Article
Environmental Sciences
Emmanuel Sunday Okeke, Timothy Prince Chidike Ezeorba, Guanghua Mao, Yao Chen, Weiwei Feng, Xiangyang Wu
Summary: Nanotechnology is a rapidly developing technology that will have a significant impact on product development. It is already being used in cosmetic, healthcare, and food industries, with potential benefits for food security, packaging, and disease detection. However, there is still limited understanding regarding the safety implications of applying nanotechnologies to agriculture and food production, highlighting the need for further research and regulatory measures.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Farooq Ahmad, Samar A. Abubshait, Haya A. Abubshait
Summary: Engineered nanomaterials (ENM) are extensively used in various industries due to their superior properties. These materials can enter the human body through different exposure routes, causing metabolic dysregulation. Advances in metabolomics technology allow us to study the metabolic disturbances induced by ENM.
Review
Engineering, Environmental
Andrea Carboni, Danielle L. Slomberg, Mohammad Nassar, Catherine Santaella, Armand Masion, Jerome Rose, Melanie Auffan
Summary: Mesocosms have emerged as a useful tool for studying the environmental impacts of engineered nanomaterials over the past decade. Study results show that mesocosm size, experiment duration, and indoor/outdoor location play major roles in defining the distribution of ENMs/metals. While benthic communities may face higher exposure levels, planktonic organisms are generally exposed to lower concentrations of potentially more reactive and toxic ENM species.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raisibe Florence Lehutso, James Wesley-Smith, Melusi Thwala
Summary: The study investigated the toxicity effects of 'form specific' engineered nanomaterials (ENMs) and ions released from nano-enabled products (NEPs) on various organisms, finding that both ENMs and ions contributed to the effects to varying extents. Daphnia magna and Spirodela polyrhiza were the most and least sensitive test organisms, respectively. The most toxic effects were from ENMs and ions released from sanitisers and sunscreens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Public, Environmental & Occupational Health
Seth McCormick, Mamadou Niang, Matthew M. Dahm
Summary: This review consolidates exposure assessment methods for occupational research on engineered nanomaterials (ENMs) within the past 5 years, highlighting the most commonly used materials and methods, emphasizing the importance of combining online and offline instruments and analyses, and pointing out the lack of consensus methods for offline analyses of most ENMs.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Michal Macko, Jan Antos, Frantisek Bozek, Jiri Konecny, Jiri Huzlik, Jitka Hegrova, Ivo Kuritka
Summary: This paper aims to enhance the EPA health risk assessment by incorporating two new variables that consider the size of nanoparticles: the toxicity multiplier and the size multiplier. A case study was performed to observe the impact of the new variables on the assessed cadmium concentration. The proposed method with adjustments resulted in a significantly higher risk value compared to the current state-of-the-art method, with nanoparticles contributing to 88% of the total risk value.
Article
Nanoscience & Nanotechnology
Melanie Kah, Linda J. Johnston, Rai S. Kookana, Wendy Bruce, Andrea Haase, Vera Ritz, Jordan Dinglasan, Shareen Doak, Hemda Garelick, Vladimir Gubala
Summary: Nanopesticides are advancing in research and development and appearing on the market, prompting the need for a comprehensive framework and guidance for human health risk assessments. The study suggests adapting existing pesticide frameworks, identifying relevant nanopesticide entities and their concentrations, and addressing additional data requirements based on the nature of the nanopesticides. The tiered approach proposed in the framework aims to support regulators and industry in making informed decisions on nanopesticide submissions.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Andrea Spinazze, Carolina Zellino, Francesca Borghi, Davide Campagnolo, Sabrina Rovelli, Marta Keller, Giacomo Fanti, Andrea Cattaneo, Domenico M. Cavallo
Summary: In this study, a probabilistic approach was used to assess the occupational risk of carbon nanotubes (CNTs). Different work events related to the production of conductive films were analyzed for exposure, with the manufacturing of SWCNT film without LEV showing a statistically significant level of occupational risk.
Article
Biotechnology & Applied Microbiology
Haniyeh Nikokherad, Abbas Esmaili-Sari, Ali Mashinchian Moradi, Nader Bahramifar, Pargol Ghavam Mostafavi
Summary: This study investigated the bioaccumulation capacity of Chlorella vulgaris and Spirulina platensis exposed to silver nanoparticles (AgNPs) and silver nitrate (AgNO3). The results showed that S. platensis could largely bioaccumulate silver nanoparticles while C. vulgaris greatly absorbed ionic silver (AgNO3). Both microalgae showed a concentration-dependent response to silver materials. AgNO3 had a significant impact on the average specific growth and yield of algal populations, and the content of pigments decreased in response to both forms of silver, with the highest severity observed for AgNO3.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Biophysics
Ana Maria Salazar-Bryam, Ingrid Yoshimura, Larissa Provasi Santos, Cinthia Cristine Moura, Caio Carvalho Santos, Vinicius Luiz Silva, Roberta Barros Lovaglio, Rodrigo Fernando Costa Marques, Miguel Jafelicci Junior, Jonas Contiero
Summary: This study utilized rhamnolipids produced from glycerol to stabilize silver nanoparticles and found that different pH values during synthesis of silver nanoparticles in the presence of rhamnolipids directly influence nanoparticle size and stability. The results indicated that increasing pH enhanced the stability of silver nanoparticles and larger particles were formed at lower pH values.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Engineering, Environmental
Ashiq Ahamed, Lili Liang, Ming Yang Lee, Johan Bobacka, Grzegorz Lisak
Summary: Engineered nanomaterials (ENMs) are a novel class of materials with superior physicochemical properties compared to conventional materials, but can potentially release into the environment and pose toxic effects. Research focuses on the transformations and potential risks of ENMs in consumer products, aiming to ensure their safe application.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yingzhu Li, Enda Cummins
Summary: This study conducted a risk assessment for the potential human health risk resulting from AgNPs released during crop production. The study found that the simulated exposure to AgNPs through consumption of crops is below the reference dose, indicating no potential hazardous effects. However, irrigation has a dominant impact on the risk assessment, especially through the consumption of leafy vegetables in Europe.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Chemistry, Multidisciplinary
Nathaniel J. Clark, Robert Clough, David Boyle, Richard D. Handy
Summary: The research used single particle inductively coupled plasma mass spectrometry to detect the content of particulate silver in fish, and found that particulate silver was present in the hind intestine in all treatment groups.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Environmental Sciences
Hyunjoo Hong, Veronique Adam, Bernd Nowack
Summary: This study conducted an environmental risk assessment of 3 ENMs using a form-specific release model and ecotoxicological data analysis, showing that the form-specific approach can influence the assessment of environmental risks of ENMs.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Environmental Sciences
Rosember Ramirez, Vicenc Marti, R. M. Darbra
Summary: This paper proposes a new model for assessing ecosystem risk in rivers and wetlands caused by accidental spills of silver nanoparticles in soil/groundwater. The model combines Monte Carlo and fuzzy logic methodologies to deal with uncertainty in modeling inputs. Two hypothetical case studies of accidental AgNP soil spills in the Llobregat River basin, Barcelona, were evaluated using the new model, showing medium and high risk assessments respectively. A sensitivity analysis was conducted, and the new model was proven to be an improvement compared to other risk assessment methodologies in dealing with uncertain and variable data.
Article
Environmental Sciences
Nina Jeliazkova, Eric Bleeker, Richard Cross, Andrea Haase, Gemma Janer, Willie Peijnenburg, Mario Pink, Hubert Rauscher, Claus Svendsen, Georgia Tsiliki, Alex Zabeo, Danail Hristozov, Vicki Stone, Wendel Wohlleben
Summary: This paper discusses methods for grouping nanoforms and evaluating data similarity, emphasizing the property-by-property evaluation of the data matrix to support grouping. Multidimensional approaches were found to offer unexpected insights from a scientific perspective, but were deemed difficult to use in a regulatory context.
Article
Environmental Sciences
V. Cazzagon, E. Giubilato, L. Pizzol, C. Ravagli, S. Doumett, G. Baldi, M. Blosi, A. Brunelli, C. Fito, F. Huertas, A. Marcomini, E. Semenzin, A. Zabeo, I. Zanoni, D. Hristozov
Summary: The safety assessment of nano-biomedical products is crucial for market authorization and must consider the safety of workers and medical professionals. Limited workplace risk assessments exist for NBMs in medical applications, but using a software-based Decision Support System can help increase knowledge in this area.
Article
Environmental Sciences
Alex Zabeo, Gianpietro Basei, Georgia Tsiliki, Willie Peijnenburg, Danail Hristozov
Summary: The proposed novel procedure for similarity assessment and grouping of nanomaterials is based on various metrics and hierarchical clustering, ensuring robust grouping independent of the dataset used, and a software tool has been developed to facilitate its application.
Article
Environmental Sciences
Georgia Tsiliki, Didem Ag Seleci, Alex Zabeo, Gianpietro Basei, Danail Hristozov, Nina Jeliazkova, Matthew Boyles, Fiona Murphy, Willie Peijnenburg, Wendel Wohlleben, Vicki Stone
Summary: The article presents a novel computational method for comparing dose-response curves of nanoforms and identifying similar nanoforms for toxicity grouping research.
Article
Chemistry, Physical
Biao Li, Xiaolong Cheng, Rusen Zou, Xiaoyu Yong, Chengfang Pang, Yanyan Su, Yifeng Zhang
Summary: The study moderated the Fe sites on carbon nitride to achieve a combination of single atoms and clusters, which enhanced catalytic activity. The research revealed that excessive exposure of the catalyst at high pH may damage the surface environment and inhibit H2O2 activation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Nanoscience & Nanotechnology
Gianpietro Basei, Hubert Rauscher, Nina Jeliazkova, Danail Hristozov
Summary: This manuscript proposes a methodology to assess the completeness and quality of physicochemical and hazard datasets for risk assessment purposes. The unique goal of this approach is to assess data quality in such a way that all the steps are automatized, thus reducing reliance on expert judgment.
Article
Food Science & Technology
Yuyue Zhong, Jinchuan Xu, Xingxun Liu, Li Ding, Birte Svensson, Klaus Herburger, Ke Guo, Chengfang Pang, Andreas Blennow
Summary: Enzymatic modification of gelatinized starch systems is well-documented, but there is a lack of review comparing the effects of granular vs. gelatinized systems. The catalytic efficiency of starch-acting enzymes is higher on amorphous gelatinized starch than on semi-crystalline granular starch, with potential strategies to enhance efficiency on granular starch including engineered granules and increased specific surface area through various pretreatment methods.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Stella Stoycheva, Alex Zabeo, Lisa Pizzol, Danail Hristozov
Summary: This manuscript presents an innovative approach to socio-economic assessment of advanced engineered nanomaterials and nano-enabled products to support safe-and-sustainable-by-design decision-making by industries. The methodology combines social life cycle analysis and multi-criteria decision analysis methods to assess socio-economic impacts over the full life cycle of a product. A user-friendly Excel-based self-assessment tool was developed to facilitate its application by industries.
Article
Instruments & Instrumentation
Alex Zabeo, Fabio Rosada, Lisa Pizzol, Fanny Caputo, Sven Even Borgos, Jeremie Parot, Robert E. Geertsma, Joost Jacob Pouw, Rob J. Vandebriel, Oihane Ibarrola Moreno, Danail Hristozov
Summary: The application of nanomaterials in medicine has great potential, but the translation of these technologies to clinical practice faces challenges. To support the development and clinical implementation of nanotechnology-enabled health products, the REFINE project has developed a Decision Support System (DSS) to assist developers in preclinical assessment and intelligent testing, improving efficiency.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Xianghui Cao, Shouliang Huo, Hanxiao Zhang, Xiaoli Zhao, Chengfang Pang, Chunzi Ma, Jiaqi Zheng, Fengchang Wu
Summary: This study used a Berkeley-Trent model to simulate benzo[alpha]pyrene exposure levels in aquatic ecosystems of coastal regions in China. The results showed that Shanghai and Tianjin had the highest potential human health risk. 80% of coastal areas were potentially affected by BaP contamination, with crustaceans being more sensitive to BaP exposure. Sustainable development strategies can help reduce BaP exposure levels and risks.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Multidisciplinary
Yunsong Mu, Xiang Li, Peihan Chen, Chengfang Pang, Fengchang Wu, John P. Giesy, Huazhen Chang, Fangang Zeng
Summary: Zinc oxide nanoparticles (n-ZnO) are widely used in consumer products due to their antibacterial properties and ability to absorb ultraviolet radiation. However, there is a substantial uncertainty in assessing the health risks associated with n-ZnO due to inadequate data on hazards and exposure. This study used probabilistic approaches to evaluate the uncertainties and risks of n-ZnO to the health of males and females. The results showed minimal risk through oral exposure, but a significant percentage of exposure scenarios through dermal exposure exceeded acceptable risk levels. The findings highlight the need for further research on hazard and exposure assessments of nanotechnologies.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Business
Michele Molin, Lisa Pizzol, Marco Pesce, Alessandro Maura, Matteo Civiero, Elisa Gritti, Simone Giotto, Alberto Ferri, Lorenzo Liguoro, Carlo Bagnoli, Elena Semenzin
Summary: This paper introduces a tool called Sustainable Development Decision-Making Framework (SDMF), which aims to help companies identify personalized and strategic paths for sustainable development. The framework supports companies in assessing material issues and externalities, adopting and implementing sustainability, and reporting non-financial externalities. Additionally, a morphological matrix has been developed to assist companies in selecting the most suitable methodologies.
CORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT
(2023)
Article
Immunology
Santosh Pandit, Lucas Jacquemin, Jian Zhang, Zhengfeng Gao, Yuta Nishina, Rikke Louise Meyer, Ivan Mijakovic, Alberto Bianco, Chengfang Pang
Summary: The absorption of antimicrobial peptide polymyxin B onto the surface of graphene oxide significantly enhances its antibacterial activity and can effectively combat bacterial biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Lisa Pizzol, Arianna Livieri, Beatrice Salieri, Lucian Farcal, Lya G. Soeteman-Hernandez, Hubert Rauscher, Alex Zabeo, Magda Blosi, Anna Luisa Costa, Willie Peijnenburg, Stella Stoycheva, Neil Hunt, Maria Jose Lopez-Tendero, Castor Salgado, Julian J. Reinosa, Jose F. Fernandez, Danail Hristozov
Summary: The European Green Deal policy aims to achieve safe and sustainable design of chemicals and materials. The H2020 SUNSHINE project has developed an operational approach to implement safe and sustainable design, focusing on multi-component nanomaterials. This approach enables assessment of safety and sustainability at each stage of product development using qualitative, semi-quantitative, and quantitative methods.
CLEANER ENVIRONMENTAL SYSTEMS
(2023)
Article
Medicine, Research & Experimental
Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Summary: Manufacturing and functionalizing materials at the nanoscale has led to the generation of various nanoforms of substances. Testing every unique nanoform for adverse effects is impossible, thus hypothesis-driven grouping and read-across approaches supported by the GRACIOUS Framework are promising alternatives for efficient risk assessment. The framework enables the assessment of similarity between nanoforms, minimizing the need for new testing and aligning with the 3R principles. The template used to generate GRACIOUS grouping hypotheses and the IATAs provide a structured approach for data gathering, facilitating decision-making.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2023)