Article
Environmental Sciences
Joanna Stragierowicz, Sylwia Stypula-Trebas, Lidia Radko, Andrzej Posyniak, Marzenna Nasiadek, Michal Klimczak, Anna Kilanowicz
Summary: The study found that 1,2,3,5,6,7-hexachloronaphthalane (PCN67) exhibited antiestrogenic activity, while both 1,3,5,8-tetrachloronaphthalene (PCN43) and PCN67 showed strong antiandrogenic effects. Exposure to PCNs, along with other endocrine disrupting chemicals, may contribute to the deregulation of sex steroid hormone signaling.
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Maria Puche-Juarez, Juan M. Toledano, Jorge Moreno-Fernandez, Yolanda Galvez-Ontiveros, Ana Rivas, Javier Diaz-Castro, Julio J. Ochoa
Summary: Endocrine disrupting chemicals (EDCs) are exogenous substances that can interfere with the regulation and function of the endocrine system, potentially causing serious health effects, especially on pregnant women and fetuses. It is important to conduct further research on the health issues caused by these substances and implement preventive measures.
Article
Environmental Sciences
Ruoyi Lei, Baode Xue, Xiaoyu Tian, Ce Liu, Yanlin Li, Jie Zheng, Bin Luo
Summary: This study analyzed the association between endocrine-disrupting chemicals (EDCs) exposure and metabolic dysfunction-associated fatty liver disease (MAFLD) in American adults. The results showed a significant association between increased exposure to three EDCs metabolites (arsenic, DiNP, and PFOA) and MAFLD. Further analysis revealed that phthalates had a strong impact on MAFLD, particularly in females and the elderly over 65. The study also found that higher body mass index (BMI) and inflammatory diet habits intensified the association between EDCs and MAFLD, while higher insulin sensitivity levels reduced the risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Public, Environmental & Occupational Health
Yajie Chen, Yang Wang, Ziqiang Cui, Wenpeng Liu, Baowang Liu, Qiang Zeng, Xin Zhao, Jian Dou, Jinglin Cao
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder, and its prevalence has been increasing due to improved living standards. Endocrine-disrupting chemicals (EDCs) are exogenous substances that mimic the effects of hormones in the body. This paper aims to summarize the major EDCs contributing to the growing burden of NAFLD and raise public awareness about the risks of EDCs to reduce the incidence of NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Anish S. Kolan, Julianne M. Hall
Summary: Several studies have shown that endocrine disrupting chemicals (EDCs) can have harmful effects on various systems of the human body. This review summarizes the investigations into the impact of EDC exposure on reproductive systems, specifically preterm birth (PTB), and the efforts of international organizations to reduce the harmful effects of EDC exposure. The studies examined the association between EDCs and PTB, and although the findings differed, they collectively provide sufficient evidence of a possible link between EDC exposure and the risk of PTB. Therefore, international organizations such as the United Nations Environmental Programme (UNEP) and World Health Organization (WHO) should continue to regulate EDC exposure globally and monitor levels among individuals of reproductive age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Mathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen
Summary: Exposure to certain flame retardants, PCBs, phthalates, and pesticides may potentially increase the risk of thyroid cancer according to existing literature, but more research is urgently needed to evaluate the carcinogenic effects of different EDCs on the thyroid gland in humans.
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Christian H. Lindh, Robin P. Peeters, Andreas Kortenkamp, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: The study found that elevated levels of certain phthalate metabolites in maternal urine during pregnancy may be associated with abnormalities in thyroid system markers. These results are in line with findings from experimental studies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Mia Q. Peng, Carrie A. Karvonen-Gutierrez, William H. Herman, Bhramar Mukherjee, Sung Kyun Park
Summary: This study examined the association between phthalate exposure and diabetes in midlife women and found that certain high-molecular-weight phthalate metabolites were potentially linked to a higher incidence of diabetes. However, the associations varied across racial/ethnic groups. Further investigation is needed to determine if phthalates cause diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Engineering, Environmental
Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang
Summary: This study evaluated the effects of exposure to mixtures containing bisphenol A and seven phthalates on liver functions and metabolic homeostasis. The results showed that exposure to EDCs at doses exceeding the human daily exposure limit had detrimental impacts on overall liver function, leading to metabolic abnormalities, steatohepatitis, and hepatic fibrosis. These findings have significant relevance for public health.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Xiaoqi Li, Xiaofan Liu, Zhenzhen Jia, Tian Wang, Hongyan Zhang
Summary: Using primary hepatocytes isolated from male crucian carp uncontaminated with estrogenic EDCs as a culture model, coupled with ELISA, allows for the detection of estrogenic endocrine-disrupting chemicals in food products.
Review
Genetics & Heredity
Nicole Robles-Matos, Tre Artis, Rebecca A. Simmons, Marisa S. Bartolomei
Summary: Genomic imprinting is an important epigenetic mechanism for mammalian development, and environmental insults may alter DNA methylation patterns leading to increased disease risk.
Article
Andrology
Richard Ivell, Anne Marie Vinggaard, Hiroaki Soyama, Ravinder Anand-Ivell
Summary: This study aimed to investigate whether maternal exposure to environmental endocrine disrupting compounds (EDCs) influences adult serum INSL3 concentration. The results showed that maternal exposure to a mixture of BPA and butylparaben significantly reduced the INSL3 concentration in adult male offspring. This suggests that maternal exposure to certain EDCs may contribute to the variation in the Leydig cell biomarker INSL3 in young adulthood.
Article
Chemistry, Physical
Claudia Carnimeo, Nicola Colatorti, Valeria D'Orazio, Pasquale Trotti, Elisabetta Loffredo
Summary: In this study, biochar obtained from poplar wood gasification was used to adsorb xenoestrogens and a herbicide from water. The surface micromorphology and functional groups composition of biochar were investigated using scanning electron microscopy and Fourier-transform infrared spectroscopy. The adsorption kinetics showed the formation of strong bonds between biochar and the compounds, and the adsorption isotherms were described by several mathematical models. Biochar exhibited strong adsorption ability at higher temperatures, and desorption was slow and scarce. This study highlights the excellent potential of biochar as a low-cost biosorbent for retaining organic compounds permanently.
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Sylwia Malgorzewicz, Grazyna Galezowska, Monika Cieszynska-Semenowicz, Joanna Ratajczyk, Lidia Wolska, Przemyslaw Rutkowski, Magdalena Jankowska, Boleslaw Rutkowski, Alicja Debska-Slizien
Article
Pediatrics
Przemyslaw M. Waszak, Pawel Zagozdzon, Magdalena Pierucka, Alicja Kubanek
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Emilia Stepnowska, Ewa Lewicka, Alicja Dabrowska-Kugacka, Ludmila Danilowicz-Szymanowicz, Pawel Zagozdzon, Rafal Kaminski, Zuzanna Lewicka-Potocka, Pawel Miekus, Dariusz Kozlowski, Wojciech Potocki, Grzegorz Raczak
Article
Medicine, Research & Experimental
Dorota Dydjow-Bendek, Pawel Zagozdzon
Article
Biochemistry & Molecular Biology
Katarzyna Wychodnik, Grazyna Galezowska, Justyna Rogowska, Marta Potryku, Alina Plenis, Lidia Wolska
Article
Biochemistry & Molecular Biology
Grazyna Galezowska, Justyna Rogowska, Ewa Olkowska, Wojciech Ratajczyk, Lidia Wolska
Summary: The study evaluated the environmental risk of PFASs in the Gulf of Gdansk, indicating that they would not generate high impact on aquatic life, but some water samples showed medium risk.
Article
Oncology
Dorota Anna Dydjow-Bendek, Pawel Zagozdzon
Summary: The study identified factors such as obesity, early alcohol use initiation, short breastfeeding duration, basic and vocational education, and residing in rural areas as increasing the risk of breast cancer in the Polish population. Therefore, there is a need for enhanced breast cancer prevention efforts targeting adolescents and young women in Poland, with a particular focus on rural areas.
Article
Biochemistry & Molecular Biology
Kinga Siatkowska, Milena Chraniuk, Piotr Bollin, Rafal Banasiuk
Summary: This study found that LED illumination is equally effective as fluorescent lamps for cultivating Drosera binata and Drosera peltata, resulting in similar production of biologically active compounds. Different media compositions may affect the morphology and secondary metabolism of the plants, but do not significantly alter the yield of secondary metabolites under assessed lighting conditions. LEDs are proposed as a more efficient, eco-friendly, and economically reasonable light source for large-scale in vitro production of plumbagin in Drosera species.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Environmental Sciences
Milena Chraniuk, Miroslawa Panasiuk, Lilit Hovhannisyan, Sabina Zoledowska, Dawid Nidzworski, Lidia Ciolek, Anna Wozniak, Agnieszka Kubis, Natalia Karska, Zbigniew Jaegermann, Sylwia Rodziewicz-Motowidlo, Monika Biernat, Beata Gromadzka
Summary: Assessing the toxicity of new biomaterials for bone regeneration is challenging, as single toxicity parameters may not provide a comprehensive evaluation. This study presents the results of two assays used to assess the toxicity of material extracts and investigates the impact of different types of controls on the results.
Article
Virology
Beata Gromadzka, Milena Chraniuk, Lilit Hovhannisyan, Karolina Uranowska, Boguslaw Szewczyk, Magdalena Narajczyk, Miroslawa Panasiuk
Summary: Our findings suggest that vaccination with triple H5N1/ NA-HA-M1 virus-like particles (VLPs) can generate broad-spectrum universal anti-HA-stalk antibodies in hens. Furthermore, these antibodies can recognize HA-stalk recombinant proteins from homologous H5N1 and heterologous H7N9 AIVs, as well as from the heterosubtypic human H1N1 influenza strain.
Article
Biotechnology & Applied Microbiology
Miroslawa Panasiuk, Karolina Zimmer, Anna Czarnota, Magdalena Narajczyk, Grazyna Peszynska-Sularz, Milena Chraniuk, Lilit Hovhannisyan, Sabina Zoledowska, Dawid Nidzworski, Anna J. Zaczek, Beata Gromadzka
Summary: The study utilized recombinant VLPs to present tumor-specific MUC1 epitopes, resulting in high titers of specific antibodies in mice, demonstrating therapeutic potential. This research provides a promising new strategy for future immunotherapy, showcasing the potential of engineered VLPs as a platform for effective cancer vaccines.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lidia Wolska, Marek Kowalewski, Marta Potrykus, Vladyslav Redko, Bartosz Rybak
Summary: This study focuses on the problems and limitations that can be encountered in the process of constructing a mathematical model describing the spread of biological contamination by E. coli bacteria in coastal seawater. The lack of data on sanitary contamination loads, the rare occurrence of E. coli concentrations exceeding 250 CFU/100 mL, and the unpredictability of precipitation and sea conditions pose challenges to building and validating the model. However, such models are considered useful in managing bathing water quality and protecting public health.
Article
Polymer Science
Milena Chraniuk, Miroslawa Panasiuk, Lilit Hovhannisyan, Sabina Zoledowska, Dawid Nidzworski, Lidia Ciolek, Anna Wozniak, Zbigniew Jaegermann, Monika Biernat, Beata Gromadzka
Summary: The study compares the direct and indirect methods described in the ISO guidelines and finds that the molecular surface of biomaterials affects cytotoxicity and proliferation. The indirect method does not provide a clear picture of the cell condition after exposure to the material surface and cannot fully assess the effects of the material.
Article
Medicine, General & Internal
Radoslaw Czernych, Artur Jerzy Badyda, Grzegorz Kozera, Pawel Zagozdzon
Summary: This study aimed to investigate whether daily cardiovascular mortality was associated with air pollutants and meteorological conditions in an urban environment with a low level of air pollution. The results showed strong evidence for a significant association between transient elevations in ambient PM2.5, PM10, NO2, SO2, and CO and higher relative risk of ischemic stroke and myocardial infarction incidents.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pawel Zagozdzon, Marzena Zarzeczna-Baran, Piotr Jedrusik, Magdalena Pierucka, Piotr Bandosz, Agnieszka Wojtecka, Tadeusz Jedrzejczyk, Piotr Popowski, Zbigniew Gaciong, Tomasz Zdrojewski
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2020)
