Article
Environmental Sciences
Yun Liu, Xue Wang, Bo Si, Tong Wang, Yun Wu, Ying Liu, Yemian Zhou, Haiyang Tong, Xinwei Zheng, An Xu
Summary: This study uncovers the advanced function of ZnO/GO nanocomposites against Cd-induced liver damage and explores their cellular detoxification mechanism. The nanocomposites competitively inhibit cellular Cd uptake and promote Cd excretion, thus reducing Cd toxicity.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
M. Kazlauskas, Z. Jurgelene, S. Semcuk, K. Joksas, N. Kazlauskiene, D. Montvydiene
Summary: This study aims to synthesize graphene oxide (GO) and investigate its phytotoxicity and its co-exposure with a metal mixture using garden cress (Lepidium sativum L.) as a test organism. The study found that the tested concentrations of the metal mixture, GO, and the mixture of both did not affect seed germination, root growth, and biomass of roots and seedlings. However, it did alter photosynthesis processes, enhance carotenoid and H2O2 production, and activate lipid peroxidation. Additionally, the study revealed that GO affects the accumulation of tested metals in the plants due to its adsorption capacity.
Article
Environmental Sciences
Naresh K. Nirmal, Kumud K. Awasthi, Placheril J. John
Summary: The study found that graphene oxide (GO) has dose-dependent toxicity to the liver of male Wistar rats, with significantly elevated levels of liver enzymes and intermediary metabolites in high-dose treated animals, along with distinct histopathological changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Yimu Wei, Jingna Cui, Wangjing Zhai, Xueke Liu, Zhiqiang Zhou, Peng Wang, Donghui Liu
Summary: The study revealed potential toxic risks of Pyriproxyfen and its metabolites to zebrafish, with hydroxylated metabolites showing higher toxicity than the parent compound. Additionally, Pyriproxyfen and its metabolites induced oxidative stress damage in zebrafish.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Aude Ratier, Sandrine Charles
Summary: This article discusses the regulatory requirement for bioaccumulation evaluation of chemicals within organisms and the use of toxicokinetic (TK) data to predict internal concentrations. To increase the availability of TK data, researchers have developed an innovative database to support TK modelling.
Article
Chemistry, Physical
Slawomir Jaworski, Barbara Strojny-Cieslak, Mateusz Wierzbicki, Marta Kutwin, Ewa Sawosz, Maciej Kamaszewski, Arkadiusz Matuszewski, Malwina Sosnowska, Jaroslaw Szczepaniak, Karolina Daniluk, Agata Lange, Michal Pruchniewski, Katarzyna Zawadzka, Maciej Lojkowski, Andre Chwalibog
Summary: Graphene has various applications in biomedicine, with delivery systems, sensors, tissue engineering, and biological agents being the main areas. Toxicity analysis of pristine graphene (PG) and graphene oxide (GO) on different biological models showed higher toxicity at higher doses. The differences in toxicity between the forms of graphene are due to their physicochemical properties and the specific biological model used for testing.
Article
Environmental Sciences
Yao Deng, Ran Wang, Bangyan Song, Ya Yang, Deyu Hu, Xin Xiao, Xiaohua Chen, Ping Lu
Summary: This study investigated the stability and isomerization of sulfoxaflor stereoisomers and its racemate, as well as their toxic effects on zebrafish. The results showed that all enantiomers were extremely unstable in water, while the racemate was stable. Zebrafish exhibited enantioselective bioaccumulation of sulfoxaflor, and the presence of sulfoxaflor caused oxidative lesions and altered enzymatic activities in the fish. These findings provide important information for assessing the ecological risk of chiral pesticides to aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Engineering, Environmental
Yanping Li, Fengyuan Chen, Ruojing Zhou, Xinqing Zheng, Ke Pan, Guanglong Qiu, Zhongjie Wu, Shiquan Chen, Daoru Wang
Summary: Seagrasses are important foundation species in coastal ecosystems, contributing to high biodiversity. However, they are increasingly affected by metal pollution, which is a significant driver of seagrass losses. Previous reviews have evaluated the usefulness of seagrasses as biomonitors for metal pollution, but a mechanistic understanding of metal bioaccumulation and detoxification is needed.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Environmental Sciences
Yingcan Zhao, Yang Liu, Xinbo Zhang, Wenchao Liao
Summary: Research on graphene oxide (GO) has been rapidly developing in both academic and industrial applications, with a focus on its environmental transformation in aquatic environments. This review aims to summarize recent developments in the field, including the photo-transformation of GO, its interaction with natural constituents in aquatic environments, its toxicity to aquatic organisms, and the potential risks it poses to the environment.
Article
Engineering, Environmental
Dorota Kowalska, Jakub Maculewicz, Piotr Stepnowski, Joanna Dolzonek
Summary: Ionic liquids have gained attention for their unique properties and potential as designer solvents, but concerns about their toxicity and persistence have been raised. The increasing production and import of ILs over 10 tonnes per year require PBT and PMT assessments to evaluate their environmental impact.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Zhuang Wang, Fan Zhang, Martina G. Vijver, Willie J. G. M. Peijnenburg
Summary: The study revealed enhanced cytotoxicity of a mixture of graphene-based carbon nanomaterials and nano-zirconium oxide to freshwater algae, attributed to intracellular oxidative stress and cellular membrane changes. Mitochondria-generated ROS played a significant role in the cellular response, indicating oxidative damage to algal cells. Additionally, reduced graphene oxide showed higher cytotoxicity and oxidative stress compared to graphene nanoplatelets.
Article
Environmental Sciences
Tong Liu, Kuan Fang, Yalei Liu, Xiaolian Zhang, Lingxi Han, Xiuguo Wang
Summary: The study revealed significant enantioselective degradation of hexaconazole in artificial soil, with the S-enantiomer showing higher acute toxicity in earthworms than the R-enantiomer. The transcriptome sequencing results indicated that S-HEX had a more pronounced impact on various biological functions than R-HEX, suggesting a higher risk to soil organisms. These findings highlight the importance of assessing environmental risks of chiral pesticides at the enantiomeric level.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Laure Meiller, Valerie Sauvinet, Anne-Esther Breyton, Harimalala Ranaivo, Christelle Machon, Anne Mialon, Alexandra Meynier, Stephan C. Bischoff, Jens Walter, Audrey M. Neyrinck, Martine Laville, Nathalie M. Delzenne, Sophie Vinoy, Julie-Anne Nazare
Summary: This pilot study aimed to analyze the kinetics of C-13-labeled gut-derived metabolites from C-13-labeled wheat bran in breath, plasma, and stools. The study found differential fermentation profiles among subjects and identified distinct excretion patterns of gases in high-CH4 producers compared to low-CH4 producers. The study also revealed different kinetics of C-13-labelled short-chain fatty acids in plasma.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Marine & Freshwater Biology
Shreya Roy, Dhruba Jyoti Sarkar, Nabanita Chakraborty, Kausik Mondal, Basanta Kumar Das
Summary: Microplastic pollution is a global issue that affects terrestrial and marine ecosystems. This study found that the accumulation of microplastics in freshwater snails can lead to changes in nonenzymatic antioxidant levels and AChE activity, which could have negative impacts on the ecosystem.
AQUATIC TOXICOLOGY
(2023)
Article
Chemistry, Physical
Soledad Aguado-Henche, Maria Lorenza Escudero, Maria Cristina Garcia-Alonso, Rosa Maria Lozano-Puerto, Celia Clemente de Arriba
Summary: This study conducted in vivo tests to assess the potential side effects of graphene. It found traces of graphene in the peritoneal cavity and changes indicating a hepatic inflammatory process in blood analysis. The results contribute to a better understanding of the toxicity and potential biomedical applications of graphene.
Article
Biochemistry & Molecular Biology
Xiaolin Xu, Chenglong Wang, Peipei Zhang, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Jia Yuan, Hongjing Dou, Guoxiong Xu
Summary: This study reveals that chemoresistant cancer cells show decreased ROS levels and increased oxidative phosphorylation. Chemoresistant cells generate more energy through oxidative phosphorylation and enhance ROS scavenging systems to resist the effects of chemotherapy. Furthermore, increased ROS production efficiently inhibits chemoresistance and promotes cell death in chemoresistant cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Orthopedics
Chenglong Wang, Liqiang Cui, Qinwen Gu, Sheng Guo, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a common cause of low back pain, and its pathological mechanism involves complex genetic, developmental, biochemical, and biomechanical factors. Non-coding RNA, especially miRNA, has been found to play a crucial role in the development of IDD through various cellular and molecular processes. However, there is still a lack of effective non-surgical treatment options for IDD.
ORTHOPAEDIC SURGERY
(2022)
Article
Integrative & Complementary Medicine
Joon-Ho Lee, Yuan-Ji Wei, Zhong-Yan Zhou, Yu-Ming Hou, Cheng-Long Wang, Li-Bo Wang, Hong-Jin Wu, Yu Zhang, Wei-Wei Dai
Summary: The herbal pair of Radix Achyranthis Bidentatae and Eucommiae Cortex can ameliorate the effects of glucocorticoid-induced osteoporosis in zebrafish, with a 1:1 dosage ratio being the most effective.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Chemistry, Multidisciplinary
Xue-Ling Chang, Lingyun Chen, Boning Liu, Sheng-Tao Yang, Haifang Wang, Aoneng Cao, Chunying Chen
Summary: This review article summarizes the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological effects. It discusses the advantages and disadvantages of stable isotope labeling compared to other quantitative methods for nanomaterials. The article also provides a summary of the quantitative information of nanomaterials in environmental and biological systems, along with biosafety data. Furthermore, it analyzes the benefits of nanomedicine in drug development based on targeting effects, persistent accumulation, and safety. Finally, the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology are discussed.
CHINESE CHEMICAL LETTERS
(2022)
Review
Physiology
Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a complex skeletal disease involving multiple factors. The piezo1 ion channel has been identified as a critical factor in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel can effectively prevent the progression of IDD.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Review
Geriatrics & Gerontology
Hongyu Pan, Hongtao Li, Sheng Guo, Chenglong Wang, Xiaoqiang Wang, Houyin Shi, Kaiquan Zhang, Hui Chen, Sen Li
Summary: Low back pain (LBP) is a common health problem caused by intervertebral disc degeneration (IDD), which is mainly attributed to aging, mechanical stress, and lack of nutrition. The pathological mechanism of IDD is complex, involving inflammatory response and cell metabolism disorder. Tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in IDD by promoting extracellular matrix degradation and inflammatory responses. Anti-TNF-alpha therapy is an effective treatment for alleviating IDD.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Geriatrics & Gerontology
Hongtao Li, Xiaoqiang Wang, Hongyu Pan, Changming Xiao, Chenglong Wang, Sheng Guo, Longhai Long, Houyin Shi, Hui Chen, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) and disability in the elderly, resulting in a significant global public health and economic burden. The mechanisms of IDD are complex and the specific targets for reversing IDD remain unclear. Interleukin-1 beta (IL-1 beta), a key mediator of IDD, has been found to regulate IVD cell death through various mechanisms, including apoptosis, pyroptosis, and ferroptosis. Inhibition of IL-1 beta has shown promise as a biological therapy for IDD by inhibiting inflammatory processes and regulating ECM degradation. This article reviews the mechanisms and functions of IL-1 beta in IDD and explores advances in IL-1 beta inhibition as a potential biotherapeutic approach for disc degeneration.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Engineering, Environmental
Chengzhuang Liang, Qinmei Zhong, Lejie Pan, Fangshi Liu, Xin Li, Jinwei Yang, Yusen Ma, Junrou Zhou, Sheng-Tao Yang
Summary: Metal-organic frameworks (MOFs) are rapidly developed materials with fantastic properties and wide applications. However, their potential threats to the environment are highlighted. The influence of organic ligands on the environmental impacts of MOFs has not been revealed.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Acoustics
Yujie Li, Wei Li, Xinyue Liu, Xueli Liu, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li, Zhongfa Zhang
Summary: Tendon injuries are common soft tissue injuries caused by overuse and degeneration. Tendon repair is slow and inefficient due to the lack of cellular structure and blood vessels. Low-intensity pulsed ultrasound (LIPUS) is a promising non-invasive method for promoting tendon healing. This review examines studies on LIPUS and summarizes its effects on tendon injury, with 87.5% of studies showing improvement. Further research on the application of LIPUS in tendon diseases is warranted.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yue-Rui Yuan, Qiang Liu, Deyu Wang, Yu-Dan Deng, Ting-Ting Du, Wen-Jing Yi, Sheng-Tao Yang
Summary: The key to gene therapy lies in the development of effective and biocompatible delivery systems. This study presents the design of a glutathione-activated aggregation-induced-emission (AIE) cationic amphiphilic lipid, QM-SS-KK, for nonviral gene delivery. QM-SS-KK exhibited efficient DNA compaction and fluorescence modulation properties, which could be activated by GSH. Liposomes composed of QM-SS-KK and DOPE showed high transfection efficiency, especially in the presence of serum, and outperformed the commercial transfection agent PEI25K. These findings highlight the potential of peptide and QM-based AIE lipids for gene delivery.
Review
Biochemistry & Molecular Biology
Yi Cai, Fangxin Luo, Yujun Guo, Feng Guo, Weilong Shi, Shengtao Yang
Summary: Zinc indium sulfide (ZnIn2S4) is a significant visible-light-responsive photocatalyst with excellent properties, but its low utilization of solar light and fast photoinduced charge carriers limit its applications. This review describes various modulation strategies for enhancing the near-infrared (NIR) photocatalytic performance of ZnIn2S4-based photocatalysts, including hybrid materials, bandgap engineering, up-conversion materials, and surface plasmon materials. The synthesis methods and mechanisms of NIR light-driven ZnIn2S4-based photocatalysts are also summarized.
Article
Materials Science, Multidisciplinary
Fangshi Liu, Suke Lan, Chun Zhang, Mengyao Shi, Xian Wu, Sheng-Tao Yang
Summary: The large surface area and porous structure of MOF materials provide binding sites for fluorescent moieties for bioimaging. In this study, we prepared a fluorescent MOF material Zn(BDC)-8HQ by modifying 8-hydroquinoline. Zn(BDC)-8HQ emitted strong fluorescence at 507 nm and had a hydrodynamic radius suitable for lymph node tracing. The low toxicity of Zn(BDC)-8HQ was confirmed by serum biochemical index and histopathological observations.
Review
Orthopedics
Shanjun Huang, Yujiao Liu, Chenglong Wang, Wei Xiang, Nianwu Wang, Li Peng, Xuanang Jiang, Xiaomin Zhang, Zhijiang Fu
Summary: Osteoarthritis (OA) is a debilitating disease with significant economic and social burden. Cartilage injury, characterized by excessive chondrocyte death, inflammation, abnormal bone metabolism, and imbalance of extracellular matrix, presents a major pathological feature of OA. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) have shown promise as both early diagnostic biomarkers and therapeutic strategies for OA, due to their important role in intercellular communication. This paper comprehensively reviews the functions and mechanisms of MSCs-EVs in cartilage repair, highlighting their potential in protecting chondrocyte death, regulating bone metabolism, balancing extracellular matrix metabolism, alleviating inflammation, and regulating angiogenesis.
ORTHOPAEDIC SURGERY
(2023)
Article
Geochemistry & Geophysics
Jie Nie, Chengyu Zheng, Chenglong Wang, Zijie Zuo, Xiaowei Lv, Shusong Yu, Zhiqiang Wei
Summary: In this paper, a scale-relation joint decoupling network (SRJDN) is proposed for the semantic segmentation of remote sensing (RS) images, which considers decoupling scales and decoupling relationships to explore more complete relationships of multiscale RS objects. The SRJDN consists of three steps: scale decoupling (SD), relation decoupling (RD), and fine-granularity guided fusion (FGF). Experimental results on two large-scale fine-resolution RS image datasets demonstrate the effectiveness and robustness of the proposed joint decoupling strategy and the FGF module in RS image semantic segmentation tasks.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Computer Science, Information Systems
Jingyu Wang, Chenglong Wang, Qicheng Yang, Chengyu Zheng, Jie Nie, Mingxing Jiang
Summary: In this paper, a Bidirectional Macro-Micro Adaptive Enhancement (BMMAEnet) framework is proposed for the re-colorization of remote sensing images. The framework consists of three modules: the Downward Micro Enhancement (DME) module, the Upward Adaptive Macro Enhancement (UAME) module, and the Macro-Micro Balance (MMB) module. Experimental results show that the proposed method outperforms other methods in terms of pixel color value restoration performance and human perceptive understanding.