/100,000 among those carrying coeliac disease-associated HLA DQ2/DQ8 after approximately 10 years of follow-up. HLA-typing could help identify a subgroup of relatives who would benefit most from re-testing.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Immunology
Sari Niinistoe, Maija E. Miettinen, David Cuthbertson, Jarno Honkanen, Leena Hakola, Reija Autio, Iris Erlund, Petra Arohonka, Arja Vuorela, Taina Haerkoenen, Heikki Hyoety, Jeffrey P. Krischer, Outi Vaarala, Mikael Knip, Suvi M. Virtanen
Summary: The study found that there were different correlations between fatty acids and immunological markers in children who developed islet autoimmunity at birth and in the first year of life compared to control children. Saturated fatty acids were more strongly correlated with immunological markers in case children, while polyunsaturated fatty acids were more strongly correlated in controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Santosh Lamichhane, Heli Siljander, Marja Salonen, Terhi Ruohtula, Suvi M. Virtanen, Jorma Ilonen, Tuulia Hyotylainen, Mikael Knip, Matej Oresic
Summary: This study aims to investigate the impact of extensively hydrolyzed infant formula (HF) on the serum lipidome compared to conventional formula (RF) and explore the association between changes in circulatory lipids and gastrointestinal biomarkers. The results suggest that HF intervention alters the circulating lipidome, including lipids associated with progression to islet autoimmunity or overt T1D.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Marisa Stahl, Qian Li, Kristian Lynch, Sibylle Koletzko, Pooja Mehta, Loren Gragert, Jill M. Norris, Carin Andren Aronsson, Katri Lindfors, Kalle Kurppa, Jorma Ilonen, Jeffrey Krischer, Beena Alkolkar, Anette-G Ziegler, Jorma Toppari, Marian J. Rewers, Daniel Agardh, William Hagopian, Edwin Liu, TEDDY Study Grp
Summary: The study examines regional differences in celiac disease (CD) development among children in Europe and the United States. The incidence of CD varied by region, with Swedish children having the highest incidence at 3%. In the United States, the incidence was highest in Colorado at 2.4%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Maria Safura Mohamad, Balkish Mahadir Naidu, Suvi M. Virtanen, Susanna Lehtinen-Jacks, Khairul Nizam Abdul Maulud
Summary: Research has shown that the associations between access to local food and physical activity environments and overweight in children in Malaysia may vary depending on the state's overweight prevalence.
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Leena Hakola, Anna-Leena Vuorinen, Hanna-Mari Takkinen, Sari Niinisto, Suvi Ahonen, Jenna Rautanen, Essi J. Peltonen, Jaakko Nevalainen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Suvi M. Virtanen
Summary: This study aimed to investigate the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). The results showed that higher intake of monounsaturated fatty acids, arachidonic acid, total n-3 fatty acids, and long-chain n-3 fatty acids was associated with a decreased risk of islet autoimmunity. Higher intake of total fat and saturated fatty acids was associated with a decreased risk of T1D only when energy adjusted.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Ecology
Wisnu Adi Wicaksono, Aisa Buko, Peter Kusstatscher, Tomislav Cernava, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen, Heikki Hyoety, Gabriele Berg
Summary: Vegetables and fruits are an important part of a healthy diet and their microbiomes are influenced by factors such as origin and cultivation methods. This study found significant differences in abundance, diversity, and community structures between apples and blueberries, which were strongly influenced by the growing system and country of origin. The study also identified specific taxonomic indicators for each group, highlighting the influence of horticultural management on the fruit microbiome. The findings suggest that the origin of fruits affects the diversity and composition of their microbiome, emphasizing the importance of considering the fruit microbiome as an external exposomic factor.
Article
Multidisciplinary Sciences
Pooja Mehta, Qian Li, Marisa Stahl, Ulla Uusitalo, Katri Lindfors, Martha D. Butterworth, Kalle Kurppa, Suvi Virtanen, Sibylle Koletzko, Carin Aronsson, William J. Hagopian, Marian Rewers, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey Krischer, Daniel Agardh, Edwin Liu
Summary: This study aimed to describe the adherence rates to a gluten-free diet in children with screening-identified celiac disease and determine the factors associated with adherence. The results showed that approximately two-thirds of the children remained strictly adherent to a gluten-free diet at 2 and 5 years after diagnosis. Parent-reported adherence did not correlate with actual gluten intake based on food records. Having a first-degree relative with celiac disease was associated with higher adherence.
Article
Endocrinology & Metabolism
Steffen U. Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M. Virtanen, Jill M. Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-Xiong She, Beena Akolkar, Stephen Rich, Carin Andren Aronsson, Ake Lernmark, Anette-Gabriele Ziegler, Jorma Toppari, Jeffrey Krischer, Hemang M. Parikh, Christina Ellervik, Jannet Svensson
Summary: It is found that iron intake and genetically determined iron overload may interact in predisposing to the development of childhood islet autoimmunity and type 1 diabetes. A U-shaped association between iron intake and risk of GAD antibody as the first autoantibody in children was found. High iron intake was associated with an increased risk of IA with insulin as the first autoantibody in children with 2 or more iron risk alleles.
Review
Gastroenterology & Hepatology
Alina Popp, Pilvi Laurikka, Diana Czika, Kalle Kurppa
Summary: Duodenal biopsy is the best method for diagnosing celiac disease, but there is increasing use of serology. Gluten challenge may be necessary if a person has reduced gluten intake before diagnosis. The optimal protocol for the challenge is still unclear.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanna Riekki, Linnea Aitokari, Laura Kivela, Siiri Lahti, Pauliina Hiltunen, Nina Vuorela, Heini Huhtala, Timo A. Lakka, Kalle Kurppa
Summary: This study investigated the prevalence, risk factors, and metabolic co-morbidities of metabolic-associated fatty liver disease (MAFLD) in overweight children. The prevalence of MAFLD was 15%, with higher rates in boys than girls, and was associated with gender, puberty stage, disturbances in glucose and lipid metabolism, age, and BMI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Iida Ahonen, Pilvi Laurikka, Sara Koskimaa, Heini Huhtala, Katri Lindfors, Katri Kaukinen, Kalle Kurppa, Laura Kivela
Summary: Vomiting and nausea appear to be specific symptoms associated with gluten ingestion in treated celiac disease. However, the overall prevalence and factors related to these symptoms during chronic gluten exposure and acute re-exposure remain unclear.
BMC GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Ulla Uusitalo, Lazarus K. Mramba, Carin Andren Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Ake Lernmark, Marian Rewers, William Hagopian, Richard Mcindoe, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris, TEDDY Study Grp
Summary: This study aimed to investigate the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to the risk of islet autoimmunity (IA). The results showed that early introduction of solid foods (<6 months) was associated with increased IA risk in children with the HLA DR3/4 genotype and no probiotic exposure during the first year of life. Introducing rice at 4-5.9 months, compared to other time periods in the US, was also associated with an increased risk of IA.
Article
Gastroenterology & Hepatology
Juha Taavela, Kalle Kurppa, Tuija Jaaskelainen, Niina E. Kaartinen, Harri Rissanen, Heini Huhtala, Markku Maki, Katri Kaukinen
Summary: The prevalence of coeliac disease in Finland has been increasing over the years, with positive TGA without EmA, TGA values in the upper normal range, and pre-existing autoimmune diseases as predictors of developing the disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)