Review
Pharmacology & Pharmacy
Miriam E. van Gent, Muhanad Ali, Peter H. Nibbering, Sylvia N. Klodzinska
Summary: The review critically evaluates the potential of lipid and polymeric AMP delivery systems and coatings in enhancing the efficacy of AMPs, reducing limitations, and prolonging half-life. However, most studies have only evaluated the antibacterial activities in vitro against planktonic bacteria, with limited research on antibiofilm activities and antibacterial effects in animal models. Further improvements in functionalization and testing in biologically relevant environments are suggested for better targeting infections.
Article
Nanoscience & Nanotechnology
Juanjuan Xu, Yuanpei Li, Haojie Wang, Mengxi Zhu, Wenpo Feng, Gaofeng Liang
Summary: The study successfully developed an AMP@PDA@AgNPs nanocomposite with excellent biocompatibility and strong antimicrobial activity, capable of disrupting bacterial biofilms. The nanocomposite showed potential in treating bacterial infections by inhibiting the expression of biofilm-related genes. The synergistic strategy of AMPs and AgNPs provided a new perspective for the treatment of bacterial infections.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Environmental
Fanyi Li, Tao Huang, Paul Pasic, Christopher D. Easton, Nicolas H. Voelcker, Daniel E. Heath, Neil M. O'Brien-Simpson, Andrea J. O'Connor, Helmut Thissen
Summary: All indwelling and implantable medical devices are at risk of infection. Strategies that combine multiple layers of defense, such as a copolymer coating with antimicrobial selenium nanoparticles, show promise in providing effective protection against pathogen colonization and biofilm formation. The antimicrobial coating demonstrated low attachment of bacteria and additional bactericidal functionality against commonly found pathogens. It also exhibited effective inhibition of bacterial growth in areas where the coating had been removed. The research shows the feasibility of modulating the release of selenium nanoparticles from the coating and confirms their superior biocompatibility compared to silver nanoparticles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Kardelen Ecevit, Eduardo Silva, Luisa C. Rodrigues, Ivo Aroso, Alexandre A. A. Barros, Joana M. M. Silva, Rui L. L. Reis
Summary: In this study, the surface of polyurethane (PU) ureteral stents was functionalized with chitosan-fatty acid (CS-FA) derivatives to prevent bacterial colonization. The modified stents showed improved antibacterial performance against Gram-negative bacteria. These findings suggest the potential use of CS-FA derivatives for surface functionalization of medical devices.
Article
Biotechnology & Applied Microbiology
Michael Worth Calfee, Shawn P. Ryan, Ahmed Abdel-Hady, Mariela Monge, Denise Aslett, Abderrahmane Touati, Michael Stewart, Susan Lawrence, Kristen Willis
Summary: This study evaluated the effectiveness of antimicrobial coatings on reducing virus concentration on stainless steel surfaces, finding some products initially reducing phi 6 virus concentration, but without a direct correlation between active ingredient or concentration and efficacy. Peel and stick films and copper alloys showed efficacy in initial testing, but spray-based products lost efficacy after abrasion, with only one polymeric film retaining efficacy in durability testing. More research and development is needed to understand effective formulations with sufficient durability as supplements to routine cleaning and disinfection.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Minchen Mu, Xunhao Wang, Matthew Taylor, Alejandro Castillo, Luis Cisneros-Zevallos, Mustafa Akbulut, Younjin Min
Summary: Bacterial fouling and biofilm formation leading to infections have significant global impact and economic ramifications. Previous coating strategies for inhibiting bacterial adhesion had limitations. To advance the state-of-art, emerging trends focus on multifunctional coatings or interfacial materials that combine antibacterial, antifouling, and anticontact effects.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Katrina Browne, Rajesh Kuppusamy, Renxun Chen, Mark D. P. Willcox, William R. Walsh, David StC Black, Naresh Kumar
Summary: Prevention and treatment of biofilm-mediated infections on medical devices are still unmet clinical needs. This study presents a versatile and simple polydopamine surface coating technique using a new class of antibiotics-antimicrobial peptidomimetics to prevent biofilm formation on implantable medical devices. The study assessed the anti-biofilm activity of peptidomimetics, characterizes their surface chemistry, quantifies their antibacterial activity, and evaluates the biocompatibility of the coated materials. Results showed that the peptidomimetic coatings completely eradicated S. aureus on surfaces and had variable activity against Gram-negative bacteria. The study provides a simple and effective antibacterial coating strategy for biomaterials to reduce biofilm-mediated infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Guillem Ferreres, Kristina Ivanova, Ivan Ivanov, Tzanko Tzanov
Summary: Biofilms are a major global health concern, responsible for the majority of nosocomial infections and leading to prolonged hospitalization and increased healthcare costs. They are organized assemblages of cells held together by a self-produced extracellular matrix, providing enhanced resistance to antibiotics and promoting the horizontal transfer of antibiotic resistance genes. Novel antibiotic-free approaches, such as quorum-quenching, EPM degradation, and bactericides, are being developed to combat biofilm infections. Nanoformulations offer advantages in terms of improved penetration and antibacterial efficacy, and they can be used as colloid suspensions or coatings on medical devices to reduce the incidence of biofilm-related infections.
Review
Environmental Sciences
Anny Leudjo Taka, Elvis Fosso-Kankeu, Eliazer Bobby Naidoo, Xavier Yangkou Mbianda
Summary: This paper discusses the improvement of conventional water treatment methods using nanotechnology, introduces the use of biopolymer-inorganic nanoparticle composites as antimicrobial compounds for water disinfection, and elaborates on their antimicrobial mechanism and microbial properties affecting their activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Microbiology
Alba Rubio-Canalejas, Aida Baelo, Sara Herbera, Nuria Blanco-Cabra, Marija Vukomanovic, Eduard Torrents
Summary: Studied the relationship between P. aeruginosa and S. aureus and its effect on antimicrobial treatment, and found that functionalized silver nanoparticles can improve antibiotic therapy. Proposed a clinical treatment combining antibiofilm enzymes and antibiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Mengjing Fu, Yijing Liang, Xue Lv, Chengnan Li, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: Bacterial infections associated with biomedical devices and implants pose a significant challenge to global healthcare systems, with bactericidal and antifouling hydrogel coatings emerging as promising strategies to prevent biofilm formation. Various chemical approaches have been developed for immobilizing hydrogels on surfaces, offering potential for both antimicrobial and antifouling activities in future clinical applications.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Microbiology
Di Wang, Timothy D. Hall, Tingyue Gu
Summary: NiMo and NiMo with embedded CeO2 nanoparticles coatings demonstrated enhanced antimicrobial properties and corrosion resistance, making them suitable for heat exchanger applications.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Duygu Kisla, Gokhan Gurur Gokmen, Gulsun Akdemir Evrendilek, Tamer Akan, Tomas Vlcko, Piotr Kulawik, Anet Rezek Jambrak, Fatih Ozogul
Summary: The recent development of nanotechnology has led to the development of surface coatings containing various nanoparticles, which can reduce or eliminate microbiological threats without continuous disinfection. This review describes the deposition techniques, mechanisms of actions, potential applications, and environmental concerns of antimicrobial coatings containing nanoparticles.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Ki Joon Heo, Dong Uk Lee, Jae Hak Shin, Junghun Park, Byeong Jin Lee, Juhun Shin, Sang Bin Jeong, Gi Byoung Hwang, Alexander J. MacRobert, Ivan P. Parkin, Jae Hee Jung, Dong Yun Choi
Summary: This study presents a transparent and visible light-activated antibacterial surface material that can effectively inhibit healthcare-associated infections. The material utilizes a sol-gel and a visible light-activated photosensitizer to generate a photochemical antibacterial effect against different types of bacteria. It demonstrates excellent mechanical stability and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Chemical
Martina Muskovic, Ivana Gobin, Nela Malatesti
Summary: Research suggests that current water disinfection methods are not effectively controlling opportunistic premise plumbing pathogens (OPPPs). Photodynamic inactivation (PDI), a method that utilizes photosensitizers, light, and oxygen, shows promise in combating these pathogens, but further research and development are needed.
Article
Chemistry, Physical
Song Xue, Jian Shang, Xiuhao Pu, Hao Cheng, Luojiang Zhang, Chenchen Wang, Chun-Sing Lee, Yongbing Tang
Summary: In this study, a dual anionic (N and Se) doping strategy was used to prepare Co9S8 (N,Se-Co9S8) as an anode material for sodium-ion batteries. The N doping increased the electron density of Co9S8, while the Se doping expanded the lattice spacing and lowered the Co-S binding energy. The synergistic combination of N and Se enabled Co9S8 to exhibit high conductivity, good Na+ affinity, and effective Na+ diffusion, resulting in fast reaction kinetics and stable performance during charging/discharging.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Physical
Tianxing Kang, Chenchen Wang, Xiaoyang Zhao, Zhiqiang Guan, Dong Shen, Tianyi Song, Yan Wu, Fan Zhang, Yongbing Tang, Zhongqiu Tong, Chun-Sing Lee
Summary: The research team has developed an electrochemically inert and catalytic sp2c-COF separator to stabilize Li plating/stripping and accommodate high mass loadings of cathode in future high energy-density rechargeable batteries with Li metal anodes (LMAs). The nano-pores of sp2c-COF enable homogeneous Li+ flux and its electrochemical inertness prevents side reactions. The cyano-groups on sp2c-COF are critical for generating an inorganic-rich solid electrolyte interphase. Li symmetrical cells demonstrate excellent Li plating/stripping behaviors, and full batteries assembled with LiCoO2 and LiNi0.8Co0.1Mn0.1O2 cathodes show impressive areal capacities. This work provides an important strategy for the stabilization of LMA in rechargeable batteries.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Bifa Ji, Jiali Gou, Yongping Zheng, Xiuhao Pu, Yehai Wang, Pinit Kidkhunthod, Yongbing Tang
Summary: It is demonstrated that the dynamic coordination network can activate the commonly inactive ionic sites for the oxygen reduction reaction (ORR) by turning them into platinum-like catalytic centers. A macrocyclic ligand coordinated yttrium single-atom moiety is identified, which exhibits a high half-wave potential in alkaline media, similar to that of the commercial Pt/C catalyst.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lei Wang, Bifa Ji, Yongping Zheng, Yongbing Tang
Summary: This study presents the theoretical prediction and experimental realization of an asymmetrically coordinated iridium single-atom catalyst for the formic acid oxidation reaction. Theoretical calculations show that the substitution of nitrogen with oxygen in the symmetric IrN4 motif can moderate the binding strength of key intermediates and achieve near-zero overpotential. The as-designed catalyst exhibits significantly higher mass activity compared to state-of-the-art Pd/C and Pt/C catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Chen Wang, Song Xue, Xin Lei, Jianfeng Wen, Xianwen Pan, Fan Zhang, Caineng Zou, Yongbing Tang
Summary: The structure design of carbon materials, such as heteroatom doping, is an effective strategy for developing high-performance sodium-ion battery (SIB) anodes. The amidation structure design approach, using mesocarbon microbead (MCMB) as a low-cost production process, achieved enlarged interlayer distances and rich -CONH2 active sites, resulting in remarkable electrochemical performance and potential for commercial production. The amidated MCMB (MCMBO-NH2) anode exhibited high specific capacity, retention rate, and stability, leading to a high energy density and excellent capacity retention rate in the symmetric sodium-ion full cell.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Green & Sustainable Science & Technology
Xin Lei, Qingyun Tang, Yongping Zheng, Pinit Kidkhunthod, Xiaolong Zhou, Bifa Ji, Yongbing Tang
Summary: This study presents a carbon catalyst design with embedded high-entropy 3d transition metal single atoms, which exhibits superior catalytic activities in the oxygen reduction and evolution reactions compared to commercial Pt/C and RuO2 catalysts in an alkaline environment. This design principle provides a sustainable solution for critical green technologies such as fuel cells, batteries, and water splitting.
NATURE SUSTAINABILITY
(2023)
Review
Electrochemistry
Qirong Liu, Qiqi Chen, Yongbing Tang, Hui-Ming Cheng
Summary: Solid-state lithium-metal batteries (SLMBs) are considered as one of the most promising next-generation devices due to their potential high safety, high energy density, and simple packing procedure. However, the practical applications of SLMBs are restricted by various static and dynamic interfacial issues. This article comprehensively summarizes the static and dynamic failure mechanisms at interfaces between solid electrolytes (SEs) and electrodes, discusses design strategies for excellent interfacial properties, and provides possible research methodologies to tackle these issues.
ELECTROCHEMICAL ENERGY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Zheng-Jie Chen, Jiuyi Dong, Jiajing Wu, Qiting Shao, Na Luo, Minwei Xu, Yuanmiao Sun, Yongbing Tang, Jing Peng, Hui-Ming Cheng
Summary: This study reports an acidic hydrogen production system that combines anodic ascorbic acid electrooxidation with cathodic hydrogen evolution. Using Fe single-atom catalysts, the highly active enol structure in ascorbic acid allows for ultralow overpotential and high Faraday efficiency for hydrogen production. The fabricated two-electrode membrane-free electrolyser achieves industrial-scale hydrogen production from biomass with reduced electricity consumption.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Min Wang, Qirong Liu, Guangming Wu, Jianmin Ma, Yongbing Tang
Summary: Researchers developed coral-like carbon nanowires doped with nitrogen as a binder-free anode material for potassium-based dual-ion batteries. The unique porous nanostructure and amorphous/short-range-ordered composite feature of the carbon nanowires enhance structural stability, facilitate ion transfer, and improve active site utilization. The anode exhibits diffusive behavior and capacitive adsorption, delivering a high capacity of 276 mAh g-1 at 50 mA g-1, good rate capability up to 2 A g-1, and long-term cycling stability with 93% capacity retention after 2000 cycles at 1 A g-1. Assembling this anode with an environmentally benign cathode yields a potassium-based dual-ion battery with high specific capacity, excellent rate capability, and long-term cycling stability.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Caiyun Chang, Sanlue Hu, Titi Li, Fanbin Zeng, Dun Wang, Songde Guo, Minwei Xu, Guojin Liang, Yongbing Tang, Hongfei Li, Cuiping Han, Hui-Ming Cheng
Summary: The construction of a stable solid-electrolyte interphase (SEI) on the zinc anode using a ternary aqueous electrolyte with DMTFA and DMF has been developed in this study. The gradient SEI layer formed provides excellent structural integrity, prevents direct contact between water and the zinc anode, and exhibits high compression modulus and electron-insulating feature. AZIBs with the gradient SEI demonstrate ultra-long cycling stability and high utilization rate under harsh conditions.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Chong Chen, Wenjiao Yao, Yongbing Tang
Summary: Sodium-metal batteries (SMBs) are considered crucial for next-generation energy storage due to their high theoretical energy and potential cost-effectiveness. This article provides a detailed explanation of the degradation mechanisms and highlights recent advances in improving the electrochemical performance of SMBs. The strategies discussed include the use of 3D conductive skeletons, protective layers, compatible electrolyte systems, and alloy anodes. The challenges and potential development directions for SMBs are also discussed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Bin Tang, Yike Wei, Rui Jia, Fan Zhang, Yongbing Tang
Summary: High-loading electrodes are crucial in designing practical high-energy batteries, but face challenges such as sluggish ion diffusion and electron conduction kinetics, as well as volume expansion. This review thoroughly discusses these challenges and summarizes solutions including doping and structural design.
Review
Chemistry, Multidisciplinary
Yuanqi Lan, Xinke Li, Guangmin Zhou, Wenjiao Yao, Hui-Ming Cheng, Yongbing Tang
Summary: Recycling cathode materials from spent lithium-ion batteries is crucial for sustainability. Direct regeneration methods offer a non-destructive and efficient way to obtain high-performance cathodes, reducing energy consumption and carbon footprint. This review discusses the development of direct regeneration and introduces various methods and studies on repairing and upgrading cathodes.
Article
Chemistry, Multidisciplinary
Liyu Zhou, Rui Yang, Siqi Xu, Xin Lei, Yongping Zheng, Jianfeng Wen, Fan Zhang, Yongbing Tang
Summary: This study reveals the critical role of saccharide additives in regulating reversible zinc plating/stripping chemistry. By continuously modulating the solvation structure of zinc ions and forming a molecular adsorption layer, saccharide additives enable uniform zinc deposition and improve cycling stability and lifespan.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Hongjin Wang, Shuangqing Zhou, Tao Wang, Zhiye Zhou, Yanggen Huang, Stephan Handschuh-Wang, Hongyu Li, Ying Zhao, Yongbing Tang
Summary: Hierarchical micro-/nano structured boron-doped diamond (BDD) electrodes were designed and synthesized to achieve efficient antifouling and water treatment. The BDD-coated electrodes demonstrated excellent antibacterial properties and reduced chemical oxygen demand, indicating their great potential for long-term water purification.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
