期刊
EPIDEMIOLOGY AND INFECTION
卷 145, 期 8, 页码 1727-1736出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268817000450
关键词
Bacterial infections; emerging infections; Haemophilus influenzae; infectious disease; molecular epidemiology
资金
- Health Support Queensland Research and Development Funding
- Wellcome Trust
Haemophilus influenzae is an important aetiological organism of both adult and child respiratory disease. The number of non-typeable (NTHi) invasive H. influenzae isolates referred to the Queensland (QLD) Public Health Microbiology laboratory has increased notably year-by-year. In this study we used whole-genome sequencing to molecularly characterise 100 referred invasive H. influenzae, including 74 NTHi isolates over a 15-year period, observing the carriage of capsular and putative virulence genes, including the major adhesins, antimicrobial resistance genes and population diversity. Encapsulated isolates were largely clonal, however NTHi isolates displayed high genetic variability by MLST and single nucleotide polymorphism typing with no dominant clone observed. The only mechanism for beta-lactam resistance identified in the QLD isolates was beta-lactamase production. No single set of virulence determinants was conclusively associated with invasive QLD NTHi isolates.
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