期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 55, 期 -, 页码 87-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2017.08.015
关键词
Endocrine disruption; Sea bream; Diethylene glycol dibenzoate; Docking simulation; Gene transcription; Metabolic disruption
Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to phthalates, on the expression of key genes involved in lipid metabolism and energy balance by using Sparta aurata juveniles as models. We also evaluated the correlation between cannabinoid receptor 1 (C81) and PPAR alpha transcriptional patterns in both liver and brain tissues. Exposure to the highest DEGB concentration differentially modulated PPAR alpha/CB1 transcriptional pathways in liver/brain tissues of seabream. We hypothesize that, at peripheral level (i.e. liver), DEGB acts as PPAR alpha agonist resulting in a potential stimulation of key lipolytic genes and a concomitant down-regulation of endocannabinoid metabolic enzyme genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据