Article
Nutrition & Dietetics
Akarsh Mathrani, Wilson Yip, Ivana R. Sequeira-Bisson, Daniel Barnett, Oliver Stevenson, Michael W. Taylor, Sally D. Poppitt
Summary: This study investigated the effects of supplementation with prebiotic polyphenol rutin on pancreatic beta-cell function and gut microbiota in individuals with overweight and normoglycemia or prediabetes. The results showed that rutin supplementation did not significantly affect pancreatic beta-cell function or gut microbiota composition. However, fasting plasma glucose was negatively correlated with the abundance of the butyrate producer Roseburia inulinivorans.
Article
Biochemistry & Molecular Biology
Yoshimi Niwano, Hidetsugu Kohzaki, Midori Shirato, Shunichi Shishido, Keisuke Nakamura
Summary: Polyphenols can improve the effects of metabolic disorders through mechanisms such as regulating gut microbiota.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Nutrition & Dietetics
Priscila dos Santos Gomes Olivares, Ana Beatriz Furlanetto Pacheco, Luciana Nicolau Aranha, Bianca da Silva Oliveira, Allan Amorim Santos, Paula Cristina Moreira dos Santos, Jose Firmino Nogueira Neto, Glorimar Rosa, Glaucia Maria Moraes Oliveira
Summary: This study investigated the gut microbiota of individuals with different metabolic phenotypes and found that metabolically healthy individuals had lower saturated fat intake and fasting glycemia. Those with unhealthy phenotypes had inflammation-associated microbiota, lower potential for butyrate production, and reduced bacterial diversity.
Review
Biochemistry & Molecular Biology
Marco Fabbrini, Federica D'Amico, Monica Barone, Gabriele Conti, Mariachiara Mengoli, Patrizia Brigidi, Silvia Turroni
Summary: Nutraceuticals have gained much attention recently due to their potential role in preventing chronic diseases. However, there is limited research on their bioavailability. While consuming these compounds at pharmacological levels can significantly increase their plasma concentration, positive effects have been observed even with regular dietary consumption. This may be attributed to the activity of metabolites produced by gut microbiota fermentation.
Article
Multidisciplinary Sciences
Huan He, Qiaozhen Qin, Fang Xu, Yitong Chen, Shuquan Rao, Chao Wang, Xiaoxia Jiang, Xiong Lu, Chaoming Xie
Summary: Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease.
Review
Chemistry, Medicinal
Leander Corrie, Ankit Awasthi, Jaskiran Kaur, Sukriti Vishwas, Monica Gulati, Indu Pal Kaur, Gaurav Gupta, Nagavendra Kommineni, Kamal Dua, Sachin Kumar Singh
Summary: Polycystic Ovarian Syndrome (PCOS) is a group of symptoms that increase the risk of various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Currently, there are no effective and safe methods to treat all the pathological symptoms of PCOS. The gut microbiota plays an important role in the incidence and progression of PCOS. Many dietary plants, prebiotics, and probiotics have been reported to improve PCOS symptoms. This comprehensive review focuses on the use of polyphenols, probiotics, and fecal microbiota therapy to modify the gut microbiota and treat PCOS.
Review
Food Science & Technology
Rocio Garcia-Villalba, Juan Antonio Gimenez-Bastida, Adrian Cortes-Martin, Maria Angeles Avila-Galvez, Francisco A. Tomas-Barberan, Maria Victoria Selma, Juan Carlos Espin, Antonio Gonzalez-Sarrias
Summary: Urolithins, metabolites produced by the gut microbiota from polyphenols, have been extensively studied for their potential health benefits. Recent research has identified 13 urolithins and their corresponding conjugated metabolites in various human fluids and tissues. The study highlights the importance of understanding the microorganisms involved in urolithin production and the composition of gut microbiota associated with urolithin metabolism. However, further in vitro studies are needed to confirm the reported activities of urolithins.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Food Science & Technology
Adrian Cortes-Martin, Carlos Eduardo Iglesias-Aguirre, Amparo Meoro, Maria Victoria Selma, Juan Carlos Espin
Summary: The study found that pomegranate extract nutraceutical has an effect on the gut microbiota in poly-medicated MetS patients, particularly in anti-hypertensive treatments. This provides a new complementary approach for MetS therapy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Guoxiang Shi, Yubi Lin, Yuanyuan Wu, Jing Zhou, Lixiang Cao, Jiyan Chen, Yong Li, Ning Tan, Shilong Zhong
Summary: This study found that Bacteroides fragilis induced dysbiosis of the gut microbiota, leading to inflammation and worsened glucose/lipid metabolism, which promoted the progression of atherosclerosis.
Review
Nutrition & Dietetics
Yoredy Sarmiento-Andrade, Rosario Suarez, Beatriz Quintero, Kleber Garrochamba, Sebastian Pablo Chapela
Summary: Obesity is a globally increasing pathology with many associated disorders. In recent years, there has been growing knowledge about the influence of the microbiota on obesity and its related pathologies. This review summarizes the biology and physiology of microbiota in obese patients, as well as the therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Piyarat Oraphruek, Charoonsri Chusak, Sathaporn Ngamukote, Vorthon Sawaswong, Prangwalai Chanchaem, Sunchai Payungporn, Tanyawan Suantawee, Sirichai Adisakwattana
Summary: This study aimed to evaluate the effects of a multispecies probiotics mixed with fructooligosaccharides on body composition, antioxidant status, and gut microbiome composition in overweight and obese individuals. The results showed that synbiotic supplementation led to a significant reduction in waist circumference and body fat percentage, as well as improvements in antioxidant capacity and gut microbiota composition. Therefore, multispecies synbiotic supplementation could be a beneficial strategy for improving body composition, antioxidant status, and gut microbiome composition in overweight and obese subjects.
Article
Biotechnology & Applied Microbiology
Bo Zheng, Yinchao He, Pengxiang Zhang, Yi-Xin Huo, Yanbin Yin
Summary: This study curated experimentally characterized polyphenol utilization proteins (PUPs) and their homologs, identified potential players in polyphenol metabolism in the human gut microbiome, and found that Africans have higher abundance and prevalence of PUP homologs and gene clusters than other populations.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Jessica M. Moon, Peter Finnegan, Richard A. Stecker, Hanna Lee, Kayla M. Ratliff, Ralf Jager, Martin Purpura, Carolyn M. Slupsky, Maria L. Marco, Craig J. Wissent, Jason Theodosakis, Chad M. Kerksick
Summary: Glucosamine supplementation can improve gastrointestinal function, reduce stomach bloating, slightly decrease constipation and hard stools, as well as induce changes in fecal microbiota and metabolome.
Article
Multidisciplinary Sciences
Chonnikant Visuthranukul, Supakarn Chamni, Tanisa Kwanbunbumpen, Puthita Saengpanit, Yuda Chongpison, Surapun Tepaamorndech, Ekkarit Panichsillaphakit, Jaraspong Uaariyapanichkul, Natthapong Nonpat, Sirinuch Chomtho
Summary: Inulin may increase fat-free mass in obese children, but has no substantial effect on adiposity. Further research on changes in gut microbiota composition is needed to determine inulin's impact on host-microbe interaction in pediatric obesity.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Minu S. Thomas, Marissa DiBella, Christopher N. Blesso, Olga Malysheva, Marie Caudill, Maria Sholola, Jessica L. Cooperstone, Maria Luz Fernandez
Summary: This study found that intake of eggs significantly increased the plasma levels of lutein and zeaxanthin in subjects with metabolic syndrome. This increase may provide additional protection against oxidative stress, which is a common condition in metabolic syndrome.
Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Review
Biochemistry & Molecular Biology
Robert van Vorstenbosch, Hao Ran Cheng, Daisy Jonkers, John Penders, Erik Schoon, Ad Masclee, Frederik-Jan van Schooten, Agnieszka Smolinska, Zlatan Mujagic
Summary: Colorectal cancer (CRC) is associated with changes in volatile metabolic profiles, making it possible for non-invasive detection. However, the origin of these volatile organic compounds (VOCs) and their relation to gut microbiome are still not fully understood. This systematic review provides a comprehensive overview of the current understanding on this topic. The analysis of seventy-one included studies revealed dysregulations in various matrices, such as feces, urine, breath, blood, tissue, and saliva, with short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to tricarboxylic acid cycle and Warburg metabolism being the most frequently reported.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most research on the human microbiome has focused on bacteria, with less attention given to fungi and their role in human health, particularly their modulation through diet. This study used a validated in vitro model of the colon to investigate the gut fungal community and its response to different dietary interventions. The results showed that the mycobiome had lower diversity and greater variability compared to the bacterial community, and that diet could influence its composition and diversity.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: This study investigated the relationships between fungi and bacteria using a complex computer-controlled in vitro model of the colon. The results showed that cross-kingdom interactions exist between fungi and bacteria, and they can influence each other. These findings are important for understanding the role of the microbial community in the human gut.
Article
Health Care Sciences & Services
Frank Christian van de Baan, Stijn Lambregts, Esther Bergman, Jasper Most, Daan Westra
Summary: The implementation of quality and safety dashboards is important for hospitals, but lack of use by health professionals often hinders performance improvement. Involving health professionals in the development process can enhance their use. This study aimed to delineate a facilitated process and identify important factors for successful development.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Endocrinology & Metabolism
Jacco J. A. J. Bastings, Koen Venema, Ellen E. Blaak, Tanja C. Adam
Summary: Recent studies have found that there is a connection between the gut microbiota and the regulation of satiety and energy intake, which are important processes in the development and pathophysiology of metabolic diseases. However, most of this connection has been established through animal and in vitro studies, with human intervention studies being limited. In this review, the focus is on recent evidence linking satiety and the gut microbiome, particularly the role of short-chain fatty acids (SCFAs) produced by gut microbes. The review provides an overview of human studies that link the intake of prebiotics with changes in gut microbial composition and satiety signaling, emphasizing the need for further research in this field.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, General & Internal
Ruud Droeghaag, Daphne Nabben, Anouk Smeets, Wouter van Hemert, Narender van Orshoven, Henk van Santbrink, Jasper Most, Inez Curfs
Summary: Spinal disorders are highly burdensome and optimizing care for these patients is essential. This study investigated the characteristics, symptoms, diagnosis, and treatment of patients referred to a specialized spinal health care center. The majority of patients received non-surgical treatments, but a significant proportion did not receive in-hospital treatment or imaging at the time of referral.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Thomay-Claire Ayala Hoelena, Martijn Schotanus, Sander van Kuijk, Caroline Bastiaenen, Bert Boonen, Jasper Most
Summary: This study investigated the relationship between socioeconomic status and patient symptoms before and after joint replacement surgery, and found that patients with lower socioeconomic status generally had more severe symptoms and less improvement in their recovery compared to patients with higher socioeconomic status. This suggests that socioeconomic status can impact patients' disease condition and recovery.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Cultural Studies
Alena Kamenshchikova, Petra F. G. Wolffs, Christian J. P. A. Hoebe, John Penders, Klasien Horstman
Summary: Complex phenomena, such as antimicrobial resistance (AMR), are often explained in biomedical sciences using analogies and metaphors. These metaphors play a crucial role in knowledge production and can shape scientific models of thought. Some metaphors, like 'AMR is an apocalypse' or 'antibiotics are weapons', are recognized immediately, but others, such as 'bacterial reservoirs' and 'bacterial colonies', are presented as literal and descriptive. However, these terms still carry historical links and can perpetuate thinking about bacteria as foreign actors.
SCIENCE AS CULTURE
(2023)
Article
Orthopedics
S. Kalaai, J. Most, B. van Dun, B. L. Kaptein, P. B. J. Tilman, B. Boonen, M. G. M. Schotanus
Summary: This study compared the wear characteristics and functional outcomes between deep-dished mobile bearing (MB) and fixed bearing (FB) cemented total knee arthroplasty (TKA). The results showed that the MB group had reduced lateral polyethylene wear compared to the FB group in a single TKA system, while the clinical outcomes were similar.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Deirdre K. Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Jamie L. Felton, Ellen C. Francis, Pieter Gillard, Veronique Gingras, Romy Gaillard, Eram Haider, Alice Hughes, Jennifer M. Ikle, Laura M. Jacobsen, Anna R. Kahkoska, Jarno L. T. Kettunen, Raymond J. Kreienkamp, Lee-Ling Lim, Jonna M. E. Mannisto, Robert Massey, Niamh-Maire Mclennan, Rachel G. Miller, Mario Luca Morieri, Jasper Most, Rochelle N. Naylor, Bige Ozkan, Kashyap Amratlal Patel, Scott J. Pilla, Katsiaryna Prystupa, Sridharan Raghavan, Mary R. Rooney, Martin Schoen, Zhila Semnani-Azad, Magdalena Sevilla-Gonzalez, Pernille Svalastoga, Wubet Worku Takele, Claudia Ha-ting Tam, Anne Cathrine B. Thuesen, Mustafa Tosur, Amelia S. Wallace, Caroline C. Wang, Jessie J. Wong, Jennifer M. Yamamoto, Katherine Young, Chloe Amouyal, Mette K. Andersen, Maxine P. Bonham, Mingling Chen, Feifei Cheng, Tinashe Chikowore, Sian C. Chivers, Christoffer Clemmensen, Dana Dabelea, Adem Y. Dawed, Aaron J. Deutsch, Laura T. Dickens, Linda A. DiMeglio, Monika Dudenhoffer-Pfeifer, Carmella Evans-Molina, Maria Merce Fernandez-Balsells, Hugo Fitipaldi, Stephanie L. Fitzpatrick, Stephen E. Gitelman, Mark O. Goodarzi, Jessica A. Grieger, Marta Guasch-Ferre, Nahal Habibi, Torben Hansen, Chuiguo Huang, Arianna Harris-Kawano, Heba M. Ismail, Benjamin Hoag, Randi K. Johnson, Angus G. Jones, Robert W. Koivula, Aaron Leong, Gloria K. W. Leung, Ingrid M. Libman, Kai Liu, S. Alice Long, William L. Lowe, Robert W. Morton, Ayesha A. Motala, Suna Onengut-Gumuscu, James S. Pankow, Maleesa Pathirana, Sofia Pazmino, Dianna Perez, John R. Petrie, Camille E. Powe, Alejandra Quinteros, Rashmi Jain, Debashree Ray, Mathias Ried-Larsen, Zeb Saeed, Vanessa Santhakumar, Sarah Kanbour, Sudipa Sarkar, Gabriela S. F. Monaco, Denise M. Scholtens, Elizabeth Selvin, Wayne Huey-Herng Sheu, Cate Speake, Maggie A. Stanislawski, Nele Steenackers, Andrea K. Steck, Norbert Stefan, Julie Stoy, Rachael Taylor, Sok Cin Tye, Gebresilasea Gendisha Ukke, Marzhan Urazbayeva, Bart Van der Schueren, Camille Vatier, John M. Wentworth, Wesley Hannah, Sara L. White, Gechang Yu, Yingchai Zhang, Shao J. Zhou, Jacques Beltrand, Michel Polak, Ingvild Aukrust, Elisa de Franco, Sarah E. Flanagan, Kristin A. Maloney, Andrew McGovern, Janne Molnes, Mariam Nakabuye, Pal Rasmus Njolstad, Hugo Pomares-Millan, Michele Provenzano, Cecile Saint-Martin, Cuilin Zhang, Yeyi Zhu, Sungyoung Auh, Russell de Souza, Andrea J. Fawcett, Chandra Gruber, Eskedar Getie Mekonnen, Emily Mixter, Diana Sherifali, Robert H. Eckel, John J. Nolan, Louis H. Philipson, Rebecca J. Brown, Liana K. Billings, Kristen Boyle, Tina Costacou, John M. Dennis, Jose C. Florez, Anna L. Gloyn, Maria F. Gomez, Peter A. Gottlieb, Siri Atma W. Greeley, Kurt Griffin, Andrew T. Hattersley, Irl B. Hirsch, Marie-France Hivert, Korey K. Hood, Jami L. Josefson, Soo Heon Kwak, Lori M. Laffel, Siew S. Lim, Ruth J. F. Loos, Ronald C. W. Ma, Chantal Mathieu, Nestoras Mathioudakis, James B. Meigs, Shivani Misra, Viswanathan Mohan, Rinki Murphy, Richard Oram, Katharine R. Owen, Susan E. Ozanne, Ewan R. Pearson, Wei Perng, Toni I. Pollin, Rodica Pop-Busui, Richard E. Pratley, Leanne M. Redman, Maria J. Redondo, Rebecca M. Reynolds, Robert K. Semple, Jennifer L. Sherr, Emily K. Sims, Arianne Sweeting, Tiinamaija Tuomi, Miriam S. Udler, Kimberly K. Vesco, Tina Vilsboll, Robert Wagner, Stephen S. Rich, Paul W. Franks
Summary: Precision medicine, as part of contemporary evidence-based medicine, aims to reduce errors and optimize outcomes in medical decisions and health recommendations. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review and highlights opportunities for clinical implementation as well as gaps in knowledge.
Article
Endocrinology & Metabolism
Maryam Kebbe, Jasper Most, Abby D. Altazan, Leanne M. Redman
Summary: The role of dietary protein on macronutrient and energy intake, maternal adiposity during pregnancy, and infant adiposity at birth was investigated in this study. The results showed that protein balance in early pregnancy was not significantly associated with energy intake or gestational weight gain, but was inversely associated with fat mass in early, mid, and late pregnancy. However, protein balance did not predict infant adiposity at birth.
Article
Multidisciplinary Sciences
Balazs Erdos, Bart van Sloun, Gijs H. Goossens, Shauna D. O'Donovan, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Coen D. A. Stehouwer, Miranda T. Schram, Ellen E. Blaak, Michiel E. Adriaens, Natal A. W. van Riel, Ilja C. W. Arts
Summary: The combination of mechanistic and data-driven modeling approaches is explored in studying individual glucose regulation, and personalized mechanistic models are found to outperform data-driven models in predicting glucose and insulin responses.
Review
Endocrinology & Metabolism
Ellen E. Blaak, Gijs H. Goossens
Summary: Given the increasing prevalence of obesity and related metabolic diseases, precision nutrition approaches are necessary to enhance prevention strategies. This review focuses on different metabolic phenotypes (metabotypes) in obesity and discusses the mechanisms and lifestyle strategies to address metabolically healthy obesity (MHO) and the transition to metabolically unhealthy obesity (MUO). The concept of tissue insulin resistant (IR) metabotypes is also explored, highlighting the potential for targeted dietary interventions to improve cardiometabolic health.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Microbiology
Danyta I. Tedjo, Jennifer A. Wilbrink, Jos Boekhorst, Harro M. Timmerman, Simon W. Nienhuijs, Arnold Stronkhorst, Paul H. M. Savelkoul, Ad A. M. Masclee, John Penders, Daisy M. A. E. Jonkers
Summary: This study investigated the changes in fecal microbiota composition in obese individuals before and after sleeve gastrectomy (SG) and found a significant shift in microbiota composition after the surgery, but not towards a leaner profile. There were no correlations found between inflammatory markers, intestinal permeability, and changes in microbial profile.
