Article
Cardiac & Cardiovascular Systems
Mark Trinder, Yanan Wang, Christian M. Madsen, Tatjana Ponomarev, Lubos Bohunek, Brendan A. Daisely, HyeJin Julia Kong, Lisanne L. Blauw, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Mark M. Wurfel, James A. Russell, Keith R. Walley, Patrick C. N. Rensen, John H. Boyd, Liam R. Brunham
Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.
Article
Biochemistry & Molecular Biology
Jun Chen, Haihua Qi, Lijun Liu, Yandong Niu, Shuping Yu, Shucun Qin, Lei He
Summary: Elevated CETP and PLTP levels were found to worsen psoriasis symptoms in a mouse model, leading to increased expression of inflammatory cytokines.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Adam J. Nelson, Allan D. Sniderman, Marc Ditmarsch, Mary R. Dicklin, Stephen J. Nicholls, Michael H. Davidson, John J. P. Kastelein
Summary: Cholesteryl ester transfer protein (CETP) facilitates the exchange of cholesteryl esters and triglycerides between HDL particles and TG-rich, apoB-containing particles. Initially, CETP inhibitors were developed to raise plasma HDL-C levels to lower the risk of ASCVD. However, recent evidence suggests that CETP inhibitors can reduce LDL-C and apoB concentrations, thereby reducing the risk of major coronary events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Alexia Rouland, David Masson, Laurent Lagrost, Bruno Verges, Thomas Gautier, Benjamin Bouillet
Summary: ApoC1 is a small apolipoprotein with significant roles in lipoprotein metabolism. It affects the metabolism of triglycerides and cholesterol and is involved in inflammation regulation. However, further studies are needed to fully understand its precise functions and its relationship with cardiometabolic diseases.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Pharmacology & Pharmacy
Nehal Mehta, Katerina Dangas, Marc Ditmarsch, Patrick C. N. Rensen, Mary R. Dicklin, John J. P. Kastelein
Summary: The main role of cholesteryl ester transfer protein (CETP) is to transfer cholesteryl esters and triglycerides between different lipoprotein particles. Inhibition of CETP has been investigated as a target for reducing cardiovascular events, and it is now understood that CETP inhibitors primarily reduce LDL cholesterol and apolipoprotein B rather than increasing HDL cholesterol. Furthermore, HDL may have important roles in diseases beyond cardiovascular disease, such as Alzheimer's disease, diabetes, and sepsis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Kanchana Ngaosuwan, Desmond G. Johnston, Ian F. Godsland, Jeremy Cox, Azeem Majeed, Jennifer K. Quint, Nick Oliver, Stephen Robinson
Summary: The study found that mortality was higher with prednisolone in patients with primary adrenal insufficiency compared to hydrocortisone. Despite the large scale of the study, the number of prednisolone-treated patients was small, and they had greater risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Neurosciences
Tetiana Poliakova, Cheryl L. Wellington
Summary: This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in vascular contributions to cognitive impairment and dementia (VCID). Studies suggest that lowering LDL cholesterol levels can reduce the risk of cardiovascular and cognitive diseases, and CETP inhibition may have the potential to lower these risks.
MOLECULAR NEURODEGENERATION
(2023)
Review
Endocrinology & Metabolism
Birgit Harbeck, Peter Kropp, Ilonka Kreitschmann-Andermahr
Summary: Patients with adrenal insufficiency (AI) receive glucocorticoid (GC) replacement therapy (GRT). However, temporary phases of hypo- and hypercortisolism are common, and prolonged phases of these can impair cognitive functioning. Little is known about the effects of dosage and duration of GC replacement therapy on cognitive functioning in AI patients. This Mini-Review provides an overview of current studies on GRT for AI and discusses their implications for clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bart De Geest, Mudit Mishra
Summary: This article reviews the impact of high-density lipoproteins (HDL) on sepsis, highlighting the role of HDL in sequestration and neutralization of inflammatory effects caused by pathogen lipid moieties. HDL also plays a key role in the removal of pathogen-associated lipids from the body. Low HDL cholesterol levels are associated with an adverse prognosis in sepsis. Potential HDL-directed interventions for sepsis treatment include apolipoprotein A-I-based therapies, recombinant phospholipid transfer protein (PLTP), and cholesterol ester transfer protein (CETP) inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marie Cecilie Paasche Roland, Kristin Godang, Pal Aukrust, Tore Henriksen, Tove Lekva
Summary: This study examined the differences in lipoproteins, CETP activity, and HDL-C between women giving birth to large-for-gestational-age and small-for-gestational-age infants. It was found that women with small-for-gestational-age infants had higher triglycerides in large VLDL and lipids/cholesterol/cholesteryl esters in small HDL. Additionally, women with higher HDL-C had lower levels of CETP expression in the placenta.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Jeremy D. Furtado, Giacomo Ruotolo, Stephen J. Nicholls, Robert Dullea, Santos Carvajal-Gonzalez, Frank M. Sacks
Summary: This study suggests that increasing HDL by inhibiting CETP does not reduce the risk of cardiovascular disease but instead increases the levels of dysfunctional HDL subspecies associated with higher risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiara Pavanello, Alice Ossoli, Arianna Strazzella, Patrizia Rise, Fabrizio Veglia, Marie Lhomme, Paolo Parini, Laura Calabresi
Summary: Mutations in the LCAT gene lead to familial LCAT deficiency, resulting in reduced CE plasma levels. Carriers of two mutant LCAT alleles show significant reduction in CE plasma levels, with enrichment of saturated fatty acids observed. This study highlights the origin of CEs in apoB-containing lipoproteins in the absence of LCAT-derived CEs.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kanchana Ngaosuwan, Desmond G. Johnston, Ian F. Godsland, Jeremy Cox, Azeem Majeed, Jennifer K. Quint, Nick Oliver, Stephen Robinson
Summary: Mortality risk is higher in adrenal insufficiency patients, especially in primary cases, with cardiovascular disease being the major cause of death, while infections are also significant contributors. Adrenal crisis plays a common role in mortality, urging early education for prompt treatment and prevention strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Prasanna D. Revanasiddappa
Summary: Cholesteryl Ester Transfer Protein (CETP) plays a crucial role in the formation of atherosclerotic plaques through its involvement in reverse cholesterol transport. This study investigates the decreased transfer rate of neutral lipids in CETP mutants using molecular dynamics simulations and free energy calculations, providing important insights for the development of novel strategies to inhibit CETP function.
BIOPHYSICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Lynn J. Leberkuhne, Sanam Ebtehaj, Lidiya G. Dimova, Arne Dikkers, Robin P. F. Dullaart, Stephan J. L. Bakker, Uwe J. F. Tietge
Article
Gastroenterology & Hepatology
Lidiya G. Dimova, Jan Freark de Boer, Josee Plantinga, Torsten Plosch, Menno Hoekstra, Henkjan J. Verkade, Uwe J. F. Tietge
Article
Nutrition & Dietetics
Lidiya G. Dimova, Nikola Zlatkov, Henkjan J. Verkade, Bernt Eric Uhlin, Uwe J. F. Tietge
NUTRITION & METABOLISM
(2017)
Article
Multidisciplinary Sciences
Lidiya G. Dimova, Mirjam A. M. Lohuis, Vincent W. Bloks, Uwe J. F. Tietge, Henkjan J. Verkade
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Lidiya G. Dimova, Simone Battista, Torsten Plosch, Rosalie A. Kampen, Fan Liu, Rikst Nynke Verkaik-Schakel, Domenico Pratico, Henkjan J. Verkade, Uwe J. F. Tietge
Article
Medicine, General & Internal
Wijtske Annema, Jan Freark de Boer, Arne Dikkers, Lidiya G. Dimova, Markus van der Giet, Stephan J. L. Bakker, Uwe J. F. Tietge
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Hematology
Laia Trigueros-Motos, Julian C. van Capelleveen, Federico Torta, David Castano, Lin-Hua Zhang, Ee Chu Chai, Martin Kang, Lidiya G. Dimova, Alinda W. M. Schimmel, Ian Tietjen, Chris Radomski, Liang Juin Tan, Chung Hwee Thiam, Pradeep Narayanaswamy, Daniel Heqing Wu, Fabian Dorninger, Gopala Krishna Yakala, Amina Barhdadi, Veronique Angeli, Marie-Pierre Dube, Johannes Berger, Geesje M. Dallinga-Thie, Uwe J. F. Tietge, Markus R. Wenk, Michael R. Hayden, G. Kees Hovingh, Roshni R. Singaraja
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)