Article
Environmental Sciences
Weiqi Liu, Qingui Zhang, Weiling Liu, Cuiqing Qiu
Summary: This retrospective cohort study investigated the association between air pollutant exposure and gestational diabetes mellitus (GDM) in pregnant women. The study found that different trimester exposures to various air pollutants were either positively or negatively associated with GDM. The correlation between air pollutants and GDM was not consistent across all trimesters, possibly due to interactions with other factors during pregnancy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Immunology
Andrea E. Cassidy-Bushrow, Charlotte Burmeister, Johnna Birbeck, Yalei Chen, Lois Lamerato, Lawrence D. Lemke, Jia Li, Gil Mor, Brendan F. O'Leary, Rosalind M. Peters, John J. Reiners Jr, F. Gianluca Sperone, Judy Westrick, Evan Wiewiora, Jennifer K. Straughen
Summary: The study found an association between ambient BTEX exposure and mid-pregnancy inflammation in African-American women, indicating a potential mechanism through which preterm birth may occur. Furthermore, results showed that both first trimester and mid-pregnancy BTEX exposure were linked to increases in IL-1 beta and tumor necrosis factor-alpha levels.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Environmental Sciences
Liyi Zhang, Pengpeng Wang, Yuhan Zhou, Yukai Cheng, Jialin Li, Xirong Xiao, Chuanmin Yin, Jiufeng Li, Xia Meng, Yunhui Zhang
Summary: This study found that gestational exposure to ozone is associated with an increased risk of gestational diabetes mellitus (GDM) and disrupted glucose homeostasis in pregnant women. There is a concentration-response relationship, and the critical window for the effects of ozone exposure on GDM development is identified as weeks 5-10 of gestation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Maayan Yitshak Sade, Liuhua Shi, Elena Colicino, Heresh Amini, Joel D. Schwartz, Qian Di, Robert O. Wright
Summary: Long-term exposure to air pollution, especially PM2.5 and NO2, is associated with an increased risk of type 2 diabetes. The study shows that even at levels below the national ambient air quality standards set by the U.S. EPA, PM2.5 and NO2 are still associated with an increased risk of diabetes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Andrew D. Williams, Jenna Kanner, Katherine L. Grantz, Marion Ouidir, Shanshan Sheehy, Seth Sherman, Candace Robledo, Pauline Mendola
Summary: Pregnant women with type 1 diabetes may be at greater risk for adverse outcomes when exposed to air pollution than women without autoimmune disease, suggesting a vulnerability to pollution-associated risks during pregnancy.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Peien Zhou, Wangjian Zhang, Yu-Jie Xu, Ru-Qing Liu, Zhengmin Qian, Stephen Edward McMillin, Elizabeth Bingheim, Li-Zi Lin, Xiao-Wen Zeng, Bo-Yi Yang, Li-Wen Hu, Wen Chen, Gongbo Chen, Yunjiang Yu, Guang-Hui Dong
Summary: The study found that long-term exposure to ozone may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD) among children. After adjusting for covariates, each increase in ozone concentration was linked to a higher risk of ADHD, ADHD-T, and ADHP. Furthermore, longer exercise time and breastfeeding may reduce the risk of ADHD.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Henry Lee, Christian P. Andersen, Peter A. Beedlow, David T. Tingey, Seiji Koike, Jean -Jacques Dubois, S. Douglas Kaylor, Kristopher Novak, R. Byron Rice, Howard S. Neufeld, Jeffrey D. Herrick
Summary: This study examines the biomass response of 16 tree species native to western and eastern North America to elevated levels of ambient O3. The results provide a reference set of parameters for assessing the risk of biomass loss due to O3 exposure and can aid in estimating biomass losses in North America. The study highlights the sensitivity of certain species to O3 exposure and emphasizes the ecological importance of these species.
ATMOSPHERIC ENVIRONMENT
(2022)
Article
Environmental Sciences
William B. Patterson, Elizabeth Holzhausen, Bridget Chalifour, Jesse Goodrich, Elizabeth Costello, Frederick Lurmann, David V. Conti, Zhanghua Chen, Lida Chatzi, Tanya L. Alderete
Summary: This study found that exposure to ambient air pollution may contribute to abnormal lipid profiles and increased risk of NAFLD among young adults through altered expression of microRNAs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Zhaoyang Pan, Xueyan Han, Man Cao, Jian Guo, Dengmin Huang, Wei Sun, Jiarun Mi, Yuanli Liu, Tao Xue, Tianjia Guan
Summary: This study aimed to investigate the association between short-term exposure to ambient ozone (O3) and electrocardiogram (ECG) abnormalities. The results showed that for every 10 μg/m3 increase in short-term O3 concentration, the odds ratio of any ECG abnormality increased by 1.055. A sublinear relationship was observed between acute O3 exposure and risk for ECG abnormalities. The study emphasizes the urgent need for controlling ambient O3 pollution to prevent cardiovascular events.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Alaa Taha-Khalde, Alon Haim, Isabella Karakis, Sagi Shashar, Ron Biederko, Alexandra Shtein, Eli Hershkovitz, Lena Novack
Summary: The study suggests that exposure to high levels of ozone and solar radiation during gestation may be related to Type 1 diabetes, but more scientific evidence is needed to support this finding.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Ulla Arthur Hvidtfeldt, Jie Chen, Sophia Rodopoulou, Maciej Strak, Kees de Hoogh, Tom Bellander, J. orgen Brandt, Francesco Forastiere, Boel Brynedal, Ole Hertel, Barbara Hoffmann, Klea Katsouyanni, Matthias Ketzel, Karin Leander, Patrik K. E. Magnusson, Gabriele Nagel, Goran Pershagen, Debora Rizzuto, Evangelia Samoli, Rina So, Massimo Stafoggia, Anne Tj Onneland, Gudrun Weinmayr, Kathrin Wolf, Emanuel Zitt, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
Summary: This study assessed the association between residential exposure to air pollution and multiple myeloma. The results showed no significant association between long-term ambient air pollution exposure and the incidence of multiple myeloma.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Chengyi Lin, Yiqun Ma, Riyang Liu, Yanchuan Shao, Zongwei Ma, Lian Zhou, Yuanshu Jing, Michelle L. Bell, Kai Chen
Summary: Previous studies on acute health effects of ozone have mainly focused on urban areas due to the lack of air pollutant measurements in rural areas. This study estimated the daily maximum 8-hour average ozone concentration in Jiangsu Province, China from 2015 to 2018 and found that short-term ozone exposure is associated with adverse health effects for both urban and rural residents.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Xiuyu Cao, Xiaojie You, Dongming Wang, Weihong Qiu, You Guo, Min Zhou, Weihong Chen, Xiaokang Zhang
Summary: A study in Ganzhou, China found that there are significantly positive associations between ambient ozone levels and hospitalizations for circulatory diseases, including hypertension, coronary heart disease, cerebrovascular disease, and heart failure. The risk of hospitalization increased with each 10 mu g/m3 increase in ozone concentration. These associations remained significant after adjusting for other air pollutants and varied in different seasons, genders, and age groups.
Article
Pediatrics
Wanting Huang, Jinzhun Wu, Xiaoliang Lin
Summary: Exposure to low concentrations of ozone increases the risk of asthma attacks in children, especially when the ozone concentration exceeds 80 μg/m(3).
FRONTIERS IN PEDIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Margaux Sanchez, Carles Mila, V Sreekanth, Kalpana Balakrishnan, Sankar Sambandam, Mark Nieuwenhuijsen, Sanjay Kinra, Julian D. Marshall, Cathryn Tonne
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2020)
Article
Multidisciplinary Sciences
Sun-Young Kim, Matthew Bechle, Steve Hankey, Lianne Sheppard, Adam A. Szpiro, Julian D. Marshall
Article
Environmental Sciences
Carles Mila, Ariadna Curto, Asya Dimitrova, V. Sreekanth, Sanjay Kinra, Julian D. Marshall, Cathryn Tonne
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Immunology
Jared J. Eddy, Kavita M. Gadani, Andrew Tibbs, John Bernardo, Jennifer Cochran, Laura F. White, C. Robert Horsburgh, Karen R. Jacobson
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Medicine, Research & Experimental
Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura F. White, Joseph P. Mizgerd
Summary: The study suggests that individuals with prior endemic coronavirus infections were tested more frequently for respiratory infections, but had similar rates of acquiring SARS-CoV-2. Additionally, patients with previous endemic coronavirus infections experienced less severe cases of COVID-19.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Anahita Mostaghim, Pranay Sinha, Catherine Bielick, Selby Knudsen, Indeevar Beeram, Laura F. White, Caroline Apovian, Manish Sagar, Natasha S. Hochberg
Article
Oncology
Patricia F. Coogan, Lynn Rosenberg, Julie R. Palmer, Yvette C. Cozier, Yolanda M. Lenzy, Kimberly A. Bertrand
Summary: The study found that heavy use of lye-containing hair relaxers may be associated with increased risk of ER+ breast cancer, while there was no association between conditioner use and breast cancer. However, more consistent results from several studies are needed before concluding the impact of certain hair relaxers on breast cancer development.
Article
Multidisciplinary Sciences
Madison Stoddard, Sharanya Sarkar, Lin Yuan, Ryan P. Nolan, Douglas E. White, Laura F. White, Natasha S. Hochberg, Arijit Chakravarty
Summary: The effectiveness of vaccines and the level of population compliance are crucial for controlling the spread of COVID-19. Only with highly effective vaccines and comprehensive measures to suppress virus transmission implemented simultaneously can complete control of SARS-CoV-2 be achieved.
Article
Biochemical Research Methods
Tenglong Li, Laura F. White
Summary: Interventions for controlling infectious diseases are often evaluated using surveillance data, but reporting delays can lead to misleading conclusions. This paper presents a method to estimate disease progression and transmission capabilities, providing a more accurate assessment of the implementation of control measures.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tara Carney, Jennifer A. Rooney, Nandi Niemand, Bronwyn Myers, Danie Theron, Robin Wood, Laura F. White, Christina S. Meade, Novel N. Chegou, Elizabeth Ragan, Gerhard Walzl, Robert Horsburgh, Robin M. Warren, Karen R. Jacobson
Summary: This study aims to assess the rate of TB exposure, risk of disease progression, and disease burden among people who use illicit drugs (PWUDs). It also aims to evaluate mechanisms for accelerated TB transmission in this population by examining illicit drug use networks.
Article
Multidisciplinary Sciences
Wenrui Li, Katia Bulekova, Brian Gregor, Laura F. White, Eric D. Kolaczyk
Summary: This study investigates the propagation of identification errors in estimating the local time-varying reproduction number of infectious diseases and proposes a Bayesian framework for estimating the true reproduction number when identification errors exist.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Biochemical Research Methods
Zhenwei Zhou, Eric D. Kolaczyk, Robin N. Thompson, Laura F. White
Summary: The reproductive number is an important metric for measuring the infectiousness of communicable diseases. A statistical method that incorporates human mobility to estimate region-specific reproductive numbers has been developed. Simulation studies and real-life applications have shown that this method can accurately estimate reproductive numbers for specific regions.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Oncology
Lauren E. Barber, Trang VoPham, Laura F. White, Hemant K. Roy, Julie R. Palmer, Kimberly A. Bertrand
Summary: Results from the Black Women's Health Study suggest that long-term night shift work may increase the risk of colorectal cancer in Black women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Immunology
Debra Van Egeren, Madison Stoddard, Laura F. White, Natasha S. Hochberg, Michael S. Rogers, Bruce Zetter, Diane Joseph-McCarthy, Arijit Chakravarty
Summary: The emergence of immune-evading viral variants of SARS-CoV-2 raises concerns about relying solely on vaccines for managing the COVID-19 pandemic. A computational study suggests that transmission rate of intermediate mutants affects the appearance of new immune-evading variants. Vaccination can lower the emergence rate, but other interventions to reduce transmission can have a similar effect. Widespread and repeated vaccination alone is insufficient to prevent the emergence of novel immune-evading strains if transmission rates remain high.
Article
Immunology
Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan, Dean Bottino, Greg Hather, Natasha S. Hochberg, Laura F. White, Arijit Chakravarty
Summary: SARS-CoV-2 vaccinations initially reduce severe disease and death, but neutralizing antibody (nAb) binding titers decrease due to PK waning and viral evolution. There is also heterogeneity in nAb response among individuals. A personalized booster strategy is proposed, considering individual differences in a PK/PD model to predict vaccinal protection variabilities. Viral evolution will reduce vaccinal protection, especially for individuals with less durable immune response. More frequent boosting may restore protection for those with weaker immune response. The ECLIA RBD binding assay predicts neutralization efficacy and could be a tool for assessing individual immunity. Vaccinal protection is not assured and a potential path forward for reducing risk to vulnerable individuals is identified.