Article
Biology
Hassan A. Hemeg
Summary: The study found that companion animals such as dogs and cats may serve as a potential reservoir for MRSA, with genetic similarity between strains recovered from these animals and their human owners, indicating that pets play an important role in the transmission and colonization of MRSA.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Junyuan Qin, Lei Yu, Fu Peng, Xin Ye, Gangmin Li, Chen Sun, Fang Cheng, Cheng Peng, Xiaofang Xie
Summary: In this study, tannins isolated from Penthorum chinense Pursh (TPCP) were found to exhibit antimicrobial and antibiofilm properties against Staphylococcus aureus. The study showed that TPCP effectively destroyed the bacterial biofilms formed by MRSA, inhibiting its growth and reducing exopolysaccharide and extracellular DNA secretion.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Yongliang Fang, Jack R. Kirsch, Liang Li, Seth A. Brooks, Spencer Heim, Cynthia Tan, Susan Eszterhas, Hao D. Cheng, Hongliang Zhao, Yan Q. Xiong, Karl E. Griswold
Summary: The urgent need for novel agents to treat drug-resistant bacterial infections like MRSA is underscored. F12, an innovative anti-MRSA lysin, shows high potency, rapid onset of action, narrow selectivity against pathogenic staphylococci, and synergy with multiple standard-of-care antibiotics. Moreover, F12 not only resensitizes normally resistant MRSA strains to beta-lactams but also exhibits mutually exclusive resistance with beta-lactam antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Xiaoyuan Ma, Huaijian Jin, Xiang Chu, Weihong Dai, Wanqi Tang, Junyu Zhu, Fangjie Wang, Xue Yang, Wei Li, Guodong Liu, Xia Yang, Huaping Liang
Summary: This study reveals the unexpected role of host CYP1A1 in microbiota-mediated cadaverine metabolism and its crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis. Inhibition of CYP1A1 or blocking cadaverine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal sepsis.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Infectious Diseases
Radek Sleha, Vera Radochova, Jiri Malis, Alexander Mikyska, Milan Houska, Karel Krofta, Katerina Bogdanova, Sylva Janovska, Jaroslav Pejchal, Milan Kolar, Pavel Cermak, Pavel Bostik
Summary: Purified beta-acids from hops showed significant antimicrobial effects against MRSA isolates in a porcine model of infected wounds, indicating potential for treating non-responsive nosocomial tissue infections by MRSA.
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Maria Stankowska, Katarzyna Garbacz, Anna Korzon-Burakowska, Marek Bronk, Monika Skotarczak, Anna Szymanska-Dubowik
Summary: This study assessed the factors influencing the infection of diabetic foot ulcers by methicillin-resistant S. aureus (MRSA) and found that MRSA infection is associated with a higher incidence of osteitis. MRSA infection is more common in men and patients with type 2 diabetes, and is often associated with the presence of Pseudomonas sp. and other non-fermenting bacilli.
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Hanbeen Kim, Jakyeom Seo
Summary: Two potential endolysins were identified, with one showing better efficacy against MRSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Low Yi Xin, Toh Hui Min, Puteri Nur Liyana Mohd Zin, Thiruchelvi Pulingam, Jimmy Nelson Appaturi, Thaigarajan Parumasivam
Summary: This study evaluates the antibacterial activities of 61 plant extracts from 49 Malaysian ethnomedicinal plants, with 7 plant extracts showing good efficacy against MSSA strains. When combined with vancomycin and ciprofloxacin, the active plant extracts showed no interaction against MSSA and MRSA strains.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)