Article
Cell Biology
Zhengyao Song, Chen Jin, Zichen Bian, Chaozhao Liang
Summary: In this study, researchers found that the combination treatment of radial extracorporeal shock wave therapy (rESWT) and Resveratrol (Res) derivative can effectively reduce inflammation and fibrosis in chronic nonbacterial prostatitis (CNP) rats. This combination treatment works by regulating the expression of SIRT1 and NF-kappa B.
Review
Biotechnology & Applied Microbiology
Mona S. Abdellateif, Ahmed K. Bayoumi, Mohammed Aly Mohammed
Summary: c-Kit is a crucial receptor tyrosine kinase involved in various biological functions. Aberrant expression and mutations of c-KIT play a key role in the pathogenesis and development of multiple cancers, making it an attractive molecular target for cancer treatment. However, accurate detection of mutation types is necessary before personalized therapy can be initiated.
ONCOTARGETS AND THERAPY
(2023)
Article
Cell Biology
Xiaoqian Bu, Yulong Liu, Lin Wang, Zhengzheng Yan, Guo Xin, Wen Su
Summary: In this study, the effect of Oct4 on colon cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) was investigated. Oct4 was found to be up-regulated in colon cancer tissues compared to normal tissues. Overexpression of Oct4 enhanced the malignant characteristics of colon cancer cells, including increased proliferation, migration, invasion, and EMT. Mechanistically, Oct4 activated the stem cell factor (SCF)/c-Kit signaling pathway, and inhibition of this pathway reversed the pro-oncogenic effects of Oct4. These findings suggest that Oct4 may have potential as a diagnostic and therapeutic target for colon cancer.
Article
Food Science & Technology
Jiyue Zhang, Ningxuan Gao, Hanqian Jiang, Haikun Li, Xingyue Cui, Siyi Tang, Chenyu Jin, Jinlong Tian, Bin Li
Summary: Kiwi berry polysaccharide and polyphenol extracts can effectively alleviate constipation by reducing body weight gain, feces quantity, and influencing gastrointestinal transit rate and time to the first dark stool.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Shelly Pathania, Olli T. Pentikainen, Pankaj Kumar Singh
Summary: Receptor tyrosine kinases, such as c-Kit, play crucial roles in cellular processes and their dysregulation can lead to diseases like cancer. Different mutant isoforms of c-Kit have been implicated in various cancers, making c-Kit inhibition a promising approach for cancer treatment. More research is needed to understand the structure, signaling pathways, and pharmacophores of c-Kit inhibitors for improved selectivity and efficacy in cancer therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Psychology, Multidisciplinary
Jian Bai, Longjie Gu, Yinwei Chen, Xiaming Liu, Jun Yang, Mingchao Li, Xiyuan Dong, Shulin Yang, Bo Huang, Tao Wang, Lei Jin, Jihong Liu, Shaogang Wang
Summary: This study found that the imbalance of psychological stress and stress systems is associated with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED). CP/CPPS and ED patients scored high on psychosocial variables, and the symptom scores of lower urinary tract symptoms (LUTS) and ED were positively linked to the severity of psychological stress. The findings suggest that the autonomic nervous system (ANS) sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, while the hypothalamic-pituitary-adrenal (HPA) axis activity is not.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Andrology
Xiaoqiang Qian, Zhengqin Gu, Wenbin Guan, Jun Qi, Ding Xu
Summary: The study showed that resveratrol could alleviate prostatic inflammation and decrease the expression of IL-6, IL-8 and TNF-alpha in rats with estradiol-induced chronic prostatitis.
Article
Physiology
Penghui Yuan, Taotao Sun, Zhengyang Han, Yinwei Chen, Qingjun Meng
Summary: Through multi-omics analysis, we identified the genetic alterations and corresponding regulatory network underlying the interaction between erectile dysfunction and chronic prostatitis/chronic pelvic pain syndrome. These findings expanded our understanding of the molecular mechanism of erectile dysfunction with chronic prostatitis/chronic pelvic pain syndrome.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nikhil S. Patil, Biao Feng, Zhaoliang Su, Christina A. Castellani, Subrata Chakrabarti
Summary: The study identified unique circRNA-mediated upregulation processes in diabetic heart tissue, namely positive regulation of endothelial cell migration and regulation of mitochondrial electron transport, while in the retina, circRNAs regulating extracellular matrix protein production and endothelial to mesenchymal transition (EndMT) were found to be upregulated.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Tohfa Kabir, Haruki Yoshiba, Afifah Zahra Agista, Halima Sultana, Yusuke Ohsaki, Chiu-Li Yeh, Ryota Hirakawa, Hiroko Tani, Tomoki Ikuta, Tomonori Nochi, Suh-Ching Yang, Hitoshi Shirakawa
Summary: The study found that Gnetin C, a derivative with health-promoting properties, can prevent nonalcoholic fatty liver disease (NAFLD), reduce weight gain and liver damage, and improve blood sugar and insulin sensitivity.
Article
Plant Sciences
Ying Xie, Xin Zhan, Jiyuan Tu, Kang Xu, Xiongjie Sun, Chunlian Liu, Chang Ke, Guosheng Cao, Zhongshi Zhou, Yanju Liu
Summary: This study confirmed the therapeutic effect of Atractylodes lanceolata oil (AO) in a rat model of IBS-D, showing that AO inhibits the SCF/c-kit pathway to reduce inflammation and protects against intestinal barrier damage via the MLCK/MLC2 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Shasha Cheng, Hongxuan Li, Yixin Ding, Jiacheng Huo, Yaping Zheng, Yujun Jiang, Yu Zhang, Chaoxin Man
Summary: This study investigated the effects of Lacticaseibacillus paracasei JY062, Lactobacillus gasseri JM1, and their combination on mice with GI motility disorder induced by loperamide. The probiotic combination was found to alleviate GI motility disorder better by increasing the secretion of excitatory GI regulators and decreasing the secretion of inhibitory GI regulators, except vasoactive intestinal peptide. The intervention also increased the number of interstitial cells of Cajal, the expression of SCF/c-kit protein, the abundance of beneficial bacteria, and improved the contents of short-chain fatty acids in mice's cecum contents.
Review
Pharmacology & Pharmacy
Nasrin Aktar, Ahmed Moudud, Tingting Chen, Xiaoqing Gao, Hanhui Min, Meng Tang, Xiaohui Zhou
Summary: Chronic prostatitis/chronic pelvic pain syndrome type III is associated with irritative voiding, sexual dysfunction, and pelvic pain. Various pharmacological treatments are used clinically, but they mainly focus on symptom relief without addressing the root cause of the condition.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Plant Sciences
Di Zhang, Ruimin Lu, Mengwei Wang, Jing Ji, Shujing Zhang, Shuyan Wang, Dongmei Zhang, Meng Chen
Summary: In this study, it was found that Banxia Xiexin Decoction (BXD) could promote the proliferation and inhibit the apoptosis of interstitial cells of Cajal (ICCs) in gastrointestinal (GI) motility disorders through regulating miR-451-5p and the SCF/c-kit signaling pathway. This provides a new therapeutic basis for the treatment of GI motility dysfunction.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lakshminarayan Reddy Teegala, Yasmine Elshoweikh, Ravindra Gudneppanavar, Sathwika Thodeti, Sabita Pokhrel, Erik Southard, Charles K. Thodeti, Sailaja Paruchuri
Summary: The proliferation of mast cells (MCs) is regulated by protein kinase C (PKC) redundancy, and inhibiting both PKC alpha and beta can prevent MC proliferation, providing new targets for the treatment of allergic diseases.
