Article
Medicine, Research & Experimental
Kai-Chia Yeh, Teng-Kuang Yeh, Chung-Yu Huang, Chih-Bo Hu, Min-Hsien Wang, Yu-Wen Huang, Ling-Hui Chou, Hsuan-Hui Ho, Jen-Shin Song, Tsu Hsu, Weir-Torn Jiaang, Yu-Sheng Chao, Chiung-Tong Chen
Summary: DBPR108 is a novel DPP-4-selective inhibitor that has demonstrated potent in vivo pharmacological effects and good safety profiles in animals. By inhibiting DPP-4 activity, it increases active GLP-1 and insulin levels while improving glucose tolerability in animals.
Article
Immunology
Yuichiro Iwamoto, Takatoshi Anno, Katsumasa Koyama, Fumiko Kawasaki, Kohei Kaku, Koichi Tomoda, Seiko Sugiyama, Yumi Aoyama, Hideaki Kaneto
Summary: DPP-4 inhibitors are closely associated with bullous pemphigoid (BP) and may lead to disruption of immune tolerance. Checking autoimmune antibodies may be important in DPP-4i-related BP, even when symptoms improve.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sharen Lee, Jiandong Zhou, Keith Sai Kit Leung, Abraham Ka Chung Wai, Kamalan Jeevaratnam, Emma King, Tong Liu, Wing Tak Wong, Carlin Chang, Ian Chi Kei Wong, Bernard Man Yung Cheung, Gary Tse, Qingpeng Zhang
Summary: Based on real-world data of type 2 diabetic patients in Hong Kong, the use of SGLT2Is was associated with lower risk of incident AF, stroke/transient ischemic attack, and cardiovascular and all-cause mortality outcomes compared to DPP4Is.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Wei-Hao Hsu, Shu-Ping Sue, Hsiu-Ling Liang, Chin-Wei Tseng, Hsiu-Chu Lin, Wei-Lun Wen, Mei-Yueh Lee
Summary: The study found that the use of DPP-4 inhibitors was associated with a lower risk of hepatocellular carcinoma in patients with type 2 diabetes and chronic HCV infection.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Immunology
Jie Huang, Xinxin Liu, Yingying Wei, Xinlu Li, Shupei Gao, Lingli Dong, Xiaoquan Rao, Jixin Zhong
Summary: DPP4 is a widely expressed protease that alters the bioactivity of its substrates by cleaving off dipeptides from their N-terminus. In addition to its enzymatic functions, DPP4 is involved in various cellular processes and plays a crucial role in immune regulation and autoimmune rheumatic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park
Summary: This study found that the reduction of HbA1c by DPP-4 inhibitors is associated with increasing age, and this association is linked with higher DPP-4 inhibition.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Peripheral Vascular Disease
Jessica R. Wilson, Erica M. Garner, Mona Mashayekhi, Scott A. Hubers, Claudia E. Ramirez Bustamante, Scott Jafarian Kerman, Hui Nian, Cyndya A. Shibao, Nancy J. Brown
Summary: DPP4 inhibition may increase catecholamine levels, but does not increase blood pressure. Increased catecholamines during concurrent use of ACE and DPP4 inhibitors may contribute to cardiovascular complications in patients predisposed to heart failure.
Article
Endocrinology & Metabolism
Andrew R. Zullo, Matthew S. Duprey, Robert J. Smith, Roee Gutman, Sarah D. Berry, Medha N. Munshi, David D. Dore
Summary: This study evaluated the effects of DPP4Is versus SUs on cognitive and physical functioning in nursing home residents. Results showed that DPP4I users had lower rates of cognitive and functional decline within 180 days, but the estimates were imprecise, calling for larger studies to provide more precise effect estimates.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ingeborg T. Hoffmann-Petersen, Charlotte B. Holt, Lisbeth Jensen, Camilla Hage, Linda G. Mellbin, Steffen Thiel, Troels K. Hansen, Jakob A. Ostergaard
Summary: DPP-4 inhibitors have been shown to inhibit the lectin pathway in vitro, but in a clinical study, no significant effect was observed on plasma levels of MBL, sMAC, and C4b. More research is needed to fully understand the clinical implications of this inhibitory effect.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Biophysics
Sadia Malik, Nida Zaidi, Mohammad Khursheed Siddiqi, Nabeela Majid, Aiman Masroor, Samreen Salam, Rizwan H. Khan
Summary: This study evaluates the anti-amyloidogenic potential of the anti-diabetic drug Vildagliptin (VLD) on human serum albumin fibrillation (HSA). The results suggest that VLD has the ability to inhibit amyloid fibrillation and could potentially be repurposed as a drug candidate for the cure of Alzheimer's disease.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Geriatrics & Gerontology
Andrew R. Zullo, Robert J. Smith, Roee Gutman, Bianca Kohler, Matthew S. Duprey, Sarah D. Berry, Medha N. Munshi, David D. Dore
Summary: This study found that among NH residents, individuals who initiated DPP4Is had a lower rate of severe hypoglycemic events compared to those who initiated SUs, with no significant differences in other severe adverse events and death rates.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Dermatology
Lula Maria Nieto-Benito, Marta Bergon-Sendin, Ana Pulido-Perez, Angel Manuel Rosell-Diaz, Veronica Parra-Blanco, Ricardo Suarez-Fernandez
Summary: A retrospective study found that DPP4i-induced BP cases are characterized by generalized lesions and scalp involvement, while gliptin-related BP cases are associated with a decrease in eosinophilic infiltrate and lower concentrations of anti-BP180 IgG.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Osama F. Elabi, Dimitra Karampatsi, Ellen Vercalsteren, Grazyna Lietzau, Thomas Nystroem, Thomas Klein, Vladimer Darsalia, Cesare Patrone, Gesine Paul
Summary: Microvascular pathology in the brain is suggested to be a mechanism underlying the increased incidence and progression of neurodegenerative diseases in people with type 2 diabetes. In this study, two clinically used antidiabetic drugs, linagliptin and glimepiride, were found to restore T2D-induced brain vascular pathology and have neuroprotective effects.
Article
Neurosciences
Won Jun Kim, Jung Hyun Noh, Kyungdo Han, Cheol-Young Park
Summary: This study found that dual therapy with metformin + thiazolidinedione and metformin + dipeptidyl peptidase-4 inhibitor was significantly associated with lower risk of various types of dementia. Additionally, the use of thiazolidinediones in dual oral therapy was significantly associated with a lower risk of dementia compared to non-users.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hugo Ramos, Patricia Bogdanov, Jordi Huerta, Anna Deas-Just, Cristina Hernandez, Rafael Simo
Summary: Sitagliptin eye drops have antioxidant and anti-inflammatory effects on the diabetic retina, reducing oxidative stress, protecting against DNA/RNA/protein damage, and preventing downregulation of antioxidant enzymes.
Letter
Rheumatology
Tsung-Kun Lin, Lung-Fa Pan, Gwo-Ping Jong
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Tsung-Kun Lin, Jing-Yang Huang, Lung-Fa Pan, Gwo-Ping Jong
Summary: The study found no significant association between the use of statins and the risk of new-onset dementia in patients with RA aged over 40 years. However, statin use may have a protective effect against developing dementia in male and older patients.
LIPIDS IN HEALTH AND DISEASE
(2021)
Letter
Rheumatology
Tsung-Kun Lin, Lung-Fa Pan, Gwo-Ping Jong
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Endocrinology & Metabolism
Tsung-Kun Lin, Ya-Hui Lin, Gwo-Ping Jong
Article
Endocrinology & Metabolism
Wun-Zhih Siao, Tsung-Kun Lin, Jing-Yang Huang, Chin-Feng Tsai, Gwo-Ping Jong
Summary: Using Taiwan's National Health Insurance Research Database, this study found that patients with type 2 diabetes who were prescribed SGLT2 inhibitors had a lower risk of incident dementia.
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
Article
Environmental Sciences
Yong-Hsin Chen, Chih-Jung Yeh, Chun-Ming Lee, Gwo-Ping Jong
Summary: Burnout is a common issue among healthcare workers, with neck and shoulder pain being closely associated with it. This study found that women are more likely than men to experience burnout and have higher levels of personal and work-related burnout. Neck and shoulder pain was identified as a key factor contributing to this gender difference.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Health Care Sciences & Services
Wun-Zhih Siao, Yong-Hsin Chen, Chin-Feng Tsai, Chun-Ming Lee, Gwo-Ping Jong
Summary: The coexistence of diabetes mellitus and heart failure is common and associated with increased risks of hospitalization and mortality. This article reviews the prevalence, prognosis, and pathophysiology of diabetic cardiomyopathy, focusing on the relationship between diabetes and heart failure. It also summarizes potential approaches for managing heart failure and diabetes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Xiang Hu, Gwo-Ping Jong, Liang Wang, Mei-Chen Lin, Shao-Qing Gong, Xue-Hong Zhang, Jiun-Jie Lin, Esther Adeniran, Yan-Long Liu, Hung-Yi Chen, Bo Yang
Summary: The study investigated the association between the use of benzodiazepines and non-benzodiazepines with the incidence of atrial fibrillation in the Taiwan National Health Insurance Database. The findings highlighted an increased risk of atrial fibrillation with hypnotics use, especially in high-dose usage.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Yong-Hsin Chen, Shu-Zon Lou, Ching-wen Yang, Hsiu-Mei Tang, Chiu-Hsiang Lee, Gwo-Ping Jong
Summary: This study found that living with spouses increased the risk of burnout among healthcare workers during the COVID-19 pandemic. Marriage influenced family roles, living conditions, and work conditions, resulting in higher levels of work-related burnout. Factors such as having children, consuming less alcohol, inadequate sleep, and engaging in leisure activities with family and friends mediated the relationship between marriage and lower levels of work-related burnout.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Yong-Hsin Chen, Ying-Hsiang Chou, Tsung-Yuan Yang, Gwo-Ping Jong
Summary: Previous research indicates that chronic diseases can be caused by musculoskeletal (MS) pain and poor sleep. It is important to note that coffee, due to its caffeine content, can negatively affect sleep duration, efficiency, and quality. This study examines the impact of frequent coffee consumption (two cups per day) on individuals experiencing MS pain and insufficient sleep during the COVID-19 period. The findings highlight a two-way relationship between long-term coffee drinking, shorter sleep duration, and neck/shoulder pain, suggesting that reducing coffee intake to less than two cups per day is advisable for individuals with MS pain or less than 6 hours of sleep.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Tsung-Yuan Yang, Yong-Hsin Chen, Wun-Zhih Siao, Gwo-Ping Jong
Summary: This article reports on a 58-year-old male patient who developed pulmonary arterial hypertension (PAH) confirmed by echocardiography and right cardiac catheterization 32 years after the diagnosis of ankylosing spondylitis (AS). This is the first detailed case description of AS associated with PAH. Physicians are recommended to be aware of this rare comorbidity in AS patients, and early echocardiographic screening is necessary for symptomatic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gwo-Ping Jong, Tsung-Kun Lin, Jing-Yang Huang, Pei-Lun Liao, Tsung-Yuan Yang, Lung-Fa Pan
Summary: Patients with chronic kidney disease (CKD) are at a higher risk for developing dementia than the general population. This study examines the association between the use of statins and new-onset dementia (NOD) in patients with CKD. The findings suggest that statin therapy may effectively reduce the risk of NOD in patients with CKD.
Letter
Rheumatology
Gwo-Ping Jong, Lung-Fa Pan, Tsung-Kun Lin, Hung-Yi Chen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Yong-Hsin Chen, Chih-Jung Yeh, Lung-Fa Pan, Gwo-Ping Jong
Summary: This study aimed to examine the causal relationship between alcohol use, work-related burnout, and musculoskeletal pain among medical staff. The results showed that various factors, such as marital status, regular exercise, and leisure activities, were negatively associated with work-related burnout, while overtime work, shift work, chronic disease, and alcohol use frequency were positively associated with burnout. Musculoskeletal pain mediated the relationship between alcohol use frequency and burnout. These findings indicate that using alcohol as a coping mechanism for musculoskeletal pain can worsen work-related burnout.
MEDICINA-LITHUANIA
(2022)
Article
Rheumatology
Wun-Zhih Siao, Chin-Hsiu Liu, Yu-Hsun Wang, James Cheng-Chung Wei, Gwo-Ping Jong
Summary: This population-based cohort study found that patients with AS had a higher risk of VHD compared to non-AS controls, particularly in terms of aortic, mitral, and tricuspid valve disease. Patients in the AS group had a higher incidence of valve replacement surgery following the onset of VHD.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)