Article
Environmental Sciences
Shiying Xu, Jiadi Sun, Yinzhi Zhang, Jian Ji, Xiulan Sun
Summary: Different estrogen metabolites, such as estrone and 2-hydroxyestrone, have opposite effects on breast cancer cell proliferation due to structural changes at the C2 site. Hydroxylation at C2 weakens estrogen activity, down-regulates mTOR and Akt pathway proteins, and enhances anti-oxidative stress and anti-inflammatory effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Economics
Bowen Xiao, Ying Fan, Xiaodan Guo, Lin Xiang
Summary: This paper re-evaluates the impact of environmental tax on the economy and individuals from an intergenerational perspective. The study finds that increasing the environmental tax within a certain range can break the pollution-growth cycle, improve the intergenerational allocation of resources, and influence individuals' health, retirement, and education behavior.
Article
Fisheries
Crystal L. Sweeney, Clarke A. M. Brown, Jessica L. Bennett, Neil W. Ross, Graham A. Gagnon
Summary: This study evaluated and validated a QuEChERS technique for extraction of estrogens from aquaculture waste solids and quantitation via LC-MS/MS. The results indicate that this method can be used for quantitation of E2 in aquaculture waste solids.
Article
Environmental Sciences
Malini S. Bapat, Hema Singh, Sudheesh K. Shukla, Prabal Pratap Singh, Dai-Viet N. Vo, Alpa Yadav, Abhineet Goyal, Ajit Sharma, Deepak Kumar
Summary: This article discusses the implications of using silver nanoparticles in agriculture, including the physiological and biochemical changes in plants due to the uptake of silver nanoparticles, as well as studies on tolerance levels or stress due to silver nanoparticles on diverse flora and fauna.
Article
Multidisciplinary Sciences
Sheersh Massey, Mohammad Aasif Khan, Safia Obaidur Rab, Saad Mustafa, Asifa Khan, Zoya Malik, Rahimunnisa Shaik, Mohit Kumar Verma, S. V. S. Deo, Syed Akhtar Husain
Summary: This study investigates the role of the MEN1 gene in breast cancer and finds that aberrant expression of MEN1 is associated with the development and progression of the disease.
Article
Geosciences, Multidisciplinary
Kyle P. Larson, Sudip Shrestha, John M. Cottle, Carl Guilmette, T. Alex Johnson, H. Daniel Gibson, Felix Gervais
Summary: This study re-examined historical specimens from Monashee complex in the Canadian Cordillera and provided new insights into the distribution of rare earth elements between garnet and monazite during metamorphism. The findings confirmed previous interpretations and showed that trace elements in monazite can be reliable markers of metamorphic reactions.
GEOSCIENCE FRONTIERS
(2022)
Article
Thermodynamics
Bodin Singpai, Desheng Dash Wu
Summary: This study used an integrative approach to analyze the causes of changes in energy consumption and CO2 emissions in countries involved in the Belt and Road Initiative, identifying labor market, demographic change, and economic situation as main drivers. Higher-income countries perform better in energy and economic efficiencies, but should focus on manufacturing.
Article
Oncology
Donald Poirier, Jenny Roy, Rene Maltais
Summary: 17 beta-Hydroxysteroid dehydrogenase type 1 (17 beta-HSD1) is crucial in estrogen-dependent breast tumor growth, making it a promising target for treatment. The development of PBRM as an irreversible inhibitor of 17 beta-HSD1 shows potential therapeutic benefits in inhibiting estrogen production and reducing tumor growth in both cell and animal models.
Article
Chemistry, Multidisciplinary
Jorge Gonzalez-Rodriguez, Maria Gamallo, Julio J. Conde, Zulema Vargas-Osorio, Carlos Vazquez-Vazquez, Yolanda Pineiro, Jose Rivas, Gumersindo Feijoo, Maria Teresa Moreira
Summary: The application of magnetic nanoparticles as catalysts for removing emerging pollutants in wastewater has been studied, with challenges such as slow reaction kinetics and mass transfer limitations. Functionalizing the nanoparticle surface and embedding them in a mesoporous matrix can improve stability and dispersion. This approach shows promise in degrading dyes and removing estrogens effectively.
Article
Environmental Sciences
Lu Lu, Xiaolei Fan, Sana Ullah, Muhammad Zeeshan Younas
Summary: The study shows that shadow economy and environmental policy stringency have significant impacts on energy consumption and economic growth in China, with a recommendation to use the latter as an economic tool for maintaining green economic growth.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Immunology
Suriya Rehman, Vijaya Ravinayagam, Insha Nahvi, Hanan Aldossary, Maha Al-Shammari, Mai Saad Al Amiri, Uday Kishore, Ebtesam A. A. Al-Suhaimi
Summary: This study discusses the significant impact of gender on morbidity and mortality of COVID-19, with factors such as innate immune response, estrogen, and microbiota potentially contributing to gender differences. It also highlights certain factors that give women greater resistance to SARS-CoV-2 infection and disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Fernanda Bento Rosa Gomes, Pedro Antonio Alves Fernandes, Sue Ellen Costa Bottrel, Emanuel Manfred Freire Brandt, Renata de Oliveira Pereira
Summary: In recent decades, the expansion of livestock and animal feeding operations has led to elevated levels of estrogens in the environment. This review examines the fate, occurrence, and removal of different forms of estrogens in livestock wastewaters. The results indicate high concentrations of estrogens in swine farming samples and frequent findings of E1 and E2 in wastewaters from bovine, swine, and other livestock effluents. Aerobic treatment processes are more effective in estrogen removal, while anaerobic systems show poor efficiency. Various treatment methods, such as constructed wetlands and membrane bioreactors, have been reported to remove up to 90% of estrogens and estrogenic activity. Monitoring these compounds in environmental matrices is crucial, given the high concentrations found in livestock wastewaters and the reported removal efficiencies of anaerobic processes commonly used for their treatment.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Renata Pavlic, Marija Gjorgoska, Eva Hafner, Masa Sinreih, Kristina Gajser, Stefan Poschner, Walter Jager, Tea Lanisnik Rizner
Summary: The study revealed that in poorly differentiated EC cell lines like KLE, there is a high expression of E1-S transporters and increased E1-S uptake, while in moderately differentiated cell lines like RL95-2, there are higher levels of sulfatase and better metabolism of E1-S to E1. Additionally, disturbed balance in expression of HSD17B genes in KLE cells led to enhanced activation of E1 to E2.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rebeka Jojart, Reka Laczko-Rigo, Mate Klement, Gabriella Kohl, Gabor Kecskemeti, Csilla Ozvegy-Laczka, Erzsebet Mernyak
Summary: The study identified crucial structural features for OATP2B1 inhibition by designing modifications at four positions of the estrane skeleton.13β-derivatives showed outstanding inhibitory action against OATP2B1, while a BODIPY-13α-estrone conjugate displayed efficient inhibitory potency.
BIOORGANIC CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Kyra Wang, Zeynep Duygu Tekler, Lynette Cheah, Dorien Herremans, Lucienne Blessing
Summary: This paper introduces a serious game called PEAR, and through a study, it was found that the game significantly improved participants' knowledge and attitudes towards climate change issues, demonstrating the potential of serious games in imparting knowledge and promoting sustainable behaviors.