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Does axillary lymph node dissection impact survival in patients with breast cancer and isolated tumour cells or micrometastasis in sentinel node?

EUROPEAN JOURNAL OF CANCER (2017)

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EUROPEAN JOURNAL OF CANCER

卷 75, 期 -, 页码 167-168

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ELSEVIER SCI LTD

DOI: 10.1016/j.ejca.2017.01.016

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Oncology

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Omari, Faris Ayasra, Abdulrahman Qasem, Yazan Alawneh, Amer Ahmad, Omar Aladawi, Bourhan Alrayes, Hanan Haidar, Shatha Husain, Faisal Qassem, Adnan Sumadi, Ala'a Abu Salhiyeh, Balqees Mahmoud Al-Manaseer, Zaid Alsunna, Hazim Ra'ed, Faten Reyad Bani Hamad, Amro Abuleil, Mohamad K. 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Borowski, Pueya Rashid Nashidengo, Milou Noltes, Pieter Steinkamp, Cameron Wells, Rebecca Teague, Brodie Elliott, David Kieser, Omar Mohyieldin, Chris Varghese, Nick McIntosh, Cheyaanthan Haran, Sarah Rennie, Jasmin King, Jeong Ha, Matthew James McGuinness, Opeoluwa Adesanya, Julius Olaogun, Akinola Akinmade, Kefas Bwala, Peter Agbonrofo, Akinwale Afolabi, Usang Usang, Sebastian Ekenze, Samson Olori, Taiwo Akeem Lawal, Justina Seyi-Olajide, Abiodun Okunlola, Ido Ekiti, Omolara Williams, Adewale Adisa, Lukman Abdur-Rahman, Stephen Kache, Danjuma Sale, Lofty-John Anyanwu, Chukwuma Okereke, Musliu Adetola Tolani, Venko Filipce, Lazar Todorovic, Sofija Pejkova, Sotir Stavridis, John George Massoud, Sareyah Alsibai, Rizwan Sultan, Humera Naz Altaf, Abu Bakar Hafeez Bhatti, Shahzad Hussain Waqar, Aliya Aziz, Asad Ali Kerawala, Lajpat Rai, Mariyah Anwer, Aiman Tariq, Bushra Ayub, Sami Ullah Niazi, Muhammad Yasir Naseem, Muhammad Zeeshan Sarwar, Muhammad Imran Khokhar, Imdad Ahmad Zahid, Haroon Javaid Majid, Nabila Talat, Muhammad Asif, Muhammad Hamid Chaudhary, Umer Farooq, Siddique Ahmad, Waleed Mabood, Syed Imran Bukhari, Muhammad Tariq, Eesha Yaqoob, Saad Javed, Muhammad Usman Malik, Hassan Nawaz Yaqoob, Moises Cukier, Glenda Marina Falcon Pacheco, Robinson Mas Melendez, Arazzelly Del Pilar Paucar Urbina, Jose Rios Chiuyari, Carlos Eduardo Otiniano Alvarado, Lorena Fuentes Rivera Lau, Giuliano Borda-Luque, Milagros Niquen-Jimenez, Claudia Arias, Sergio Zegarra, Jenner Betalleluz Pallardel, Regina Amparo Ugarte Oscco, Gian Mendiola, Yahaira Tatiana Carpio Colmenares, Carlos Shiraishi Zapata, Maria Rosa Ortiz, Marie Dione Sacdalan, Piotr Major, Filipe Castro Borges, Octavio Viveiros, Pedro Serralheiro, Paulo Santos-Costa, Filipa Mendes, Miguel Rocha Melo, Paulo Cardoso, Ana Soares, Jose Azevedo, Rita Goncalves Pereira, Nelson Silva, Andre Caiado, Maria Luis Sacras, Pedro Azevedo, Rui Almeida-Reis, Miguel F. 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Alzaidi, Azah Althumairi, Mohammad Alyami, Abdulrahman Al Amri, Azah Althumairi, Abdullah AlFakhri, Amal Alhefdhi, Sharfuddin Chowdhury, Thamer Nouh, Ameen Alshehri, Abdulrahman Alzahrani, Yousef Alalawi, Selmy Awad, Ibrahima Konate, Abdourahmane Ndong, Jacques Tendeng, Nan Zun Teo, Frederick Koh, Jurij Ales Kosir, Uros Bele, Sabra Aqil, Cristina Barrena Lopez, Ana Sanchez Mozo, Antonio Rodriguez Infante, Patricia Caja Vivancos, Mikel Prieto, Igor Alberdi San Roman, Laura Gomez Fernandez, Josep Maria Munoz Vives, Anna Carreras-Castaner, Berta Diaz-Feijoo, Ramon Sieira-Gil, Victor Turrado-Rodriguez, Anna Sanchez Lopez, Santiago Sanchez-Cabus, Marta Jimenez Toscano, Ma Pilar Canals Sin, Saura Garcia Laura, Oriol Martin Sole, Pedro Palazon Bellver, Sonia Perez-Bertolez, Jordi Prat-Ortells, Mireia Riba Martinez, Josep Rubio-Palau, Xavier Tarrado, Jorge Nunez, Veronica Alonso Mendoza, Coro Bescos, Eloy Espin-Basany, Martin Espinosa-Bravo, Daniel Gil-Sala, Susana Gonzalez-Suarez, Nuria Montferrer Estruch, Lucia Porteiro Marino, Ana Rodriguez-Tesouro, Fabian Rojas Portilla, M. 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Teresa Gavalda Pellice, Misericordia Jorda Sole, Enrique Jose Ruiz Velasquez, Bernardo Nunez, Raul Jimenez, Jon Zabaleta, Maria Jose Gonzalez-Gimeno, Irene Ortega Vazquez, Antonio Perez Ferrer, Ruben Martin-Laez, Marcelo Moreno Suarez, Miguel Angel Freiria Eiras, Irene Ramallo-Solis, Juan-Carlos Gomez-Rosado, Jose Ramon Oliver Guillen, Mar Achalandabaso Boira, Juan Carlos Catala Bauset, Julio Domenech, Rafael Badenes, Juan Carlos Bernal-Sprekelsen, Jorge Sancho-Muriel, Beatriz De Andres-Asenjo, Francisco J. Tejero-Pintor, Marc Vallve-Bernal, Alba Vazquez Melero

Summary: The study aimed to investigate the impact of pre-operative isolation on postoperative pulmonary complications during the global COVID-19 pandemic. The results showed that pre-operative isolation may be associated with a slight increase in the risk of postoperative pulmonary complications, especially in patients with isolation periods longer than 3 days.

ANAESTHESIA (2021)

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Article Surgery

Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation: Lessons from the National Multicenter Implant Breast Reconstruction Evaluation Study

Benjamin G. Baker, Emma Sewart, James Harvey, Shelley Potter

Summary: This study examined the clinical and patient-reported outcomes of women undergoing immediate implant-based breast reconstruction following previous augmentation. The results showed that the outcomes of this approach were similar to those of patients without cosmetic implants.

PLASTIC AND RECONSTRUCTIVE SURGERY (2022)

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Article Gastroenterology & Hepatology

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

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Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J. Price, Daniel M. Fountain, Michael D. Jenkinson, Peter Hutchinson, Hani J. Marcus, Rory J. Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K. Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G. Schache, Stuart C. Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K. Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Yl Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T. S. Shylasree, Rajkumar Kottayasamy Seenivasagam, Joe Ng, Keiichi Fujiwar, Grant D. 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Kovacevic, I Krdzic, B. Lieske, N. Almgla, A. Boutall, A. Herman, C. Kloppers, D. Nel, S. Rayamajhi, Paniagua Garcia M. Senorans, V. Vigorita, E. Acrich, Baena E. Sanfeliu, O. Barrios, T. Golda, C. Santanach, M. Serrano-Navidad, Sorribas M. Grifell, R. V. Vives, D. Escola, A. Jimenez, J. A. Alcazar, M. Angoso-Clavijo, F. Blanco-Antona, A. Carabias-Orgaz, Diaz R. Maag, J. Garcia, A. G. P. Garcia-Plaza, J. Gonzalez-Munoz, L. Munoz-Bellvis, Sanchez J. M. Tocino, A. B. Sanchez-Casado, J. Trebol, Hernandez J. Gutierrez, Tebar A. Zamora, P. Palma, Cayetano L. Paniagua, Gomez L. Fernandez, Collera P. Ormazabal, Diaz R. del Gobbo, Farre R. Font, Flores R. Clotet, Gomez C. J. Diaz, N. Guardia, C. A. Guariglia, Osorio A. Ramos, Sanchez R. Jimenez, L. Sanchon, Soto C. Montesinos, L. Alonso-Lamberti, J. Garcia-Quijada, Jimenez J. Miramon, V Jimenez, J. M. Jover, R. Leon, J. L. Rodriguez, A. Salazar, Valle A. Rubio, Aguado H. Lopez, Bravo R. Infante, F. B. De Lacy, A. M. Lacy, A. 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Maurel, Martin L. F. Anoro, L. Ponchietti, Rodriguez J. M. Artigas, Roldon M. Golet, Utrilla A. Fornals, Estaire M. Gomez, Fernandez A. Camunas, Garcia E. P. Santos, Jimenez E. Higuera, C. Martinez-Pinedo, V Munoz-Atienza, D. Padilla-Valverde, Picon R. Rodriguez, S. Sanchez-Garcia, D. Sanchez-Pelaez, Curtis C. Martinez, L. Sanchez-Guillen, R. C. Colombari, E. Del Valle, M. Fernandez, Lozano P. Lominchar, L. Martin, Rey C. Valcarcel, Zorrilla J. Ortuzar, Alcaide F. Matas, Garcia J. M. Perez, Troncoso P. Pereira, Blas J. L. Laina, B. Cros, J. Escartin, Garcia J. Egea, A. Nogues, Talal El-Abur, C. Yanez, I Mora-Guzman, Achalandabaso M. Boira, Sales R. Mallafre, H. Marin, Prieto M. Calvo, Villalabeitia Ateca, De Andres U. Olabarria, Duran M. Ballesteros, Fernandez F. J. Pablos, F. J. Ibanez-Aguirre, Sanz A. Larrainzar, B. Ugarte-Sierra, Acosta M. A. Merida, Ortiz D. Lopez, Yepes A. F. Cano, Correa A. Bonito, Delgado L. Burdalo, M. Di Martino, Garcia J. Septiem, Maqueda R. Gonzalez, E. Martin-Perez, Calvo P. Espino, Guillamot P. Ruano, Colao L. Garcia, Diaz D. Perez, Esteban E. Agusti, Galindo P. Jara, Gutierrez M. Samaniego, Hernandez M. A. Bartolome, Serrano J. Gonzalez, Alonso A. Poza, B. Dieguez, M. Garcia-Conde, M. Hernandez-Garcia, M. Losada, E. Alvarez, N. Chavarrias, Gegundez A. Simon, Gortazar S. de Las Casas, J. Guevara-Martinez, Prieto M. Nieto, P. Ramos-Martin, I Rubio-Perez, J. Saavedra, A. Urbieta, D. Aparicio-Lopez, Cantalejo M. Diaz, De Miguel M. D. C. Ardevines, Dobon M. A. Rascon, V Duque-Mallen, Gascon Ferrer, Gonzalez-Nicolas M. T. Trebol, C. Gracia-Roche, Herrero M. Lopez, H. Kalviainen, Martinez A. German, M. Matute, Sanchez N. Fuentes, M. S. Santero-Ramirez, S. Saudi, Blazquez A. Martin, Diez M. Alonso, P. Hernandez, F. Mendoza-Moreno, Ovejero E. Merino, Vera C. Mansilla, B. Matias-Garcia, A. Quiroga-Valcarcel, A. G. Barranquero, Cerro C. Zaballos, J. Nunez, J. Ocana, D. Ramos, Acebes F. Garcia, M. Bailon-Cuadrado, Bueno A. D. Canones, Choolani E. Bhojwani, P. Marcos-Santos, T. Miguel, Pacheco D. Sanchez, B. Perez-Saborido, Sanchez J. Gonzalez, F. J. Tejero-Pintor, F. Alconchel, A. Conesa, Gil J. Martinez, Gutierrez A. Fernandez, Lopez A. Abad, T. Nicolas-Lopez, Ramirez P. Romero, Roca M. J. Calvo, K. Rodrigues, Ruiz J. J. Manzanera, A. Soriano, A. Cano, L. Capitan-Morales, Cintas J. Catena, J. Gomez-Rosado, Oliva F. Mompean, Perez M. A. Sanchez, Rio F. D. Lafuente, Torres C. Arcos, J. Valdes-Hernandez, H. Cholewa, M. Frasson, Martinez C. Chicote, J. Sancho-Muriel, B. Estraviz, Fernandez Gomez L. Cruzado, Gonzalez M. de Miguel, A. Landaluce-olavarria, A. Abad-Gurumeta, A. Abad-Motos, E. Martinez-Hurtado, J. Ripolles-Melchor, A. Ruiz-Escobar, A. Cuadrado-Garcia, Garcia-Sancho L. Tellez, Heras J. Aznar, Mate P. Mate, Ortega Vazquez, A. L. Picardo, Rojo J. A. Lopez, Sanchez Cabezudo F. Noguera, Serralta D. de Colsa, Cagigas C. Fernandez, Caina R. Ruiz, Gomez M. Ruiz, P. Martinez-Perez, Santarrufina S. Martinez, Valbuena V. Jabares, Cagigal E. P. Ortega, I Cervera, Diaz P. Pena, J. Gonzalez, Marqueta M. De Salas, Perez M. Gonzalez, Ramos A. Bonilla, Rodriguez L. Gomez, Alfonso M. Garcia, A. Craus-Miguel, Fernandez L. Vega, E. Ferrer-Inaebnit, Gil A. Catalan, Gonzalez F. X. Argente, S. Jeri, A. Oseira, Pujol N. Cano, J. J. Segura-Sampedro, Soldevila C. Verdeguer, B. Villalonga, R. Blanco-Colino, E. Espin-Basany, G. Pellino, S. Srishankar, S. P. B. Thalgaspitiya, Ali A. A. Karar, M. H. Y. Elhafiz, Adam Essa M. E. Adam, M. Saleh, S. Arkani, J. Freedman, E. Angenete, J. Park, G. Heinius, M. Nordberg, E. Pieniowski, N. Lofgren, M. Rutegard, M. Arigoni, M. Bernasconi, D. Christoforidis, M. Di Giuseppe, D. La Regina, F. Mongelli, M. Chevallay, O. Dwidar, E. Gialamas, M. Sauvain, M. Adamina, A. S. Crugnale, L. Guglielmetti, G. Peros, M. Gass, J. Metzger, A. Scheiwiller, M. Turina, T. Al Asadi, S. Alkhateb, R. Altom, B. Bakkar, Maa S. Albared, S. Melhem, A. Hammed, S. Hammed, M. J. Kacem, H. Maghrebi, A. Sebai, A. Aghayeva, I Hamzaoglu, I Sahin, E. Akaydin, Z. Aliyeva, E. Aytac, B. Baca, V Ozben, B. B. Ozmen, A. E. Arikan, I. A. Bilgin, H. Kara, T. Karahasanoglu, C. Uras, A. Akbas, Y. Altinel, F. Calikoglu, G. Ercan, C. Ercetin, S. Meric, M. Tokocin, T. Vartanoglu, H. Yigitbas, M. Dogangun, N. Iflazoglu, O. Cennet, Dincer Ha, T. Erol, A. Alhamed, S. Ergun, A. N. Sanli, S. S. Uludag, M. Velidedeoglu, A. K. Zengin, Y. Kara, M. A. Bozkurt, A. Kocatas, K. Eyuboglu, A. Guner, M. A. Usta, E. Balik, D. Bugra, C. B. Kulle, S. A. Guler, O. C. Tatar, N. Z. Utkan, A. Yildirim, E. Yuksel, A. Abbasov, H. Yanar, E. Akin, F. Altintoprak, G. Cakmak, H. Demir, E. Dikicier, N. Firat, E. Gonullu, M. B. Kamburoglu, I. F. Kucuk, B. Mantoglu, G. O. Kucuk, M. S. Uyanik, B. Goksoy, E. Bozkurt, E. Capkinoglu, O. Guven, M. Mihmanli, S. Omeroglu, M. Tanal, G. Yetkin, M. Akalin, C. Arican, E. K. Avci, C. Aydin, Demirli S. Atici, M. Emiroglu, T. Kaya, Kilinc G. Tuncer, Y. Kirmizi, S. Salimoglu, C. Tugmen, K. Tuncer, G. Uslu, A. Yildiz, Gultekin Fa, H. Lule, B. Oguttu, J. Agilinko, A. Ahmeidat, M. Bekheit, L. K. Cheung, B. S. Kamera, G. Mignot, S. Shaikh, P. Sharma, A. Al-Mohammad, S. Ali, J. Ashcroft, O. Baker, P. Coughlin, R. J. Davies, H. Kyriacou, C. Mitrofan, A. Morris, W. Raby-Smith, S. M. Rooney, A. A. Singh, X. S. Tan, A. Townson, E. Tweedle, A. Kattakayam, R. Lunevicius, A. Sheel, A. Sud, M. Sundhu, D. Angelou, M. Choynowski, B. McAree, A. McCanny, D. Neely, F. Kamel, L. Kumar, R. Madani, P. Nisar, M. Creanga, M. Elniel, J. Law, F. Mosley, L. Arrowsmith, W. Campbell, T. Grove, C. Kontovounisios, O. Warren, T. Doulias, Li M, E. Martin, H. Rodwell, R. Clifford, N. Eardley, E. Krishnan, N. Manu, Roy S. Mahapatra, O. L. Serevina, C. Smith, D. Vimalachandran, K. Emslie, Labib Pl, G. Minto, J. Natale, P. Panahi, L. J. Rogers, A. Abubakar, Akhter M. M. Rahman, H. O'Brien, K. Sasapu, H. J. Ng, A. Day, A. Hunt, N. Laskar, A. Gupta, J. Steinke, S. Thrumurthy, E. Massie, K. McGivern, D. Rutherford, M. Wilson, T. Bacarese-Hamilton, M. Ip, A. James, G. Salerno, T. Stockdale, S. Handa, M. Kaushal, A. Kler, P. Patel, J. Redfern, S. Tezas, Y. Aawsaj, C. Barry, L. Blackwell, H. Emerson, A. Fisher, M. Katory, A. Mustafa, L. Kretzmer, L. Lalou, B. Manku, I Parwaiz, J. Stafford, M. Abdelkarim, A. Asqalan, T. Gala, S. Ibrahim, A. Maw, R. Mithany, R. Morgan, Sundaram G. Venkatesan, D. Banfield, M. Boal, O. Brown, H. Dean, A. J. Boulton, C. M. Hardie, C. McNaught, S. Karandikar, D. Naumann, F. Chen, J. Cheung, J. Ayorinde, T. Chase, T. Cuming, A. Ghanbari, L. Humphreys, S. Tayeh, Aboelkassem A. Ibrahim, C. Evans, H. Ikram, M. Loubani, S. Nazir, A. Robinson, T. Sehgal, A. Wilkins, J. Dixon, M. Jha, S. Thulasiraman, Y. Viswanath, T. Curl-Roper, C. Delimpalta, C. C. L. Liao, V. Velchuru, E. Westwood, G. Bond-Smith, S. Mastoridis, G. D. Tebala, C. Verberne, N. Anscomb, R. Baldwin-Smith, M. Davies, C. Grainger, A. Haji, A. Haq, J. W. Nunoo-Mensah, M. Rizk, M. Bhatti, H. Boyd-Carson, E. Elsey, E. Gemmill, P. Herrod, M. MohammedJibreel, E. Lenzi, T. Saafan, D. Sapre, T. Sian, N. Watson, A. Athanasiou, J. Burke, F. Costigan, H. Elkadi, J. Johnstone, C. Nahm, S. Annamalai, C. Ashmore, A. Kourdouli, C. S. Chean, S. Dharamavaram, N. Kulkarni, I Pereira, K. Shanthakunalan, B. Srikumar, A. Askari, N. Cirocchi, S. Kudchadkar, K. Patel, J. Sagar, R. Talwar, M. Abdalla, O. Ismail, K. Newton, N. Stylianides, A. Aderombi, O. Bajomo, K. Beatson, W. Garrett, V Ng, R. Al-Habsi, G. S. Divya, F. Dixon, B. D. Keeler, R. J. Egan, I Fabre, R. Harries, Li Z, K. Parkins, N. Spencer, D. Thompson, C. Gemmell, C. Grieco, L. Hunt, Mahmoud F. Ali, K. Seebah, I Shaikh, L. Sreedharan, M. Youssef, J. Shah, M. Baguley, ,

Summary: This study compared the resectability of colorectal cancer patients undergoing delayed surgery versus non-delayed surgery. The results suggest that surgical delay does not compromise resectability, but may affect long-term survival.

COLORECTAL DISEASE (2022)

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Article Obstetrics & Gynecology

Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study

Christina Fotopoulou, Tabassum Khan, Juraj Bracinik, James Glasbey, Nadeem Abu-Rustum, Luis Chiva, Anna Fagotti, Keiichi Fujiwara, Rahel Ghebre, Murat Gutelkin, Thomas O. Konney, Joseph Ng, Rene Pareja, Rajkumar Kottayasamy Seenivasagam, Jalid Sehouli, Shylasree T. S. Surappa, Aneel Bhangu, Elaine Leung, Sudha Sundar

Summary: This study evaluated the changes in care and short-term outcomes of surgical patients with gynecologic cancers during the COVID-19 pandemic. It found that about 20.7% of patients had their care adjusted and about 11.2% experienced a delay in surgery of more than 8 weeks, which was associated with adverse outcomes. About 7.9% of patients did not receive their planned operations, with a mortality rate of about 2.7% and about 18% experiencing disease progression or death within 3 months of the decision for surgery by the multidisciplinary team.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Article Medicine, General & Internal

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

James C. Glasbey, Tom E. F. Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P. Arnaud, Brittany Bankhead-Kendall, M. K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas-Chavarri, Miguel F. Cunha, Justine I. Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J. Edward Fitzgerald, Maria Fourtounas, Alex James Fowler, Kay Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R. Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter Hutchinson, Gabriella Hyman, Arda Isik, Umesh Jayarajah, Haytham M. A. Kaafarani, Bryar Kadir, Ismail Lawani, Hans Lederhuber, Elizabeth Li, Markus W. Loffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D. McClain, Kenneth A. McLean, John G. Meara, Antonio Ramos-De La Medina, Mengistu Mengesha, Ana Minaya, Maria Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabrielle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana Filipa Ferreira Simoes, Neil Smart, Richard Sulliva, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H. Taylor, Mary L. Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu

Summary: This study developed and validated a novel index (SPI) to support the strengthening of local elective surgical systems and address growing backlogs. The findings showed that hospitals with a higher SPI were associated with an increased planned surgical volume ratio, independent of income status, COVID-19 burden, and hospital type. Annual self-assessment of surgical preparedness is recommended to identify areas for improvement and enhance the resilience of local surgical systems.

LANCET (2022)

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Article Oncology

Radio-frequency identification (RFID) tag localisation of non-palpable breast lesions a single centre experience

Hend Almalki, Adeline C. Rankin, Arne Juette, Mina M. G. Youssef

Summary: This study aimed to report the surgical experience and outcomes of pre-operative localisation of non-palpable breast lesions using the RFID tag system. The results showed that the RFID tag system has been effective in accurately locating breast lesions in recent years.

BREAST (2023)

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Article Oncology

Lateral chest wall perforator flaps in partial breast reconstruction

Ahmed Orabi, Mina M. G. Youssef, Tamer M. Manie, Mohamed Shaalan, Tarek Hashem

Summary: This study evaluated the outcome of lateral chest wall perforator flaps as an oncoplastic procedure for breast reconstruction. The results showed that these flaps are a reliable and safe option with good aesthetic outcomes.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2022)

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Article Oncology

The impact of Oncotype DX testing on adjuvant chemotherapy decision making in 1-3 node positive breast cancer

Yogeshkumar Malam, Mohamed Rabie, Konstantinos Geropantas, Susanna Alexander, Simon Pain, Mina Youssef

Summary: In node positive breast cancer patients, Oncotype DX gene assay testing impacts the decision of receiving adjuvant chemotherapy, reducing overtreatment and helping to select patients who will benefit from chemotherapy by evaluating the recurrence score (RS).

CANCER REPORTS (2022)

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Article Surgery

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

K. A. McLean, S. K. Kamarajah, D. Chaudhry, R. R. Gujjuri, K. Raubenheimer, I Trout, E. AlAmeer, B. Creagh-Brown, E. M. Harrison, D. Nepogodiev, A. C. Roslani, E. Li, F. Pata, A. Ramos-De la Medina, G. H. van Ramshorst, R. Sayyed, J. Simoes, N. Smart, A. Bhangu, J. C. Glasbey, R. A. Khaw, W. Ahmed, M. Akhbari, D. Baker, A. Borakati, E. Mills, V Murray, R. Thavayogan, I Yasin, J. Glasbey, W. Ridley, M. Sarrami, G. Zhang, N. Egoroff, P. Pockney, T. Richards, M. Edwards, M. Lee, T. Pinkney, R. Pearse, R. Vohra, C. Sohrabi, A. Jamieson, M. Nguyen, A. Rahman, C. English, L. Tincknell, P. Kakodkar, I Kwek, N. Punjabi, J. Burns, S. Varghese, M. Erotocritou, S. McGuckin, S. Vayalapra, E. Dominguez, J. Moneim, S. Bhatia, O. Kouli, M. Salehi, H. L. Tan, A. Yoong, L. Zhu, B. Seale, Z. Nowinka, N. Patel, B. Chrisp, J. Harris, I Maleyko, F. Muneeb, M. Gough, C. E. James, O. Skan, A. Chowdhury, N. Rebuffa, H. Khan, B. Down, Hussain Q. Fatimah, K. Siaw-Acheampong, R. A. Benson, E. Bywater, B. E. Dawson, J. P. Evans, E. Heritage, C. S. Jones, C. Khatri, J. M. Keatley, A. Knight, S. Lawday, H. S. Mann, E. J. Marson, S. C. Mckay, E. C. Mills, G. Pellino, M. Picciochi, E. H. Taylor, A. Tiwari, J. F. F. Simoes, I. M. Trout, M. L. Venn, R. J. W. Wilkin, N. J. Smart, A. Minaya-Bravo, G. Gallo, S. Moug, S. Di Saverio, A. Vallance, D. Vimalchandran, E. A. Griffiths, R. P. T. Evans, P. Townend, K. Roberts, S. McKay, J. Isaac, S. Satoi, J. Edwards, A. S. Coonar, A. Marchbank, E. J. Caruana, G. R. Layton, A. Patel, A. Brunelli, S. Ford, A. Desai, A. Gronchi, M. Fiore, M. Almond, F. Tirotta, S. Dumitra, A. Kolias, S. J. Price, D. M. Fountain, M. D. Jenkinson, P. Hutchinson, H. J. Marcus, R. J. Piper, L. Lippa, F. Servadei, I Esene, C. Freyschlag, I Neville, G. Rosseau, K. Schaller, A. K. Demetriades, F. Robertson, A. Alamri, R. Shaw, A. G. Schache, S. C. Winter, M. Ho, P. Nankivell, J. Rey Biel, M. Batstone, I Ganly, R. Vidya, A. Wilkins, J. K. Singh, D. Thekinkattil, S. Sundar, C. Fotopoulou, E. Leung, T. Khan, L. Chiva, J. Sehouli, A. Fagotti, P. Cohen, M. Gutelkin, R. Ghebre, T. Konney, R. Pareja, R. Bristow, S. Dowdy, S. T. S. Rajkumar, J. Ng, K. Fujiwara, G. D. Stewart, B. Lamb, K. Narahari, A. McNeill, A. Colquhoun, J. McGrath, S. Bromage, R. Barod, V Kasivisvanathan, T. Klatte, T. E. F. Abbott, S. Abukhalaf, M. Adamina, A. O. Ademuyiwa, A. Agarwal, M. Akkulak, D. Alderson, F. Alakaloko, M. Albertsmeiers, O. Alser, M. Alshaar, S. Alshryda, A. P. Arnaud, K. Magne Augestad, F. Ayasra, J. Azevedo, B. K. Bankhead-Kendall, E. Barlow, D. Beard, R. Blanco-Colino, A. Brar, K. A. Breen, C. Bretherton, I. Lima Buarque, J. Burke, M. Chaar, S. Chakrabortee, P. Christensen, D. Cox, M. Cukier, M. F. Cunha, G. H. Davidson, T. M. Drake, J. G. Edwards, M. Elhadi, S. Emile, S. Farik, E. J. Fitzgerald, T. Garmanova, G. Gallo, D. Ghosh, G. Mendonca Ataide Gomes, G. Grecinos, M. Grundl, C. Halkias, I Hisham, P. J. Hutchinson, S. Hwang, A. Isik, P. Jonker, H. M. A. Kaafarani, D. Keller, S. Kruijff, I Lawani, H. Lederhuber, S. Leventoglu, A. Litvin, A. Loehrer, M. W. Loffler, M. Aguilera Lorena, M. Marta Modolo, P. Major, J. Martin, H. N. Mashbari, D. Mazingi, S. Metallidis, H. M. Mohan, R. Moore, D. Moszkowicz, J. S. Ng-Kamstra, M. Maimbo, I Negoi, M. Niquen, F. Ntirenganya, M. Olivos, K. Oussama, O. Outani, M. Parreno-Sacdalanm, C. Jose Perez Rivera, T. D. Pinkney, W. van der Plas, A. Qureshi, D. Radenkovic, M. Rutegard, J. J. Segura-Sampedro, I Santos, R. Sayyed, A. Schache, A. A. Schnitzbauer, J. O. Seyi-Olajide, N. Sharma, S. Shu, K. Soreide, A. Spinelli, M. Sund, S. Tabiri, G. Tsoulfas, D. Vimalachandran, O. J. Warren, D. Wedderburn, N. Wright, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larranaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, J. S. Garcia, P. M. Garcia, J. Gerchunoff, S. M. Lucchini, M. A. NIgra, L. Vargas, T. Hovhannisyan, A. Stepanyan, T. Gould, R. Gourlay, B. Griffiths, S. Gananadha, M. McLaren, J. Cecire, N. Joshi, S. Salindera, A. Sutherland, J. H. Ahn, G. Charlton, S. Chen, N. Gauri, R. Hayhurst, S. Jang, F. Jia, C. Mulligan, W. Yang, G. Ye, H. Zhang, M. Ballal, D. Gibson, D. Hayne, J. Moss, P. Viswambaram, U. G. Vo, J. Bennetts, T. Bright, M. Brooke-Smith, R. Fong, B. Gricks, Y. H. Lam, B. S. Ong, M. Szpytma, D. Watson, K. Bagraith, S. Caird, E. Chan, C. Dawson, D. Ho, E. Jeyarajan, S. Jordan, A. Lim, G. J. Nolan, A. Oar, D. Parker, H. Puhalla, A. Quennell, L. Rutherford, M. Von Papen, M. Wullschleger, A. Blatt, D. Cope, M. Fenton, J. Gani, N. Lott, N. Shugg, M. Elliott, D. Phung, D. Phan, D. Townend, C. Bong, J. Gundara, A. Frankel, S. Bowman, G. R. Guerra, J. Bolt, K. Buddingh, N. N. Dudi-Venkata, S. Jog, H. M. Kroon, T. Sammour, R. Smith, C. Stranz, K. Lah, W. McGahan, D. Mitchell, A. Morton, A. Pearce, M. Roberts, G. Sheahan, B. Swinson, N. Alam, S. Banting, L. 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Troncoso, I Mora-Guzman, M. Abellan, Boira M. Achalandabaso, R. Jorba, Ikuga R. Memba, C. Olona, Mallafre R. Sales, Busquets P. Cavalle, Pellice M. G. P. Gavalda, Pena J. Salinas, Achig E. J. Aragon, L. Barbier, Vivancos P. Caja, A. Gainza, Gutierrez J. J. Garcia, Ormaechea G. Mallabiabarrena, H. Marin, Playa P. Martin, Corcostegui Melchor, Calvo M. Prieto, Fraga A. Rodriguez, Ateca Villalabeitia, Olabarria U. De Andres, Ballesteros M. Duran, Pablos F. J. Fernandez, F. J. Ibanez-Aguirre, Larrainzar A. Sanz, B. Ugarte-Sierra, Rodriguez A. De la Hoz, M. Di Martino, Septiem J. Garcia, E. Martin-Perez, de Nova J. L. Munoz, Espino P. Calvo, Ruano P. Guillamot, Garcia L. Colao, Perez D. Diaz, Agusti E. Esteban, Jara P. Galindo, Samaniego M. Gutierrez, Bartolome M. A. Hernandez, Gonzalez J. Serrano, Poza A. Alonso, B. Dieguez, M. Garcia-Conde, M. Hernandez-Garcia, M. Losada, C. M. Chiesa-Estomba, Garcia J. A. Gonzalez, E. Larruscain, J. A. Sistiaga-Suarez, E. Alvarez, N. Chavarrias, L. Frias, Pineda Garcia, Simon A. Gegundez, S. Gortazar, M. Gracia, J. Guevara, Gutierrez A. Hernandez, A. Loayza, Dolores D. T. Maria, C. Marti, M. Melendez, E. Moreno-Palacios, Y. Perez, Nieto M. Prieto, P. Ramos-Martin, I Rubio-Perez, J. Saavedra, J. Sanchez-Mendez, Ridruejo J. Siegrist, A. Urbieta, I Zapardiel, Diaz M. Cantalejo, Ardevines M. D. C. De Miguel, V Duque-Mallen, Ferrer Gascon, Trebol M. T. Gonzalez-Nicolas, C. Gracia-Roche, Lopez M. Herrero, Ferrer U. M. Jariod, A. Lanzon, German A. Martinez, M. Matute, C. Redondo, Fuentes N. Sanchez, ,

Summary: This study compared the impact of pulmonary complications on postoperative mortality before and during the COVID-19 pandemic, finding that although lower-risk patients were selected for surgery during the pandemic, the mortality rate still significantly increased, with over half of the excess deaths being attributed to SARS-CoV-2 infection.

BRITISH JOURNAL OF SURGERY (2021)

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Article Surgery

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Dmitri Nepogodiev, Aneel Bhangu

Summary: Preoperative SARS-CoV-2 vaccination can support safer elective surgery. The number needed to vaccinate (NNV) to prevent COVID-19-related deaths is more favorable in surgical patients compared to the general population. Prioritizing preoperative vaccination of patients needing elective surgery globally could prevent additional COVID-19-related deaths in 1 year.

BRITISH JOURNAL OF SURGERY (2021)

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Article Surgery

Y Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

Laura Bravo, Dmitri Nepogodiev, James C. Glasbey, Elizabeth Li, Joana F. F. Simoes, Sivesh K. Kamarajah, Maria Picciochi, Tom E. F. Abbott, Adesoji O. Ademuyiwa, Alexis P. Arnaud, Arnav Agarwal, Amanpreet Brar, Muhammed Elhadi, Dennis Mazingi, Victor Roth Cardoso, Samuel Lawday, Raza Sayyed, Omar M. Omar, Antonio Ramos de la Madina, Luke Slater, Mary Venn, Georgios Gkoutos, Aneel Bhangu, Andreas Karwath, Kwabena Siaw-Acheampong, Leah Argus, Daoud Chaudhry, Brett E. Dawson, Rohan R. Gujjuri, Conor S. Jones, Chetan Khatri, James M. Keatley, Harvinder Mann, Ella J. Marson, Kenneth A. Mclean, Elliott H. Taylor, Abhinav Tiwari, Isobel M. Trout, Mary L. Venn, Richard J. W. Wilkin, Irida Dajti, Arben Gjata, Luis Boccalatte, Maria Marta Modolo, Daniel Cox, Peter Pockney, Philip Townend, Felix Aigner, Irmgard Kronberger, Kamral Hossain, Gabrielle VanRamshorst, Ismail Lawani, Gustavo Ataide, Glauco Baiocchi, Igor Buarque, Muhammad Gohar, Mihail Slavchev, Arnav Agarwal, Janet Martin, Maricarmen Olivos, Jose Calvache, Carlos Jose Perez Rivera, Ana Danic Hadzibegovic, Tomislav Kopjar, Jakov Mihanovic, Jaroslav Klat, Rene Novysedlak, Peter Christensen, Alaa El-Hussuna, Sylvia Batista, Eddy Lincango, Sameh H. Emile, Mengistu Gebreyohanes Mengesha, Samuel Hailu, Hailu Tamiru, Joonas Kauppila, Johanna Laukkarinen, Alexis Arnaud, Markus Albertsmeiers, Hans Lederhuber, Markus Loffler, Stephen Tabiri, Symeon Metallidis, Georgios Tsoulfas, Maria Aguilera Lorena, Gustavo Grecinos, Tamas Mersich, Daniel Wettstein, Dhruv Ghosh, Gabriele Kembuan, Peiman Brouk, Mohammad Khosravi, Masoud Mozafari, Ahmed Adil, Helen M. Mohan, Oded Zmora, Marco Fiore, Gaetano Gallo, Francesco Pata, Gianluca Pellino, Sohei Satoi, Faris Ayasra, Mohammad Chaar, Ildar R. 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Mari, A. Spinelli, G. Mercante, G. Spriano, F. Gaino, F. Ferreli, A. De Virgilio, V Rossi, M. M. Carvello, F. Di Candido, H. Kurihara, E. Marrano, G. Torzilli, C. Castoro, F. M. Carrano, F. Martinelli, A. Macchi, M. Fiore, S. Pasquali, S. P. B. Cioffi, M. Baia, C. Abatini, C. Sarre, A. Mosca, D. Biasoni, A. Gronchi, D. Citterio, V Mazzaferro, P. Cadenelli, M. Gennaro, V Capizzi, M. Guaglio, L. Sorrentino, G. Bogani, G. Sarpietro, L. Giannini, L. Comini, L. Rolli, S. Folli, F. Raspagliesi, C. Piazza, M. Cosimelli, R. Salvioni, B. Antonelli, L. Baldari, L. Boni, E. Cassinotti, L. Pignataro, G. Rossi, S. Torretta, G. A. Beltramini, A. Gianni', M. Tagliabue, R. De Berardinis, G. Pietrobon, F. Chu, S. Cenciarelli, L. Adamoli, M. Ansarin, U. Fumagalli Romario, F. Mastrilli, N. M. Mariani, V Nicastro, P. Cellerino, F. Colombo, A. Frontali, A. Bondurri, C. Guerci, A. Maffioli, L. Ferrario, M. Candiani, G. Bonavina, J. Ottolina, L. Valsecchi, P. Mortini, F. Gagliardi, M. Piloni, M. Medone, G. Negri, A. Bandiera, P. De Nardi, P. Sileri, M. Carlucci, D. Pelaggi, R. Rosati, A. Vignali, P. Parise, U. Elmore, N. Tamini, L. C. Nespoli, M. Rennis, L. Pitoni, M. F. Chiappetta, E. Vico, R. Fruscio, T. Grassi, D. Sasia, M. Migliore, A. Gattolin, R. Rimonda, E. Travaglio, E. Olearo, A. Tufo, E. Marra, P. Maida, G. Marte, P. Tammaro, P. Incollingo, F. Izzo, A. Belli, R. Patrone, V Albino, M. Leongito, V Granata, M. Piccirillo, R. Palaia, E. Francone, S. Gentilli, H. Nikaj, A. Fiorini, C. Norcini, A. Chessa, M. Marino, A. Mirabella, G. Vaccarella, L. Musini, L. Ampollini, M. Bergonzani, A. Varazzani, L. Bellanti, M. Domenichini, E. Cabrini, A. Fornasari, A. Freyrie, D. O. Dejana, G. D'Angelo, G. Bertoli, F. Di Lella, G. Bocchialini, M. Falcioni, D. Lanfranco, T. Poli, M. Giuffrida, A. Annicchiarico, G. Perrone, F. Catena, A. Raffaele, A. De Manzoni Garberini, E. Baldini, L. Conti, M. Ribolla, P. Capelli, S. M. Isolani, P. Maniscalco, M. Cauteruccio, C. Ciatti, C. Puma Pagliarello, S. Gattoni, R. Galleano, M. Malerba, M. Ciciliot, F. Farnesi, M. Calabro, N. S. Pipitone Federico, E. G. Lunghi, A. Muratore, G. Di Franco, M. Palmeri, D. Tartaglia, F. Coccolini, M. Chiarugi, T. Simoncini, A. Gadducci, M. Caretto, A. Giannini, A. Perutelli, L. Domenici, S. Garibaldi, R. Capanna, L. Andreani, N. Furbetta, S. Guadagni, M. Bianchini, D. Gianardi, E. Pinotti, M. Montuori, F. Carissimi, G. Baronio, M. Zizzo, C. Castro Ruiz, V Annessi, M. T. Montella, G. Falco, S. Mele, G. Ferrari, V Mastrofilippo, V. D. Mandato, L. Aguzzoli, C. Corbellini, C. Baldi, G. M. Sampietro, G. M. Palini, N. Zanini, G. Garulli, R. Barone, A. Murgese, S. Mungo, M. Grasso, C. Marafante, S. L. Birolo, E. Moggia, M. Caccetta, A. Masciandaro, A. Deirino, M. Garino, R. Perinotti, F. Maiello, L. Gordini, C. P. Lombardi, F. Marzi, A. A. Marra, C. Ratto, M. Di Muro, F. Litta, V De Simone, V Cozza, F. Rosa, A. Agnes, A. Parello, S. Alfieri, G. Sganga, P. Lapolla, A. Mingoli, G. De Toma, E. Fiori, F. La Torre, P. Sapienza, G. Brachini, B. Cirillo, I. Iannone, M. Zambon, A. Chiappini, S. Meneghini, G. B. Fonsi, P. M. Cicerchia, P. Bruzzaniti, A. Santoro, A. Frati, G. Marruzzo, D. Ribuffo, A. Sagnotta, L. Marino Cosentino, S. Mancini, G. Lisi, D. Spoletini, V Bellato, M. Campanelli, G. Sica, L. Siragusa, L. Bonavina, E. Asti, D. Bernardi, A. Lovece, T. Perra, A. Porcu, A. Fancellu, C. F. Feo, A. M. Scanu, F. Tuminello, A. Franceschi, A. Langone, F. Fleres, A. Spolini, P. Bordoni, M. Franzini, G. Clarizia, A. Grechi, A. Longhini, E. Guaitoli, G. Manca, U. Grossi, S. Novello, G. Zanus, M. Romano, S. Rossi, G. Pirozzolo, A. Recordare, S. Paiella, G. Turri, S. Rattizzato, T. Campagnaro, A. Guglielmi, C. Pedrazzani, A. Ruzzenente, E. Poletto, S. Conci, L. Casetti, M. Fontana, R. Salvia, G. Malleo, A. Esposito, L. Landoni, M. De Pastena, C. Bassi, M. Tuveri, S. Nobile, G. Marchegiani, L. Bortolasi, F. Ferrara, M. La Torre, E. Sambugaro, M. Malavolta, G. Moretto, H. Impellizzeri, M. Inama, G. Barugola, F. Ascari, G. Ruffo, S. Granieri, C. Cotsoglou, M. Berselli, M. Desio, V Marchionini, E. Cocozza, S. Di Saverio, G. Ietto, D. Iovino, G. Carcano, F. Ayasra, A. Qasem, Y. Ayasra, M. Al-Masri, M. K. Abou Chaar, H. Al-Najjar, K. Ghandour, F. Alawneh, R. Abdel Jalil, S. Al Abdel, M. Elayyan, R. Ghanem, I Lataifeh, O. Alsaraireh, F. J. Abu Za'nouneh, T. Fahmawee, A. Ibrahim, K. Obeidat, K. J. Lee, S. J. Shin, H. Chung, I Albader, J. Alabbad, M. A. S. Albader, A. Bouhuwaish, A. S. Taher, M. S. M. Omar, E. Abdulwahed, M. Biala, M. Morgom, A. Elhadi, A. Alarabi, A. Msherghi, F. Elhajdawe, A. Alsoufi, A. Salamah, H. Salama, M. Bulugma, H. Almabrouk, D. Venskutonis, E. Dainius, E. Kubiliute, S. Bradulskis, A. Parseliunas, J. Kutkevicius, A. Subocius, Y. J. Cheong, M. S. Masood, C. W. Ngo, R. Saravanan, N. Abdul Maei, F. Hayati, N. Amin Sahid, G. Yanowsky Reyes, J. Orozco Perez, R. Damian, R. Santana Ortiz, C. A. Colunga Tinajero, F. Cordera, A. Gomez-Pedraza, A. Maffuz-Aziz, J. A. Posada, M. A. De la Rosa Abaroa, M. R. Alvarez, R. Arrangoiz, R. Hernandez, K. Bozada Gutierrez, M. Trejo-Avila, C. Valenzuela-Salazar, J. Herrera-Esquivel, M. Moreno-Portillo, V. M. Pinto-Angulo, E. E. Sosa-Duran, H. Ziad-Aboharp, X. Jimenez Villanueva, C. E. Soule Martinez, A. Lupian-Angulo, J. J. Martinez Zarate, E. Reyes Rodriguez, G. Montalvo Dominguez, F. C. Becerra Garcia, J. Melchor-Ruan, D. Vilar-Compte, E. Romero-Banuelos, A. Herrera-Gomez, A. Meneses-Garcia, D. Isla-Ortiz, R. A. Salcedo-Hernandez, J. M. Hernandez-Nava, J. E. Morales-Castelan, O. E. Posadas-Trujillo, G. A. Buerba, A. Alfaro-Goldaracena, E. Pena Gomez-Portugal, G. Lopez-Pena, C. A. Hinojosa, M. A. Mercado, A. Ramos-De la Medina, L. Martinez, I Duran, D. S. Gonzalez, M. J. Martinez, A. Nayen Sainz de la Fuente, L. Miguelena, L. Hernandez Miguelena, S. M. Louraoui, A. El Azhari, M. Rghioui, E. Khya, A. Ghannam, A. Souadka, B. El Ahmadi, Z. H. Belkhadir, M. A. Majbar, A. Benkabbou, R. Mohsine, M. Y. Oudrhiri, H. Bechri, Y. Arkha, A. El Ouahabi, H. Frima, S. Bachiri, L. C. Groen, T. Verhagen, F. M. ter Brugge, J. C. G. Scheijmans, M. A. Boermeester, R. Hompes, E. M. Meima-van Praag, S. Sharabiany, A. B. J. Borgstein, S. S. Gisbertz, M. I. van Berge Henegouwen, S. Gans, P. Van Duijvendijk, T. Herklots, T. De Hoop, M. R. De Graaff, D. Sloothaak, M. Bolster-van Eenennaam, J. Baaij, J. H. G. Klinkenbijl, R. Van Eekeren, E. J. Spillenaar Bilgen, S. W. Van der Burg, N. J. Harlaar, F. H. W. Jonker, M. Vermaas, K. R. Voigt, D. Nellensteijn, E. A. B. Bensi, L. Posma-Bouman, M. Van Sambeek, M. Holscher, W. T. Van den den Broek, S. H. Kruijff, J. P. P. M. De Vries, P. J. Steinkamp, P. K. C. Jonker, W. Y. Van der Plas, W. Bierman, Y. Janssen, J. Franken, S. Oosterling, E. G. Boerma, D. Schweitzer, M. H. F. Keulen, S. Ketting, J. A. Wegdam, T. S. de Vries Reilingh, E. Schipper, P. H. E. Teeuwen, E. R. Hendriks, A. A. W. Van Geloven, M. Emous, R. Poelstra, M. Teunissen, S. L. Gerritsen, D. Boerma, P. R. De Reuver, F. Thunnissen, B. A. M. Vermeulen, A. Groen, T. M. Van Ginhoven, C. L. Vietor, M. J. W. van der Oest, P. W. H. E. Vriens, T. Houwen, J. Heisterkamp, A. S. van Petersen, W. van der Meij, C. T. Stevens, A. Pronk, W. J. Bakker, M. C. Richir, M. R. Vriens, M. D. Filipe, M. Uittenbogaart, W. K. G. Leclercq, J. M. L. Sijmons, P. J. Vancoillie, J. Konsten, M. Van Heinsbergen, N. A. M. Dekker, F. C. den Boer, A. Akinmade, A. Adeyeye, E. Enoch, S. Fayose, A. Okunlola, A. A. Adeniyi, O. T. Adeyemo, I. O. Adebara, A. Bakare, O. F. Babalola, O. H. Abiyere, O. O. Banjo, S. Olori, O. G. Akaba, E. T. Agida, I. H. Abdullahi, I. K. Egbuchulem, D. Olulana, T. A. Lawal, O. Ogundoyin, O. A. Oyelakin, O. G. Nwaorgu, S. O. Sule, C. C. Makwe, B. B. Afolabi, J. O. Seyi-Olajide, A. O. Ademuyiwa, C. O. Bode, O. Atoyebi, O. A. Elebute, A. A. Okunowo, O. M. Williams, N. G. Eke, O. A. Oshodi, O. M. Faboya, A. S. Adeniran, O. A. Omisanjo, Y. A. Oshodi, A. A. Ogunyemi, K. M. Atobatele, I Aremu, O. Olasehinde, L. Abdur-Rahman, J. Bello, A. Popoola, T. O. Sayomi, H. O. Raji, N. Adeleke, B. Lawal, O. Habeeb, O. Agodirin, M. A. Tolani, T. T. Sholadoye, S. E. Nwabuoku, M. Abubakar, T. Risteski, V. Cvetanovska Naunova, L. Jovcheski, E. Lazova, I Agledahl, R. G. Breuer, J. Massoud, S. H. Waqar, I Rashid, A. Ayubi, A. B. H. Bhatti, M. U. Younis, A. Ghouri, B. Ayub, R. H. Sayyed, A. Saleem, K. Turk, A. Alvi, J. Abassy, S. Khan, M. Arshad, K. Ahmed, T. Siddiqui, A. Pirzada, A. A. Kerawala, A. Jamal, L. Rai, R. Nafees Ahmed, A. S. Memon, A. U. Qureshi, M. Ayyaz, M. Umar, U. Butt, M. Kashif, W. H. Khan, M. Waris Farooka, T. Wasim, N. Talat, W. Tahir, J. Naseem, A. Akbar, S. Afroze, L. Ali, A. Sultan, H. B. Ali, M. H. Janjua, A. Janjua, S. Asghar, M. S. Farooq, M. Z. Sarwar, S. A. Naqi, K. M. Gondal, S. Bukhari, M. Tariq, S. Javed, E. Yaqoob, U. Mahmood, K. Raja Shabbir, S. A. Abukhalaf, A. Amro, J. M. Cabada Lee, A. Aguilar, E. Rodriguez, K. Castillo, M. Cukier, H. Rodriguez-Zentner, E. Arrue, R. Isaacs Beron, A. Rodriguez Gonzalez, V Panduro-Correa, D. K. Cornelio, C. E. Otiniano Alvarado, V. D. Caballero Sarabia, X. P. Vasquez-Ojeda, G. Lizzetti-Mendoza, M. Niquen-Jimenez, S. B. Shu-Yip, J. L. Leon Palacios, G. Borda-Luque, S. A. Zegarra, E. Huaman Egoavil, C. Suazo Carmelo, R. Castro de la Mata, D. Rivas, J. Targarona, Y. Trujillo, M. Olivera Villanueva, A. Lahoud-Velaochaga, K. Cabillas, W. Castaneda, J. Colina Casas, J. Betalleluz Pallardel, F. Camacho Zacarias, E. Valez Segura, D. L. Cruz Condori, E. Huaman, R. Ugarte Oscco, C. Vergel Cabrera, Y. T. Carpio Colmenares, L. A. Garcia Barrionuevo, D. Cardenas Ruiz de Castilla, P. Mansilla Doria, M. R. Li Valencia, A. Salazar, A. Sarmiento, C. Diaz, E. Morales, E. Ore, H. Zegarra, J. Siccha, M. Guardia, M. Sandoval, G. C. Mendiola, M. Mimbela, R. Diaz-Ruiz, L. A. Zeta, E. Cordova-Calle, H. M. Nunez, M. R. Ortiz-Argomedo, J. Caballero-Alvarado, A. Salazar-Tantalean, R. Espinoza-Llerena, M. Aliaga-Ramos, O. Asodisen, E. Jabagat, C. M. Tedoy, R. A. Ramos, M. P. J. Lopez, K. L. E. Violago, R. Aram, P. Carlos Santos, R. F. Filarca, A. Carlos, P. Santos, R. L. Filarca, E. J. Domingo, K. J. O. Khu, M. C. Lapitan, M. D. P. Sacdalan, M. J. N. Kho, R. E. Baticulon, S. L. R. Bravo, M. A. C. Cueto, C. L. Ramos, J. R. Fuentes, H. Sadian, A. Gumarao, A. Barraquio, E. M. Cruz, A. D. Gonzales, J. A. S. Reyes, J. A. Salud, E. G. Tancinco, R. D. Rivera, J. A. Lim, J. C. Barcelon, J. A. Chiu, M. Carballo, P. Major, I Gawron, R. Jach, F. Borges, P. Matos Costa, S. Henriques, S. C. Rodrigues, N. Goncalves, J. M. Curvas, A. Cabeleira, C. Branco, P. Serralheiro, R. Alves, T. Teles, A. Lazaro, C. Canhoto, J. Simoes, M. Costa, A. C. Almeida, O. Nogueira, A. Oliveira, R. Athayde Nemesio, M. Silva, C. Lopes, M. J. Amaral, A. Valente da Costa, R. Andrade, R. Martins, A. Guimaraes, P. Guerreiro, A. Ruivo, C. Camacho, M. Duque, E. Santos, D. Breda, J. M. Oliveira, A. L. De Oliveira Lopez, S. Garrido, M. Colino, J. De Barros, S. Correia, M. Rodrigues, P. Cardoso, J. Teixeira, A. P. Soares, H. Morais, R. Pereira, T. Revez, M. Manso, J. C. Domingues, P. Henriques, R. Ribeiro, V. Ribeiro, N. Cardoso, S. Sousa, G. Martins dos Santos, L. Carvalho, C. Osorio, J. Antunes, S. Lourenco, P. Balau, M. Godinho, A. Pereira, N. Silva, A. Kam da Silva Andrade, A. Pereira Rodrigues, N. Borges, J. Correia, I Vieira, T. Ribeiro, J. Catarino, R. Correia, F. Pais, R. Carreira Garcia, R. Bento, J. Cardoso, M. Luis, J. Henriques, J. Patena Forte, J. Maciel, J. Pinheiro Santos, T. P. Silva, A. Branquinho, A. Caiado, P. Miranda, R. Garrido, M. Peralta Ferreira, J. Ascensao, B. Costeira, C. Cunha, L. Rio Rodrigues, M. Sousa Fernandes, P. Azevedo, J. Ribeiro, I Lourenco, H. Gomes, G. Mendinhos, A. Nobre Pinto, A. Ribeiro, C. G. Gil, C. Lima-da-Silva, C. Pereira, F. Tavares, I Ferraz, J. Almeida, J. Marialva, L. Lopes, M. J. M. A. Costa, M. Nunes-Coelho, M. J. Teixeira, N. Machado, J. P. Alfonso, P. Saraiva, R. L. Silva, R. Santos, R. Almeida-Reis, T. Correia-de-Sa, V Fernandes, J. Almeida-Pinto, J. P. Goncalves, H. Santos-Sousa, S. Cavaleiro, A. M. Leite-Moreira, A. Pereira-Neves, C. S. Faria, J. M. Monteiro, J. Nogueiro, M. Sampaio-Alves, M. Magalhaes Maia, P. Vieira, T. Pina-Vaz, F. Jacome, V Devezas, A. Almeida, H. Silveira, S. Vaz, S. Castanheira Rodrigues, D. Costa Santos, J. Grilo, A. Abreu da Silva, M. Claro, A. C. Deus, R. Branquinho, P. M. D. D. Santos, B. Patricio, A. C. Vieira Paiva Lopes, J. M. Mendes, M. F. Carvalho, C. M. Oliveira, A. Tojal, J. Pinto, A. Abutaka, A. Zarour, M. Abdelkareem, S. M. Ali, M. Al Tarakji, R. Alfkey, K. Mukhtar, I. R. Wani, R. Singh, N. Bouchiba, H. Mahdi, S. Abdelaziem Mustafa, A. Al Ansari, R. Drasovean, A. Caziuc, E. Galliamov, M. Agapov, V Kakotkin, E. Semina, ,

Summary: The study analyzed data from 8492 patients in 69 countries to develop the COVIDsurg Mortality Score, demonstrating the safety of restarting a wide range of surgical services for selected patients.

BRITISH JOURNAL OF SURGERY (2021)

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Article Oncology

Genomic profiling of tissue and blood predicts survival outcomes in patients with resected pleural mesothelioma

Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo

Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Perioperative NALIRIFOX in patients with resectable pancreatic ductal adenocarcinoma: The open-label, multicenter, phase II nITRO trial

Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi

Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort

Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri

Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Impact of colorectal cancer screening on survival after metachronous metastasis

Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman

Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Sentinel-node biopsy in apparent early stage ovarian cancer: final results of a prospective multicentre study (SELLY)

Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia

Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

The features and management of acquired resistance to PD1-based therapy in metastatic melanoma

Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies

Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Major cardiovascular adverse events in older adults with early-stage triple-negative breast cancer treated with adjuvant taxane plus anthracycline versus taxane-based chemotherapy regimens: A SEER-medicare study

Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond

Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.

EUROPEAN JOURNAL OF CANCER (2024)

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Letter Oncology

Osimertinib-induced urticarial vasculitis in a patient with lung cancer: A rare cutaneous toxicity

Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Deep learning based histological classification of adnex tumors

Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank

Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

FOLFIRINOX chemotherapy modulates the peripheral immune landscape in pancreatic cancer: Implications for combination therapies and early response prediction

Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen

Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Immunotherapy response in microsatellite stable metastatic colorectal cancer is influenced by site of metastases

Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li

Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Peptide absent sequences emerging in human cancers

Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares

Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.

EUROPEAN JOURNAL OF CANCER (2024)

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