Article
Cardiac & Cardiovascular Systems
Matti A. Vuori, Jaakko Reinikainen, Stefan Soderberg, Ellinor Bergdahl, Pekka Jousilahti, Hugh Tunstall-Pedoe, Tanja Zeller, Dirk Westermann, Susana Sans, Allan Linneberg, Licia Iacoviello, Simona Costanzo, Veikko Salomaa, Stefan Blankenberg, Kari Kuulasmaa, Teemu J. Niiranen
Summary: The main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Sinning, Nataliya Makarova, Henry Voelzke, Renate B. Schnabel, Francisco Ojeda, Marcus Doerr, Stephan B. Felix, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Ben Schoettker, Hermann Brenner, Giovanni Veronesi, Giancarlo Cesana, Paolo Brambilla, Tarja Palosaari, Kari Kuulasmaa, Inger Njolstad, Ellisiv Bogeberg Mathiesen, Tom Wilsgaard, Stefan Blankenberg, Stefan Soederberg, Marco M. Ferrario, Barbara Thorand
Summary: This study found a significant association between elevated HbA(1c) levels and increased risk of cardiovascular outcomes, even in participants without diabetes. The findings suggest the importance of monitoring HbA(1c) levels in the general population for cardiovascular risk assessment.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Chaterina Sujana, Veikko Salomaa, Frank Kee, Simona Costanzo, Stefan Soderberg, Jens Jordan, Pekka Jousilahti, Charlotte Neville, Licia Iacoviello, Viktor Oskarsson, Dirk Westermann, Wolfgang Koenig, Kari Kuulasmaa, Jaakko Reinikainen, Stefan Blankenberg, Tanja Zeller, Christian Herder, Ulrich Mansmann, Annette Peters, Barbara Thorand
Summary: NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.
Article
Clinical Neurology
Weijian Li, Zegui Huang, Wei Fang, Xianxuan Wang, Zefeng Cai, Guanzhi Chen, Weiqiang Wu, Zhichao Chen, Shouling Wu, Youren Chen
Summary: Studies have found a correlation between remnant cholesterol and the risk of ischemic stroke. This study aimed to investigate the impact of visit-to-visit variability in remnant cholesterol concentration on the development of ischemic stroke in the general population. The results showed that greater remnant cholesterol variability was associated with a higher risk of ischemic stroke.
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Alexandre Vallee
Summary: This study investigated the relationship between socio-economic status (SES) and 10-year atherosclerotic cardiovascular disease (ASCVD) risk among the general UK Biobank population. The findings showed that education level, income level, employment status, and Townsend deprivation were associated with ASCVD risk, suggesting the importance of considering SES factors in cardiovascular disease prevention.
Article
Cardiac & Cardiovascular Systems
Ramon Luengo-Fernandez, Marjan Walli-Attaei, Alastair Gray, Aleksandra Torbica, Aldo P. Maggioni, Radu Huculeci, Firoozeh Bairami, Victor Aboyans, Adam D. Timmis, Panos Vardas, Jose Leal
Summary: The study found that cardiovascular disease costs the EU 282 billion annually, with 55% allocated to health and long-term care, accounting for 11% of EU health expenditure. This provides important evidence for policymaking to address the economic burden of CVD.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Tiberiu A. Pana, Mamas A. Mamas, Nicholas J. Wareham, Kay-Tee Khaw, Dana K. Dawson, Phyo K. Myint
Summary: This study aims to understand the sex-specific lifetime trajectories of different heart and circulatory disorders and their relationship with death from heart disease. The results of the study show that men have a higher lifetime risk of heart and circulatory disorders compared with women. Men are more likely to experience myocardial infarction as the first manifestation, while women are more likely to develop atrial fibrillation and stroke after a certain age. The excess risk of death from heart disease observed in men with pre-existing heart disease is attenuated compared with those free of heart disease at baseline. In conclusion, our study highlights the marked sex disparities in heart disease and death over the very long-term, emphasizing the need for tailored heart disease prevention efforts for both men and women.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Viktor Oskarsson, Mats Eliasson, Veikko Salomaa, Jaakko Reinikainen, Satu Mannisto, Luigi Palmieri, Chiara Donfrancesco, Susana Sans, Simona Costanzo, Giovanni de Gaetano, Licia Iacoviello, Giovanni Veronesi, Marco M. Ferrario, Teresa Padro, Barbara Thorand, Cornelia Huth, Tanja Zeller, Stefan Blankenberg, Annie S. Anderson, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Stefan Soderberg
Summary: This study confirmed a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans. Subgroup analyses by sex, age, and decade and season of sampling showed consistent results.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Seung Hyeok Han, Soo Wan Kim
Summary: This study aimed to investigate the association between serum non-HDL-C levels and cardiovascular outcomes in non-dialysis chronic kidney disease patients. The study found that high serum non-HDL-C levels were associated with an increased risk of adverse cardiovascular outcomes, and this association was not affected by clinical factors such as age, gender, body mass index, estimated glomerular filtration rate, and albuminuria.
Article
Hematology
Jing-Wei Gao, Si You, Zhao-Yu Liu, Qing-Yun Hao, Jing-Feng Wang, Dominique A. Vuitton, Shao-Ling Zhang, Pin-Ming Liu
Summary: The study found that metabolically healthy obesity (MHO) is associated with an increased risk of coronary artery calcium (CAC) progression and subsequent cardiovascular disease events. However, MHO individuals have a lower risk of cardiovascular disease compared to metabolically healthy individuals with normal weight.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Shunming Zhang, Huiping Li, Gunnar Engstrom, Kaijun Niu, Lu Qi, Yan Borne, Emily Sonestedt
Summary: The study found that higher intake of non-fermented milk was associated with increased risks of cardiovascular disease (CVD) and CVD mortality, while higher intake of fermented milk was associated with decreased risks of CVD and CVD mortality. The genotype associated with higher milk intake was also linked to higher risks of coronary heart disease (CHD) and CVD. Additionally, non-fermented milk intake was associated with leptin and HDL levels, while no associations were found between fermented milk intake or LCT-13910 C/T genotype and plasma proteins or lipoprotein subfractions.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Qingan Fu, Lijuan Hu, Yuan Xu, Yingping Yi, Long Jiang
Summary: The study found an inverse association between Lipoprotein(a) levels and the risk of type 2 diabetes in the Chinese population. Male patients, especially those aged over 60 with Lipoprotein(a) levels > 28.72 mg/dL, are at low risk for type 2 diabetes.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Henning Witt, Jochen Walker, Marion Ludwig, Bastian Geelhoed, Nils Kossack, Marie Schild, Robert Miller, Paulus Kirchhof
Summary: This study used machine learning techniques to explore predictors of incident atrial fibrillation (AF) in German health claims data. The study found that using ICD-coded clinical variables can improve the identification of patients at risk of newly diagnosed AF. This can help target AF screening efforts to high-risk populations in primary care and stroke survivors.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Transplantation
Xinting Cai, Barbara Thorand, Simon Hohenester, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Jana Nano
Summary: This German cohort study aimed to evaluate the relationship between fatty liver and kidney function/chronic kidney disease (CKD). The study found that fatty liver is associated with kidney function and CKD, and this association is partially mediated by metabolic factors such as inflammation, diabetes, and hypertension.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Simona Esposito, Marialaura Bonaccio, Emilia Ruggiero, Simona Costanzo, Augusto Di Castelnuovo, Alessandro Gialluisi, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: This study explores the relationship between the degree of food processing and the risk of central nervous system (CNS) tumors. It is found that the intake of ultra-processed food (UPF) is associated with an increased risk of CNS tumors, especially malignant tumors, while processed food is inversely related to the risk of this disease.
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Kishore Surendra, Sylvia Nuernberg, Jan P. Bremer, Marius S. Knorr, Frank Ueckert, Jan Per Wenzel, Ramona Bei Der Kellen, Dirk Westermann, Renate B. Schnabel, Raphael Twerenbold, Christina Magnussen, Paulus Kirchhof, Stefan Blankenberg, Johannes Neumann, Benedikt Schrage
Summary: The study aims to develop a practical screening tool for heart failure at the general population level. By using a convolutional neural network (CNN) built on digital electrocardiograms (ECGs), the researchers achieved comparable predictive accuracy for heart failure as the logistic regression model and the random forest classifier. The study suggests that this screening tool could be integrated into the clinical routine of general practitioners, alleviating the underdiagnosis of heart failure.
Article
Psychiatry
Susanne Hansen, Merete Osler, Sanne Marie Thysen, Juri J. Rumessen, Allan Linneberg, Line Lund Karhus
Summary: This study found that patients with celiac disease may have an increased risk of developing neuropsychiatric disorders. The study compared the development of neuropsychiatric diseases in patients with celiac disease and a control group during an 18-year follow-up period. The results showed that patients with celiac disease had a higher risk of developing neuropsychiatric disorders compared to the control group.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Andrea Amerio, Chiara Stival, Alessandra Lugo, Tiziana Fanucchi, Luca Cavalieri d'ORo, Licia Iacoviello, Anna Odone, David Stuckler, Alberto Zucchi, Gianluca Serafini, Silvano Gallus, LOST Lombardia Study Investigators
Summary: This study examined the prevalence of depressive and anxiety symptoms, hopelessness, and insomnia in older adults before and during the COVID-19 pandemic. The results showed significant increases in depressive symptoms, anxiety symptoms, insufficient sleep, and unsatisfactory sleep during the pandemic. Certain subgroups, such as women, those who decreased physical activity, and those with pre-existing chronic diseases, were at higher risk of experiencing worsening mental health outcomes. The use of psychotropic drugs also increased during the pandemic.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Computer Science, Information Systems
Giorgos Koliopanos, Francisco Ojeda, Andreas Ziegler
Summary: This work introduces a simple-to-use R package called "Mock Data Generation (modgo)" that can be used to simulate data from existing study data for continuous, ordinal categorical, and dichotomous variables. The core method combines rank inverse normal transformation with the calculation of a correlation matrix for all variables. modgo allows for flexibility in changing the correlation between variables, performing perturbation analysis, handling multicenter data, and changing inclusion/exclusion criteria.
METHODS OF INFORMATION IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Paulien Vermunicht, Mihaela Grecu, Jean-Claude Deharo, Claire M. Buckley, Elena Pala, Georges H. Mairesse, Michal M. Farkowski, Marco Bergonti, Helmut Puererfellner, Coral L. Hanson, Lis Neubeck, Ben Freedman, Henning Witt, Mellanie T. Hills, Jenny Lund, Katrina Giskes, Daniel Engler, Renate B. Schnabel, Hein Heidbuchel, Lien Desteghe
Summary: This study evaluated the perception of general practitioners about the value and practicalities of implementing screening for atrial fibrillation (AF), focusing on opportunistic single-time point screening with a single-lead electrocardiogram device. The results showed that general practitioners perceive a strong need for a standardized AF screening approach and feel confident ruling out AF on a single-lead ECG. However, additional education and assistance services are desired.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Mueller, Annette Peters, Barbara Thorand
Summary: This study investigated the associations of 233 plasma proteins with chronic kidney disease (CKD). The results identified 21 proteins associated with kidney function decline and incident CKD, with a potential causal association between higher levels of TNFRSF11A and kidney function decline.
Article
Public, Environmental & Occupational Health
Augusto Di Castelnuovo, Marialaura Bonaccio, Simona Costanzo, Patrick McElduff, Allen Linneberg, Veikko Salomaa, Satu Mannisto, Jean Ferrieres, Jean Dallongeville, Barbara Thorand, Hermann Brenner, Marco Ferrario, Giovanni Veronesi, Abdonas Tamosiunas, Sameline Grimsgaard, Wojciech Drygas, Sofia Malyutina, Stefan Soederberg, Maria Nordendahl, Frank Kee, Guido Grassi, Salim Dabboura, Rossana Borchini, Dirk Westermann, Benedikt Schrage, Tanja Zeller, Kari Kuulasmaa, Stefan Blankenberg, Maria Benedetta Donati, Licia Iacoviello, Giovanni de Gaetano
Summary: This study investigated the association between socioeconomic status (SES) and alcohol-related diseases, and examined whether the relationship between moderate drinking and all-cause mortality is influenced by educational level (EL). The findings showed that moderate drinking was associated with a lower mortality rate in individuals with higher EL, while heavy drinking was associated with a higher mortality rate in those with lower EL. Therefore, recommendations to reduce alcohol intake should particularly target individuals with a low level of education.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Blaum, A. Gossling, B. Bay, L. Koester, J. Rohde, T. Lorenz, T. Zeller, R. Schnabel, M. Seiffert, P. Kirchhof, S. Blankenberg, F. Brunner, C. Waldeyer
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Chen, Jennifer Erley, Kai Muellerleile, Dennis Saering, Charlotte Jahnke, Ersin Cavus, Jan N. Schneider, Stefan Blankenberg, Gunnar K. Lund, Gerhard Adam, Enver Tahir, Martin Sinn
Summary: This study demonstrates the predictive value of contrast-enhanced and non-contrast mapping CMR techniques for the development of left ventricular (LV) remodeling following acute myocardial infarction (AMI), and may help define CMR endpoints in myocardial infarction trials.
EUROPEAN RADIOLOGY
(2023)
